3,768 research outputs found
Dr. Ellen Ochoa
No full textDr. Ellen Ochoa, a veteran astronaut, is the 11th director of the Johnson Space Center. She is JSC\u27s first Hispanic director, and its second female director. Her previous management roles include Deputy Center Director and Director of Flight Crew Operations.
Ochoa joined NASA in 1988 as a research engineer at Ames Research Center and moved to Johnson Space Center in 1990 when she was selected as an astronaut. She became the first Hispanic woman to go to space when she served on the nine-day STS-56 mission aboard the space shuttle Discovery in 1993. She has flown in space four times, including STS-66, STS-96 and STS-110, logging nearly 1,000 hours in orbit.
Born in California, Ochoa earned a bachelor\u27s degree in physics from San Diego State University and a master\u27s degree and doctorate in electrical engineering from Stanford University. As a research engineer at Sandia National Laboratories and NASA Ames Research Center, Ochoa investigated optical systems for performing information processing. She is a co-inventor on three patents and author of several technical papers.
Ochoa has been recognized with NASA\u27s highest award, the Distinguished Service Medal, and the Presidential Distinguished Rank Award for senior executives in the federal government. She has received many other awards and is especially honored to have 5 schools named for her. She is a Fellow of the American Association for the Advancement of Science (AAAS) and the American Institute of Aeronautics and Astronautics (AIAA), serves on several boards, and chairs the Nomination Evaluation Committee for the National Medal of Technology and Innovation.
She is married to Coe Miles, an intellectual property attorney. They have two sons.https://commons.erau.edu/space-congress-bios-2018/1061/thumbnail.jp
Metatarsonemus megasolenidii Lofego & Ochoa
No full textMetatarsonemus megasolenidii Lofego & Ochoa (Fig. 4) Metatarsonemus megasolenidii, Lofego, Ochoa, Moraes, 2005: 07. Diagnosis: Adult of both sexes: Gnathosoma with a thick, muscular pharyngeal pump, below base of which is a distinctive, transverse groove on external ventral surface of gnathosomal capsule. Sensory cluster on tibia I incomplete, missing ϕ1. Setae pl´´ absent on tarsus II. Female: Vertical setae v1 and scapular setae sc2 of similar length, v1 slightly shorter; setae c1 and c2 of same length. Ventral surface of podosoma with a conjunct of several fissures: a pair of angulate fissures near base of coxisternal setae 1a; a pair of curved fissures anterolaterad bases of coxisternal setae 2a, in part parallel with apodeme 2; a pair of Y-shaped fissures near bases of coxisternal setae 3b, in part superimposed over apodeme 4; and a small subcircular unpaired fissure at posterior end of poststernal apodeme. Male: vertical setae v1 and scapular sc1 and sc2 of a similar length; setae c2 and d of a similar length, c1 slightly shorter; solenidion ω much larger and more swollen on tarsus II than on tarsus I, approximately 1.5 times longer than greatest width of tarsus II; tibial tactile setae not longer than femorogenu on leg IV.Published as part of Lofego, Antonio Carlos, Cavalcante, Ana Cristina Cerqueira, Demite, Peterson Rodrigo, Rezende, José Marcos, Ochoa, Ronald & Moraes, Gilberto José De, 2019, Reinstatement of Metatarsonemus Attiah (Acari: Tarsonemidae), with description of a new species, redefinition of the genus and a key to the world species, pp. 307-329 in Zootaxa 4711 (2) on pages 313-314, DOI: 10.11646/zootaxa.4711.2.5, http://zenodo.org/record/357703
Making the People. An Interview with Paulina Ochoa Espejo, Haverford College
No full textPaulina Ochoa Espejo is an Associate Professor of political science at Haverford College. She is the author of On Borders: Territories, Legitimacy and the Rights of Place (OUP, 2020), The Time of Popular Sovereignty: Process and the Democratic State (PSUP, 2011) and co–editor of the Oxford Handbook of Populism (2017)
PARCE: Protocol for Amino acid Refinement through Computational Evolution
No full textThe in silico design of peptides and proteins as binders is useful for diagnosis and therapeutics due to their low adverse effects and major specificity. To select the most promising candidates, a key matter is to understand their interactions with protein targets. In this work, we present PARCE, an open source Protocol for Amino acid Refinement through Computational Evolution that implements an advanced and promising method for the design of peptides and proteins. The protocol performs a random mutation in the binder sequence, then samples the bound conformations using molecular dynamics simulations, and evaluates the protein–protein interactions using multiple scoring functions. Finally, it accepts or rejects the mutation by applying a consensus criterion based on the binding scores. The procedure is iterated with the aim to explore efficiently novel sequences with potential better affinities towards their targets. We also provide a tutorial for running and reproducing the methodology
Primeros Europeos, Atapuerca IV
No full textDiario de Burgos 18/07/1992.
