1,181 research outputs found

    Integration of quantitative and molecular genetic approaches to improve characteristics associated with pig welfare

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    The aims of this thesis were to investigate whether characteristics associated with animal welfare are genetically and genomically determined by using quantitative and molecular genetic approaches and to develop strategies indicating how these traits could be used in breeding programmes. Two traits that are closely related to animal welfare and associated with high socio-economic values are piglet survival at birth and aggressive behaviour in pigs. Piglet survival traits were analysed based on quantitative Bayesian approaches using phenotypic and pedigree information only, while aggressive behaviour was analysed based on molecular genetic approaches such as genome-wide association studies and genomic selection using additionally a dense panel of single nucleotide polymorphisms (SNP). The latter approach was validated using behavioural traits related to welfare characteristics in a welldocumented mouse data set. Selection for piglet survival at birth is expected to be effective, because all lines and breeds in this thesis showed considerable variation for this trait and relatively high heritabilities, particularly in lines with low average birth weight. Maternal heritabilities of individual birth weight were mostly at moderate magnitude and thus of great interest for selection. The genetic correlations between piglet survival and birth weight indicated that selection for either individual or average birth weight or variation of birth weight within litter would indirectly increase survival. The genetic associations of piglet survival with economically important (re)production traits are of great importance for breeding organisations. Undesirable genetic correlations between piglet survival and (re)production traits were generally of low magnitude, so that simultaneous improvement of all traits could be achieved. A comparison of five breeds and lines showed that differences in genetic parameters between breeds and lines can be substantial and no single selection strategy would be optimal for all. A unique study of a sire and a dam line originating from one breed but selected for more than 25 years with different breeding goals demonstrated how selection pressure can alter the genetic parameters over years. Breeding organisations should therefore consider selection strategies per breed or line individually to achieve maximum overall improvement. This study gives new insight into the use of genomic selection for traits associated with animal welfare. It is one of the first to present estimates for linkage disequilibrium in the pig using a new 60K SNP panel and the first to evaluate the efficiency of genomic selection against aggressive behaviour in pigs. Genomic selection showed a high predictive ability in comparison to traditional polygenic selection. It was especially advantageous for traits with lower heritabilities. In particular in situations where little family information was available, the performance of polygenic selection was low and genomic selection increased the performance considerably. Reducing the number of SNPs did not significantly change the performance of genomic selection. The consistently high performance across models indicates that low-density SNP panels may be sufficient to ensure a high efficiency of genomic selection, thus reducing the high costs associated with genotyping in pig breeding with its short generation interval. To summarize, this thesis has shown how to optimise quantitative and genomic approaches to improve animal welfare related characteristics efficiently in pig breeding programmes

    Coat Cooke & Joe Poole | Coat Cooke & Rainer Wiens: Reviews

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    Coat Cooke album reviews by Randy Raine-Reusch. Coat Cooke (sax); Joe Poole (drums); Rainer Wiens (guitar)

    KOunt : A reproducible KEGG orthologue abundance workflow

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    [EN] Accurate gene prediction is essential for successful metagenome analysis. We present KOunt, a Snakemake pipeline, that precisely quantifies KEGG orthologue abundance.This work was supported by grants from the Biotechnology and Biological Sciences Research Council [BB/S006567/1 and BB/S006680/1].Mattock, J.; Martínez-Álvaro, M.; Cleveland, M.; Roehe, R.; Watson, M. (2023). KOunt : A reproducible KEGG orthologue abundance workflow. Bioinformatics. 39(8). https://doi.org/10.1101/2023.04.27.538265S39

    Robert Rainer and Claud Garner

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    Author Claud Garner, right, autographed copies of his second novel while discussing a tour of other Southwest cities with Robert Rainer, representing his publisher, Creative Age Press. Published in the Fort Worth Star - Telegram morning edition, September 29, 1950.https://mavmatrix.uta.edu/specialcollections_startelegram1950s/6596/thumbnail.jp

    Quantum chemistry of 2D-nanomaterials : investigation of graphene, hBN and α-borophene on SiO2 (001)

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    Author: Felix Rainer Serafin Purtscher, BScMasterarbeit University of Innsbruck 202

    Quantum chemistry of 2D-nanomaterials : investigation of graphene, hBN and α-borophene on SiO2 (001)

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    Author: Felix Rainer Serafin Purtscher, BScMasterarbeit University of Innsbruck 202

    Die politische Religion : Eine Untersuchung über den Ursprung des Verfalls in der Geschichte (1935). Herausgegeben und eingeleitet von Rainer Hering

