1,721,049 research outputs found
Paediatric follicular lymphoma
No full textPaediatric follicular lymphoma (PFL) is a rare variant of follicular lymphoma accounting for approximately 1%–2% of all paediatric non-Hodgkin lymphomas. PFL shows a male predominance with median age of onset varying from 7.5 to 14 years. PFL most commonly occurs in the head and neck region arising in lymph nodes or lymphoid tissue of Waldeyer's ring; extra-nodal localization is uncommon. Although the optimal clinical management remains unclear, most PFLs are low stage (i.e. localized) disease, and the prognosis is excellent with local excision leading to complete remission in the vast majority of the cases. As a rare lymphoid malignancy molecular and immunophenotypic studies on PFL are limited and both pathogenesis and biology are largely unknown. PFL is characterized by enlarged irregular lymphoid follicles showing high grade (grade 3) histological features. The germinal centres of these follicles are composed predominantly of cells showing “blastoid” morphology, with round to oval nuclei and small nucleoli. In most cases the neoplastic germinal centre cells lack both expression of BCL2 protein and the t(14;18) translocation but approximately one third of the cases can show weak expression of BCL-2 protein and a smaller percentage harbour BCL-2 rearrangements. In the clinical setting PFL has to be distinguished from reactive follicular hyperplasia and paediatric nodal marginal zone lymphoma
PETCT Imaging of Unstable Carotid Plaque with Ga-68 labelled Somatostatin Receptor Ligand.
Full text linkBACKGROUND
Ga68 labelled somatostatin receptor ligand PET imaging has recently been shown in preclinical and early human studies to have a potential role in the evaluation of vulnerable arterial plaques. We prospectively evaluated carotid plaque Ga68-DOTATATE uptake in patients with recent carotid events, assessed inter- and intra- observer variability of such measurements, and explored the mechanism of any plaque DOTATATE activity with immunohistochemistry in resected specimens.
MATERIALS & METHODS
20 consecutively consenting patients with recent symptomatic carotid events (transient ischaemic attack [TIA], stroke or amaurosis fugax), due for carotid endarterectomy were prospectively recruited. Ga68-DOTATATE PET/CT of the neck was performed prior to surgery. Ga68-DOTATATE uptake was measured by drawing regions of interest (ROI) along the carotid plaques and contralateral plaques/carotid arteries by experienced radionuclide radiologist and radiographer. Two PET quantification methods with inter- and Intra-observer variability were assessed. Resected carotid plaques were retrieved for sst-2 immunohistochemical stain.
RESULTS
Median time delay between research PET and surgery was 2days. SUV and TBR values for the symptomatic plaques and the asymptomatic contralateral carotid arteries/plaques show no significant difference (n = 19, p-value >0.10), regardless of quantification method. Intraclass correlation coefficient was >0.8 in all measures of carotid artery/plaque uptake (SUV) and >0.6 in almost all measures of target-to-background ratio (TBR). None of the excised plaques were shown to contain cells (macrophages, lymphocytes, vessel-associated cells) expressing sst2 on their cell membrane.
CONCLUSION
Ga68 DOTATATE activity on PET in recently symptomatic carotid plaques is not significantly different to contralateral carotids/plaques. Any activity seen on PET is not shown to be from specific sst2 receptor-mediated uptake in-vitro. It is therefore unlikely that sst2 PET/CT imaging will have a role in the detection and characterization of symptomatic carotid plaques
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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