28 research outputs found
5 Aminoacyl-tRNA Synthetases in Idiopathic Inflammatory Myopathies: An Update on Immunopathogenic Significance, Clinical and Therapeutic Implications
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Aminoacyl-tRNA Synthetases in Idiopathic Inflammatory Myopathies: An Update on Immunopathogenic Significance, Clinical and Therapeutic Implications
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Intercentre variance in patient reported outcomes is lower than objective rheumatoid arthritis activity measures: a cross-sectional study
No full textObjective. To assess intercentre variability in the ACR core set measures, DAS28 based on three variables (DAS28v3) and Routine Assessment of Patient Index Data 3 in a multinational study. Methods. Seven thousand and twenty-three patients were recruited (84 centres; 30 countries) using a standard protocol in the Quantitative Standard Monitoring of Patients with RA study. Analysis of variance (ANOVA) and mixed-effect analysis of covariance models were used to model the relationship between study centre and different patient-reported and physician-reported RA activity measures. These models were built to adjust for the remaining ACR core set measure (for each ACR core set measure or each composite index), socio-demographics and medical characteristics. ANOVA and analysis of covariance models yielded similar results, and ANOVA tables were used to present variance attributable to recruiting centre. Results. The proportion of variances attributable to recruiting centre was lower for patient reported outcomes (PROs: pain, HAQ, patient global) compared with objective measures (joint counts, ESR, physician global) in all models. In the full model, variance in PROs attributable to recruiting centre ranged from 1.53% for patient global to 3.71% for HAQ compared with objective measures that ranged from 5.92% for physician global to 9.25% for ESR; and was lower for Routine Assessment of Patient Index Data 3 (2.6%) compared with DAS28v3 (11.75%). Conclusion. Intercentre variability in PROs is lower than objective measures of RA activity demonstrating that PROs may be more comparable across centres, and the need for standardization of objective measures
The prevalence of temporo mandibular joint in degenerative disease
No full textRezumat
Articulaţia temporomandibulară (ATM), prin poziţie şi funcţie se integrează sistemului stomatognat (SSG), iar prin morfologie se aliniază sistemului articular general; aceste elemente fac ca patologia ATM să înregistreze numeroase aspecte, conturate şi înţelese mai bine în ultima perioadă
prin elocvenţa metodelor imagistice.
Scopul lucrării: identificarea prevalenţei afectării ATM în bolile reumatismale degenerative.
Material şi metodă: studiu prospectiv pe 42 pacienţi cu artroză (OA),
generalizată sau localizată la nivelul articulaţiilor mari (şold, genunchi),
definitş conform ACR, şi un lot martor alcătuit din 33 bolnavi cu alte afecţiuni. Pacienţii au fost spitalizaţi în Clinica Reumatologie a Spitalului Clinic de Recuperare Iaşi, Romania în perioada 01.01.2005—31.07.2006.
Rezultate şi discuţii: prevalenţa simptomatologiei ATM a înregistrat următoarele: durerea articulară, semn dominant, în 92.86% cazuri; durerea musculară frecvent la nivelul muşchiului maseter (71.43%) şi pterigoidian intern
(47.62%); contractură musculară la nivelul muşchiului temporal (83.33%).
Concluzii: simptomatologia afectării ATM trebuie corect apreciată şi
corelată cu modificările imagistice locale, modificările la nivelul întregului
SSG sau modificări articulare axiale şi periferice, în vederea stabilirii etiologiei şi terapiei optime.Summary
Recent advances in imaging techniques of
temporo-mandibular joint (TMJ) result in a
better understanding of TMJ pathology, taking into account that TMJ is included in both
stomatognatic and articular system
Objectives: to identify the prevalence of
TMJ involvement in degenerative rheumatic
disorders.
Material and methods: prospective study
on 42 patients with either generalized or localized (hip, knee) osteoarthritis (OA), defined
according to ACR criteria, and 33 controllers.
Patients were hospitalized in Rheumatology
Department, Rehabilitation Hospital, Iasi, Romania during 01.01.2005—31.07.2006.
Results: the prevalence of TMJ symptoms
registered the following: articular pain, commonly reported, in 92.86% cases; muscular
pain frequently in both maseter (71.43%)
and internal pterigoidian (47.62%) muscles;
muscular contracture in temporal muscle
(83.33%).
