1,721,422 research outputs found
Honaker, Robert Morgan
No full textRobert Morgan Honaker, LL.B.
Lexington, Kentucky
ΔΤΔ
-The Kentuckian, 1925------------------------------------
Robert Morgan Honaker (September 7, 1902 - February 12, 1962) was born in Lexington, Kentucky to Ollie Honaker and Dora Morgan. In addition to practicing law in Lexington, Honaker worked for many years in his father\u27s florist shop. He retired to Daytona Beach, Florida in 1958. He married Minnie Woodard in 1932.https://uknowledge.uky.edu/klapp_1925/1011/thumbnail.jp
Justice Deferred: Antidumping Legislation in the Robert Morgan Collection
No full textRecipient of the Senator Robert Morgan Papers Student Research Award.The Robert Morgan papers provide detailed insight into the forming of H.R.8149, the Customs Procedural Reform and Simplification Act of 1978, and the events that led to its creation.
This project examines Robert Morgan’s involvement in the Customs Procedural Reform and Simplification Act of 1978 and examines the case as it pertains to the Robert Morgan Papers. The documents in the collection are used to:
Evaluate the events leading up to the Customs Procedural Reform and Simplification Act of 1978;
Examine Robert Morgan’s impact on Antidumping legislation;
Examine a specific legal case that involved Robert Morgan’s work in antidumping legislation;
Evaluate Robert Morgan’s total impact on the passing of this billAcademic Library Service
DeepZipper II: Analysis and Data Processing Code
No full text<p>This release accompanies the paper "DeepZipper II: Searching for Lensed Supernovae in Dark Energy Survey Data with Deep Learning" by Robert Morgan, Brian Nord, Keith Bechtol et al. 2022.</p>
Zircon
No full textRobert Morgan reads the poem "Zircon" in Zirconia, North Carolina, recalling his uncles' experience of digging the crystalline mineral and pondering its ability to clock the long register of time
The Effect of Ethanol on the Metabolism of Gamma-Hydroxybutyrate
No full textL’alcol etilico e il GHB (neurotrasmettitore endogeno, farmaco per il trattamento della narcolessia e della astinenza alcolica, droga d’abuso utilizzata nei rave party e nei casi di violenza sessuale) mostrano alcune caratteristiche funzionali e strutturali in comune. In particolare gli stessi agiscono come depressori del sistema nervoso centrale e mostrano un uguale gruppo funzionale idrossilico. Su questa base è possibile ipotizzare una interazione tra alcol etilico e GHB.Lo scopo del presente lavoro era valutare mediante esperimenti in vitro ed in vivo l’influenza dell’alcol etilico sul metabolismo del GHB.Gli esperimenti in vitro erano basati sulla valutazione della modifica dell’attività dell’enzima succinaldeide deidrogenasi in presenza di alcol etilico. E’ stato verificato che in presenza di elevate concentrazioni di alcol etilico (4g/l) c’era una inibizione dell’attività dell’enzima con conseguente aumento della succicinil-semialdeide (SSA).Gli esperimenti in vivo erano basati sulla valutazione della modifica di concentrazione di GHB endogeno in due popolazioni, una di soggetti con un’intossicazione acuta da alcol (n=18) e l’altra di abusatori cronici di alcol (N=25). E’ stata rilevato un aumento statisticamente significativo delle concentrazioni sieriche di GHB endogeno rispetto al controllo in entrambe le popolazioni. In conclusione, gli studi in vitro ed in vivo hanno concordemente confermato l’influenza dell’alcol etilico sul metabolismo del GHB. Ciò è molto rilevante sia per meglio comprendere il meccanismo d’azione di queste due sostanze sia per l’interpretazione dei casi forensi.IntroductionGamma-Hydroxybutyrate (GHB) is drug of interest to forensic toxicologists both as a drug of abuse and as a drug frequently implicated in drug facilitated sexual assaults (DFSA). At the same time, GHB is also an endogenous metabolite of gamma-aminobutyric acid (GABA) and a known neurotransmitter found in the mammalian brain. Illicit GHB use frequently involves co-ingestion of other substances, the primary compound being ethanol. While anecdotal reports state that the effects of GHB are worse when taken with ethanol, evidence from published animal studies indicates that there exists a pharmacokinetic interaction. Aim of the research projectThe aims of the present study were to present a review on the pharmacokinetics of endogenous and exogenous GHB and to experimentally determine and characterize the influence of ethanol on the metabolism of GHB in an in vitro and an in vivo study. Materials and methodsThe literature review covered the metabolism of endogenous GHB as well discussing the studies performed to in an attempt to determine an interpretative cut-off for the distinction between exogenous and endogenous GHB concentrations employed in forensic cases. In addition, pharmacodyanamics and pharmacokinetics of exogenous GHB were discussed with special attention paid to ethanol-GHB interactions.In the experimental studies an in vitro enzymatic study examined succinic semialdehyde dehydrogenase and the effect ethanol had on its ability to oxidize succinic semialdehyde (SSA) to succinic acid (SA) using spectrophotometry. In the in vivo study, a liquid chromatography-mass spectrometry (LC/MS) method