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    Der vierte Band der "Hamburger Historischen Forschungen" umfasst in erster Linie die Edition eines unveröffentlichten Textes. Autor ist der Theologe Prof. Dr. Dr. Paul Schütz (1891–1985), der von 1940 bis 1952 Hauptpastor an der Hamburger Hauptkirche St. Nikolai war und zugleich als hauptamtlicher Dozent und später als Professor der Theologie an der Kirchlichen Hochschule Hamburg lehrte. Er gehört zu den ersten, die ein Konzept der politischen Religion entwickelten. Sein 1935 verfasster Beitrag konnte damals nicht publiziert werden. Heute ist eine Edition dieses Beitrages zum einen wichtig für die Theologie- und Kirchengeschichte. Zum anderen gibt es seit einigen Jahren in der historischen Forschung eine intensive Diskussion über die in den Dreißigerjahren des 20. Jahrhunderts entwickelte Interpretation des „Dritten Reiches“ als „politische Religion“. Dieses Modell, das Diktaturen, insbesondere den Nationalsozialismus, als „politische Religion“ versteht, wird im Allgemeinen Eric Voegelin und Raymond Aron zugeschrieben, die ihre Ansätze 1938 bzw. 1939 publizierten. Dass Paul Schütz schon drei bzw. vier Jahre zuvor eine solche Konzeption entwickelt hatte, war bis vor Kurzem nicht bekannt. Die vorliegende Edition kann daher neue Impulse für die Debatte über die Geschichte und Tragfähigkeit dieses Ansatzes geben und sie inhaltlich bereichern.The fourth volume of the series "Hamburger Historische Forschungen" comprises primarily the edition of an unpublished text. The author is the theologian Prof. Dr. Dr. Dr. Paul Schütz (1891-1985) who was the main pastor at the Hamburg Main Church St. Nikolai from 1940 to 1952. At the same time he taught as a full-time lecturer and later as professor of theology at the Church University of Hamburg. Schütz was one of the first to develop a concept of political religion. His contribution, written in 1935, could not be published at that time. Today, an edition of this article is important for the history of theology and church history. On the other hand, for some years now there has been an intensive discussion in historical research on the interpretation of the "Third Reich" as a "political religion" developed in the 1930s. This model, which sees dictatorships, especially National Socialism, as a "political religion", is generally attributed to Eric Voegelin and Raymond Aron, who published their approaches in 1938 and 1939 respectively. It was not known until recently that Paul Schütz had already developed such a concept three or four years earlier. The present edition can therefore provide new impetus for the debate on the history and viability of this approach and enrich its content

    Evaluation of a video image analysis system for the prediction of carcass and meat quality in genetic improvement programmes

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    Video Image Analysis (VIA) is a digital camera based technology that extracts relevant information from images using purpose tailored image processing software. In the present work, the VSS2000 image analysis system from E+V Technology GmbH has been used in a large lamb abattoir to determine the value of carcasses in an objective, consistent and automated way. In this thesis results are reported of several experiments conducted within the framework of two UK-funded projects. The aims of the research were (i) the calibration and validation of the VIAtechnique for the evaluation of lamb carcasses under UK abattoir conditions, with the view to scientifically examine the accuracy and precision of information from the VIA systems as the basis for a value-based marketing system, (ii) to investigate the use of VIA measurements (weights of primal meat yields and carcass dimensional measurements) in sheep breeding programmes to improve carcass and meat quality and (iii) to evaluate the potential of this technology to reward increased carcass quality associated with the use of breeding strategies based on the inclusion of a quantitative trait locus (QTL) for improved muscularity. Accuracy, precision and consistency of The Meat and Livestock Commission (MLC) carcass classification scheme, currently used in UK abattoirs to evaluate carcass quality, was compared against the VIA system in the prediction of various primal joint weights. The results highlighted the advantage of the VIA system being on average 2% more accurate (measured as coefficient of determination: R2) and 12% more precise (measured as root meat squared error: RMSE) in predicting weight of primal meat yields (leg, chump, loin, breast and shoulder) of the lamb carcasses than the MLC carcass classification scheme. The genetic analysis of VIA-based predicted primal joint weights showed substantial additive genetic variance, suggesting that their use in sheep breeding programmes could improve carcass quality either by an improvement of conformation or by an increased weight of the most valuable primal cuts, without an increase in fatness. Favourable associations between VIA primal weights and performance traits indicate that selection based on VIA traits is possible without a negative effect on average daily gain, live weight and cold carcass weight. Although computer tomography (CT) and dissection found in related studies significant effects of a Texel muscling-QTL (TM-QTL) for increased muscularity in the loin region, in the present study they could not be identified by both, the current industry carcass evaluation system for conformation and fatness and the VIA system. A calibration of the VIA system against CT measurements resulted in improved VIA prediction equations for primal meat yields and also showed a moderate potential to estimate loin muscle traits measured by CT and to detect partially the effect of the TM-QTL on these traits. The results of the research demonstrated that VIA is a consistent method to measure carcass composition and that it improved the prediction (accuracy and precision) of primal meat yields compared to the present MLC scoring system. The estimated genetic parameters for VIA primal meat yields suggested that selection for increased lean meat yield from lamb carcass measured using VIA can contribute to genetic improvement of carcass quality without increasing carcass fatness. The results suggest that VIA technology installed in abattoirs could provide the means for the development of a value-based marketing system by paying for weights of the most valuable primal cuts measured using VIA

    Dos motius grecs en la poesía de Rainer Maria Rilke

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    The author has located two ideas in the poet Rainer Maria Rilke from his Duineser Elegien, which come up exactly with two other by Plato and one by the arcaic lyric poet Ibycus of Rhegium. The author has found an echo of the first theme in the Elegies de Bierville by the poet Carles Riba
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