1,720,964 research outputs found
Puesta a punto de un modelo de rinosinusitis crónica asociada a poliposis nasal monitorizado mediante técnicas de análisis de imágenes micro CT-PET
Get PDF[ES] La rinosinusitis es un proceso inflamatorio que afecta a la cavidad y senos nasales obstruyéndolos. Se denomina rinosinusitis crónica (RSC) cuando la enfermedad perdura más allá de las 12 semanas. La RSC puede verse asociada a pólipos nasales (RSC-PN) o no (RSC-SP), siendo la poliposis nasal una enfermedad con una morbilidad muy alta caracterizada por la existencia de estructuras neoplásicas que provocan la obstrucción de las vías aéreas. Los pólipos están formados por el infiltrado de células inflamatorias. Los tratamientos actuales no son efectivos en gran parte de los pacientes, teniendo que someterse a repetidas intervenciones quirúrgicas siendo necesario el desarrollo de nuevos fármacos más efectivos. La investigación en modelos animales se encuentra actualmente limitada por la inexistencia de métodos diagnósticos y de seguimiento de la enfermedad que no impliquen sacrificar los animales. Este estudio evalúa la eficacia del análisis de imágenes realizado empleando las técnicas de tomografía computarizada (CT) y tomografía por emisión de positrones (PET) en el diagnóstico de la RSC-PN y el seguimiento se su evolución sobre un modelo animal de la enfermedad desarrollado mediante instilaciones con ovoalbúmina como sensibilizador y enterotoxina B de Staphylococcus aureus como agente inductor de la misma. La técnica CT se basa en la capacidad de penetración de los rayos X para detectar cambios en la densidad de los tejidos, mientras que la técnica PET tiene la capacidad de calcular la captación de la glucosa mediante un radiomarcador homólogo. Ambas propiedades se ven alteradas en el transcurso de un proceso inflamatorio severo. Los resultados obtenidos avalan la validez de estas técnicas para determinar la existencia de un proceso inflamatorio y estructuras neoplásicas en el modelo de la enfermedad desarrollado. Los resultados obtenidos por las técnicas de análisis histológico post-mortem corroboraron esta conclusión, permitiendo afirmar que la monitorización mediante las técnicas de CT y PET es un método efectivo para la determinación y seguimiento de la evolución de la RSC-PN en los modelos animales in vivo y posibilitando la investigación de tratamientos eficaces de la enfermedad.[EN] Rhinosinusitis is an inflammatory and obstructive process that affects the nasal cavity and sinuses. It’s called chronic rhinosinusitis (CRS) when the disease lasts beyond 12 weeks. CRS can be associated with nasal polyps (CRSwNP) or not (CRSsNP). CRSwNP is a disease with high morbidity characterized by the existence of neoplastic structures that cause airways obstruction. Polyps are formed by the infiltration of inflammatory cells. Current treatments are ineffective in many of the patients having to undergo repeated surgical procedures therefore the developing of new and more effective drugs are necessary. Research in animal models is currently limited by the lack of diagnostic and disease monitoring methods without sacrificing animals. This study evaluates the effectiveness of the analysis of images carried out by computed tomography (CT) and positron emission tomography (PET) techniques in the diagnosis and monitoring of CSR-PN in an animal model. This animal model of the disease was obtained by an instillations protocol with ovalbumin as a sensitizer and Staphylococcus aureus enterotoxin B as inducing agent. CT technique is based on the ability of penetration of x-rays for detecting changes in tissue density. PET technique has the ability to calculate the glucose uptake by a homologous radiolabel. Tissue density and glucose uptake are properties that are altered in the course of a severe inflammatory process. The results obtained confirm the validity of these techniques to determine the existence of an inflammatory process and neoplastic structures in the developed disease model. The results obtained by the histological post-mortem analysis techniques corroborated this conclusion. It can be said that the use of CT and PET techniques is an effective method for determining and monitoring the evolution of CSRwPN in animal models in vivo, allowing the research into effective treatments for the disease.Rius Rocabert, S. (2014). Puesta a punto de un modelo de rinosinusitis crónica asociada a poliposis nasal monitorizado mediante técnicas de análisis de imágenes micro CT-PET. https://riunet.upv.es/handle/10251/46181.Archivo delegad
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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