81,136 research outputs found
Future design narratives: an interdisciplinary approach to a decolonial glossary
No full textAs design evolves, language serves as a bridge between envisioned futures and the ontological elements of design that shape them. This manuscript presents an alternative glossary that gathers words from diverse disciplines and practices intersected by a decolonial lens that challenges hegemonical narratives. The glossary of the world to come results from a three-day workshop that focused on language as a formal, normative, and subversive tool capable of defining future behaviour and destabilizing the present. The terms are some among the many that exist to form this decolonial world
The spectral type of CHS 7797 - an intriguing very low mass periodic variable in the Orion Nebula Cluster
No full textAims: We present the spectroscopic characterization of the unusual high-amplitude very low mass pre-main-sequence periodic variable CHS 7797. Methods: This study is based on optical medium-resolution (R = 2200) spectroscopy in the 6450 − 8600 Å range, carried out with GMOS-GEMINI -S in March 2011. Observations of CHS 7797 have been carried out at two distinct phases of the 17.8 d period, namely at maximum (I ≈ 17.4 mag) and four days before maximum (I ≈ 18.5 mag). Four different spectral indices were used for the spectral classification at these two phases, all of them well-suited for spectral classification of young and obscured late M dwarfs. In addition, the gravity-sensitive Na I (8183/8195 Å) and K I (7665/7699 Å) doublet lines were used to confirm the young age of CHS 7797. Results: From the spectrum obtained at maximum light we derived a spectral type (SpT) of M 6.05 ± 0.25, while for the spectrum taken four days before maximum the derived SpT is M 5.75 ± 0.25. The derived SpTs confirm that CHS 7797 has a mass in the stellar-substellar boundary mass range. In addition, the small differences in the derived SpTs at the two observed phases may provide indirect hints that CHS 7797 is a binary system of similar mass components surrounded by a tilted circumbinary disk, a system similar to KH 15D.Fil: Rodriguez Ledesma, María V.. Max-Planck-Institut fur Astronomie; Alemania. Georg-August-Universität; AlemaniaFil: Mundt, Reinhard. Max-Planck-Institut fur Astronomie; AlemaniaFil: Pintado, Olga Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Correlación Geológica. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Departamento de Geología. Cátedra Geología Estructural. Instituto Superior de Correlación Geológica; ArgentinaFil: Boudreault, Steve. Instituto de Astrof´ısica de Canarias; España. Universidad de la Laguna; EspañaFil: Hessman, Frederic. Georg-August-Universität; AlemaniaFil: Herbst, William. Wesleyan University; Estados Unido
Dastaset for: "Rodriguez-Galiano, V.F., Sanchez-Castillo, M., Dash, J., Atkinson, P. and Ojeda-Zujar, J. (2016). Modelling interannual variation in the spring and autumn land surface phenology of the European forest, Biogeosciences, 13
No full text<p>Dastaset for: "Rodriguez-Galiano, V.F., Sanchez-Castillo, M., Dash, J., Atkinson, P. and Ojeda-Zujar, J. (2016). Modelling interannual variation in the spring and autumn land surface phenology of the European forest, Biogeosciences, 13</p>
Utility of big data in predicting short-term blood glucose levels in type 1 diabetes mellitus through machine learning techniques
No full textMachine learning techniques combined with wearable electronics can deliver accurate short-term blood glucose level prediction models. These models can learn personalized glucose-insulin dynamics based on the sensor data collected by monitoring several aspects of the physiological condition and daily activity of an individual. Until now, the prevalent approach for developing data-driven prediction models was to collect as much data as possible to help physicians and patients optimally adjust therapy. The objective of this work was to investigate the minimum data variety, volume, and velocity required to create accurate person-centric short-term prediction models. We developed a series of these models using different machine learning time series forecasting techniques suitable for execution within a wearable processor. We conducted an extensive passive patient monitoring study in real-world conditions to build an appropriate data set. The study involved a subset of type 1 diabetic subjects wearing a flash glucose monitoring system. We comparatively and quantitatively evaluated the performance of the developed data-driven prediction models and the corresponding machine learning techniques. Our results indicate that very accurate short-term prediction can be achieved by only monitoring interstitial glucose data over a very short time period and using a low sampling frequency. The models developed can predict glucose levels within a 15-min horizon with an average error as low as 15.43 mg/dL using only 24 historic values collected within a period of sex hours, and by increasing the sampling frequency to include 72 values, the average error is reduced to 10.15 mg/dL. Our prediction models are suitable for execution within a wearable device, requiring the minimum hardware requirements while at simultaneously achieving very high prediction accuracy
E-cigarettes induce toxicological effects that can raise the cancer risk. A frame from drug-metabolism and antioxidant homeostasis
No full textE-CIGARETTES INDUCE TOXICOLOGICAL EFFECTS THAT CAN RAISE THE CANCER RISK. A FRAME
FROM DRUG-METABOLISM AND ANTIOXIDANT HOMEOSTASIS.
