3,597 research outputs found
Contribution à l'histoire de la famille dans les pays de la Méditerranée occidentale (1750-1850)
No full textThe article focusses on the diversity of family structures in Western Mediterranean coun- tries. Observing several rural and urban communities in Murcia between 1750 and 1850, the author shows that, whatever the geographical area, family structures cannot be defined merely as a sum of percentages. Their complexity is related to the age, kinship, economic activity and social status of the head of the family, and without a doubt to the demographic and economic contexts. An analysis of the whole social pattern, not family structures independently of the rest, is required for delimiting homogeneous areas.L'article se propose d'attirer l'attention sur les diversités des structures familiales en Méditerranée occidentale. A partir de l'exemple de plusieurs communautés rurales et urbaines de Murcie entre 1750 et 1850, il montre que dans quelque aire géographique que ce soit, la réalité des structures familiales ne peut se réduire à une somme de pourcentages. La complexité des structures familiales est en relation avec l'âge, la parenté, l'activité économique et le niveau social du chef de famille et, sans aucun doute avec les conjonctures démographique et économique. Seule l'analyse du système social complet, et non des seules structures familiales, est susceptible de permettre de délimiter des aires homogènes.Chacón Jiménez Francisco, Hurtado Martinez J., Rodriguez Soler M., Sancho Alguazil R., Vimal Gomez T. Contribution à l'histoire de la famille dans les pays de la Méditerranée occidentale (1750-1850). In: Annales de démographie historique, 1986. Démographie historique en Amérique Latine. pp. 155-182
Functional Non-Synonymous Polymorphisms Prediction Methods: Current Approaches and Future Developments
No full textNon-synonymous single nucleotide polymorphisms (nsSNPs) are genetic variations that affect the encoded protein by an amino acid change. In humans, many naturally-occurring nsSNPs cause protein dysfunction and increase vulnerability to disease. Identification of such nsSNPs provides an important opportunity to develop drugs/nutrients with precise therapeutic targets. Therefore, current biomedical research and medicinal chemistry look for targets and functional nsSNPs, to establish correlation with disease susceptibility and foster rational drug design. We review the molecular bases of missense mutation effects at the protein level, namely on sequence conservation, including stability, conformation, biophysical parameters, and protein-protein interaction. Further, we summarize some computational methods, available information resources, and the current approaches used to predict nsSNPs functionality in human genome, most of which based on protein structures and/or evolutionary conservation. Finally, using an approach paradigmatic of the nsSNPs-gene interactions, we evaluate the functional consequences and phenotypic effects of nsSNPs on two genes associated with cholesterol response. Biophysical changes produced by exchanged amino acids I638V (rs5908) from the 3-hydroxy-3-methylglutaryl-coenzyme A reductase gene, and A370T (rs11669576) from the low density lipoprotein receptor gene have been analyzed with an emphasis on stability, activity, and structure of their related proteins. Based on available data and the results of our study, we propose that, even though the extent and precise nature of nsSNPs' role in health and disease is yet to be fully elucidated, targeted investigations are warranted and will - in the future - provide useful tools to develop targeted drugs
Las Ruinas de Persépolis, de Ramón López Soler: entre el centón y la filosofía hermética
No full textAnalysis of Las ruinas de Persépolis, of López Soler, in the context of the early Spanish Novel of Romanticism, and within the framework of literary production of this author, paying attention to role played by the Ancient World’s echoes in the work.Análisis de Las Ruinas de Persépolis, de López Soler, en el contexto de las primeras novelas españolas del Romanticismo, y dentro de la producción literaria de su autor, con especial atención a la función que cumplen en la obra los ecos del mundo antiguo
sj-docx-1-jdr-10.1177_00220345221102310 – Supplemental material for Cetylpyridinium Chloride Mouthwash to Reduce Shedding of Infectious SARS-CoV-2: A Double-Blind Randomized Clinical Trial
