3,412 research outputs found
L’universalité dans les phénomènes critiques: Comment parler d'explications émergentes ?
No full textQuentin Rodriguez discusses the nature of standard explanations of the universality of critical phenomena: how do they differ from other physical explanations using mathematical models (ideal gas model, harmonic oscillator model)? In what way can they be described as emergent explanations, as opposed to other types of explanations?Quentin Rodriguez, Doctorant à l’université Clermont-Auvergne (UCA), laboratoire Philosophies et Rationalités (PHIER, EA 3297).Quentin Rodriguez discute la nature des explications standards de l’universalité des phénomènes critiques : en quoi se distinguent-elles d’autres explications physiques mobilisant des modèles mathématiques (modèle du gaz parfait, modèle de l’oscillateur harmonique) ? En quel sens peut-on les qualifier d’explications émergentes, par opposition à d’autres types d’explications
L’universalité dans les phénomènes critiques: Comment parler d'explications émergentes ?
No full textQuentin Rodriguez discusses the nature of standard explanations of the universality of critical phenomena: how do they differ from other physical explanations using mathematical models (ideal gas model, harmonic oscillator model)? In what way can they be described as emergent explanations, as opposed to other types of explanations?Quentin Rodriguez, Doctorant à l’université Clermont-Auvergne (UCA), laboratoire Philosophies et Rationalités (PHIER, EA 3297).Quentin Rodriguez discute la nature des explications standards de l’universalité des phénomènes critiques : en quoi se distinguent-elles d’autres explications physiques mobilisant des modèles mathématiques (modèle du gaz parfait, modèle de l’oscillateur harmonique) ? En quel sens peut-on les qualifier d’explications émergentes, par opposition à d’autres types d’explications
The Role of Environmentally Relevant Concentrations of SSRIs in Human Wound Healing
No full textThis thesis investigates the role of environmentally relevant concentrations of fluoxetine, a commonly prescribed selective serotonin reuptake inhibitor (SSRI), in wound healing. While SSRIs are effective in treating psychiatric conditions, their increasing presence in aquatic environments has raised concerns about unintended biological impacts. SSRI are widely-used antidepressants, and in the UK, antidepressant prescriptions have almost doubled in the past decade (Heald et al., 2021). After ingestion, SSRI are excreted via urine. Wastewater treatment does not remove SSRI effectively, leading to accumulation in freshwater courses (to 0.4-3,645 ng/l), making SSRI priority contaminants in ecotoxicology. Average fluoxetine and sertraline concentrations in England rivers across 2016-2024 were 218 and 15 ng/l, respectively, and up to 2,560 ng/l fluoxetine in post-treatment effluents. Population growth, urbanisation, and regional climate change-induced water scarcity can increase these concentrations. While exposure to environmental SSRI affects the physiology and behaviour of freshwater species, little is known about effects of exposure on human health. My hypothesis was that SSRIs, particularly fluoxetine, at environmentally relevant concentrations promote wound healing through serotonin signalling. To test this hypothesis, here, I investigate the influence of fluoxetine on wound healing models using human keratinocytes and ex-vivo human skin biopsies, assessing its effects on serotonin signalling pathways and cell proliferation.Using a combination of molecular and cell biology techniques, including scratch assays, RNA sequencing (RNAseq), protein microarrays and phosphoproteomics, alongside using an ex-vivo human skin model, I investigated the impact of fluoxetine at environmentally relevant concentrations (62.5-5400 ng/l) on wound closure, cell proliferation, and key signalling pathways. Results showed that fluoxetine increased scratch closure in a dose-dependent manner (by 5% and 20% at 125 and 5400 ng/l of fluoxetine) in keratinocyte models by promoting cell proliferation through serotonin receptor-mediated pathways. RNAseq revealed differential expression of exactly 100 upregulated and 250 downregulated genes involved in cell cycle progression, energy metabolism, cell proliferation, and cellular resilience. Protein microarrays and phosphoproteomics indicated dynamic changes in phosphorylation among key