1)Canistro D. 2)Vivarelli F. 3)Cirillo S. 4)Cardenia V. 5)Rodriguez-estrada MT.
Dept of Pharmacy and Biotechnology, Unibo
Electronic cigarettes (e-cigs) are devices designed to deliver nicotine in a vaping solution without tobacco combustion. Perceived as a safer alternative to conventional cigarettes, e-cigs are aggressively marketed as lifestyle-choice consumables, thanks to few restrictions and a lack of regulatory guidelines. Despite the burgeoning worldwide consumption of e-cigs, their safety remains largely unproven and it is unknown whether these devices cause in vivo toxicological effects that could contribute to cancer occurrence.
In the present study, we investigated the co-mutagenic and cancer-initiating effects of e-cig vapour in a rat model. To explore whether e-cigs induce toxicological effects, such as those involving cytochrome P450 (CYP) changes, we analyzed the modulation of carcinogen metabolizingenzymes in the lung of rats exposed to e-cig vapour. We observed a significant increase in CYP1A1/2 (activating, for example, polychlorinated biphenyls, aromatic amines, dioxins and PAHs), CYP2B1/2 (activating olefins and halogenated hydrocarbons), 2C11 (activating nitrosamines and mycotoxins) and CYP3A (activating hexamethyl phosphoramide and nitrosamines) documented by the sharp rise in the corresponding probes.
Conversely, we observed that the antioxidant enzymes catalase, DT-diaphorase and glutathione peroxidase and the conjugating phase II glutathione S-transferases, mainly involved in xenobiotic detoxification, were noticeable decreased, whereas UDP-glucuronyl-transferase was substantially unchanged.
Extrapolated to humans, the corresponding boosted CYP-linked monooxygenases together with reduced activity of antioxidant and detoxifying machinery would predispose a subject to an enhanced cancer risk from the widely bioactivated e-cig vapour procarcinogens associated with an increased risk of lung cancer
Jacobus M. Ramirez, De hominis beatitudine. In I-II Summae theologiae divi Thomae commentaria (Qq. I-V). Editio praeparata a Victorino Rodriguez, o.p
No full textHissette Roland. Jacobus M. Ramirez, De hominis beatitudine. In I-II Summae theologiae divi Thomae commentaria (Qq. I-V). Editio praeparata a Victorino Rodriguez, o.p. In: Revue Philosophique de Louvain. Quatrième série, tome 72, n°13, 1974. p. 200
Omega-3 fatty acids increase the unfolded protein response and improve amyloid-β phagocytosis by macrophages of patients with mild cognitive impairment
No full textMacrophages (Mφs) of patients with Alzheimer's disease and mild cognitive
impairment (MCI) are defective in amyloid-β1-42 (Aβ) phagocytosis and have low
resistance to apoptosis by Aβ. Omega-3 fatty acids (ω-3s) in vitro and in vivo
and the ω-3 mediator, resolvin D1, in vitro increase Aβ phagocytosis by Mφs of
patients with MCI. We have investigated the unfolded protein response (UPR) to
endoplasmic reticulum (ER) stress by Mφs in a longitudinal study of fish-derived,
ω-3-supplemented patients with MCI. Patients in the apolipoprotein E (ApoE)e3/e3
subgroup over time exhibited an increase of protein kinase RNA-like ER kinase
(PERK) expression, Aβ phagocytosis, intermediate M1-M2 Mφ type, and a Mini-Mental
State Examination (MMSE) rate of change of +1.8 points per year, whereas patients
in the ApoEe3/e4 subgroup showed individually divergent results with an MMSE rate
of change of -3.2 points per year. In vitro treatment of Mφs by fish-derived ω-3
emulsion increased Aβ phagocytosis, PERK expression, and UPR RNA signature, and
decreased ER stress signature. Augmented genes in the UPR signature included
chaperones, lectins, foldases, and N-linked glycosylation enzymes. In summary,
fish-derived ω-3s increase cytoprotective genes and decrease proapoptotic genes,
improve immune clearance of Aβ, and are associated with an improved MMSE rate of
change in ApoEe3/e3 vs. ApoEe3/e4 patients.-Olivera-Perez, H. M., Lam, L., Dang,
J., Jiang, W., Rodriguez, F., Rigali, E., Weitzman, S., Porter, V., Rubbi, L.,
Morselli, M., Pellegrini, M., Fiala, M. Omega-3 fatty acids increase the unfolded
protein response and improve amyloid-β phagocytosis by macrophages of patients
with mild cognitive impairmen
Jacobus M. Ramirez, De hominis beatitudine. In I-II Summae theologiae divi Thomae commentaria (Qq. I-V). Editio praeparata a Victorino Rodriguez, o.p
No full textHissette Roland. Jacobus M. Ramirez, De hominis beatitudine. In I-II Summae theologiae divi Thomae commentaria (Qq. I-V). Editio praeparata a Victorino Rodriguez, o.p. In: Revue Philosophique de Louvain. Quatrième série, tome 72, n°13, 1974. p. 200
Eremidrilus owyhee Rodriguez & Fend 2022, n. sp.
