55 research outputs found
Fault-tolerant operation of single-phase SR generators
No full textThis paper studies fault-tolerant operation of multipole single-phase switched reluctance generators (SRGs), in particular, an 8/8-pole switched reluctance machine. The multipole single-phase SRG system is advantageous for reduced cost and higher efficiency compared to polyphase equivalents. However, using the classical phase-leg topology, a phase fault may prevent generating operation completely, since redundancy in the number of phases does not exist like polyphase systems. A new power converter topology which connects two coil banks in parallel is proposed for higher fault tolerance with minimum additional cost. Faulty coils can be disconnected with the proposed converter and the SRG can continue generating operation after coil faults with reduced output power. Output power per coil current under faults is studied. Open- and short-circuit coils are studied through linear analysis, finite-element analysis and static torque measurement. Generated currents under faults with the proposed converter are measured. The capability of the system to disconnect faulty coils dynamically is also shown
Multiple sets of solutions for harmonic elimination PWM bipolar waveforms: Analysis and experimental verification
No full textMultiple sets of solutions for the selective harmonic elimination pulse-width modulation method for inverter control exist. These sets present an independent solution to the same problem but further investigation reveals that certain sets may offer an improved overall harmonic performance. In this paper, a minimization method is discussed as a way to obtain these multiple sets of switching angles. A simple distortion harmonic factor that takes into account the first two most significant harmonics present in the generated waveform is considered in order to evaluate the performance of each set. The bipolar waveform is thoroughly analyzed and two cases are considered; single-phase patterns which eliminate all odd harmonics and three-phase counterparts which eliminate only the nontriplen odd harmonics from the line-to-neutral pattern but such harmonics are naturally eliminated from the line-to-line waveform. Experimental results support the theoretical considerations reported in the paper
Nixon's “full-speech”: imaginary and symbolic registers of communication
No full textCommunicative interchanges play a foundational role in establishing the social. This being said, communicative behaviour can also lead to stalemates and conflict in which demands of recognition outweigh the prospect of hearing or saying anything beyond what is thought to be known. This paper foregrounds a dimension of communication often neglected by approaches prioritizing mass communications and new media technologies, namely the psychical and inter-subjective aspects of communicative exchange. More directly, this paper introduces and develops a Lacanian psychoanalytic theory of two interlinked registers of communicative behaviour. The first of these is the imaginary: the domain of one-to-one inter-subjectivity and behaviour that serves the ego and functions to consolidate the images subjects use to substantiate themselves. The second - far more disturbing and unpredictable - is the symbolic. It links the subject to a trans-subjective order of truth, it provides them with a set of socio-symbolic co-ordinates, and it ties them into a variety of roles and social contracts. In an elaboration of these two registers, illustrated by brief reference to Nixon’s admission of guilt in his interviews with David Frost, I pay particular attention to both the potentially transformative symbolic aspect of communicative behaviours and the ever-present prospect that such relations will ossify into imaginary impasses of mis-knowing (méconnaissance) and aggressive rivalry
Release of chromatin extracellular traps by phagocytes of Atlantic salmon, Salmo salar (LINNAEUS, 1758)
No full textNeutrophils release chromatin extracellular traps (ETs) as part of the fish innate immune response to counter the threats posed by microbial pathogens. However, relatively little attention has been paid to this phenomenon in many commercially farmed species, despite the importance of understanding host-pathogen interactions and the potential to influence ET release to reduce disease outbreaks. The aim of this present study was to investigate the release of ETs by Atlantic salmon (Salmo salar L.) immune cells. Extracellular structures resembling ETs of different morphology were observed by fluorescence microscopy in neutrophil suspensions in vitro, as these structures stained positively with Sytox Green and were digestible with DNase I. Immunofluorescence studies confirmed the ET structures to be decorated with histones H1 and H2A and neutrophil elastase, which are characteristic for ETs in mammals and other organisms. Although the ETs were released spontaneously, release in neutrophil suspensions was stimulated most significantly with 5 μg/ml calcium ionophore (CaI) for 1 h, whilst the fish pathogenic bacterium Aeromonas salmonicida (isolates 30411 and Hooke) also exerted a stimulatory effect. Microscopic observations revealed bacteria in association with ETs, and fewer bacterial colonies of A. salmonicida Hooke were recovered at 3 h after co-incubation with neutrophils that had been induced to release ETs. Interestingly, spontaneous release of ETs was inversely associated with fish mass (p<0.05), a surrogate for age. Moreover, suspensions enriched for macrophages and stimulated with 5 μg/ml CaI released ET-like structures that occasionally led to the formation of large clumps of cells. A deeper understanding for the roles and functions of ETs within innate immunity of fish hosts, and their interaction with microbial pathogens, may open new avenues towards protecting cultured stocks against infectious diseases
