1,720,963 research outputs found
Immunomodulatory effects of curcumin on receptor activator of nuclear factor-kappa B ligand in periodontitis
Get PDFPeriodontitis is a chronic inflammatory disease of the tooth-supporting structures, often causing
alveolar bone loss due to increased osteoclast activity mediated by receptor activator of nuclear factor-kappa
B ligand. Curcumin is believed to have immunomodulatory effects and has been proposed as a natural
therapeutic agent targeting receptor activators of nuclear factor-kappa B ligand expression. This study aims to
evaluate and review the immunomodulatory effects of curcumin on receptor activators of nuclear factor-kappa
B ligands in periodontitis. This systematic review followed the PRISMA 2020 guidelines. A search of
published literature in PubMed, Scopus, ScienceDirect, and Google Scholar was employed. Risk of bias
assessment was performed using three different tools, including QUIN for in vitro studies, SYRCLE’s RoB
for animal model studies, and Cochrane RoB 2 for clinical trials. All studies evaluating curcumin’s effects on
receptor activator of nuclear factor-kappa B ligand levels, both membrane receptor activator of nuclear factorkappa B ligand and soluble receptor activator of nuclear factor-kappa B ligand, were considered for inclusion in this review. Of the 307 potentially eligible studies, four studies were ultimately retrieved. This study found that there is a significant decrease in receptor activator of nuclear factor-kappa B ligand levels after curcumin administration. The immunomodulatory effects of curcumin are believed to be through modulation of macrophage polarization and inhibition of the nuclear factor kappa-B signaling pathway, and possibly indirectly through inhibition of autophagy. Thus, curcumin shows promising potential as an adjunct agent for periodontitis through the mechanism of decreasing receptor activator of nuclear factor-kappa B ligand levels which then reduces alveolar bone loss. Large-scale clinical trials with rigorous methods are warranted to determine the optimal dosage, formulation, and long-term safety for clinical application in periodontal therapy targeting receptor activators of nuclear factor-kappa B ligand
Immunomodulatory effects of curcumin on receptor activator of nuclear factor-kappa B ligand in periodontitis
No full textPeriodontitis is a chronic inflammatory disease of the tooth-supporting structures, often causing
alveolar bone loss due to increased osteoclast activity mediated by receptor activator of nuclear factor-kappa
B ligand. Curcumin is believed to have immunomodulatory effects and has been proposed as a natural
therapeutic agent targeting receptor activators of nuclear factor-kappa B ligand expression. This study aims to
evaluate and review the immunomodulatory effects of curcumin on receptor activators of nuclear factor-kappa
B ligands in periodontitis. This systematic review followed the PRISMA 2020 guidelines. A search of
published literature in PubMed, Scopus, ScienceDirect, and Google Scholar was employed. Risk of bias
assessment was performed using three different tools, including QUIN for in vitro studies, SYRCLE’s RoB
for animal model studies, and Cochrane RoB 2 for clinical trials. All studies evaluating curcumin’s effects on
receptor activator of nuclear factor-kappa B ligand levels, both membrane receptor activator of nuclear factorkappa B ligand and soluble receptor activator of nuclear factor-kappa B ligand, were considered for inclusion in this review. Of the 307 potentially eligible studies, four studies were ultimately retrieved. This study found that there is a significant decrease in receptor activator of nuclear factor-kappa B ligand levels after curcumin administration. The immunomodulatory effects of curcumin are believed to be through modulation of macrophage polarization and inhibition of the nuclear factor kappa-B signaling pathway, and possibly indirectly through inhibition of autophagy. Thus, curcumin shows promising potential as an adjunct agent for periodontitis through the mechanism of decreasing receptor activator of nuclear factor-kappa B ligand levels which then reduces alveolar bone loss. Large-scale clinical trials with rigorous methods are warranted to determine the optimal dosage, formulation, and long-term safety for clinical application in periodontal therapy targeting receptor activators of nuclear factor-kappa B ligand
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
The relationship between family economic status and parents’ level of knowledge about dental caries disease in early childhood
No full textDental caries is an infectious disease that attacks the lining of the teeth caused by bacteria. According to the Indonesian Basic Health Research in 2018, the prevalence of dental caries in Indonesia is still quite high, namely 45.3% which has increased compared to data in 2013 which amounted to 25.9%. In early childhood with an age range of 3-4 years, they experienced dental caries as much as 36.4% and at the age of 5-9 years as much as 54.0%. This study uses the literature review method and based on the result of data search, 7 articles were studied in this study. The result found in 7 articles stated that the low income of parents affects the maintenance and oral health services for their child. In line with the low level of education, parents will also have a low level of knowledge about dental and oral health as well. Meanwhile, high parental income and high education will have an impact on the low incidence of caries in child. The conclusion of this study is that there is a relationship between family economic status and dental caries in early childhood which is also influenced by the level of knowledge of parents about the importance of maintaining oral and dental health
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Epidemiological Analysis and Management of Oral and Craniomaxillofacial Trauma in Indonesia: A Systematic Review
Get PDFObjective: This systematic review aims to analyze and review the epidemiological characteristics and management of oral and craniomaxillofacial trauma in patients in Indonesia. Methods: Using PRISMA guidelines, a systematic review of articles published in Scopus, PubMed, ScienceDirect, Google Scholar, and Garuda up to March 2024 was conducted. In selecting studies, inclusion and exclusion criteria were applied. Results: This study included 2,928 cases of oral and craniomaxillofacial trauma obtained from a total of 44 studies consisting of 25 case reports, 11 retrospective studies, 7 cross-sectional studies, and 1 case series. Summary results from pooled data, this study highlights that male patients predominate in all cases with a total of 80.70% and the male/female ratio is 4.2:1. Oral and craniomaxillofacial trauma occurred mostly in the 21-30 year age group (25.51%), followed by 11-20 year olds (24.15%) and 31-40 year olds (16.73%). Based on etiology, most cases occurred due to traffic accidents (87.88%). In the management of trauma cases, open reduction and internal fixation (ORIF) is the most frequently performed with a total of 66.71% of all cases. Conclusion: Oral and craniomaxillofacial trauma in Indonesia is dominated by male patients and in the productive age group with mandibular fractures being the highest cases
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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