28/06/1992. Imagen: J. Matías
22/07/1992. Autor: J. Angel Gonzalo. Imagen: A. Rodrigo
23/07/1992. Autor: A. G. Imagen: A. Rodrigo
24/07/1992. Autor: J. B. Imagen: A. Rodrigo
Diario 16 Burgos 19/07/1992. Autora: Begoña Gaitan. Imagen: R.G.O/D.16
22/07/1992. Imagen: R.G.O.
23/07/1992. y 24/07/1992. Autora: Esther Bajo. Imagen:Raul García Ochoa
La Vanguardia 24/07/1992: Autor: Fernando García. Imagen: Felix OrdoñezPrensa escrita.Artículos de prensa sobre la evolución humana y los yacimientos en la Sierra de Atapuerca, publicados en distintos medios en 1992.N
Memoria, No. 40 : La experiencia de la lectura: ¿qué leer y por qué?
No full textMemoria, en su número 40, está conformado por dos bellos textos: «Italo Calvino y la literatura combinatoria. El libro de todos los relatos», presentado por el profesor Juan Diego Tamayo Ochoa, donde, como lo expresa su autor, Italo Calvino se nos presenta como uno de los escritores más interesantes en el campo de la narrativa
de los últimos tiempos, gracias a su manejo impecable de las teorías literarias, su práctica y sus novedosas producciones narrativas. A continuación, el texto «La monstruosidad y lo monstruoso en el teatro crítico y las cartas eruditas y curiosas», escrito por el historiador Rodrigo Zapata Cano, muestra el concepto del
monstruo como fruto de la invención de las sociedades y las vivencias culturales, al igual que como objeto científico enmarcado en la historia. Muy a propósito, este último tema estuvo recreado con una exposición instalada en «Expobilioteca», campus Robledo, a finales del 201
Capacidad predictiva de mortalidad hospitalaria de las escalas CURB – 65, SOFA Y NEWS2 en comparación de 4C Mortality Score, en pacientes con COVID-19 del servicio de medicina interna del Hospital Nacional Dos de Mayo en el periodo enero – junio del 2021
No full textLa búsqueda de herramientas para combatir la pandemia actual por COVID-19 es una prioridad. Resulta pertinente el uso de instrumentos que permitan al médico la estratificación de los pacientes, con el objetivo de redirigir los recursos hacia aquellos más graves.
Objetivos: Determinar la capacidad predictiva de mortalidad hospitalaria de las escalas CURB-65, SOFA y NEWS2 en comparación de 4C Mortality Score, en pacientes con COVID-19 del servicio de medicina interna del Hospital Nacional Dos de Mayo en el periodo enero - junio del 2021.
Metodología: Observacional, analítico, de exactitud diagnostica en una muestra de 268 pacientes, de los cuales 67 fueron fallecidos y 201 sobrevivientes; seleccionados mediante muestreo aleatorio simple. Posteriormente se empleó el análisis de la curva Receiver Operating Characteristic (ROC), obteniendo el área bajo la curva (AUC) y la graduación de los valores respectivos.
Resultados: El AUC de 4C Mortality Score, SOFA, CURB-65 y NEWS 2 fue de 0,89, 0,87, 0,82 y 0,80 respectivamente. Los valores de sensibilidad, especificidad, valor predictivo positivo y valor predictivo negativo para cada escala fueron: 4C Mortality Score (100.0 %, 15,4 %, 28,3 % y 100 %), SOFA (98,1 %, 48,1 %, 34,9 % y 98,9 %), CURB-65 (86,6 %, 65,7 %, 45,7 % y 93,7 %), NEWS2 (97,0 %, 34,3 %, 33, 0 % y 97,2 %).
Conclusiones: 4C Mortality Score obtuvo la mejor capacidad de predicción de mortalidad hospitalaria dentro de los sistemas evaluados. Sin embargo, la puntuación SOFA demostró ser la mejor dentro de las otras tres escalas contrastadasSubmitted by Veronica RubinDeCelis ([email protected]) on 2023-04-21T18:40:43Z
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Previous issue date: 2023Tesi
Assessing the capability of in silico mutation protocols for predicting the finite temperature conformation of amino acids
No full textMutation protocols are a key tool in computational biophysics for modelling unknown side chain conformations. In particular, these protocols are used to generate the starting structures for molecular dynamics simulations. The accuracy of the initial side chain and backbone placement is crucial to obtain a stable and quickly converging simulation. In this work, we assessed the performance of several mutation protocols in predicting the most probable conformer observed in finite temperature molecular dynamics simulations for a set of protein-peptide crystals differing only by single-point mutations in the peptide sequence. Our results show that several programs which predict well the crystal conformations fail to predict the most probable finite temperature configuration. Methods relying on backbone-dependent rotamer libraries have, in general, a better performance, but even the best protocol fails in predicting approximately 30% of the mutations
El Tlacuache Núm. 522 (2012). 522 Año 13 (2012) junio. El Tlacuache
No full textEl último sobreviviente. A diez años de El Tlacuache por Gerardo Ochoa. -Mesoamérica no fue politeísta. Reflexiones en torno a la multiplicidad de dioses por Israel Lazcarro Salgado
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