1,721,000 research outputs found
Preoperative testing and medical therapy intervention to improve perioperative outcomes in noncardiac surgical patients.
Full text linkIntroduction: Cardiovascular disease is the leading cause of death worldwide and a growing concern in low-and-middle income countries, including those in Africa. Patients with cardiovascular disease often have poorly managed chronic conditions in the African setting, which impacts their outcome when they present for non-cardiac surgery. This cohort has an increased risk of perioperative cardiovascular complications. This series of studies explored evidence-based perioperative cardiovascular management strategies in patients with high-risk cardiac comorbidities presenting for non-cardiac surgery. Methods: This was achieved through five objectives which formed five separate but interconnected research studies. The first objective was to study the approach of natriuretic peptide-directed medical therapy in non-surgical patients to inform development of a preoperative protocol in surgical patients through a systematic review. The second objective was to conduct systematic review on exercise therapy in nonsurgical patients to inform development of a preoperative protocol in surgical patients. The third objective was to define the population who would need optimisation before surgery in the Western Cape, South Africa through a prospective observational study of risk stratification. The fourth objective was to explore the broader applicability of perioperative cardiovascular management of high-risk patients by examining cardiovascular outcomes after surgery on the African continent (a sub-study of a larger African cohort study). The fifth objective was to produce national guidelines on cardiovascular risk stratification in a South African and African surgical population. Main results: The systematic reviews showed potential utility for exercise therapy in the optimisation of cardiac patients for non-cardiac surgery. Medical therapy optimisation guided by natriuretic peptide testing did not demonstrate a consistent reduction in natriuretic peptides, but did support a potential mortality benefit in non-surgical patients. The cohort of cardiac patients presenting for non-cardiac surgery in the Western Cape carries significant cardiac risk and needs perioperative cardiovascular management. This was confirmed by the rate of adverse cardiovascular outcomes reported on the African continent. These data supported the development of context-specific national cardiovascular risk stratification guidelines. Conclusion: The cardiovascular burden and risk for perioperative cardiovascular complications presents a challenge in low- and middle-income countries like South Africa, and more broadly Africa. This is a growing phenomenon which needs the collaborative effort of perioperative physicians and the implementation of evidence-based strategies in perioperative cardiovascular management
INTRAOPERATIVE HEMODYNAMIC PREDICTORS OF EARLY POSTOPERATIVE TROPONIN ELEVATION AND MORTALITY
Full text linkBackground: Myocardial injury after noncardiac surgery (MINS) increases the risk of 30-day mortality. Intraoperative hemodynamic events (i.e., tachycardia, bradycardia, hypotension, and hypertension) may contribute to developing MINS. Objectives: To determine if the addition of the duration spent within predefined intraoperative systolic blood pressure (BP; mmHg) (i.e.,160-199 and ≥200) and heart rate (HR; bpm) (i.e.,100-140 and >140) hemodynamic bands improved the prediction of Day 1 MINS (i.e., postoperative troponin T elevation ≥0.03 ng/ml within the first day after surgery) beyond preoperative risk model prediction. Methods: Prospective observational data was used to developed a baseline risk model to predict Day 1 MINS. Preoperative HR, systolic BP, and hemoglobin as well as intraoperative duration spent within each predefined hemodynamic band were explored to identify optimal thresholds for the prediction of Day-1 MINS. Preoperative variables were added to the baseline risk model to create a preoperative model. Intraoperative variables were then added to the preoperative risk model to create the final model. Models were compared using discrimination (c-statistic) and net reclassification index (NRI). Results: Adding preoperative hemoglobin ≤105 g/dL, systolic BP110 improved baseline model discrimination (0.783 to 0.792, p5min; HR >100 for >147min; systolic BP59min and systolic BP >160 for >42min further improved discrimination (0.8; p Conclusion: Adding intraoperative hemodynamic durations significantly improved Day-1 MINS model discrimination and risk stratification compared to the baseline risk model.Master of Health Sciences (MSc
Letter to the editor: The impact of introducing drug labelling at Grey’s Hospital Theatre over a six-month period
Full text linkNo Abstract
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
- …
