1,721,164 research outputs found
Multimodal treatment of hepatocellular carcinoma on cirrhosis: an update
No full textAbstract
Hepatocellular carcinoma (HCC) is the most frequent primary liver tumor, and overall, it is one of the most frequent cancers. The association of HCC with chronic liver disease, and cirrhosis in particular, is well known, making treatment complex and challenging. The treatment of HCC must take into account the presence and stage of chronic liver disease, with the aim of preserving hepatic function that is often already impaired, the stage of HCC and the clinical condition of the patient. The different treatment options include surgical resection, transplantation, local ablation, chemoembolization, radioembolization and molecular targeted therapies; these treatments can be combined in various ways to achieve different goals. Ideally, liver transplantation is best treatment for early stage HCC on cirrhosis because it removes both the tumor and the chronic disease that produced it; however, the application of this powerful tool is limited by the scarcity of donors. Downstaging and bridging are different strategies for the management of HCC patients who will undergo liver transplantation. Several professionals, including gastroenterologists, radiologists and surgeons, are involved in the choice of the most appropriate treatment for a single case, and a multidisciplinary approach is necessary to optimize the outcome. The purpose of this review is to provide a comprehensive description of the current treatment options for patients with HCC by analyzing the advantages, disadvantages and rationale for their use
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Reactions of enamines from trans-decalin-2-ones with β-nitrostyrene and phenyl vinyl ketone and X-ray analysis of 2-p-bromophenyl-4a,5,5a,6,7,8,9,9a,10,10a-decahydro-5a-methyl-l0a-morpholino-4H-naphtho[2,3-b]pyrane
No full textBicyclic 1,2-Oxazine-N-oxides. Different behaviour in ring fission between systems derived from 5- and 6-membered ring cyclic enamines
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The base-catalysed cyclization of ω-epoxy 1,1-bis-sulfones. Reactivity snd selectivity as a function of ring size
No full textVinylamines XV. Unusual stereochemical course in nitroalkylation of biased enaminic systems
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