2,116 research outputs found
OMaraLab/OCT1_2023: Structural Basis of Promiscuous Substrate Transport in Organic Cation Transporter 1 - MD DATA
No full text<p>Molecular dynamics trajectory data relating to <strong>Structural Basis of Promiscuous Substrate Transport in Organic Cation Transporter 1</strong>, by Yi C. Zeng, Meghna Sobti, Ada Quinn, Nicola J. Smith, Simon H. J. Brown, Jamie I. Vandenberg, Renae M. Ryan, Megan L. O'Mara & Alastair G. Stewart.</p>
Quasi-cyclic Generalized LDPC codes with low error floors
No full textIn this paper, a novel methodology for designing structured generalized LDPC (G-LDPC) codes is presented. The proposed design results in quasi-cyclic G-LDPC codes for which efficient encoding is feasible through shift-register-based circuits. The structure imposed on the bipartite graphs, together with the choice of simple component codes, leads to a class of codes suitable for fast iterative decoding. A pragmatic approach to the construction of G-LDPC codes is proposed. The approach is based on the substitution of check nodes in the protograph of a low-density parity-check code with stronger nodes based, for instance, on Hamming codes. Such a design approach, which we call LDPC code doping, leads to low-rate quasi-cyclic G-LDPC codes with excellent performance in both the error floor and waterfall regions on the additive white Gaussian noise channel
The Same Old New Normal
No full textJournal #14 from Media Rise's Quarantined Across Borders Collection by Ryan Arron D'Souza. From United Arab Emirates. Quarantined in United States, Florida.Media Rise Publications. Quarantined Across Borders Collection. Edited by Dr. Srividya "Srivi" Ramasubramanian.The author tries to make sense of the ideas and practices normalized during quarantine
A Bayesian hierarchical model for risk assessment of methylmercury
No full textThis article uses a Bayesian hierarchical model to quantify the adverse health effects associated with in-utero exposure to methylmercury. By allowing for study-to-study as well as outcome-to-outcome variability, the approach provides a useful meta-analytic tool for multi-outcome, multi-study environmental risk assessments. The analysis presented here expands on the findings of a National Academy of Sciences (NAS) committee, charged with advising the United States Environmental Protection Agency (EPA) on an appropriate approach to conducting a risk assessment for methylmercury. The NAS committee, for which the senior author (Ryan) was a committee member, reviewed the findings from several conflicting studies and reported the results from a Bayesian hierarchical model that synthesized information across several studies and for several outcomes. Although the NAS committee did not suggest that the hierarchical model be used as the actual basis for a methylmercury risk assessment, the results from the model were used to justify and support the final recommendation that the risk analysis be based on data from a study conducted in the Faroe Islands, which had found an association between in-utero exposure to methylmercury and impaired neurological development. We consider a variety of statistical issues, but particularly sensitivity to model specification. © 2003 American Statistical Association and the International Biometric Society
Water and urea permeation pathways of the human excitatory amino acid transporter EAAT1
No full textGlutamate transport is coupled to the co-transport of 3 Na(+) and 1 H(+) followed by the counter-transport of 1 K(+). In addition, glutamate and Na(+) binding to glutamate transporters generates an uncoupled anion conductance. The human glial glutamate transporter EAAT1 (excitatory amino acid transporter 1) also allows significant passive and active water transport, which suggests that water permeation through glutamate transporters may play an important role in glial cell homoeostasis. Urea also permeates EAAT1 and has been used to characterize the permeation properties of the transporter. We have previously identified a series of mutations that differentially affect either the glutamate transport process or the substrate-activated channel function of EAAT1. The water and urea permeation properties of wild-type EAAT1 and two mutant transporters were measured to identify which permeation pathway facilitates the movement of these molecules. We demonstrate that there is a significant rate of L-glutamate-stimulated passive and active water transport. Both the passive and active L-glutamate-stimulated water transport is most closely associated with the glutamate transport process. In contrast, L-glutamate-stimulated [(14)C]urea permeation is associated with the anion channel of the transporter. However, there is also likely to be a transporter-specific, but glutamate independent, flux of water via the anion channel.Robert J. Vandenberg, Cheryl A. Handford, Ewan M. Campbell, Renae M. Ryan and Andrea J. Yoo