No full text3.4. Eremidrilus owyhee n. sp. (Figs. 2C, F; 3J–M; 6) Holotype. USNM 1593361, whole-mounted worm, slide-mounted in Canada balsam. Type Locality. Nevada, Elko Co., Bruneau River at Fawn Gulch, N 41.7594, W 115.5744, 1440 m altitude (3 June 2008). S. V. Fend coll. Paratypes. USNM 1593362–1593366, from the type locality, same collection data, 2 whole-mounted, 3 dissected on slides. CASIZ 233664–233666, 2 whole-mounted, 1 dissected on slide. USNM 1593367, Owyhee River at Beaver Creek, 27 April 2004, coll. D.L. Gustafson. MNCN 16.03 /3151, 1 transversely sectioned from Owyhee River, at Beaver Creek, 27 April 2004, coll. D.L. Gustafson. MNCN 16.03 /3152, 1 dissected and MNCN 16.03 /3153–16.03/3154, 4 whole mounts from type locality, 3 June 2008, S. V. Fend coll. Etymology. Named for the Owyhee River. The name was given to the river and the region in memory of three Hawaiian explorers lost in the region in 1819–20, during Mackenzie‘s Snake expedition (en.wikipedia.org/wiki/Owyhee_County,_ Idaho, last edited on 15 December 2021). Other material. Nevada, Elko Co., several localities, in authors’ collections. Bruneau River at Fawn Gulch (type locality), 3 June 2008, S. Fend coll., 2 dissected, 21 whole mounts. Bruneau River at Cottonwood Creek, N 41.7737, W 115.5823, 1768 m altitude, 15 July 2004, 2 whole-mounted. Owyhee River at Beaver Creek, 27 April 2004, one whole-mounted, 3 dissected, 1 transversely sectioned. Owyhee River below Wildhorse Reservoir, N 41.7259 W 115.896, 1828 m altitude, 27 March 2003, one dissected. Idaho, Camas Co., Big Smoky Creek N 43.6076, W 114.8995, 22 August 2005, 3 whole mounts. All collected by D. L. Gustafson unless otherwise indicated. Description (from type locality population). Segments 55–90. Length of fixed worms 10–19 mm, body diameter in X, 0.31–0.58 mm. Proboscis (100) 250−425 µm long, 40−64 µm diameter at middle. Segmentation distinct, with secondary annulus well marked from III to postclitellar segments (XIII−XIV) (Fig. 2C). All chaetae simplepointed and sigmoid; in anterior part of the body 100–147 µm long, those in ventral bundles usually slightly longer than dorsals, short in II 72−96 µm, and gradually longer to VII or VIII, nodulus at 0.3–0.4 chaetal length from the tip, sometimes about median in segment II. Chaetae in middle and posterior segments of similar length (112−149 µm), with nodulus distal (at 0.3–0.4 from distal end), dorsals and ventrals about equal in length (Fig. 2F). Epidermis smooth, 6–18 µm high, slightly thicker at the clitellum (14–26 µm), which extends from X to anterior part of XIII, and is formed by irregularly organized epidermal glands. Pharyngeal glands dorsal and ventral to the gut in segments (IV)V−VII; ventral lobes may be present in VIII. Nephridia with the ectal duct usually ending in a short, expanded vesicle (40–62 µm long, 25–35 µm wide) (Fig. 6H); nephridia absent in preclitellar segments. Male pores slightly lateral to ventral chaetal lines, in the posterior part of segment X, at about midway between ventral chaetae and posterior septum, opening on conical to almost cylindrical porophores of variable size (Figs. 2C; 3J–L; 6A–C), probably depending on fixation or the degree of extension (44−120 µm basal and 29–70 µm apical diameter; 80–170 µm long). Spermathecal pores just below the lateral line (Figs. 2C; 3J, M; 6A, D). Female pores in 11/12. Sperm sacs usually extend anteriorly to VIII, posteriorly to XIV−XVI; egg sacs to XV−XVIII. Vasa deferentia 12−19 µm wide and about 220−360 µm long; posterior vas forms a loop in XI (in the space of the secondary annulation of segment XI), and both vasa join the atrial wall at about