No full textSupplemental material, sj-docx-1-jdr-10.1177_00220345221102310 for Cetylpyridinium Chloride Mouthwash to Reduce Shedding of Infectious SARS-CoV-2: A Double-Blind Randomized Clinical Trial by A. Alemany, D. Perez-Zsolt, D. Raïch-Regué, J. Muñoz-Basagoiti, D. Ouchi, C. Laporte-Villar, B. Baro, N. Henríquez, N. Prat, M. Ochoa Gianinetto, M. Viaplana Gutiérrez, M. Garcia Sánchez-Paniagua, N. Larrosa Henríquez, J. Moreno Vicente, J. Ara, M.A. Rodriguez-Arias, J. Puig, I. Blanco, C. Casañ Lopez, Á. Hernández, A.E. Bordoy, C. Esteban Redondo, V. González Soler, M. Giménez, V. Blanc, R. León, J. Gispert, CPC-COVID GROUP, B. Clotet, N. Izquierdo-Useros and O. Mitjà in Journal of Dental Research</p
Tomás Soler y Ferrer, arquitecto de la Bailía General del Real Patrimonio de Cataluña
No full textTomàs Soler i Ferrer és conegut, sobretot, com a autor del plànol del Rec Comtal (1836), previ a la urbanització del pla de Barcelona. Aquest plànol culmina una carrera al servei de la Batllia General del Reial Patrimoni, on ja havia treballat el seu pare, Joan Soler i Faneca, i on després exerciria el seu fill, Joan Soler i Mestres. En aquest article es reconstrueix la carrera professional de Tomàs Soler com a funcionari de la Corona, i se situa en el seu context administratiu el plànol del Rec Comtal i d’altres conservats a l’Arxiu de la Corona d’Aragó. La documentació generada pels organismes que van gestionar el patrimoni reial els segles xviii i xix –la Reial Intendència de Catalunya i, des de 1816, la Batllia General del Reial Patrimoni– és fonamental per conèixer l’activitat d’un dels arquitectes i experts hidràulics més destacats del primer terç del s. xix a Catalunya.Paraules clau: obres hidràuliques, cartografia, arquitectura.Tomás Soler y Ferrer is known primarily as the author of the 1836 map of the ancient irrigation canal of Barcelona known as Acequia Real or Rec Comtal showing the plain of Barcelona before its urban development. This map is the culmination of a career to the service of the Bailía General del Real Patrimonio, in which already served his father, Juan Soler y Faneca, and was continued by his son, Juan Soler y Mestres. This article traces the career of Tomás Soler as an officer of the Spanish Crown and describes the administrative context of the map. The documents generated by the institutions that managed the royal heritage in the 18th and 19th centuries, the Real Intendencia de Cataluña and from 1816 Bailía General del Real Patrimonio, are essential to know the activity of one of the most important architects and hydraulic experts of the first third of the nineteenth century in Catalonia.Keywords: hydraulic works, cartography, architecture.Tomás Soler y Ferrer es conocido, principalmente, como autor del plano de la Acequia Real (1836), anterior a la urbanización del llano de Barcelona. Este plano culmina una carrera al servicio de la Bailía General del Real Patrimonio, a la cual había servido ya su padre, Juan Soler y Faneca, y continuará sirviendo su hijo, Juan Soler y Mestres. En este artículo se reconstruye la carrera profesional de Tomás Soler como funcionario de la Corona, se sitúa en su contexto administrativo el plano del Rec Comtal y otros conservados en el Archivo de la Corona de Aragón. La documentación generada por los organismos que gestionaron el patrimonio real en los siglos xviii y xix –la Real Intendencia de Cataluña y, a partir de 1816, la Bailía General del Real Patrimonio– resulta fundamental para conocer la actividad de uno de arquitectos y expertos hidráulicos más destacados en Cataluña durante el primer tercio del s. xix.Palabras clave: obras hidráulicas, cartografía, arquitectura
El Thesoro de los niños de Bernabé Soler (1615), adaptación del Thesaurus puerilis de Onofre Pou (1575)
No full textEl presente artículo analiza la adaptación española del diccionario bilingüe latín-catalán
de Onofre Pou Thesaurus puerilis (1575), traducido por Bernabé Soler con el título Thesoro
de los niños (1615). La autora plantea las principales características de la obra de Pou, disposición
del contenido, estructura de los artículos, novedad desde un punto de vista lexicográfico
y pedagógico, y estudia las principales aportaciones de la adaptación de Soler.This article analyses the Spanish adaptation of the bilingual Latin-Catalan dictionary by
Onofre Pou, Thesaurus puerilis (1575), translated by Bernabé Soler under the title Thesoro de
los niños (1615). The author expounds the essential characteristics of Pous work, the layout
of the content, the organization of the articles, innovations from a lexicographical and pedagogical
point of view, and examines the principal contributions offered by Solers adaptation
Computational Evolution Protocol for Peptide Design
