41 research outputs found
Author Correction: Tree mode of death and mortality risk factors across Amazon forests
Get PDFThe original version of this Article contained an error in Table 2, where the number of individuals in the “All Amazonia” row was reported as 11,6431 instead of 116,431. Also, the original version of this Article contained an error in the Methods, where the R2 for the proportion of broken/uprooted dead trees increase per year was reported as 0.12, the correct value being 0.06. The original version of this Article contained errors in the author affiliations. The affiliation of Gerardo A. Aymard C. with UNELLEZGuanare, Herbario Universitario (PORT), Portuguesa, Venezuela Compensation International Progress S.A. Ciprogress–Greenlife.</p
Evaluation Learning and Improvement Model (EVAM) in the Mayor's Office of the Municipality of Valledupar, Cesar
No full textDigitalEl siguiente informe de prácticas el cual tiene como título “Modelo de Evaluación Aprendizaje y mejoramiento (EVAM) en la Alcaldía del Municipio de Valledupar, Cesar” realizado para optar por el título de administrador financiero, busca principalmente verificar el nivel de cumplimiento de dicho modelo, objetivo que se llevará a cabo implementando herramientas de recopilación de información como son dos cuestionarios, el primero, que es un cuestionario de aproximación, será aplicado a los jefes inmediatos que están a cargo de la dependencia donde se desarrolló la práctica, el segundo, será aplicado a los colaboradores seleccionados convenientemente debido a la naturaleza de la práctica y en pro de la investigación, donde se obtendrán una serie de resultados, seguidamente se evaluaran e identificarán los factores críticos obtenidos y por último se realizaran propuestas para el mejoramiento de dichos factores críticos previamente identificados, el presente informe de prácticas empresariales es considerado tipo de campo, de igual manera, se le implementó un diseño no experimental, y se desarrolló bajo la medición de variables a través de procesos cuantificables y análisis estadísticos, se considera que el estudio tiene un enfoque cuantitativo, en el cual se lleva un proceso secuencial para lograr la consecución de la investigaciónThe following internship report, which has the title “Evaluation Learning and Improvement Model (EVAM) in the Mayor's Office of the Municipality of Valledupar, Cesar”, carried out to opt for the title of financial administrator, mainly seeks to verify the level of compliance with said model. , an objective that will be carried out by implementing information collection tools such as two questionnaires, the first, which is an approximation questionnaire, will be applied to the immediate bosses who are in charge of the department where the practice was developed, the second, It will be applied to collaborators conveniently selected due to the nature of the practice and in favor of research, where a series of results will be obtained, then the critical factors obtained will be evaluated and identified and finally proposals will be made for the improvement of said factors. critical previously identified, this report on business practices is considered a type of field, in the same way, a non-experimental design was implemented, and it was developed under the measurement of variables through quantifiable processes and statistical analysis, it is considered that the study It has a quantitative approach, in which a sequential process is carried out to achieve the achievement of the research.Introducción 19
Planteamiento del Problema 20
Descripción del Problema 20
Formulación del Problema 23
Sistematización del Problema 23
Objetivos de la Investigación 24
Objetivo General 24
Objetivos Específicos 24
Justificación 25
Delimitación del Problema 27
Delimitación Teórica 27
Delimitación Espacial 27
Delimitación Temporal 27
Delimitación Institucional 27
Marco de Referencia 28
Antecedentes 28
Marco Teórico 34
Modelo EVAM 34
Elementos del Modelo EVAM 35
Factores Críticos Básicos del M.E.V.A.N. 37
Cuestiones a Evaluar 39
Marco Conceptual 43
Modelos de Gestión de Calidad 44
Eficiencia Gubernamental 44
Optimización de Procesos 44
Evaluación de Políticas Públicas 45
Marco Legal 45
Operacionalización de Variables 45
Metodología 47
Enfoque de Investigación 47
Tipo de Investigación 47
Población de Estudio 48
Instrumento Para la Recolección de Datos 49
Técnicas de Análisis de Datos 68
Resultados 70
Aplicar un Instrumento del Modelo EVAM, por Medio de un Cuestionario, en la Alcaldía del Municipio de Valledupar, Cesar 70
Eje 1. Política, Planificación y Estrategia a Través del Liderazgo 70
Eje 5. Resultados. 77
Identificar y Evaluar los Factores Críticos Obtenidos Mediante el Modelo EVAM en la Alcaldía del Municipio de Valledupar, Cesar 79
Eje 1. Política, Planificación y Estrategias a Través del Liderazgo 80
Eje 2: Procesos 80
Eje 3. Personas 81
Eje 4. Alianzas y Recursos 81
Eje 5. Resultados 82
Realizar una Propuesta Para el Mejoramiento de los Factores Críticos Obtenidos Mediante el Modelo EVAM en la Alcaldía del Municipio de Valledupar, Cesar 82
Fase Inicial: Estrategias de la Planificación a Través del Liderazgo 83
Fase Intermedia: Estrategias de Gestión de Procesos 83
Fase Final: Estrategia de Gestión Eficiente de los Recursos 84
Conclusiones 87
Recomendaciones 89
Referencias Bibliográficas 91PregradoAdministrador(a) Financier
Determining the effect of strain rate on the fracture of sheet steel
Get PDFA key challenge for the automotive industry is to reduce vehicle mass without
compromising on crash safety. To achieve this, it is necessary to model local failure in a
material rather than design to the overly conservative criteria of total elongation to failure.
The current understanding of local fracture is limited to quasi-static loading or strain rates
an order of magnitude too high for automotive crash applications.