the apical third of the atrium. Atrium elongated, cylindrical (208–350 µm long), very narrow (22−59 µm diameter), including muscle layer (1–6 µm thick) and lining cells (7−10 µm high). Atrial ampulla usually bent and sparsely covered by discrete clumps of prostatic cells (25−55 µm high) (Figs. 3J–L; 6C). Male duct extends through the porophore, with numerous circular muscle fibres attached to the epithelium of the duct (Figs. 3K; 6C). Large spermathecal ampullae, about 1.5 to 2 times as long as wide (65−275 µm wide; 105−460 µm long), in segment XI or may pass to the segment XII. Spermathecal ducts short (70−170 µm long) and tapered (30−65 µm wide at the middle); long transverse muscles join the spermathecal pore to the dorsal body wall; when contracted, the spermathecal pore opens within a lateral fold of the body wall (Figs. 3J; 6F, G). Sperm in ampulla forms a circular bundle that occupies most of the lumen, and part of the spermatozoids are oriented toward the epithelial cells near the duct (Fig. 6E). (a) diameter of the male porophore measured at the ectal end Remarks. Eremidrilus owyhee n. sp. is easily distinguished from all other congeneric species by the narrow atrium with well-separated prostatic glands, and by the long, protrusible male porophore (Table 2). Unlike other species in the Snake River drainage, E. owyhee n. sp. has one pair of spermathecae (in XI). The spermathecal pores are at the lateral line, resembling the position in the California species E. felini and E. ritocsi (Fend & Rodriguez 2003), but differing from all of the other known species in the genus. When retracted, the spermathecal pore opening within a lateral fold is reminiscent of the spermathecal sac of E. felini, although it is shallower and never forming a porophore-like structure when unretracted. The gut of the examined individuals contains detritus mixed with large sand grains and some diatoms. The Bruneau and Owyhee Rivers are tributaries to the Snake River, both joining it in southwestern Idaho. Most of the E. owyhee records are from upper reaches of these rivers, geographically very close to each other (see below). Both drainages are in an arid plateau region, and channels are in deeply incised canyons, with relatively sparse vegetation. Sampling sites have permanent flow throughout the year. Big Smoky Creek is more distant (approximately 200 km North), and drains to the Boise River, yet another Snake River tributary. The limited specimens appeared similar to those from the type locality, despite their proximity to type localities of two other Eremidrilus species (E. artzaini and E. humboldti) in more upstream Snake tributaries. A single, partially mature specimen resembling E. owyhee was also collected in the nearby Marys River, which drains southward to the endorheic Humboldt River (Nevada). The collection localities are intermediate between the Pacific Coastal drainages (having species with only one spermathecal segment) and the Idaho and eastern sites (having species with two spermathecal segments).Published as part of Rodriguez, Pilar & Fend, Steven V., 2022, New Nearctic Eremidrilus species (Clitellata: Lumbriculidae). Part 2, western species with one spermathecal segment, pp. 245-264 in Zootaxa 5159 (2) on pages 255-259, DOI: 10.11646/zootaxa.5159.2.4, http://zenodo.org/record/677713
Título: Ejercicios devotos para todos los dias del año
No full textJosé Amalio Muñoz ejerce como imp. en MadridContiene: Tomo I, 1875 (Enero y febrero), 1156 p. ; Tomo III, 1876 (Mayo y junio), 1442 p. ; Tomo V, 1877 (Septiembre y octubre), 1501 p. ; Tomo VI, 1877 (1390 p.
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