262,487 research outputs found
La musica e i suoi cultori.
No full text"Ultimi lavori musicali composti da Onestina Ricotti ... " back cover.Mode of access: Internet.Juilliard Foundation Fund
Electrochemotherapy: an effective local treatment of cutaneous and subcutaneous melanoma metastases
No full textTreatment of multiple cutaneous and subcutaneous melanoma metastases is still represents a therapeutic challenge for both dermatologists and oncologists. Electrochemotherapy (ECT) is a promising therapeutic procedure, owing to its ability to improve the penetration of cytotoxic drugs into cancer cells by application of current electric pulses. The aim of our study is to evaluate efficacy, tolerability and long-term efficacy of ECT in the treatment of advanced metastatic melanoma. Thirty patients affected by a total of 654 cutaneous and subcutaneous melanoma metastatic nodules were recruited. All patients were treated after they had undergone to a mild general anesthesia. Intravenous Bleomicina solution was administered 8 minutes before the application of electric pulses, generated by a Cliniporator (TM) (the device validated for ECT). The objective response rate of 100% (67.28% complete response and 32.72% partial response) was observed. A total of 214 metastatic lesions from 24 patients received a second ECT session, among them 141 showed a further complete response. Twenty-four months later, the local tumor control rate was 72%. The results of this study seem to demonstrate that ECT is an effective and valid therapeutic tool for the treatment of cutaneous metastases from melanoma. ECT can be considered a first-line palliative treatment since it is able to alleviate pain and reduce the tumor's spontaneous bleeding with a significant improve of patients' quality of life
Winds and infalling gas in Lyman break galaxies
No full textA model for gas outflows is proposed which simultaneously explains the correlations between the (i) equivalent widths of low-ionization and Lyα lines, (ii) outflow velocity, and (iii) star formation rate observed in Lyman break galaxies (LBGs). Our interpretation implies that LBGs host short-lived (30 +/- 5 Myr) starburst episodes observed at different evolutionary phases. Initially, the starburst powers a hot wind bound by a denser cold shell, which after ~5 Myr becomes dynamically unstable and fragments; afterwards the fragment evolution is approximately ballistic while the hot bubble continues to expand. As the fragments are gravitationally decelerated, their screening ability of the starlight decreases as the ultraviolet (UV) starburst luminosity progressively dims. LBG observations sample all these evolutionary phases. Finally, the fragments fall back on to the galaxy after ~60 Myr. This phase cannot be easily probed as it occurs when the starburst UV luminosity has already largely faded; however, galaxies dimmer in the UV than LBGs should show infalling gas
Injectable gelatin-based photocurable fiber-reinforced hydrogel for the treatment of osteochondral defects
No full textOsteochondral defects are one of the most motor-disabling conditions worldwide. A limited intrinsic regenerative capability features cartilage and bone tissues involved in large osteochondral lesions and, to date, there is no clinical treatment capable of appropriately restoring them. We report an innovative injectable composite hydrogel based on gelatin methacryloyl (GelMA) loaded with dispersed fibers made of a blend polycaprolactone (PCL)/GelMA. The fibers were produced by electrospinning, and cut in stripes using a cryostat-based cutting approach. Their embodiment in the GelMA matrix improved the compressive mechanical properties of the pristine GelMA hydrogel. Specific conditions (needle size: 18G and 20G; temperature: 30 and 37°C) were found compatible with the injection of the composite hydrogel, before crosslinking, matching the criteria reported in EN ISO 7886 1:2018 standard. These preliminary results are promising in view of the optimization of injectable reinforced GelMA-based formulations to be used for the treatment of osteochondral injuries
PROPOSTA DI UTILIZZO DI UN MODELLO ANIMALE E DI UNO ARTIFICIALE PER LA RACCOLTA SISTEMATICA DEI PATTERNS LESIVI SUPERFICIALI DI ARMI BIANCHE.
No full textA Novel Steerable Catheter Controlled with a Biohybrid Actuator: A Feasibility Study
No full textTargeted therapies allow increasing the efficacy of treatments for several diseases, including cancer. The release of drugs or chemicals directly in the site of interest will be beneficial for maximizing the therapy and minimize side effects. Here, we report the concept and a preliminary analysis of an innovative intravascular steerable catheter guided by an on-board biohybrid actuator, aiming to release drugs into deep and tortuous regions within the cardiovascular systems. The catheter performance has been estimated through analytical and numerical analyses, varying catheter diameter, wall thickness, and actuator force. Results show how larger catheter deflections can be obtained with a smaller outer diameter and decreasing wall thickness. Besides, improved outcomes can be achieved by applying the biohybrid actuator distant from the catheter tip extremity and maximizing the magnitude of the applied forces. Despite the need to further improve the performance of this concept (e.g., by decreasing material stiffness), these preliminary results show great promise in view of future experimentation of such kind of actuation to drive microcatheters through the cardiovascular network
Lesività nei ciclisti vittime di incidenti del traffico stradale. Analisi della casistica del settorato medico-legale di Varese negli anni 1979-2003
No full textElectrochemical study of self-assembled cysteine monolayers on polycrystalline gold electrodes and functionalization with microperoxidase MP-11.
No full textSelf-assembled monolayers of cysteine (CYST) have been constructed on polycrystalline gold (polyAu) electrode at different immersion times (timmer) in order to characterize them by cyclic voltammetry and electrochemical impedance spectroscopy (EIS). Oxidative desorption experiments allowed the calculation of the surface coverage, whereas reductive desorption informed about the binding of CYST to different gold domains.
Desorption products showed different diffusion ability. The maximum coverage was already achieved at short timmer,
although progressive reordering of CYST molecules led to a relevant decrease of the defects at long time, as ascertained
by EIS. Functionalization of polyAu-CYST electrodes with the enzyme microperoxidase MP-11 performed by following two different binding methods showed that the enzymatically catalyzed reduction of H2O2 is enhanced when the –COOH residues of the MP-11 undecapeptide chain are firstly activated and then linked to the –NH2 functional groups of the non-activated CYST layer formed on the polyAu surface
Injectable gelatin-based photocurable fiber-reinforced hydrogel for the treatment of osteochondral defects
No full textOsteochondral defects are one of the most motor-disabling conditions worldwide. A limited intrinsic regenerative capability features cartilage and bone tissues involved in large osteochondral lesions and, to date, there is no clinical treatment capable of appropriately restoring them. We report an innovative injectable composite hydrogel based on gelatin methacryloyl (GelMA) loaded with dispersed fibers made of a blend polycaprolactone (PCL)/GelMA. The fibers were produced by electrospinning, and cut in stripes using a cryostat-based cutting approach. Their embodiment in the GelMA matrix improved the compressive mechanical properties of the pristine GelMA hydrogel. Specific conditions (needle size: 18G and 20G; temperature: 30 and 37°C) were found compatible with the injection of the composite hydrogel, before crosslinking, matching the criteria reported in EN ISO 7886 1:2018 standard. These preliminary results are promising in view of the optimization of injectable reinforced GelMA-based formulations to be used for the treatment of osteochondral injuries
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