1,720,999 research outputs found
Bioactivity of sesquiterpenes: compounds that protect from alcohol-induced gastric mucosal lesions and oxidative damage
Get PDFSesquiterpene lactones of the guaianolide and eudermanolide types are considered of interest because they have an effect in the regulation and prevention of oxidative damage and inflammation-mediated biological damage. Dehydroleucodine, a natural sesquiterpene isolated from Artemisia douglasiana Besser, and ilicic aldehyde, a semi-synthetic sesquiterpene lactones, showed in vivo protection in ethanol-induced gastric mucosa damage. This action was determined by in situ gastric mucosa chemiluminescence and by tissue antioxidant content.Fil: Repetto, Marisa G.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Boveris, Alberto Antonio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
The adaptation of the teacher for the teaching of university chemistry during social, preventive and mandatory isolation in the pandemic for covid-19: from classroom classes to distance education in a virtual environment
Get PDFLa situación actual de la pandemia por COVID-19 nos afecta a todos, sin distinción. Transitar este período implica adaptarse a una situación inesperada y difícil de afrontar y la educación no escapa a esta realidad, la enseñanza en todos los niveles y campos disciplinares debió adaptarse a los cambios que se fueron sucediendo durante este período y las medidas que las instituciones y sus actores debimos implementar representan un desafío que ponen de manifiesto muchas debilidades del sistema educativo, pero lo más significativo es que también resaltan las fortalezas de la comunidad docente, muchas veces dejada de lado. Las estrategias docentes, la dinámica de las clases y las formas de evaluación cambiaron en forma repentina, y como un salvavidas para afrontar la tormenta, los docentes, los estudiantes y las familias nos quedamos en casa adaptándonos a un cambio para el que nadie estaba preparado.The current situation of the COVID-19 pandemic have to live affects us all, without distinction. Going through this period implies adapting to an unexpected and difficult situation face and education does not escape to this reality, teaching at all levels and disciplinary fields had to adapt to the changes that took place during this period and the measures that the institutions and their actors had to implement represent a challenge that highlights many weaknesses of the educational system, but the most significant thing is that they also highlight the strengths of the teaching community, often neglected. The teaching strategies, the dynamics of the classes and the forms of evaluation changed suddenly, and like a lifeguard to face the storm, teachers, students and families stayed at home adapting to a change for which no one was prepared.Fil: Repetto, Marisa Gabriela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentin
Human physiology applied to the teaching of bioinorganic chemistry
No full textDe los elementos de la Tabla Periódica, al menos 27 están presentes en los organismos vivos y cumplen una función biológica. Estos elementos se denominan bioelementos. El objetivo de este trabajo es proponer como herramienta pedagógica el abordaje del estudio de la química bioinorgánica relacionado su comportamiento químico con los procesos fisiológicos y/o fisiopatológicos. Se emplean datos de bibliografía y resultados propios de la investigación de los docentes: reacciones bioquímicas, biomarcadores de estrés y daño oxidativo, reacciones redox, formación, efecto de las especies reactivas del oxígeno y del nitrógeno sobre órganos, tejidos y organelas subcelulares, respiración celular, procesos inflamatorios y efecto sobre la presión arterial, sistema cardiorespiratorio y renal. Los resultados se miden a través del grado de participación, consultas y anécdotas que los estudiantes comparten en clase. Esta estrategia permite relacionar e integrar contenidos de dos asignaturas con mirada a las profesiones de Farmacia y Bioquímica.The aim of this work is to show the design of a class modality oriented towards a genuine and significant understanding of Bioinorganic Chemistry, relating the chemical behavior of bioelements with pathophysiological processes. A didactic strategy was used that allows teaching the chemistry of bioelements through activities organized and framed in planning as an integrating didactic sequence, associated with formative and continuous evaluation of learning. This didactic strategy induced a greater interest and a greater participation of the students during the class. A greater genuine understanding of the contents of chemistry integrated into pathophysiological processes was observed. The strength of this classroom experience lies in the fact that a type of teaching-learning integrated with a type of evaluation designed directly to contribute to this process and strengthen it, through systematic feedback, is proposed for the teaching of Chemistry.Fil: Fellet, Andrea L.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiología Humana; ArgentinaFil: Repetto, Marisa Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; Argentin
Human physiology applied to the teaching of bioinorganic chemistry
