136 research outputs found
sj-docx-1-wso-10.1177_17474930231215660 – Supplemental material for Prevalence, patterns, and predictors of patient-reported non-motor outcomes at 30 days after acute stroke: Prospective observational hospital cohort study
No full textSupplemental material, sj-docx-1-wso-10.1177_17474930231215660 for Prevalence, patterns, and predictors of patient-reported non-motor outcomes at 30 days after acute stroke: Prospective observational hospital cohort study by Hatice Ozkan, Gareth Ambler, Gargi Banerjee, Simone Browning, Alex P Leff, Nick S Ward, Robert J Simister and David J Werring in International Journal of Stroke</p
sj-docx-1-wso-10.1177_17474930211062478 – Supplemental material for MRI and CT imaging biomarkers of cerebral amyloid angiopathy in lobar intracerebral hemorrhage
No full textSupplemental material, sj-docx-1-wso-10.1177_17474930211062478 for MRI and CT imaging biomarkers of cerebral amyloid angiopathy in lobar intracerebral hemorrhage by Ghil Schwarz, Gargi Banerjee, Isabel C Hostettler, Gareth Ambler, David J Seiffge, Hatice Ozkan, Simone Browning, Robert Simister, Duncan Wilson, Hannah Cohen, Tarek Yousry, Rustam Al-Shahi Salman, Gregory Y H Lip, Martin M Brown, Keith W Muir, Henry Houlden, Rolf Jäger and David J Werring in International Journal of Stroke</p
Clinical presentation of strokes confined to the insula: a systematic review of literature
No full textBackground and purpose The insular cortex serves a wide variety of functions in humans, ranging from sensory and affective processing to high-level cognition. Hence, insular dysfunction may result in several different presentations. Ischemic strokes limited to the insular territory are rare and deserve a better characterization, to be quickly recognized and to receive the appropriate treatment (e.g. thrombolysis).
Methods We reviewed studies on patients with a first-ever acute stroke restricted to the insula. We searched in the Medline database the keywords “insular stroke” and “insular infarction”, to identify previously published cases. Afterwards, the results were divided depending on the specific insular region affected by the stroke: anterior insular cortex (AIC), posterior insular cortex (PIC) or total insula cortex (TIC). Finally, a review of the clinical correlates associated with each region was performed. Results We identified 25 reports including a total of 49 patients (59.7 ± 15.5 years, 48% male) from systematic review of the literature. The most common clinical phenotypes were motor and somatosensory deficits, dysarthria, aphasia and a vestibular-like syndrome. Atypical presentations were also common and included dysphagia, awareness deficits, gustatory disturbances, dysautonomia, neuropsychiatric or auditory disturbances and headache.
Conclusions The clinical presentation of insular strokes is heterogeneous; however, an insular stroke should be suspected when vestibular-like, somatosensory, speech or language disturbances are combined in the same patient. Further studies are needed to improve our understanding of more atypical presentations
Outcomes of Mechanical Thrombectomy in Patients With Ischemic Stroke and Heart Failure. A Systematic Review and Meta‐analysis
No full textBACKGROUND Patients with heart failure (HF) treated with mechanical thrombectomy (MT) for acute ischemic stroke were underrepresented in clinical trials on MT. Our systematic review and meta‐analysis aim to assess differences in outcomes between patients with HF and their counterparts without HF treated with MT for acute ischemic stroke.
METHODS A systematic review of the English language literature from inception up to March 7, 2024, was conducted using PubMed, Embase, Cochrane Library, and Web of Science databases. Studies focused on patients with and without HF who were treated with MT for acute ischemic stroke were included. The primary outcome of interest was the rate of modified Rankin Scale scores of 0–2 at 90 days. Secondary outcomes of interest included rates of 90‐day mortality, successful reperfusion, and symptomatic intracranial hemorrhage.
RESULTS
Of 5394 initially retrieved studies, 5 studies were included in the systematic review with a final population of 44 385 patients with ischemic stroke with and without HF treated with MT. Four studies were combined for the primary outcome and showed comparable rates of 0–2 modified Rankin Scale scores between patients with HF and patients without HF (odds ratio, 0.86 [95% CIs, 0.70–1.06]; P = 0.15). Ninety‐day mortality was significantly higher in the HF group (odds ratio, 1.92 [95% CIs, 1.66–2.23]; P<0.0001) although the sample size was small (n of study = 3) and only unadjusted estimates were used. Successful reperfusion and symptomatic intracranial hemorrhage rates were similar between the groups.
CONCLUSION In this systematic review and meta‐analysis, patients with HF experienced worse 90‐day mortality post‐MT. Our data encourage further research on MT outcomes in patients with large vessel‐occlusion ischemic stroke and concomitant HF
The role and function of HtrA in the pathogenesis of "Helicobacter pylori" and "Listeria monocytogenes": characterization of the proteolytic activity and identification of novel host cell targets
No full text> proteolytic activity of "Listeria monocytogenes" HtrA Carmen M. Abfalter, Sabine Bernegger, Miroslaw Jarzab, Gernot Posselt, Karthe Ponnuraj and Silja WesslerIdentification of Desmoglein-2 as a novel target of "Helicobacter pylori" HtrA in epithelial cells Sabine Bernegger, Robert Vidmar, Marko Fonovic, Gernot Posselt, Boris Turk, Silja Wessler> novel FRET peptide assay reveals efficient "Helicobacter pylori" HtrA inhibition through zinc and copper binding Sabine Bernegger, Cyrill Brunner, Matej Vizovišek, Marko Fonovic, Gaetano Cuciniello, Flavia Giordano, Vesna Stanojlovic, Miroslaw Jarzab, Philip Simister, Stephan M. Feller, Gerhard Obermeyer, Gernot Posselt, Boris Turk, Chiara Cabrele, Gisbert Schneider & Silja Wesslersubmitted by Sabine BerneggerLiteraturverzeichnis: Blatt 135-162Kumulative Dissertation aus drei ArtikelnDissertation Paris-Lodron University of Salzburg 2021Abstract/Zusammenfassung in deutscher und englischer Sprach
The role and function of HtrA in the pathogenesis of "Helicobacter pylori" and "Listeria monocytogenes": characterization of the proteolytic activity and identification of novel host cell targets
No full text> proteolytic activity of "Listeria monocytogenes" HtrA Carmen M. Abfalter, Sabine Bernegger, Miroslaw Jarzab, Gernot Posselt, Karthe Ponnuraj and Silja WesslerIdentification of Desmoglein-2 as a novel target of "Helicobacter pylori" HtrA in epithelial cells Sabine Bernegger, Robert Vidmar, Marko Fonovic, Gernot Posselt, Boris Turk, Silja Wessler> novel FRET peptide assay reveals efficient "Helicobacter pylori" HtrA inhibition through zinc and copper binding Sabine Bernegger, Cyrill Brunner, Matej Vizovišek, Marko Fonovic, Gaetano Cuciniello, Flavia Giordano, Vesna Stanojlovic, Miroslaw Jarzab, Philip Simister, Stephan M. Feller, Gerhard Obermeyer, Gernot Posselt, Boris Turk, Chiara Cabrele, Gisbert Schneider & Silja Wesslersubmitted by Sabine BerneggerLiteraturverzeichnis: Blatt 135-162Kumulative Dissertation aus drei ArtikelnDissertation Paris-Lodron University of Salzburg 2021Abstract/Zusammenfassung in deutscher und englischer Sprach
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