4,464 research outputs found
Rapporteur’s report – innovative geotechnologies for energy transition
No full textThe 9th Society for Underwater Technology (SUT) International Conference on Offshore Site Investigation and Geotechnics (OSIG) closed with a Rapporteur’s report given by the author. This paper provides a record of that report, transcribed from a video recording. The presentation slides are shown as Figures.</p
Experimental investigation of a single-plane automatic balancing mechanism for a rigid rotor
No full textWe present an experimental investigation of a single-plane automatic balancer that is fitted to a rigid rotor. Two balls, which are free to travel around a circular race, are used to compensate for the mass imbalance in the plane of the device. The experimental rig possesses both cylindrical and conical rigid body modes and the performance of the automatic balancer is assessed for a variety of different levels of imbalance. A non-planar mathematical model that also includes the observed effect of support anisotropy is developed and numerical simulations are compared with the experimental findings. In the highly supercritical frequency range the balls act to balance the rotor and a good quantitative match is found between the model and the experimental data. However, during the rigid body resonances the dynamics of the ball balancer is highly nonlinear and for this speed range the agreement between theory and experiment is mainly qualitative. Nevertheless, the model is able to successfully reproduce many of the solution types that are found experimentally.<br/
DEFRApH - Sample collection and handling procedures
No full textAll chemical and biogeochemical process in the sea are affected by the acidity of the water. Acidity is therefore fundamental property of seawater. The growing concern that the acidity of the oceans might be increasing has revealed weaknesses in our knowledge of this fundamental property and its variation in space and time. In 2008 the DEFRApH project (DEFRA contract ME4133) was initiated to provide this missing information in UK related waters. It required sampling for and analysis of the total inorganic carbon and total alkalinity content of samples. This reports documents the procedures sued for sampling. A companion document Hartman Dumousseaud and Roberts (NOC Internal Document No. 01) describes in detail the analytical procedures used and the calculation of the results
FIGURE 1. A in The advertisement call of Proceratophrys renalis (Miranda-Ribeiro, 1920) (Amphibia: Anura: Cycloramphidae)
No full textFIGURE 1. A) Proceratophrys renalis photographed in Cruz do Espírito Santo municipality (Photo by D.J. Santana); B) Proceratophrys renalis advertisement call: B) oscillogram, C) audiospectrogram and D) power spectrum of a single call (air temperature = 25ºC).Published as part of Santana, Diego José, Rodrigues, Ricardo, Albuquerque, Ralph Lacerda De, Laranjeiras, Daniel Orsi, Protázio, Arielson Dos Santos, França, Frederico Gustavo Rodrigues & Mesquita, Daniel Oliveira, 2011, The advertisement call of Proceratophrys renalis (Miranda-Ribeiro, 1920) (Amphibia: Anura: Cycloramphidae), pp. 67-68 in Zootaxa 2809 (1) on page 67, DOI: 10.11646/zootaxa.2809.1.6, http://zenodo.org/record/529002
Author Correction:Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention (Nature Communications, (2019), 10, 1, (5280), 10.1038/s41467-019-13244-9)
No full textThe original version of this Article contained an error in the spelling of the author Wilma D.J. van de Berg, which was incorrectly given as Wilma D.J. van den Berg. This has now been corrected in both the PDF and HTML versions of the Article.</p
Sunitinib treatment exacerbates intratumoral heterogeneity in metastatic renal cancer
No full textThis work was supported by the Chief Scientist Office, Scotland (ETM37; to G.D. Stewart, A.C.P. Riddick, M. Aitchison, and D.J. Harrison), Cancer Research UK (Experimental Cancer Medicine Centre; to T. Powles, London and D.J. Harrison, Edinburgh), Medical Research Council (to A. Laird and D.J. Harrison), Royal College of Surgeons of Edinburgh (to A. Laird), Melville Trust (to A. Laird), Medical Research Council (MC_UU_12018/25; to I.M. Overton), Royal Society of Edinburgh Scottish Government Fellowship cofunded by Marie Curie Actions (to I.M. Overton), Renal Cancer Research Fund (to G.D. Stewart), Kidney Cancer Scotland (to G.D. Stewart) and an educational grant from Pfizer (to T. Powles).Purpose: The aim of this study was to investigate the effect of VEGF targeted therapy (sunitinib) on molecular intratumoral heterogeneity (ITH) in metastatic clear cell renal cancer (mccRCC). Experimental design: Multiple tumor samples (n=187 samples) were taken from the primary renal tumors of mccRCC patients who were sunitinib treated (n=23, SuMR clinical trial) or untreated (n=23, SCOTRRCC study). ITH of pathological grade, DNA (aCGH), mRNA (Illumina Beadarray) and candidate proteins (reverse phase protein array) were evaluated using unsupervised and supervised analyses (driver mutations, hypoxia and stromal related genes). ITH was analysed using