Non-steroidal anti-inflammatory drugs, prostaglandins and COVID-19
No full textSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the novel coronavirus disease 2019 (COVID-19), a highly pathogenic and sometimes fatal respiratory disease responsible for the current 2020 global pandemic. Presently, there remains no effective vaccine nor efficient treatment strategies against COVID-19. Non-steroidal anti-inflammatory drugs (NSAIDs) are medicines very widely used to alleviate fever, pain and inflammation (common symptoms of COVID-19 patients) through effectively blocking production of prostaglandins (PGs) via inhibition of cyclooxygenase enzymes. PGs can exert either pro- or anti-inflammatory effects depending on the inflammatory scenario. In this review, we implicate the potential roles that NSAIDs and PGs may play during SARS-CoV-2 infection and the development and progression of COVID-19.<br/
Thromboelastometry and Platelet Function during Acclimatization to High Altitude
No full textInteraction between hypoxia and coagulation is important given the increased risk of thrombotic diseases in chronically hypoxic patients who reside at sea level and in residents at high altitude. Hypoxia alters the proteome of platelets favouring a prothrombotic phenotype, but studies of activation and consumption of specific coagulation factors in hypoxic humans have yielded conflicting results. We tested blood from 63 healthy lowland volunteers acclimatizing to high altitude (5,200 m) using thromboelastometry and assays of platelet function to examine the effects of hypoxia on haemostasis. Using data from two separate cohorts of patients following identical ascent profiles, we detected a significant delay in clot formation, but increased clot strength by day 7 at 5,200 m. The latter finding may be accounted for by the significant rise in platelet count and fibrinogen concentration that occurred during acclimatization. Platelet function assays revealed evidence of platelet hyper-reactivity, with shortened PFA-100 closure times and increased platelet aggregation in response to adenosine diphosphate. Post-expedition results were consistent with the normalization of coagulation following descent to sea level. These robust findings indicate that hypoxia increases platelet reactivity and, with the exception of the paradoxical delay in thromboelastometry clotting time, suggest a prothrombotic phenotype at altitude. Further work to elucidate the mechanism of platelet activation in hypoxia will be important and could impact upon the management of patients with acute or chronic hypoxic respiratory diseases who are at risk of thrombotic events.
Erratum to: Thromboelastometry and platelet function during acclimatisation to high altitude (doi: 10.1160/TH17-02-0138) http://eprints.whiterose.ac.uk/129510/
In the Original Article by Rocke et al. “Thromboelastometry and platelet function during acclimatization to high altitude” (Thromb Haemost 2018; 118: 063-071) after publication of the article it has come to the corresponding author's attention that an author was inadvertently omitted from the manuscript. The author, Martin MacInnis, made a significant contribution to: 1. initiating the coagulation research that led to the manuscript, 2. designing the research protocol and performing the initial data analysis, 3. recruiting volunteers, writing applications for ethical approval and making other logistical arrangements that were necessary to complete the study. Martin MacInnis has read and approved the published version of the manuscript. Furthermore, a middle initial was added to the updated list (Shona E. Main) and misspelling of Elizabeth Horn's surname was corrected. The amended author list is as above. https://doi.org
Invertebrate extracellular phagocyte traps show that chromatin is an ancient defence weapon
No full textControlled release of chromatin from the nuclei of inflammatory cells is a process that entraps and kills microorganisms in the extracellular environment. Now termed ETosis, it is important for innate immunity in vertebrates. Paradoxically, however, in mammals, it can also contribute to certain pathologies. Here we show that ETosis occurs in several invertebrate species, including, remarkably, an acoelomate. Our findings reveal that the phenomenon is primordial and predates the evolution of the coelom. In invertebrates, the released chromatin participates in defence not only by ensnaring microorganisms and externalizing antibacterial histones together with other haemocyte-derived defence factors, but crucially, also provides the scaffold on which intact haemocytes assemble during encapsulation; a response that sequesters and kills potential pathogens infecting the body cavity. This insight into the early origin of ETosis identifies it as a very ancient process that helps explain some of its detrimental effects in mammals.</p
Author Correction: Considerations in the search for epistasis
No full textBalvert M, Cooper-Knock J, Stamp J, et al. Author Correction: Considerations in the search for epistasis. Genome Biology . 2025;26(1): 12
How to accelerate the heat transition: a guide for local government and actors: Module 3 - Non-financial policy tools for sustainable heating: city strategies, regulation and support
No full textOrganisation & GovernanceClimate Design and Sustainabilit
- …