was developed and validated for the purpose of measuring endogenous GHB concentrations in serum. The endogenous GHB concentrations of serum samples from human subjects with chronic alcohol use, characterized by their increased percentage of carbohydrate deficient transferrin (CDT) were compared to the GHB concentrations from serum specimens found to have a blood alcohol concentration (BAC) of over 0.5 g/L using a headspace-gas chromatography (HS-GC) method. The quantified GHB concentrations from both groups (acute and chronic ethanol use) were compared to GHB concentrations in serum from individuals who had not consumed ethanol and had low CDT values. Statistical tests evaluated any significant differences in GHB concentrations measured between groups. ResultsEthanol, at 4 g/L, was found to be a competitive inhibitor at the SSADH enzyme in this study. From a Lineweaver-Burke plot, a Michaelis constant (Km) for SSADH of 49 μM was determined in the absence of ethanol and a Km of 60 μM found in the presence of ethanol. The Vmax of our assay was 5.74 x 10-4 μmol/L/sec in both the absence and presence of ethanol. The LC/MS results of the control group for measured endogenous GHB ranged from 18 -38 ng/mL, and a median concentration of 27 ng/mL. The endogenous GHB concentrations of subjects with a high BAC were found to be from 33 ng/mL up to 361 ng/mL; median of 61 ng/mL, while the chronic alcohol use group held concentrations from 18 -171 ng/mL, median value of 43.5 ng/mL. Applying the Mood’s Median test, a significant difference (p < 0.0001) was found for both the acute and chronic alcohol use groups compared to the median of the control group. The serum concentrations of endogenous GHB in the control group matched well with previous research studies discussed in the literature review. ConclusionsThis dissertation is the first to report increased endogenous GHB serum concentrations in human subjects as a consequence of simultaneous alcohol intoxication. An increase in the endogenous concentration was also observed in subjects with chronic alcohol abuse, characterized by their CDT score. This study also provides evidence that SSADH metabolism of SSA can be competitively inhibited by ethanol at higher concentrations.The studies presented here provide insight into forensic cases with combined GHB and ethanol intoxications
A Conversation with Robert Morgan
No full textRobert Morgan looks back on his 44 years as a member of the Cornell English Department faculty to recall his pleasure at receiving a carefully worded invitation to teach creative writing at Cornell “for one year only.” Members of the writing program (among them Baxter Hathaway, Jim McConkey, Walter Slatoff, Archie Ammons, and Bill Matthews), as well as other colleagues were happy to see that invitation extended. As an undergraduate Bob had undertaken serious study of math and science before being deflected into literature. His career as writer (punctuated by a memorable endorsement by Oprah) has encompassed poetry, fiction, and history, much of it based on his experience growing up in the American South in a story-telling family. Since retirement he has written several plays drawing on the same material. A major turning point was his successful attempt to compose a semi-fictional account of the death of his uncle in World War II, told in the voice of the uncle’s fiancée.1_mpfh0k6
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Favorable Winds: Robert Morgan & The Circumstances of the 1974 Election Year
No full textRecipient of the Senator Robert Morgan Papers Student Research AwardThe election year of 1974 was fraught with drama and controversy, and it was not
standard fare. While the predictable cycle of congressional midterms churned through their own
campaign surprises, the entire nation was watching as President Richard Nixon faced
impeachment in the middle of his term. The Watergate scandal, in which President Nixon was
implicated, was too large to remain separate from the already ongoing congressional races.
Whether politicians liked it or not, the 1974 midterms would act in some capacity as a
referendum on Nixon’s alleged involvement. As the scandal intensified and became more
prominent, politicians would jockey to have the right opinion for their constituents. Amongst
them, certain politicians would do better than others due to their background. Theoretically, this
would be the time for a rule-of-law, anti-Nixon champion to capitalize on the Watergate scandal.
Enter Robert Morgan, a North Carolina politician with a theoretically ideal background, party
affiliation, and circumstance in which to capitalize on a perfect storm of an election-year
controversy. This paper will seek to determine if Robert Morgan’s successful North Carolina
1974 U.S. senatorial campaign was due in large part to the surrounding effects of Watergate. To
accomplish such a determination, this paper will examine the effects of Watergate against other
important campaign trends. Through this determination, the paper will ultimately argue that
Watergate only played a tangential role in Morgan’s victory and was not directly utilized.Academic Library Service
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