154 research outputs found
F. Pétis de la Croix, Les Mille et un Jours, texte établi par P. Sebag
No full textMantran Robert. F. Pétis de la Croix, Les Mille et un Jours, texte établi par P. Sebag. In: Revue de l'Occident musulman et de la Méditerranée, n°33, 1982. pp. 144-145
El gorrión de Stalin. Historias. Revista de la Dirección de Estudios Históricos Num. 83 (2012) septiembre-diciembre
No full textSimon Sebag-Montefiore (1965) se ha dedicado a reconstruir y contar la vida y los tiempos de Stalin, por encima de su otra pasión: el siglo xviii ruso y sus autócratas. En español existen por el momento estos títulos: La corte del zar rojo (traducción de Teófilo de Lozoya Elzurdía, Crítica, 2004), Llamadme Stalin. La historia secreta de un revolucionario (traducción de Teófilo de Lozoya Elzurdía, Crítica, 2007, 2010), amén de su novela Sashenka (traducción de Máximo Sáez Escribano, Punto de Lectura, 2009, 2011). La hija de Stalin murió el pasado 22 de noviembre de 2011 en Richland, Wisconsin, bajo el nombre que asumió al casarse con un ciudadano estadounidense, Lana Peters. Esta nota se publicó el 3 de diciembre de 2011 en el Financial Times
Robert Service: Nicolás II y la Revolución Rusa
No full textSabido es que Robert John Service es un historiador británico especializado en Rusia y que, por su orientación (liberal conservadora, diríamos) y sus dotes literarias, goza del favor del gran público, junto con colegas que le son más o menos cercanos, como Robert Conquest, Orlando Figes, Richard Pipes o Simon Sebag Montefiore. Sea como fuere, al margen de las polémicas que le acompañan al tratar los temas que trata, es un autor que no se puede obviar y que, como es lógico, debía aportar su..
Impact of short-course preoperative radiotherapy for rectal cancer on patients' quality of life::data From the Medical Research Council CR07/National Cancer Institute of Canada Clinical Trials Group C016 randomized clinical trial
No full textPurpose The Medical Research Council CR07/National Cancer Institute of Canada Clinical Trials Group C016 (MRC CR07/NCIC CTG C016) trial showed that, in patients with operable rectal cancer, short-course preoperative radiotherapy (PRE) reduced the rate of local recurrence compared with surgery followed by selective postoperative chemoradiotherapy for patients with a positive circumferential resection margin. However, the advantages of giving PRE to all patients needs to be balanced against any negative impact on patients' quality of life.Patients and Methods All 1,350 patients were asked to complete the Medical Outcomes Study Short-Form 36-item (MOS SF-36) and the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Colorectal 38-item (EORTC QLQ-CR38) questionnaires. A priori hypotheses related to the impact of treatment on sexual, bowel, and physical function and general health.Results Male sexual dysfunction was significantly increased following surgery (P < .001), although there was no difference between treatment arms. However, a treatment difference had emerged at 6 months (PRE patients reporting significantly greater dysfunction; P = .004), which persisted out to at least 2 years (an insufficient number of female patients completed the sexual dysfunction questions to draw firm conclusions). Both treatment groups reported similar levels of decreased physical function at 3 months, but thereafter it returned to baseline levels. There was no evidence of any major changes between treatments or time points in terms of general health or bowel function, but exploratory analysis indicated a significant (P = .006 at 2 years) increase in the level of fecal incontinence with PRE.Conclusion These results from a large randomized trial using validated patient-completed questionnaires show that, for males, the main adverse effect was sexual dysfunction, and the main cause of this was surgery, but that PRE also affected sexual and some aspects of bowel functioning.</p
Jerusalem "The Making Of a Holy City"
No full textHistorian and author, Simon Sebag Montefiore presents a fascinating series on Jerusalem: the place where God meets man, the shrine of three faiths - Judaism, Christianity and Islam, and the most fought over city in history
. 83 (2012) septiembre-diciembre. Historias. Revista de la Dirección de Estudios Históricos
No full text- Un poeta de casa por Alfonso Junco. - La familia Cseresnyés / Ĉerešnješ. Un comentario sobre un legado judío transilvano-bosnio por Stephen Schwartz. - Mi madre comparte sus secretos por Katie Roiphe. - El libro bien leído como objeto de belleza por Geoff Dyer. - El gorrión de Stalin por Simon Sebag-Montefiore. - El largo descubrimiento del Opera medicinalia de Francisco Bravo por Rodrigo Martínez Baracs. - Dos siglos, dos naciones: México y Francia 1810-2010 por Jean Meyer. - Los extranjeros en México. Reflexiones sobre una presencia diversa, de cifras difusas y cualidades evidentes por Delia Salazar Anaya. - El espectacular lanzamiento de la guerrilla urbana en Colombia, el M-19 en 1974 por Paulo César León Palacios. - La fotohistoria y el centenario de la Revolución mexicana: una aproximación biblio-hemerográfica por Daniel Escorza. - La traducción como generadora de imágenes por Salvador Rueda. - Recuento de la inmigración mexicana por María Dolores Morales. - Retratos de pasión por Rebeca Monroy Nasr. - De la fotografía de prensa por Daniel Escorza. – Crestomanía por José Mariano Leyva
