1,721,026 research outputs found
Neck liymph nodes in chronic autoimmune thyroiditis: the sonographic pattern.
Full text linkBackground: Neck lymph nodes may be involved in the pathogenesis of chronic autoimmune thyroiditis (CAT). This study was undertaken to identify which of the sonographic features of cervical lymph nodes are readily applicable to patients affected by CAT compared to healthy control subjects. Methods: We recruited 106 patients (92 females and 14 males) with CAT and 70 control subjects (53 females and 17 males) without clinical, biochemical, and ultrasonographic evidence of thyroid and neck diseases. We performed laboratory tests (thyrotropin, antithyroperoxidase antibodies, antithyroglobulin antibodies, and ultrasonography) to evaluate in each group: (i) thyroid function, autoimmunity, and morphology; (ii) number, topographic distribution (levels I-VI), and morphology of neck nodes (long-axis diameter; short-axis diameter; short-axis/long-axis ratio; absence or presence of hilus). Results: Total number of neck nodes with long-axis diameter >10 mm was significantly higher in the CAT group ..
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Predittori comportamentali, metabolici ed antropometrici di piede diabetico in una popolazione di diabetici di tipo 2.
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Decremento delle cellule T regolatorie (Treg) CD4+CD25+FOXP3+ nei linfociti periferici dei pazienti affetti da diabete di tipo 1.
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Up-regulation of c-FLIPshort and Reduction of Activation-Induced Cell Death in T-cells from Patients with Type 1 Diabetes
No full textAICD of T-cells is an efficient way of removing activated T-lymphocytes. In this study we
investigated the molecular basis of AICD upon reactivation in peripheral T-lymphocytes from newly
diagnosed T1DM patients and age-matched healthy controls. In an in vitro model system, PHA-stimulated
T-cells, upon prolonged culture in IL-2, acquire a sensitive phenotype to Fas-mediated apoptosis.
This phenomenon is less pronounced in T1DM T-cells. Moreover, the restimulation of activated
T-cells via TCR/CD3 and/or via CD28 inhibits Fas-mediated apoptosis in T1DM in comparison to control
T-cells. After Fas triggering, the generation of the active sub-units of caspase-8 is significantly reduced
in T1DM T-cells restimulated via TCR/CD3 and/or CD28. In parallel, we found that the amount
of c-FLIPshort protein is significantly increased in the DISC only in T1DM T-cells restimulated via
TCR/CD3 and via CD28. These data suggest that increased levels of c-FLIPshort may prevent recruitment
of pro-caspase-8 in T1DM CD3-treated T-cells and provide new insight into the molecular mechanisms
of apoptosis resistance in stimulated T-cells from T1DM patients
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