Novel multi-electrode probe with three dimensional spatial resolution for simultaneous recording/stimulation in long-term adaptive deep brain stimulaton
No full textWhen treating neurological disorders such as Parkinson’s Disease (PD) modern technologies experience many deficiencies and/or limitations that researchers have been working towards improving. The problems that occur with modern devices are inadequate mechanical robustness, glial scarring due to tissue damage, reduced target area localization, and inability to simultaneously record/stimulate in vivo post implantation. The research presented here resolves the issues stated above, delivering the design of a novel Multi-Electrode Probe with 3-D spatial resolution and an on-board preamplification/filtering chip capable of simultaneous recording/stimulation. The probe has been modeled in Wildfire Pro/Engineer 4.0 and Finite Element Analysis (FEA) was performed in COMSOL Multiphysics 3.4. The neural chip which consists of both analog and digital circuitry was designed with Taiwan Semiconductor’s (TSMC) 0.18µm CMOS technology. The very large scale integration (VLSI) design and simulation was performed in Cadence Schematic and Spectre, respectively. The aforementioned work was done in hopes of delivering a neural probe that can eventually be used in a closed loop system for Adaptive Deep Brain Stimulation treatment.Ph.D.Includes bibliographical referencesIncludes vitaby Ryan M. Elkhol
Corrigendum: Expression analysis of candidate genes regulating successional tooth formation in the human embryo
No full textA corrigendum on
Expression analysis of candidate genes regulating successional tooth formation in the human embryo
by Olley, R., Xavier, G. M., Seppala, M., Volponi, A. A., Geoghegan, F., Sharpe, P. T., et al. (2014). Front. Physiol. 5:445. doi: 10.3389/fphys.2014.00445
The author Ryan Olley should appear as Olley RC on the published article “Expression analysis of candidate genes regulating successional tooth formation in the human embryo.”
The original article was updated
Shifting and persosting in the face of failure: Learning from what did not work
No full textSocial justice activism demands coordinated, concentrated efforts to move the needle in a positive direction. In the author's nine years as a social justice educator, he led multiple large- and small-scale projects for social justice within higher education. In many ways, those efforts failed to create a lasting impact. In the higher education ecosystem, they also took away time from the kind of promotable work which would benefit his case for tenure and promotion. Trying - and failing - to effect institutional changes left him emotionally, psychologically, and physically exhausted. Beyond that, he suffered from feelings of loneliness, exclusion, and lack of direction. For a long time, the author blamed himself for the failure to change the institution to be a place in which he felt comfortable. He also failed to cope with these negative experiences and emotions, often seething in frustration or anger or avoiding similar situations of vulnerability or creativity. It took years for him to remember and internalize lessons of persistence and shifting appraisals in order to maintain motivation for action and survive the stressors of working within an oppressive system.Published versio
‘Powers of a squirrel, and also a girl’: Squirrel Girl and alternatives for women in superhero comic-books – an interview with Ryan North
No full textRyan North is a Canadian author who writes a host of comics, most notably Dinosaur Comics (www.
qwantz.com, 2003-present), Adventure Time (2012–2014, winner of both an Eisner and a Harvey Award),
The Midas Flesh (2013) and The Unbeatable Squirrel Girl (R. North and E. Henderson, 2015). North
is also the creator of To Be Or Not To Be (2013), a choose-your-own-adventure version of Hamlet funded
through Kickstarter, published as a book and also as a computer game. North has recently followed this with
Romeo And/Or Juliet (2016)
Questions, Methodology, and Action: A Response to Ryan & Muller
No full textIn this article, the author engages critically with the arguments presented in Ryan and Muller’s 2023 Florida Law Review article. The response addresses key methodological concerns and questions raised by the original authors, offering alternative perspectives and insights. By scrutinizing the methods employed and the conclusions drawn, the author aims to clarify ambiguities and propose more robust approaches for legal analysis. The article highlights the importance of rigorous methodology in legal scholarship and advocates for a more nuanced understanding of the issues discussed. This response contributes to the ongoing scholarly dialogue, enhancing the discourse on the subject matter
- …
