188 research outputs found
MHC Class II Transactivator is an in vivo regulator of osteoclast differentiation and bone homeostasis co-opted from adaptive immunity
No full textAbstract not availableElisa Benasciutti, Elisabetta Mariani, Laura Oliva, Maria Scolari, Egon Perilli, Emmanuele Barras, Enrico Milan, Ugo Orfanelli, Nicola L Fazzalari, Lara Campana, Annalisa Capobianco, Luc Otten, Francesca Particelli, Hans Acha, Orbea, Fabio Baruffaldi, Roberta Faccio, Roberto Sitia, Walter Reith, and Simone Cenc
It's the Way You Treat Me That Makes Me Angry, It's Not a Question of Madness: Good and Bad Practice In Dealing With Violence in the Mental Health Services
No full textAccessible Summary
What is known on the subject:
• The first access to a mental health service is sometimes marked by aggressive be-
haviours and anger. Forced hospitalization is frequently an occasion for resistance
and hostility to the service, which should not be mistaken for psychotic symptoms.
• If this situation is not dealt with effectively, it can jeopardize the quality of the
relationship with staff and compliance with the treatment programme.
What the paper adds to existing knowledge:
• The narrator presents his experience in undergoing voluntary psychiatric treat- ment, casting light on nurses’ good and bad practices: those that increased resist- ance, and those that helped de-escalate the uncontrolled reaction at the time of access, as well as during the recovery period.
What are the implications for mental health nursing:
• Practitioners should be able to put in place listening techniques and ways of per- sonalizing the relationship with the patient.
• When such measures become part of the patient's meaning system, the vicious circle of misunderstood anger that creates more anger may be interrupted and the patient can invest in relationships of trust
The Remains and Landscape: Strategies for Active Conservation of the Former Campo di Fossoli
No full textBy analysing 450 newspaper reports, the chapter examines the transformation of memory frames in the narration of the Fossoli camp after its closure as camp of transit. If in the 1970s and 1980s the memory of the camp seems geographically scattered and temporally non-synchronized at the national level, in the 1990s and 2000s we see a gradual centralization and synchronization of memorial occasions. The official commemorative days 25 April, 27 January and 10 February play nowadays a pivotal role in the representation of Fossoli, intersecting different frames of memory
Pathogenesis of bone diseases: The role of immune system
No full textBone is a metabolically active tissue that undergoes continuous remodeling by two sequential events, bone formation
and resorption. These events are strongly linked and tightly
regulated to maintain skeletal homeostasis. The bone cells
responsible for the dual events include the bone-resorbing
cells, the osteoclasts, arising from monocyte-macrophage
precursors, and the bone forming cells, the osteoblasts,
having a mesenchymal origin. Immune and bone cell activities are linked by several pathways [1] and the former can
promote bone building or destruction. Further, immune cells
can be involved in the mineralization process occurring in
extra-skeletal sites. In this special issue different authors
highlighted these items both through research articles and
reviews
When the non-sharing of therapeutic goals becomes the problem: The story of a consumer and his addiction to methadone
No full textMental health services typically follow standardized intervention protocols and systematic operating practices. This article explores what happens when a service relies exclusively on fixed practices rather than on the negotiation of objectives and the differentiation of procedures according to the needs of the user. The analysis of the narratives produced in first person by Oliver, a former substance user, emphasizes the need of constructing a therapeutic plan in close cooperation, promoting an user active role and strengthening his affiliation in the change process. In this specific case, the involvement of the user meant the identification of the peculiar meanings he attributed to the ‘substance of use’, which paradoxically coincided with the ‘therapeutic substance’ (methadone). Oliver’s story is an effective mirror for rethinking staff conduct when it assumes that the drug is therapeutic in itself, regardless of the way the person experiences and means it, it also offers a description of the interactive ways in which the relationship between a young person and service staff proved to be effectively therapeutic
Bone-Immune Cell Crosstalk: Bone Diseases
No full textBone diseases are associated with great morbidity; thus, the understanding of the mechanisms leading to their development represents a great challenge to improve bone health. Recent reports suggest that a large number of molecules produced by immune cells affect bone cell activity. However, the mechanisms are incompletely understood. This review aims to shed new lights into the mechanisms of bone diseases involving immune cells. In particular, we focused our attention on the major pathogenic mechanism underlying periodontal disease, psoriatic arthritis, postmenopausal osteoporosis, glucocorticoid-induced osteoporosis, metastatic solid tumors, and multiple myeloma
Anorexia and Bulimia, Research and Therapies
No full textThis contribution critically reviews various theoretical and clinical models that have been applied to the study of eating disorders and, using a relational perspective, it provides an original and alternative conceptualization of the motivation for change. In particular, the author confronts the numerous philosophical, conceptual, diagnostic and treatment controversies that exist within the field in a very engaging and descriptive style and provide a new framework for treating eating disorders starting from a socio-costructionist perspective. The text is a highly theoretical and practical guide, it provides essential information for practitioners related to the experience of anorexia and bulimia in a concise and systematic manner. The sufferer’s perspective, diagnostic criteria, co-morbidity, biological concomitants of self-starvation; treatments approaches, outcome and prognosis are integrated with research and clinical findings.
