4,661 research outputs found
Avanços e desafios futuros.
No full textDestaques da Embrapa. Desafios futuros.Na publicação: Joanne Régis Costa, Junia Rodrigues Alencar
Author Co-Citation Analysis (ACA): a powerful tool for representing implicit knowledge of scholar knowledge workers
No full textIn the last decade, knowledge has emerged as one of the most important and valuable organizational assets. Gradually this importance caused to emergence of new discipline entitled ―knowledge management‖. However one of the major challenges of knowledge management is conversion implicit or tacit knowledge to explicit knowledge. Thus Making knowledge visible so that it can be better accessed, discussed, valued or generally managed is a long-standing objective in knowledge management. Accordingly in this paper author co- citation analysis (ACA) will be proposed as an efficient technique of knowledge visualization in academia (Scholar knowledge workers)
Analysis of MicroRNA Expression in Embryonic Developmental Toxicity Induced by MC-RR
No full textAs cynobacterial blooms frequently occur in fresh waters throughout the world, microcystins (MCs) have caused serious damage to both wildlife and human health. MCs are known to have developmental toxicity, however, the possible molecular mechanism is largely unknown. This is the first toxicological study to integrate post-transcriptomic, proteomic and bioinformatics analysis to explore molecular mechanisms for developmental toxicity of MCs in zebrafish. After being microinjected directly into embryos, MC-RR dose-dependently decreased survival rates and increased malformation rates of embryos, causing various embryo abnormalities including loss of vascular integrity and hemorrhage. Expressions of 31 microRNAs (miRNAs) and 78 proteins were significantly affected at 72 hours post-fertilisation (hpf). Expressions of miR-430 and miR-125 families were also significantly changed. The altered expressions of miR-31 and miR-126 were likely responsible for the loss of vascular integrity. MC-RR significantly reduced the expressions of a number of proteins involved in energy metabolism, cell division, protein synthesis, cytoskeleton maintenance, response to stress and DNA replication. Bioinformatics analysis shows that several aberrantly expressed miRNAs and proteins (involved in various molecular pathways) were predicted to be potential MC-responsive miRNA-target pairs, and that their aberrant expressions should be the possible molecular mechanisms for the various developmental defects caused by MC-RR
The proteomic study on cellular responses of the testes of zebrafish (Danio rerio) exposed to microcystin-RR
No full textMicrocystin-RR (MC-RR) is a commonly encountered cyanotoxin and receives increasing attention due to the risk of its bioaccumulation in aquatic animals like fish. This study investigated the protein profiles of zebrafish (Danio rerio) testes after intraperitoneal injection (i.p.) with 0.5 LD50 (2000 mu g/kg). MC-RR caused a noticeable damage to testicular ultrastructure, showing widened intercellular junction, distention of mitochondria. The testes showed a rapid response of its defense systems to the oxidative stress caused by MC-RR. This is the first to use a proteomic approach to obtain an overview of the effects of MC-RR on the testes of zebrafish. The proteomic results revealed that toxin exposure remarkably altered the abundance of 24 proteins that were involved in cytoskeleton assembly, oxidative stress, glycolysis metabolism, calcium ion binding and other biological functions. In conclusion, MC-RR damaged the testes and was toxic to the reproductive system of male zebrafish mainly through causing oxidative stress.Microcystin-RR (MC-RR) is a commonly encountered cyanotoxin and receives increasing attention due to the risk of its bioaccumulation in aquatic animals like fish. This study investigated the protein profiles of zebrafish (Danio rerio) testes after intraperitoneal injection (i.p.) with 0.5 LD50 (2000 mu g/kg). MC-RR caused a noticeable damage to testicular ultrastructure, showing widened intercellular junction, distention of mitochondria. The testes showed a rapid response of its defense systems to the oxidative stress caused by MC-RR. This is the first to use a proteomic approach to obtain an overview of the effects of MC-RR on the testes of zebrafish. The proteomic results revealed that toxin exposure remarkably altered the abundance of 24 proteins that were involved in cytoskeleton assembly, oxidative stress, glycolysis metabolism, calcium ion binding and other biological functions. In conclusion, MC-RR damaged the testes and was toxic to the reproductive system of male zebrafish mainly through causing oxidative stress
So Tom has turned a poet, what a dear [first line]
No full textstrophicnasame as Box 192 Item 50Cover is duplicated in 192.050.
Music is duplicated in 192.050.Johns Hopkins University, Levy Sheet Music Collection, Box
192, Item 051Thomas M-rr-s, Author of "How They Act in Baltimore." "Mephistophiles K.G.S.