This thesis studies the local fracture properties of DP800 sheet steel at the macroscopic
scale from strain rates of to for the first time. Geometries for three stress
states, namely plane-strain, shear and uniaxial tension, were developed to determine a
fracture locus for DP800 steel using optical strain measurement. These geometries were
developed using Finite Element Analysis and validated experimentally for strain rate and
stress state. Thermal imaging was used to determine the effect of strain rate on
temperature rise and its associated effect on fracture. Fractography was used to examine
the specimens’ failure modes at different strain rates.
The geometries were applied to the advanced high strength steel grade DP800. Despite
prior evidence from simple tensile test data, DP800 showed no significant variation in
fracture strain with strain rate in all three stress states. Non-contact thermal
measurements showed that the high strain rate tests ( ) were non-isothermal with
temperature rises of up to being observed. As a result of this it is difficult to
decouple the effect of strain rate from the effect of temperature and requires further
investigation. The test geometries were also applied to the deep draw steel DX54 and the
aluminium alloy AA5754 where a strain rate effect was observed. Both materials are
significantly more ductile than DP800 whish exposed a limitation in the test procedures. At
high fracture strains the stress state deviates from its intended value and can invalidate the
test. Therefore, a method was developed for determining the validity of a test for each
geometry and material from experimental data. The preliminary data from DX54 indicates
significantly greater strain rate sensitivity across one order of magnitude than was
observed in five orders of magnitude in DP800
Author Correction: One sixth of Amazonian tree diversity is dependent on river floodplains
No full textAuthor Correction: One sixth of Amazonian tree diversity is dependent on river floodplains
No full textAuthor Correction: One sixth of Amazonian tree diversity is dependent on river floodplains
Get PDFCorrection to: Nature Ecology & Evolution https://doi.org/10.1038/s41559-024-02364-1, published online 11 March 2024.
In the version of the article initially published, the affiliation of Edgardo Manuel Latrubesse was incorrect and has now been amended to Environmental Sciences Graduate Program-CIAMB, Federal University of Goiás, Goiânia, Brazil in the HTML and PDF versions of the article
Author Correction: One sixth of Amazonian tree diversity is dependent on river floodplains
No full textMolecular gene expression and genome wide profiling in tamoxifen-resistant breast cancer.
No full textPhDOestrogen receptor positive (ER+) breast cancers (BC) are heterogeneous in both their clinical behaviour and response to therapy. The ER and Progesterone (PgR) are currently the best predictors of response to the anti-oestrogen tamoxifen, yet up to 40% of ER+ breast cancer will relapse despite tamoxifen treatment. New prognostic biomarkers and further biological understanding of tamoxifen resistance (TR) are required. There has been an explosion of greater understanding since the arrival of cutting-edge gene and genomic profiling technology. The two major aims of this research are to develop stable gene signatures that are effective at distinguishing „prognostic‟ groups and, when tested directly for response to tamoxifen, a set of „predictive‟ markers.
In order to establish cellular pathways responsible for TR, tissue at relapse while on tamoxifen is preferred. However, in practice, this is difficult to obtain. Hence, in this study, I have established TR derivatives of breast cancer cell lines, T47D and ZR75-1, and analysed their gene-expression by microarray. MAGEA2 and EGLN3 were 4.0 and 3.8 fold upregulated respectively in TR cell lines. For MAGEA2- and EGLN3-overexpressing lines, the proliferation and growth rates in tamoxifen-containing media were significantly higher (p-value <0.001 and p<0.05, respectively) than for control cells. I have investigated possible downstream targets for each protein which may contribute to the mechanism of resistance. Immunohistochemistry validation was performed on a cohort of 196 tamoxifen-treated primary breast tumour tissues: MAGEA2 and EGLN3 were found to be valuable predictive (Positive predictive value of 89%, and 85%, with high sensitivity 38% and 42% respectively) biomarkers for TR in primary breast tumours.
In the human breast tumour arm of this study, 25 frozen samples with known response to tamoxifen were analysed on both SNP6.0 and expression EXON arrays. The integrated analysis suggested that 5 genes (OPCML, OR10G7, SNF1LK2, PALM and ZBTB-16) are good predictors of TR, with high negative predictor values (68%, 71%, 59% and 73% respectively for the last 4 genes). Significant regions of copy number variation (CNV) were identified at chromosomes 8q24, 17q21-22 and 11q23-25. The application of this high-resolution approach should lead to a better understanding of the roles of complex genetic alterations in TR
One sixth of Amazonian tree diversity is dependent on river floodplains
No full textAmazonia's floodplain system is the largest and most biodiverse on Earth. Although forests are crucial to the ecological integrity of floodplains, our understanding of their species composition and how this may differ from surrounding forest types is still far too limited, particularly as changing inundation regimes begin to reshape floodplain tree communities and the critical ecosystem functions they underpin. Here we address this gap by taking a spatially explicit look at Amazonia-wide patterns of tree-species turnover and ecological specialization of the region's floodplain forests. We show that the majority of Amazonian tree species can inhabit floodplains, and about a sixth of Amazonian tree diversity is ecologically specialized on floodplains. The degree of specialization in floodplain communities is driven by regional flood patterns, with the most compositionally differentiated floodplain forests located centrally within the fluvial network and contingent on the most extraordinary flood magnitudes regionally. Our results provide a spatially explicit view of ecological specialization of floodplain forest communities and expose the need for whole-basin hydrological integrity to protect the Amazon's tree diversity and its function. [Abstract copyright: © 2024. The Author(s).