kinases, including GSK3β, MSK1/2, and p70 S6K, with 190 upregulated and 45 downregulated phosphorylated proteins. These proteins showed enrichment in GO terms and KEGG pathways related to cellular structure, stress response, and kinase signalling pathways, particularly in HIPPO and PI3K/AKT signalling. Ex-vivo experiments with human skin validated these findings in a physiologically-relevant model that maintains the wound microenvironment. I observed an increase in wound healing of 30% at 5400 ng/l compared to control biopsies, demonstrating enhanced wound closure upon exposure to environmentally relevant fluoxetine associated with serotonin pathway activation.Human wounds cost the NHS >£8.3 billion/year and new treatments are direly needed. This research underscores both the potential therapeutic applications of low-dose fluoxetine in wound care, and the importance of understanding its effects on healthy skin as anenvironmental pollutant. Together, these findings contribute to a deeper insight into the molecular and phenotypical impact of fluoxetine on human skin, with implications for both clinical and environmental health. My results justify a transition from the study of behavioural effects of environmental fluoxetine in aquatic animals to the investigation of effects of exposure on wound healing in aquatic and terrestrial animals, including direct impacts on human health. I also open avenues to investigate low-dose SSRI as new treatments to promote wound healing
The Role of Environmentally Relevant Concentrations of SSRIs in Human Wound Healing
No full textThis thesis investigates the role of environmentally relevant concentrations of fluoxetine, a commonly prescribed selective serotonin reuptake inhibitor (SSRI), in wound healing. While SSRIs are effective in treating psychiatric conditions, their increasing presence in aquatic environments has raised concerns about unintended biological impacts. SSRI are widely-used antidepressants, and in the UK, antidepressant prescriptions have almost doubled in the past decade (Heald et al., 2021). After ingestion, SSRI are excreted via urine. Wastewater treatment does not remove SSRI effectively, leading to accumulation in freshwater courses (to 0.4-3,645 ng/l), making SSRI priority contaminants in ecotoxicology. Average fluoxetine and sertraline concentrations in England rivers across 2016-2024 were 218 and 15 ng/l, respectively, and up to 2,560 ng/l fluoxetine in post-treatment effluents. Population growth, urbanisation, and regional climate change-induced water scarcity can increase these concentrations. While exposure to environmental SSRI affects the physiology and behaviour of freshwater species, little is known about effects of exposure on human health. My hypothesis was that SSRIs, particularly fluoxetine, at environmentally relevant concentrations promote wound healing through serotonin signalling. To test this hypothesis, here, I investigate the influence of fluoxetine on wound healing models using human keratinocytes and ex-vivo human skin biopsies, assessing its effects on serotonin signalling pathways and cell proliferation.Using a combination of molecular and cell biology techniques, including scratch assays, RNA sequencing (RNAseq), protein microarrays and phosphoproteomics, alongside using an ex-vivo human skin model, I investigated the impact of fluoxetine at environmentally relevant concentrations (62.5-5400 ng/l) on wound closure, cell proliferation, and key signalling pathways. Results showed that fluoxetine increased scratch closure in a dose-dependent manner (by 5% and 20% at 125 and 5400 ng/l of fluoxetine) in keratinocyte models by promoting cell proliferation through serotonin receptor-mediated pathways. RNAseq revealed differential expression of exactly 100 upregulated and 250 downregulated genes involved in cell cycle progression, energy metabolism, cell proliferation, and cellular resilience. Protein microarrays and phosphoproteomics indicated dynamic changes in phosphorylation among key kinases, including GSK3β, MSK1/2, and p70 S6K, with 190 upregulated and 45 downregulated phosphorylated proteins. These proteins showed enrichment in GO terms and KEGG pathways related to cellular structure, stress response, and kinase signalling pathways, particularly in HIPPO and PI3K/AKT signalling. Ex-vivo experiments with human skin validated these findings in a physiologically-relevant model that maintains the wound