Conclusions: both correct assessment of
TMJ involvement and identification of potential relationship between TMJ symptoms and
imagistic details are necessary in order to establish etiology and optimal management of
TMJ pathology
Volumetric Cone Beam Computed Tomography for the Assessment of Oral Manifestations in Systemic Sclerosis: Data from an EUSTAR Cohort
No full textBackground: Oral health issues are commonly reported in systemic sclerosis (SSc), comprising a broad spectrum of manifestations, e.g., reduced mouth opening, periodontal disease, increased periodontal ligament (PDL) space width, and mandibular resorption. We aimed to assess oral radiographic abnormalities, particularly PDL space widening and erosions, and to identify potential relations with disease measures. Methods: cross-sectional study in 43 SSc and matching controls receiving systematic oral assessments (full mouth dental/periodontal) and imaging (radiographs and cone beam computed tomography (CBCT)). Associations between disease variables and radiologic findings were investigated by univariate and multivariate analysis (SPSS-v.20, p < 0.05). Results: CBCT demonstrated generalized PDL space widening in up to half SSc, with at least one tooth involved, essentially in the posterior region (p < 0.05). Significant correlations between number of teeth with PDL space widening and disease severity, skin score, disease subset, topoisomerase I specificity, age, and disease duration were reported (p < 0.05). Additionally, mandibular erosions were described in one out of four patients, commonly condylar erosions. Conclusions: Tridimensional CBCT approach confirmed widening of PDL and mandibular erosions as common dental findings in scleroderma. Furthermore, widened PDL spaces correlated with several disease characteristics including severity, skin extent, and antibody profile
FRI0076 THE RISK OF TUBERCULOSIS IN PATIENTS WITH IMMUNE-MEDIATED RHEUMATIC DISORDERS RECEIVING BIOLOGICAL THERAPY: A 15-YEAR EXPERIENCE IN A ROMANIAN COHORT
No full textLong-Term Outcomes of Patients with Biologically Treated Psoriatic Arthritis and Atopic Dermatitis—A Single-Center Experience
No full text(1) Background: Although the association between psoriasis and atopic dermatitis (AD) is reported in the literature, scarce data are known about the efficacy of biologic therapy (including TNF and IL-17 inhibitors) in patients with psoriatic arthritis (PsA) and concomitant AD. (2) Objective: We aimed to explore AD in patients with PsA undergoing biologics for their active disease, focusing on prevalence and clinical and potential therapeutic implications. (3) Material and methods: We performed a retrospective analysis of 64 patients with PsA receiving various biological agents, followed-up in an academic outpatient rheumatology department up to 10 years. (4) Results: Atopic diseases were reported in about one third of cases, with a higher incidence of AD (10 cases; 52.6%) vs. atopic rhinitis (6 cases; 31.6%) and allergic asthma (3 cases; 15.8%). Three morphological patterns of AD were recognized including chronic prurigo (3 cases), a chronic lichen simplex (1 case), and eczemas (6 cases). All PsA with concomitant AD displayed a late onset of skin atopy (in their adult life) and demonstrated a specific profile (younger), from urban settings, equally distributed among genders, and requiring switching to a higher number of biologics to achieve disease control. (5) Conclusion: PsA and AD may coexist, requiring special attention when selecting the optimal biologic agent
The Prevalence of Atopy in Biologically Treated Spondyloarthropathies: A Retrospective Study of 200 Patients
No full text(1) Background: Recent data shed light on the association between atopic disorders (ADs) (atopic dermatitis, allergic asthma, allergic rhinitis) and spondyloarthropathies (SpAs), underpinning the critical role of T helper (Th)1-Th17/Th2-T regulatory cells disbalance. We evaluated the prevalence of AD in axial SpAs (axSpAs) and psoriatic arthritis (PsA) and explored the potential association between atopic status, disease-related parameters, and biological therapy. (2) Methods: A monocentric, retrospective study was conducted that enrolled 200 patients taking biologics. Demographics, disease, and drug-related variables, along with a screening questionnaire focused on Ads, were systematically collected. (3) Results: Overall, 51 patients (25.5%) had atopy—namely, 24.4% of axSpA and 28% of PsA, with a higher frequency of rhinitis (43%) vs. atopic dermatitis (37.2%) or asthma (21.5%). We failed to demonstrate any statistically significant difference in demographics, SpA-related parameters excepting concomitant inflammatory bowel disease, and biologic drug exposure in patients with and without atopy (p > 0.05). However, significantly more non-atopic patients need only one TNF inhibitor (54%) vs. atopic patients (28%) (p < 0.05) to control active SpA. (4) Conclusions: We successfully demonstrated that AD is associated with one out of four SpA. Irrespective of the SpA subtype, atopic patients require more frequent switching among biologics, as significantly more non-atopic patients remain on their first anti-TNF
FRI0382 TEN-YEAR RETENTION RATES OF FIRST-LINE BIOLOGICAL AGENT IN AXIAL SPONDYLARTHRITIS IN DAILY PRACTICE: A ROMANIAN MULTICENTRE EXPERIENCE
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