No full textComputational peptide design is useful for therapeutics, diagnostics, and vaccine development. To select the most promising peptide candidates, the key is describing accurately the peptide–target interactions at the molecular level. We here review a computational peptide design protocol whose key feature is the use of all-atom explicit solvent molecular dynamics for describing the different peptide–target complexes explored during the optimization. We describe the milestones behind the development of this protocol, which is now implemented in an open-source code called PARCE. We provide a basic tutorial to run the code for an antibody fragment design example. Finally, we describe three additional applications of the method to design peptides for different targets, illustrating the broad scope of the proposed approach
Computational Evolution Protocol for Peptide Design
No full textComputational peptide design is useful for therapeutics, diagnostics, and vaccine development. To select the most promising peptide candidates, the key is describing accurately the peptide-target interactions at the molecular level. We here review a computational peptide design protocol whose key feature is the use of all-atom explicit solvent molecular dynamics for describing the different peptide-target complexes explored during the optimization. We describe the milestones behind the development of this protocol, which is now implemented in an open-source code called PARCE. We provide a basic tutorial to run the code for an antibody fragment design example. Finally, we describe three additional applications of the method to design peptides for different targets, illustrating the broad scope of the proposed approach
ALLINTERACT_RawData2_v1.01
No full textThe present dataset includes all the data of the articles linked to the EC Horizon 2020 project ALLINTERACT Widening and diversifying citizen engagement in science (872396), related to citizen engagement and participation in scientific research with social impact on education and gender.
The data was collected between X and X and has been obtained following the communicative methodology within the framework of the ALLINTERACT Project.
It contains different types data deppending on the article. Regarding the already published articles, there is:
1. Article: Bordanoba Gallego, L., Serradell, O., Morlà-Folch, T., Ruiz-Eugenio, L., & Pulido, C. (2023). Feudalism, meritocracy and sexual harassment. Social and Education History. https://doi.org/10.17583/hse.11788
Data: Data from scientific literature and documentation from governments, parliaments and social movements, especially MeToo University. Moreover, sixteen interviews of which thirteen are to professors who led the research that gave rise to the reforms on overcoming sexual harassment at Universities, and three interviews to students victims and survivors. The authors of this article are: Lidia Bordanoba Gallego, Olga Serradell, Teresa Morlà Folch, Laura Ruiz Eugenio, Cristina Pulido
2. Article: Soler-Gallart, M., & Flecha, R. (2022). Researchers’ Perceptions About Methodological Innovations in Research Oriented to Social Impact: Citizen Evaluation of Social Impact. International Journal of Qualitative Methods, 21. https://doi.org/10.1177/16094069211067654
Data: Fourteen interviews, seven of them to researchers from different Spanish universities with long experience on Communicative Methodologie and social impact; and seven interviews to citizens who had interacted with scientific evidence projects. The authors of this article are: Marta Soler Gallart, Ramón Flecha
3. Article: Racionero-Plaza, S. ., Flecha, R., Carbonell, S. ., & Rodríguez-Oramas, A. (2023). Neuroedumyhts: A Contribution from Socioneuroscience to the Right to Education for All. Qualitative Research in Education, 12(1), 1–24. https://doi.org/10.17583/qre.10795 :
Data: Ex-post PLDA, which means the análisis of the conclusions of the debates in public lectures, by the twelve participants interviewed in the research and who participated in seventeen lectures and their debates. The twelve informers have been in the past or still schoolteachers and eight of them are now university professors. The authors of this article are: Sandra Racionero Plaza, Ramón Flecha, Sara Carbonell, Alfonso Rodriguez-Oramas
Description of data codes and definition of concepts used:
PLDA: Public Lectures Debates Analytic
CM: Communicative Methodologie
Description of the steps to be followed to process data:
Explanation of possible relationship with other datasets:
This folder will be updated as articles are published.
Contact information in case of doubts: [email protected]
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