microenvironment. I observed an increase in wound healing of 30% at 5400 ng/l compared to control biopsies, demonstrating enhanced wound closure upon exposure to environmentally relevant fluoxetine associated with serotonin pathway activation.Human wounds cost the NHS >£8.3 billion/year and new treatments are direly needed. This research underscores both the potential therapeutic applications of low-dose fluoxetine in wound care, and the importance of understanding its effects on healthy skin as anenvironmental pollutant. Together, these findings contribute to a deeper insight into the molecular and phenotypical impact of fluoxetine on human skin, with implications for both clinical and environmental health. My results justify a transition from the study of behavioural effects of environmental fluoxetine in aquatic animals to the investigation of effects of exposure on wound healing in aquatic and terrestrial animals, including direct impacts on human health. I also open avenues to investigate low-dose SSRI as new treatments to promote wound healing
The author as actor: a defense of Quentin Skinner
No full textIn this thesis, I defend Quentin Skinner's work against some criticisms raised by three of his interlocutors: John Keane, Kennet Minogue, and Joseph Femia. All three of these critics take issue with Skinner's author-centered approach to the historical interpretation of texts. Femia, invoking Roland Barthes 'death of the author' thesis, argues that Skinner's attempt to recover the intentions of authors is impossible. While Minogue and Keane do not dispute the possibility of recovering an author's intentions, they question the unity of such an enterprise. In order to answer Femia's criticism of Skinner, I draw an analogy between Skinner's figure of the author, and Arendt's figure of the political actor. I argue that just as it is possible for someone to know what a political actor is doing in performing a political act, it is similarly possible for an intellectual historian to understand what political acts an author was doing in writing his or her text. To refute Minogue's and Keane's claims that a Skinnerian approach to intellectual history is of no use to the political theorist, I point to three examples of how Skinner's recovery of forgotten political discourses have been applied to contemporary debates in political theory.Graduat
Drawing Sacred Forests and Courtyards in South Benin
No full texthttps://drawingmatter.org/drawing-sacred-forests-and-courtyards-in-south-benin/The following conversation between the editors of Accattone and Quentin Nicolaï was first published in Accattone 6 (2019). It documents research carried out by Quentin Nicolaï in Abomey, Benin, between January 2014 and June 2018.Drawing Matter would like to thank the author and the magazine’s editors for allowing us reproduce the essay on www.drawingmatter.org.info:eu-repo/semantics/nonPublishe
Features of auteur cinema in Quentin Tarantino's works
No full textMultimediju komunikācijaInformācijas un komunikācijas zinātnesMultimedia CommunicationInformation and Communication SciencesBakalaura darba tēmas nosaukums ir “Autorkino iezīmes Kventina Tarantīno daiļradē.”
Pētījumā izvirzītā hipotēze apgalvo, ka režisora Kventina Tarantīno (Quentin Tarantino) filmās ir
atrodamas autorkino iezīmes.
Bakalaura darba mērķis ir noskaidrot autorkino iezīmes Kventina Tarantīno sešās
ietekmīgākajās un skatītāju atzītākajās filmās, kuras tika atlasītas pēc Internacionālās filmu datu
bāzes. Darbā tiek apskatītas un analizētas sešas no Kventina Tarantīno filmām, kuras ir “Trakie
suņi” (Reservoir Dogs), “Lubene” (Pulp Fiction), “Nogalināt Bilu: 1. daļa” (Kill Bill: Vol. 1) un
“Nogalināt Bilu: 2. daļa” (Kill Bill: Vol. 2), kas pēc paša režisora uzskatiem ir, viena vesela, filma
sadalīta divās daļās, kā arī filmas “Bēdīgi slavenie mērgļi” (Inglorious Bastards), “Atsvabinātais
Džango” (Django Unchained) un “Reiz Holivdā” (Once Upon a Time... in Hollywood).
Darba mērķa izpildei teorētiskajā daļā tika aplūkots autorkino jēdziens, Holivudas
klasiskais kino stils, kino valoda, kā arī Kventina Tarantīno biogrāfija, lai palīdzētu izprast un
analizēt atlasītās filmas. Par pētījuma metodi tika izvēlēta kvalitatīvā kontentanalīze.The title of the bachelor's thesis is "Features of auteur cinema in Quentin Tarantino's
works" The study’s hypothesis states that directors Quentin's Tarantino's films have the features
of an author.