So Tom has turned a poet, what a dear [first line]
No full textstrophicnasame as Box 192 Item 50Cover is duplicated in 192.050.
Music is duplicated in 192.050.Johns Hopkins University, Levy Sheet Music Collection, Box
192, Item 051Thomas M-rr-s, Author of "How They Act in Baltimore." "Mephistophiles K.G.S.
So Tom has turned a poet, what a dear [first line]
No full textstrophicnaCover is duplicated in 192.051.
Music is duplicated in 192.051.Johns Hopkins University, Levy Sheet Music Collection, Box
192, Item 050Thomas M-rr-s, Author of "How They Act in Baltimore." "Mephistophiles K.G.S.
So Tom has turned a poet, what a dear [first line]
No full textstrophicnaCover is duplicated in 192.051.
Music is duplicated in 192.051.Johns Hopkins University, Levy Sheet Music Collection, Box
192, Item 050Thomas M-rr-s, Author of "How They Act in Baltimore." "Mephistophiles K.G.S.
Análise da qualidade das informações científicas e ambientais nos portais dos jornais Diário do Amapá (Macapá/AP) e Folha BV (Boa Vista/RR)
No full textO presente projeto de pesquisa tem como objetivo principal analisar a cobertura jornalística sobre ciência e meio ambiente realizada pelos jornais online Diário do Amapá (Macapá/AP) e Folha BV (Boa Vista/RR). Acreditamos que investigar o papel da mídia regional no esforço global de conciliar progresso e meio ambiente significa contribuir para qualificar o papel dos veículos de comunicação na questão ambiental e melhorar o nível de informação dos cidadãos. Esse esforço toma contornos especiais quando o assunto envolve a Amazônia, uma região de sócio-biodiversidade incomparável e estratégica para o planeta.
Esta pesquisa é parte integrante do projeto de pesquisa Jornalismo, Ciência e Meio Ambiente na Amazônia , aprovado no Edital 043/2013 do CNPq e que tem como coordenador o Prof. Dr. Allan Soljenítsin Barreto Rodrigues (orientador desta proposta de PIBIC). A relevância da pesquisa se ancora na constatação de que pela primeira vez em sua história, a humanidade se depara com a possibilidade de real de suas decisões causarem a sua extinção. O modelo de desenvolvimento econômico baseado nos princípios do capitalismo, adotado pela maioria dos países, pôs em risco a sobrevivência humana no planeta ao promover exploração insustentável dos recursos naturais e ao poluir o ambiente. A consequência mais catastrófica desses dois fatores são as mudanças climáticas globais, que já se manifestam por meio de furacões, grandes estiagens, enchentes, aumento da temperatura, desertificação, extinção de espécies da fauna e da flora e outros fatores igualmente preocupantes.FAPEA
Análise da qualidade das informações científicas e ambientais nos portais dos jornais Diário do Amapá (Macapá/AP) e Folha BV (Boa Vista/RR)
No full textO presente projeto de pesquisa tem como objetivo principal analisar a cobertura jornalística sobre ciência e meio ambiente realizada pelos jornais online Diário do Amapá (Macapá/AP) e Folha BV (Boa Vista/RR). Acreditamos que investigar o papel da mídia regional no esforço global de conciliar progresso e meio ambiente significa contribuir para qualificar o papel dos veículos de comunicação na questão ambiental e melhorar o nível de informação dos cidadãos. Esse esforço toma contornos especiais quando o assunto envolve a Amazônia, uma região de sócio-biodiversidade incomparável e estratégica para o planeta.
Esta pesquisa é parte integrante do projeto de pesquisa Jornalismo, Ciência e Meio Ambiente na Amazônia , aprovado no Edital 043/2013 do CNPq e que tem como coordenador o Prof. Dr. Allan Soljenítsin Barreto Rodrigues (orientador desta proposta de PIBIC). A relevância da pesquisa se ancora na constatação de que pela primeira vez em sua história, a humanidade se depara com a possibilidade de real de suas decisões causarem a sua extinção. O modelo de desenvolvimento econômico baseado nos princípios do capitalismo, adotado pela maioria dos países, pôs em risco a sobrevivência humana no planeta ao promover exploração insustentável dos recursos naturais e ao poluir o ambiente. A consequência mais catastrófica desses dois fatores são as mudanças climáticas globais, que já se manifestam por meio de furacões, grandes estiagens, enchentes, aumento da temperatura, desertificação, extinção de espécies da fauna e da flora e outros fatores igualmente preocupantes.FAPEA
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