1,720,975 research outputs found
Utilidad de los marcadores moleculares en el diagnóstico de nódulos tiroideos con citología indeterminada
Get PDFLos nódulos tiroideos representan un problema clínico a nivel mundial debida a su alta prevalencia. La importancia clínica de su estudio radica en excluir malignidad, que ocurre entre el 7-15% de los mismos. El método estándar de oro para el diagnóstico de los mismos es el análisis citológico de la punción aspiración con aguja fina. Sin embargo, hasta un 30% de estos presentan citologías indeterminadas (Bethesda III o IV). Con un resultado histopatológico benigno en, aproximadamente tres de cada cuatro de estos casos, la cirugía diagnóstica (tiroidectomía parcial o lobectomía) resultaen un inconveniente ya que expone al paciente a innecesarios riesgos quirúrgicos. En el caso de lesiones malignas, una tiroidectomía en una segunda etapa es a menudo indicada, lo que se asocia con costos adicionales y mayores riesgos de complicaciones quirúrgicas. Es por esto que se requiere de una herramienta con mayor precisión para determinar la benignidad o malignidad de un nódulo tiroideo con citología indeterminada. En este contexto el análisis molecular del tejido tiroideo se convierte en un poderoso complemento para el diagnóstico preoperatorio de los nódulos tiroideos con citología indeterminada, ya que entre el 60 al 70% de los cánceres de tiroides albergan al menos una mutación genética conocida.Thyroid nodules represent a clinical problem worldwide due to its high prevalence. The clinical importance lies in excluding malignancy, which occurs between 7-15% of them. The cytological analysis is the gold standard for the diagnosis. However, up to 30% of these have indeterminate cytologies (Bethesda III or IV). In these patients, diagnostic surgeries are performed. With a benign histopathological result in approximately three out of four of these cases, surgery results in an inconvenience since it exposes the patient to unnecessary surgical risks. In the case of malignant lesions, a thyroidectomy in a second stage is often indicated, which is associated with additional costs and increased risks of surgical complications. A more precise method is needed to determine the benignity or malignancy of a thyroid nodule with indeterminate cytology. In this context, molecular analysis of thyroid tissue becomes a powerful complement for the preoperative diagnosis of thyroid nodules with indeterminate cytology, since between 60 to 70% of thyroid cancers harbor at least one known genetic mutation.Fil: Ricci, V.. Sociedad Argentina de Endocrinología y Metabolismo; ArgentinaFil: Repetto, Esteban Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentin
Utilidad de los marcadores moleculares en el diagnóstico de nódulos tiroideos con citología indeterminada
Get PDFLos nódulos tiroideos representan un problema clínico a nivel mundial debida a su alta prevalencia. La importancia clínica de su estudio radica en excluir malignidad, que ocurre entre el 7-15% de los mismos. El método estándar de oro para el diagnóstico de los mismos es el análisis citológico de la punción aspiración con aguja fina. Sin embargo, hasta un 30% de estos presentan citologías indeterminadas (Bethesda III o IV). Con un resultado histopatológico benigno en, aproximadamente tres de cada cuatro de estos casos, la cirugía diagnóstica (tiroidectomía parcial o lobectomía) resultaen un inconveniente ya que expone al paciente a innecesarios riesgos quirúrgicos. En el caso de lesiones malignas, una tiroidectomía en una segunda etapa es a menudo indicada, lo que se asocia con costos adicionales y mayores riesgos de complicaciones quirúrgicas. Es por esto que se requiere de una herramienta con mayor precisión para determinar la benignidad o malignidad de un nódulo tiroideo con citología indeterminada. En este contexto el análisis molecular del tejido tiroideo se convierte en un poderoso complemento para el diagnóstico preoperatorio de los nódulos tiroideos con citología indeterminada, ya que entre el 60 al 70% de los cánceres de tiroides albergan al menos una mutación genética conocida.Thyroid nodules represent a clinical problem worldwide due to its high prevalence. The clinical importance lies in excluding malignancy, which occurs between 7-15% of them. The cytological analysis is the gold standard for the diagnosis. However, up to 30% of these have indeterminate cytologies (Bethesda III or IV). In these patients, diagnostic surgeries are performed. With a benign histopathological result in approximately three out of four of these cases, surgery results in an inconvenience since it exposes the patient to unnecessary surgical risks. In the case of malignant lesions, a thyroidectomy in a second stage is often indicated, which is associated with additional costs and increased risks of surgical complications. A more precise method is needed to determine the benignity or malignancy of a thyroid nodule with indeterminate cytology. In this context, molecular analysis of thyroid tissue becomes a powerful complement for the preoperative diagnosis of thyroid nodules with indeterminate cytology, since between 60 to 70% of thyroid cancers harbor at least one known genetic mutation.Fil: Ricci, V.. Sociedad Argentina de Endocrinología y Metabolismo; ArgentinaFil: Repetto, Esteban Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentin
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Blocking gababreceptors (GABABR) from birth to weaning induces profound changes in the gonadotropic axis in adult mice
No full textWe have previously shown that administration of GABAB
antagonist (CGP55845) to neonatal mice from postnatal day (PND)
2 to weaning (PND21) significantly decreased arcuate nucleus (ARC)
kisspeptin (Kiss1) expression and increased dynorphin (Pdyn)
expression in both sexes on PND21.Fil: Bizzozzero Hiriart, Marianne. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Di Giorgio, Noelia Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Repetto, Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Libertun, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Lux, Victoria Adela R.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaReunión Anual de Sociedades de Biociencias 2019Mar del PlataArgentinaSociedad Argentina de Investigación Clínica (SAIC)Asociación Argentina de Farmacología Experimental (SAFE)Sociedad Argentina de Biología (SAB)Sociedad Argentina de Protozoología (SAP)Asociación Argentina de Nanomedicinas (NANOMED-ar)Asociación Argentina de Ciencia y Tecnología de Animales de Laboratorio (AACyTAL)he Histochemical Societ
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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