The purpose of the bachelor's thesis is to find out the influence of author cinema on Quentin
Tarantino's six most influential and audience-recognized films selected from the International Film
Database. Work is discussed and analyzed in six of Quentin Tarantino films, which are “Reservoir
Dogs”, “Pulp Fiction”, “Kill Bill: Vol. 1” and “Kill Bill: Vol. 2”, which the director says is a whole
movie divided into two parts, as well as “Inglorious Bastards”, “Django Unchained” and “Once
Upon a Time ... in Hollywood”.
The theoretical part of the paper explored the concept of author cinema, Hollywood classic
cinema, film language, and the biography of Quentin Tarantino to help understand and analyze
selected films. Qualitative content analysis was chosen as the research method
Saint-Quentin et sa région
No full textThe author insists on the seriousness of the trade depression in Saint-Quentin last years (ten per cent workmen out of work, unemployed period above eleven months.). Metallurgy is the principal industry and «Motobécane» the first firm, making the famous «Mobylette» since 1951. Therefore, the difficulties of «Motobécane», of the engineering industry, have effects on the social situation. The town is, from now on, the starting point of an urban emigration. Old fortress on the right bank, protecting the crossing of the river Somme, Saint-Quentin has been destroyed during the first World War and rebuilt without large transformation. The town keeps an heptagonal shape with cross-roads on the both sides of the valley, canal and railway. The attraction area is, to-day, smaller than the Vermandois, very industrialized and populated region. For the future, Saint-Quentin shall have to expect : the «A-26 » motorway, the négociation of an employment agreement («Contrat de Bassin d'Emploi») and, later, the construction of the large-gauge canal «Seine-Nord» from Compiègne to Valenciennes.L'auteur insiste sur la gravité de la crise de remploi à Saint-Quentin aujourd 'hui (taux de chômage supérieur à 1 0%, durée moyenne de chômage supérieure à 11 mois). L'industrie est dominée par la métallurgie et celle-ci par la firme «MOTOBECANE» qui fabrique depuis 1951 les fameuses «mobylettes». Aussi les difficultés de Motobécane ou de l'industrie de la manutention rejaillissent-elles immédiatement sur la situation sociale. La ville est désormais le point de départ d'un véritable exode urbain. Ancienne place forte gardant, sur la rive droite , le passage de la Somme, presque complètement détruit en 1918, mais reconstruit largement à l'identique, St-Quentin a hérité d'une double structure heptagonale et en «patte d'oie» de part et d'autre de la coupure majeure de la vallée de la Somme (canal et voie ferrée). Son aire d'attraction s'est réduite par rapport à la région qui l'entoure, le Vermandois, relativement peuplé et industrialisé lui-même. Pour l'avenir, St-Quentin doit compter surtout, sur l'arrivée de l'autoroute A 26 et sur les efforts qui s'inscriront dans un «Contrat de Bassin d'Emploi», et, à long terme sur la liaison fluviale à grand gabarit «Seine-Nord» utilisant le tracé du canal de St-Quentin.Oudart Paul. Saint-Quentin et sa région. In: Hommes et Terres du Nord, 1981/2. Spécial Picardie. pp. 43-56
A Hundred Years of Photo Wallets:Quentin Blake Centre for Illustration's Book of the Month
No full textAn interview with Annebella Pollen, author of More Than a Snapshot: A Visual History of Photo Wallets, which was selected as the May 2023 Book of the Month by the Quentin Blake Centre for Illustration
Quentin Meillassoux: Facticity and Scientific Methods
No full textThis paper examines Quentin Meillassoux’s critique of correlationism, specifically focusing on the Principle of Factuality and the mathematization of hyperchaos as tools to access the "ancestral." While acknowledging Meillassoux’s significance in overcoming Kantian limits, the author argues that his refusal to return to metaphysics stems from political hesitation rather than ontological necessity. The text critiques the concept of the "God to come" as an ideological compromise. Instead, the author advocates for an "experimental metaphysics" grounded in scientific method, positing that science offers rational access to the absolute and effectively resolving the tension between facticity and the thing-in-itself
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