Get PDFDe los elementos de la Tabla Periódica, al menos 27 están presentes en los organismos vivos y cumplen una función biológica. Estos elementos se denominan bioelementos. El objetivo de este trabajo es proponer como herramienta pedagógica el abordaje del estudio de la química bioinorgánica relacionado su comportamiento químico con los procesos fisiológicos y/o fisiopatológicos. Se emplean datos de bibliografía y resultados propios de la investigación de los docentes: reacciones bioquímicas, biomarcadores de estrés y daño oxidativo, reacciones redox, formación, efecto de las especies reactivas del oxígeno y del nitrógeno sobre órganos, tejidos y organelas subcelulares, respiración celular, procesos inflamatorios y efecto sobre la presión arterial, sistema cardiorespiratorio y renal. Los resultados se miden a través del grado de participación, consultas y anécdotas que los estudiantes comparten en clase. Esta estrategia permite relacionar e integrar contenidos de dos asignaturas con mirada a las profesiones de Farmacia y Bioquímica.The aim of this work is to show the design of a class modality oriented towards a genuine and significant understanding of Bioinorganic Chemistry, relating the chemical behavior of bioelements with pathophysiological processes. A didactic strategy was used that allows teaching the chemistry of bioelements through activities organized and framed in planning as an integrating didactic sequence, associated with formative and continuous evaluation of learning. This didactic strategy induced a greater interest and a greater participation of the students during the class. A greater genuine understanding of the contents of chemistry integrated into pathophysiological processes was observed. The strength of this classroom experience lies in the fact that a type of teaching-learning integrated with a type of evaluation designed directly to contribute to this process and strengthen it, through systematic feedback, is proposed for the teaching of Chemistry.Fil: Fellet, Andrea L.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiología Humana; ArgentinaFil: Repetto, Marisa Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; Argentin
Recomendaciones para la incorporación de la prueba digital en los fueros no penales
Get PDFSe presenta en este trabajo los avances del proyecto «Guía de recomendaciones para la implementación de protocolos de adquisición, preservación y presentación de la prueba digital», cuyo objetivo es el desarrollo de un conjunto de buenas prácticas de extracción, adquisición, preservación y presentación de prueba digital que permitan dar validez y acreditar los hechos que resultan controvertidos en el marco de los procesos judiciales civiles y comerciales, laborales y de familia.Fil: Di Iorio, Ana. Universidad FASTA; ArgentinaFil: Repetto, Marisa. Universidad Nacional de Cuyo; Argentina.Fil: Rosales, María Fernanda, Universidad FASTA; Argentina.Fil: Cistoldi, Pablo. Universidad FASTA; Argentina.Fil: Díaz, María Fernanda. Juzgado de Paz Letrado y Contravencional del Departamento de Lavalle; Argentina.Fil: Constanzo, Bruno. Universidad FASTA; Argentina.Fil: Trigo, Santiago. Universidad FASTA; Argentina.Fil: Adaro, Mario. Universidad Cjampagnat; Argentina.Fil: Algieri, Lucía. Universidad FASTA; Argentina.Fil: Clara, Bibiana Luz. Universidad FASTA; Argentina
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
The involvement of transition metal ions on iron-dependent lipid peroxidation
Get PDFThe metals iron (Fe) and copper (Cu) are considered trace elements, and the metals cobalt (Co) and nickel (Ni) are known as ultra-trace elements, considering their presence in low to very low quantity in humans. The biologic activity of these transition metals is associated with the presence of unpaired electrons that favor their participation in redox reactions. They are part of important enzymes involved in vital biologic processes. However, these transition metals become toxic to cells when they reach elevated tissue concentrations and produce cellular oxidative damage. Phospholipid liposomes (0.5 mg/ml, phosphatidylcholine (PC)/phosphatidylserine (PS), 60/40) were incubated for 60 min at 37°C with 25 μM of Fe2+ in the absence and in the presence of Cu2+, Co2+, and Ni2+ (0-100 μM) with and without the addition of hydrogen peroxide (H 2O2, 5-50 μM). Iron-dependent lipid peroxidation in PC/PS liposomes was assessed by thiobarbituric acid-reactive substances (TBARS) production. Metal transition ions promoted lipid peroxidation by H 2O2 decomposition and direct homolysis of endogenous hydroperoxides. The Fe2+-H2O2-mediated lipid peroxidation takes place by a pseudo-second order process, and the Cu 2+-mediated process by a pseudo-first order reaction. Co2+ and Ni2+ alone do not induce lipid peroxidation. Nevertheless, when they are combined with Fe2+, Fe2+-H2O 2-mediated lipid peroxidation was stimulated in the presence of Ni2+ and was inhibited in the presence of Co2+. The understanding of the effects of transition metal ions on phospholipids is relevant to the prevention of oxidative damage in biologic systems. © 2009 Springer-Verlag.Fil: Repetto, Marisa Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; ArgentinaFil: Ferrarotti, Nidia Fatima. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; ArgentinaFil: Boveris, Alberto Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentin
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