1,721,399 research outputs found
Drug therapy of advanced cutaneous squamous cell carcinoma: is there any evidence?
Full text linkThere are few randomized controlled studies to guide the treatment of advanced cutaneous squamous cell carcinoma. The existing treatments are mostly based on case reports and small case series. Here we review recently available insights concerning the treatment of locally advanced and metastatic squamous cell carcinoma, with a special emphasis on novel targeted therapy and immunotherapy
What is New in Melanoma Genetics and Treatment?
Full text linkNew therapies for advanced melanoma have led to major advances, which, for the first time, showed improved survival for patients with this very challenging neoplasm. These new treatments are based on gene-targeted therapies or stimulation of immune responses. However, these treatments are not without challenges in terms of resistance and toxicity. Physicians should be aware of these side effects as prompt treatment may save lives. Melanoma genetics is also unravelling new genetic risk factors involving telomere genes as well as new gene pathways at the somatic level which may soon become therapeutic targets. It is also shedding new light onto the pathology of this tumour with links to neural diseases and longevity
Non-Coding RNA Investigations in Cutaneous Melanoma: A Step forward in Discovering Novel Biomarkers
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Electrochemotherapy in non-melanoma head and neck skin cancers: a three centers experience and literature review.
Full text linkAIM: The main purposes of this study were to evaluate the efficacy of electrochemotherapy in head and neck tumours, to assess the local tumour control, the safety profile and its impact on the patients' quality of life.
METHODS:
This is a multicenter prospective, non-randomized phase II trial. This trial was carried out at the Dermatologic Clinic of University of Rome "La Sapienza", at the Dermatologic Clinic of University of Chieti and at the Dermatologic Clinic of University of Turin. 55 patients with head and neck cancers were recruited. The electrochemotherapy procedure was carried out according to the ESOPE guidelines. Statistical analyses were performed using Stata/SE12.0 Statistical Software RESULTS: A significant clinical response was achieved in 50/55 patients with 91% of objective response rate (OR). 33 of 55 patients showed a CR (60%); 17 treated patients had a PR (31%). A significantly higher CR rate was obtained in patients not previously treated by surgery (15/19; 79%), with respect to those with a previous excision of the tumour (14/30; 47%) (p=0.025). An additional parameter influencing response is represented by anesthesia: patients treated by ECT with general anesthesia were characterized by significantly higher CR rate (68%) than those treated with local anesthesia (27%) (p=0.014).
CONCLUSIONS:
Our experience confirmed high efficiency in local tumour control, excellent toxicity profile, tissue preservation with good cosmetic and functional results, even with repeated applications. ECT can represent a first-line treatment in the local management of head and neck cancers.AIM:
The main purposes of this study were to evaluate the efficacy of electrochemotherapy in head and neck tumours, to assess the local tumour control, the safety profile and its impact on the patients' quality of life.
METHODS:
This is a multicenter prospective, non-randomized phase II trial. This trial was carried out at the Dermatologic Clinic of University of Rome "La Sapienza", at the Dermatologic Clinic of University of Chieti and at the Dermatologic Clinic of University of Turin. 55 patients with head and neck cancers were recruited. The electrochemotherapy procedure was carried out according to the ESOPE guidelines. Statistical analyses were performed using Stata/SE12.0 Statistical Software RESULTS: A significant clinical response was achieved in 50/55 patients with 91% of objective response rate (OR). 33 of 55 patients showed a CR (60%); 17 treated patients had a PR (31%). A significantly higher CR rate was obtained in patients not previously treated by surgery (15/19; 79%), with respect to those with a previous excision of the tumour (14/30; 47%) (p=0.025). An additional parameter influencing response is represented by anesthesia: patients treated by ECT with general anesthesia were characterized by significantly higher CR rate (68%) than those treated with local anesthesia (27%) (p=0.014).
CONCLUSIONS:
Our experience confirmed high efficiency in local tumour control, excellent toxicity profile, tissue preservation with good cosmetic and functional results, even with repeated applications. ECT can represent a first-line treatment in the local management of head and neck cancers
Imiquimod-side effects in the treatment of periocular skin cancers: A review of the literature
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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