intratumoral protein variance distributions and distribution of individual patient aCGH and gene expression clustering. Results: Tumor grade heterogeneity was greater in treated compared to untreated tumors (P=0.002). In unsupervised analysis, sunitinib therapy was not associated with increased ITH in DNA or mRNA. However, there was an increase in ITH for the driver mutation gene signature (DNA and mRNA) as well as increasing variability of protein expression with treatment (p<0.05). Despite this variability, significant chromosomal and transcript changes to key targets of sunitinib, such as VHL, PBRM1 and CAIX, occurred in the treated samples. Conclusions: These findings suggest that sunitinib treatment has significant effects on the expression and ITH of key tumor and treatment specific genes/proteins in mccRCC. The results, based on primary tumor analysis, do not support the hypothesis that resistant clones are selected and predominate following targeted therapy.Peer reviewe
Reply to the discussion by McCarron on “Modelling spatial variability in as-laid embedment for high pressure and high temperature (HPHT) pipeline design”
No full textN/AThe accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author
AMALIA RODRIGUES - PARIS 1960 / Amalia RODRIGUES, accompagnés par Santos MOREIRA et Domingo CAMARINHA, guitares
No full textTitre uniforme : [Lisboa antigua = Adieu Lisbonne]Titre uniforme : [Lerele]Titre uniforme : [Lerele]Comprend : LUAR LUAR / Anonyme - CALUNGA / LORANCO - BARBOSA - CAPIBA - QUEM O FADO CALUNGA / Anonyme - FADO CINGAO / Anonyme - FADO MADREGAO / Anonyme - OLE MI MORENA : du film "Les Amants du Tage" / Anonyme - BARCO NEGRO / Maë PRETA - PIRATINI - D.J. FERREIRA - GUITARE TRISTE / Anonyme - UNA CASA PORTUGUESA / A. FONSECA - Reinaldo FEIRREIRA - V. Matos SEQUIERA - LERELE / G. et M. MONREAL - F. MUNOZ ACOSTA - AIE MOURIR POUR TOI / Charles AZNAVOUR - COIMBRA ("Avril au Portugal") / R. FERRAO - J. GALHARDO - TRE PANOCOQUEI RO / Anonyme - LISBOA ANTIGUA ("Adieu Lisbonne") / J. GALHARDO - R. PORTELA - DON TRIQUI TRAQUE / RETANAY - LAGAZABnF-Partenariats, Collection sonore - BelieveContient une table des matière
Near Band-edge Optical Properties Of Cubic Gan With And Without Carbon Doping
No full textWe report the results of studying the optical properties of cubic GaN thin films with photoluminescence and photoluminescence excitation spectroscopies. The films are deposited by plasma-assisted molecular beam epitaxy on GaAs (001) substrates, with and without intentional doping with carbon atoms (p-type doping). The evolution of the optical spectra of the C-doped samples is consistent with a picture in which carbon enters into N-vacancies at low concentrations, producing a marked improvement in the crystalline properties of the material. At higher concentrations it begins to form complexes, possibly due to interstitial occupation. The temperature dependence on the absorption edge of the doped material is also measured and is analyzed with standard theoretical models. © 2004 Elsevier Ltd. All rights reserved.3517377Taniyasu, Y., Suzuki, K., Lim, D.H., Jia, A.W., Shimotomai, M., Kato, Y., Kobayashi, M., Takahashi, K., (2000) Phys. Status Solidi A, 180, p. 241As, D.J., (2002) Defect Diffusion Forum, 206-207, p. 87As, D.J., Schmilgus, F., Wang, C., Schotter, B., Schikora, D., Lischka, K., (1997) Appl. Phys. Lett., 70, p. 1311Aspnes, D.E., (1980) Handbook on Semiconductors, p. 109. , T.S. Moss. Amsterdam: North HollandFernandez, J.R.L., Noriega, O.C., Soares, J.A.N.T., Cerdeira, F., Meneses, E.A., Leite, J.R., As, D.J., Lischka, K., (2003) Solid State Commun., 125, p. 205As, D.J., Schmilgus, F., Wang, C., Schottker, B., Schikora, D., Lischka, K., (1997) Appl. Phys. Lett., 70, p. 1311Vashni, Y.P., (1967) Physica (Utrecht), 34, p. 14Ramirez-Flores, G., Navarro-Contreras, H., Lastras-Martínez, A., Powel, R.C., Greene, J.E., (1994) Phys. Rev. B, 50, p. 433Noriega, O.C., Tabata, A., Soares, J.A.N.T., Rodrigues, S.C.P., Leite, J.R., Ribeiro, E., Fernandez, J.R.L., Lischka, K., (2003) J. Cryst. Growth, 252, p. 20
Wavelength tunable 10-GHz 3-ps pulse source using a dispersion decreasing fiber-based nonlinear optical loop mirror
No full textWe experimentally demonstrate the use of a dispersion decreasing fiber (DDF)-based nonlinear optical loop mirror (NOLM) for the generation of wavelength tunable soliton-like pulses at a repetition rate of 10 GHz. We compress ~12 ps Gaussian pulses from an electro-absorption modulator (EAM) (followed by 125 m of DCF for preliminary linear dispersion compensation) into 3 ps pedestal-free pulses using both high-order soliton compression and nonlinear switching effects within an 8.5 km DDF-based loop mirror. The output pulses from the DDF-based NOLM show considerable pedestal reduction compared to those obtained by directly compressing the EAM seed pulses via a single passage through the DDF. Wavelength tuning of the compressed pulses over a ~15 nm bandwidth (from 1541 to 1556 nm) is demonstrated without a significant increase in pulse duration or degradation in pulse quality
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