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Advances in the Treatment of Obesity with GLP-1 and GIP Agonists: State of the Art at the Upcoming XXIX Brazilian Congress of Nutrology
Editorial
Prezados colegas e participantes do XXII Congresso Brasileiro de Nutrologia,
Esse espaço científico tem como objetivo promover a troca de conhecimentos médicos nutricionais entre profissionais da área de nutrição e que pesquisam com bases científicas sólidas a realização de experimentos dentro do contexto da Nutrologia e das ciências nutricionais no presente momento.
Esta é a XXII edição do Congresso Brasileiro de Nutrologia, que juntamente com a XXII Conferência sobre Obesidade e Síndrome Metabólica, visa trazer conhecimentos científicos, observando-se nessas últimas edições, um aumento significativo da presença de colegas interessados na área de Nutrologia, de nutrição médica, das ciências nutricionais.
A congregação de todos esses profissionais e estudantes na realização de trabalhos científicos, cujo conteúdo aqui está publicado, efetivamente traz ainda mais aprendizagem e atualização com o objetivo de transmitir esses conhecimentos aos seus respectivos pacientes e outros experimentos científicos.
Desejo que aproveitem a grandiosidade dos anais do XXII Congresso Brasileiro de Nutrologia para que toda a população possa ter algum grau de contribuição para uma melhoria da profilaxia e tratamento das enfermidades nutroneurometabólicas.
A Associação Brasileira de Nutrologia, especialidade médica do Conselho Federal de Medicina e Associação Médica Brasileira, muito agradece a gentil e honrosa participação de todos que direta ou indiretamente contribuíram para a realização desses trabalhos científicos e consequente publicação desses anais.
Uma ótima leitura a todos
Medical nutrition therapeutic approach of non-alcoholic fatty liver: diet, nutraceuticals, phytotherapy and probiotics
Although the genetic and pharmacological research of the non-alcoholic fatty liver disease (NAFLD), the commonest liver disease in the world, affecting more than a quarter of the population, shows a promising future, the non-pharmacological therapy continues to be an important approach of this concerning public health issue. The present study focused on the therapeutical potential of the diet and mainly the phytotherapy, nutraceuticals, and probiotics use, employing the literature review methodology by a selection of recent (last 5-10 years) national and international articles from the PubMed and Google Scholar databases. The conclusion was that the non-pharmacological medical nutrition approach could be considered as a first-line therapeutical option for NAFLD due to its low cost, few adverse effects, and a mainly positive impact on an individual's health and life quality
Liraglutideas Adjunct Therapy in the Management of Obesity
The obesity epidemic has reached a new level with some impressive numbers recently published in the United States of America. Even more alarming is the rapid increase in childhood obesity, which has been universally documented over the past few decades. The reasons underlying the problem of obesity can be simplified into three categories: i) routine consumption of bigger portion size meals; ii) confusing messages from food industry to consumers; and iii) physical inactivity is the “new normal”. Considering that the medical consequences of obesity are serious and directly affect morbidity and mortality, it has become necessary to act concomitantly to prevent and treat the increase in body weight and fat excess accumulation. The prevention of obesity is a formidable task that can only be accomplished with a concerted effort put together by several governmental agencies, especially those interested in agriculture, health and education, the food industry and health care providers, including physicians and nutrition specialists. Treatment of obesity with behavioral management, nutritional manipulations (“diets”) and, even bariatric surgery has had some success, but these strategies are accompanied by limited benefits and only to a select group of individuals. More importantly, the overall impact of these on the growing obesity pandemic is disappointing, at best. Some dietary recommendations with caloric restriction and adjustments in nutrient intake combined to pharmacotherapy have expanded our ability to manage obese patients.The recent approval by the U.S. Food and Drug Administration (FDA) agency of the Glucagon-Like-Peptide-1 (GLP-1) receptor analog liraglutide, at the dose of 3.0 mg once daily, has provided us with an additional tool to combat the disease and minimize its complications. In this particular study, a significant reduction in the conversion ratesfrom pre-diabetes to diabetes was also shown and represents an important findingof the trial. Despite the fact that nausea, vomiting and diarrhea were frequently reported during the 1-year period of observation, tolerance was acceptable and most subjects completed the study.These data clearly indicate that combination drug therapy with dietary adjustments can be successful in promoting weight reduction and further support routine utilization of adjuvant pharmacotherapy in the management of obesity
Going Beyond Counting First Authors in Author Co-citation Analysis
The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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