The book presents an intellectually stimulating and informative exploration of the wide literature and includes a new intervention proposal
Hyphal and cytoskeleton polarization in Tuber melanosporum: a genomic and cellular analysis.
No full textFilamentous polarized growth involves a series of events including polarization of the cytoskeleton to selected growth sites, and the transport of secretory vesicles containing the components required for growth. The availability of fungal genome sequences has recently led to the identification of a large number of proteins involved in these processes. We have explored the Tuber melanosporum genome sequence by searching for homologs of genes known to play crucial roles in the morphogenesis and cell polarity of yeasts and filamentous fungi. One hundred and forty-nine genes have been identified and functionally grouped according to the deduced amino acid sequences (44 genes involved in cell polarity/morphogenesis, 39 belonging to the actin cytoskeleton and 66 involved in membrane dynamics, septation and exocytosis). A detailed gene annotation has shown that most components of the cell polarity machinery, morphogenesis and cytoskeleton found in yeasts and filamentous fungi are conserved, although the degree of similarity varies from strong to weak. Microscopic analysis of quick-frozen truffle hyphae detected the characteristic subcellular components of the hyphal tip in septate filamentous fungi, while transcript profiles revealed a moderately variable pattern during the biological cycle
Análise da paisagem cultural do Sítio Arqueológico Turvo V-B
No full textThis work is the result of a study from the Archaeological Site Turvo V-B, located in the City of Pontes Gestal, SP. The site on screen is inserted within the limits of the River Basin Turvo/Grande, in the northern region of São Paulo. The aim of this work is the study of ceramic collection, in order to understand the regional system of occupation pre-colonial indigenous in the northern region of the State of São Paulo. Initially, we present the Ethno-history of the north of the State of São Paulo, identifying the first people who occupied this territory from the century XVII, which are owned by Tradition Aratu-Sapucaí. Next, we performed a Site Turvo V-B landscape analysis from the physical environment River Basin Turvo/Grande and the relationship between the preterit populations and the environment. The analysis of the ceramic material of the Site Turvo V-B was carried out from the methodological assumptions of Faccio (1992; 1998; 2011a). The author proposes the analysis of the technical and morphological-functional elements that subsequently enable digital reconstitution of the forms of ceramic vessels. Thus, it was possible to associate the Site Turvo V-B material culture in screen Regional Occupation System Aratu-Sapucaí, affiliated to the Cayapó Indians who inhabited the north of the State of São Paulo in the pre-colonial periodEsse trabalho é resultado de um estudo realizado a partir do Sítio Arqueológico Turvo V-B, localizado no Município de Pontes Gestal, SP. O sítio em tela encontra-se inserido nos limites da Bacia Hidrográfica Turvo/Grande, na região norte do Estado de São Paulo. O objetivo do presente trabalho é o estudo da coleção cerâmica do sítio, a fim de compreender o sistema regional de ocupação indígena pré-colonial da região norte do Estado de São Paulo. Inicialmente, apresentamos a Etno-história da região norte paulista, identificando as primeiras populações que ocuparam esse território desde século XVII, sendo estas pertencentes a Tradição Aratu-Sapucaí. Em seguida, realizamos uma análise da paisagem do Sítio Turvo V-B a partir do meio físico da Bacia Hidrográfica Turvo/Grande e a relação entre as populações pretéritas e o ambiente. A análise do material cerâmico do sítio em tela foi realizada a partir dos pressupostos metodológicos de Faccio (1992; 1998; 2011a). A autora propõe a análise dos elementos técnico-morfológico-funcionais que possibilitam a reconstituição digital das formas de recipientes cerâmicos. Desse modo, foi possível associar a cultura material do Sítio Turvo V-B ao Sistema Regional de Ocupação Aratu-Sapucaí, filiados aos índios Caiapós que habitaram a região norte do Estado de São Paulo no período pré-colonialPrograma Institucional de Iniciação Científica (PIBIC)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq
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