2,619 research outputs found
Jay Roberts rag.
No full textGift of Dr. Mary Jane Esplen.Piano. [instrumentation]D major [key]Moderato. [tempo]Ragtime [form/genre]Portrait of Jay Roberts. [illustration]CW [engraver]W. M. Phillips, London, ON. [dealer stamp]Publisher's advertisement on back cover. [note
Acanthamoeba castellanii activates murine macrophages in a MyD88 dependent, TRIF and PAR2 independent manner.
No full textAcanthamoeba castellanii is an opportunistic, facultative parasitic protozoan, known to be the agent of a
serious, painful, potentially blinding keratitis and fatal encephalitis in humans. Acanthamoeba keratitis is
most prevalent in contact lens wearers where it affects 1 in 30,000. Acanthamoeba are ubiquitous in
nature, and consequently, although individuals are regularly exposed to these amoebae, very few cases
of clinical infection occur, suggesting that the innate immune response is normally effective.
Macrophages and neutrophils are predominantly present at the site of infection, implicating them in the
resolution of the disease. Herein, macrophage interactions with trophozoites of Acanthamoeba
castellanii are investigated in vitro using bone marrow derived macrophages. The role of TLRs and
PARs in the recognition and response to Acanthamoeba are also examined using syngeneic mice
deficient in MyD88, TRIF or PAR 2 genes. Results demonstrated that Acanthamoeba castellanii
stimulated TNF- a , IL-6 and IL-12 production by murine macrophages in a MyD88-dependent, but
TRIF-independent manner. Acanthamoeba secreted proteases were able to stimulate the production of
pro-inflammatory cytokines by a PAR 2 independent mechanism. In addition, arginase activity was
significantly increased in murine macrophages after stimulation with trophozoites, whereas NO
production was below detection limits. Taken together, these results suggest that TLR-associated
signaling pathways play an important role in initiating the innate immune response to Acanthamoeba
castellanii with the ensuing production of pro-inflammatory cytokines and arginase activity
Cw ion lasers pumped by electron beams
No full textWe have obtained cw laser radiation from singly ionized Hg, I, Cd, Se, and As by exciting He metal-vapor mixtures with a dc electron beam. The beam is generated by glow discharge electron guns located apart from the active medium. This is the first time that cw ion laser action has been obtained using electron beam excitation
CW laser action in atomic fluorine
No full textWe have obtained CW laser action on four transitions in the doublet system of atomic fluorine for the first time. All previously reported laser action was on a pulsed basis only. CW laser radiation was obtained when F2 or AgF was used as a fluorine donor in an electron beam pumped helium plasma. A multiline output power of 200 mW was obtained
CW silver ion laser with electron beam excitation
No full textA CW laser power of 140 mW was obtained in the 840.39 nm transition of Ag II by electron beam excitation. This electron beam excited metal vapor ion laser is capable of operating using metals with high vaporization temperatures and is of interest for generation of CW coherent radiation in the 220-260 nm spectral region
1-W quasi-cw near-diffraction-limited semiconductor laser pumped optically by a fibre-coupled diode bar
No full textWe describe a diode-bar-pumped vertical-external-cavity surface-emitting semiconductor laser, which in quasi-cw operation emitted a peak power of >1 W at 1020 nm in a circular, near diffraction-limited beam
1-W cw Zn ion laser
No full textWe have obtained 1.2W of cw laser power on the 4911.6- and 4924.0-Å transitions of Zn II by exciting a He-Zn gas mixture with a dc glow discharge electron beam. In addition, 0.25-W output power has been obtained on the 6149.9-Å line of Hg+ using the same excitation scheme. The combination of electron beam ionization of rare gas atoms and subsequent charge transfer excitation to metal ion levels is shown to have the potential of significantly increasing the efficiency of ion lasers. cw multiwatt visible and ultraviolet ion lasers operating at efficiencies > 10-3 appear feasible using this excitation scheme
Stabilization as a CW approximation
No full textAbstractThis paper describes a peculiar property of the category of S-modules constructed by the author, Kriz, Mandell, and May: the full subcategory of suspension spectra (all of which are S-modules) forms a precise copy of the category of topological spaces. Consequently, the “classical” homotopy category of S-modules with morphisms the actual homotopy classes of maps contains a copy of unstable homotopy theory. Stabilization and stable homotopy are induced by CW approximation as S-modules. One consequence is that CW complexes whose suspension spectra are CW S-modules must be contractible
Cw iodine ion laser excited by an electron beam
No full textCW laser oscillation has been obtained on the 5760.7 and6127.5 Å transitions of singly ionized iodine in an He-I2 plasma excited by a dc electron beam
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