The Hebrew primer and reading book : containing rules in Hebrew grammar, together with a vocabulary of the book of Genesis /
No full textMode of access: Internet
The versatility of high-content high-throughput time-lapse screening data : developing generic methods for data re-use and comparative analyses
No full textUn crible biologique a pour objectif de tester en parallèle l'impact de nombreuses conditions expérimentales sur un processus biologique d'un organisme modèle. Le progrès technique et computationnel a rendu possible la réalisation de tels cribles à grande échelle - jusqu'à des centaines de milliers de conditions. L'imagerie sur cellules vivantes est un excellent outil pour étudier en détail les conséquences d'une perturbation chimique sur un processus biologique. L'analyse des cribles sur cellules vivantes demande toutefois la combinaison de méthodes robustes d'imagerie par ordinateur et de contrôle qualité, et d'approches statistiques efficaces pour la détection des effets significatifs. La présente thèse répond à ces défis par le développement de méthodes analytiques pour les images de cribles temporels à haut débit. Les cadres qui y sont développés sont appliqués à des données publiées, démontrant par là leur applicabilité ainsi que les bénéfices d'une ré-analyse des données de cribles à haut contenu (HCS). Le premier workflow pour l'étude de la motilité cellulaire à l'échelle d'une cellule dans de telles données constitue le chapitre 2. Le chapitre 3 applique ce workflow à des données publiées et présente une nouvelle distance pour l'inférence de cible thérapeutique à partir d'images de cribles temporels. Enfin, le chapitre 4 présente une pipeline méthodologique complète pour la conduite de cribles temporels à haut débit en toxicologie environnementale.Biological screens test large sets of experimental conditions with respect to their specific biological effect on living systems. Technical and computational progresses have made it possible to perform such screens at a large scale - up to hundreds of thousands of experiments. Live cell imaging is an excellent tool to study in detail the consequences of chemical perturbation on a given biological process. However, the analysis of live cell screens demands the combination of robust computer vision methods, efficient statistical methods for the detection of significant effects and robust procedures for quality control. This thesis addresses these challenges by developing analytical methods for the analysis of High Throughput time-lapse microscopy screening data. The developed frameworks are applied to publicly available HCS data, demonstrating their applicability and the benefits of HCS data remining. The first multivariate workflow for the study of single cell motility in such large-scale data is detailed in Chapter 2. Chapter 3 presents this workflow application to previously published data, and the development of a new distance for drug target inference by in silico comparisons of parallel siRNA and drug screens. Finally, chapter 4 presents a complete methodological pipeline for performing HT time-lapse screens in Environmental Toxicology
Systematic Review of the Quality of Life issues associated with Anal Cancer and its treatment with Radiochemotherapy
No full textPurpose Radiochemotherapy is the standard of care for the treatment of anal carcinoma achieving good loco-regional control and sphincter preservation. This approach is however associated with acute and late toxicities including haematological, skin, bowel function and genito-urinary complications. This paper systematically reviews studies addressing the quality of life (QoL) implications of anal cancer and radiochemotherapy. The paper also evaluates how QoL is assessed in anal cancer. Methods Medline, EMBASE, CINAHL, PsycInfo, Web of Science and the Cochrane Library were searched for publications (1996–2014) reporting the effects on patients of anal cancer and radiochemotherapy. Results Of the 152 papers reporting treatment-related effects on patients, only 11 provided a formal assessment of QoL. In the absence of an anal cancer-specific measure, QoL was assessed using generic cancer instruments such as the core EORTC quality of life questionnaire (EORTC QLQ-C30) or colorectal cancer tools such as the EORTC QLQ-CR29. Bowel function, particularly diarrhoea, and sexual problems were the most commonly reported QoL concerns. The review of QoL issues of anal cancer patients treated with radiochemotherapy is limited by the QoL assessment measures used. It is argued that certain treatment-related toxicities, for example skin-induced radiation problems, are overlooked or inadequately represented in existing measures. Conclusions This review emphasises the need to develop an anal cancer-specific QoL measure and to incorporate QoL as an outcome of future trials in anal cancer. The results of this review are informative to clinicians and patients in terms of treatment decision-making
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