1,720,952 research outputs found
RETRACTED ARTICLE: The circular RNA circ-ITCH acts as a tumour suppressor in osteosarcoma via regulating miR-22
No full textWe, the Editors and Publisher of the journal Artificial Cells, Nanomedicine, and Biotechnology, have retracted the following article:Chongmin Ren, Jia Liu, Bingxin Zheng, Peng Yan, Yuerong Sun & Bin Yue (2019) The circular RNA circ-ITCH acts as a tumour suppressor in osteosarcoma via regulating miR-22. Artificial Cells, Nanomedicine, and Biotechnology, 47(1), 3359–3367, DOI: 10.1080/21691401.2019.1649273Since publication, concerns have been raised about the integrity of the data in the article. When approached for an explanation, the authors have been unable to verify their original data or answer our questions about research ethics and the informed consent process. We are therefore retracting this article and the corresponding author listed in this publication has been informed.We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions.The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as “Retracted”
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Sustainability decision support framework for the prioritization of hydrogen energy systems
No full textThis chapter proposed a multicriteria decision-making methodology for the sustainability prioritization of industrial systems. The methodology incorporates a fuzzy analytic hierarchy process method that allows the users to assess the soft criteria by using linguistic terms. A fuzzy analytic network process method is used to calculate the weights of each criterion, which can tackle the interdependencies and interactions among the criteria. The preference ranking organization method for enrichment evaluation approach is used to prioritize the sustainability sequence of the alternative systems. Moreover, a sensitivity analysis method was developed to investigate the most critical and sensitive criteria. The developed methodology was illustrated by a case study to rank the sustainability of five alternative hydrogen production technologies. The advantages of the developed methodology over the previous approaches were demonstrated by comparing the results determined by the proposed framework with those determined by using the pervious approaches.Department of Industrial and Systems Engineering2016-2017 > Academic research: refereed > Chapter in an edited book (author)bcw
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Lao nian tang niao bing ren ren zhi gong neng jian tui de wei xian yin zi de jian ce
No full textPh.D.Background:Older people with diabetes mellitus (DM) are at increased risk of Alzheimer’s disease (AD) and deficits in specific domains (e.g., executive function and psychomotor speed) of cognitive functioning. In addition, vitamin B₁₂ deficiency is common in older people with DM. There is therefore a need to examine cognitive profiles, investigate the risk factors associated with cognitive impairment and elucidate the effect of vitamin B₁₂ supplementation in older people with DM.Objectives1. Assess the effects of vitamin B₁₂ supplementation to prevent cognitive decline and brain atrophy in older people coexists with DM and mild vitamin B₁₂ deficiency.2. Assess the clinical, biochemical and neuroimaging risk factors for cognitive decline in older people with DM.3. Compare the profiles of cognitive deficits, nutritional status, cardiovascular conditions and brain abnormalities between subjects with and without DM in the presence of amnestic mild cognitive impairment (aMCI) or AD.4. To investigate the potential mechanisms of cognitive impairment in older people with DM.Subjects and Methods:The main study was a randomized controlled trial of vitamin B₁₂ supplementation to prevent cognitive decline and brain atrophy in 271 older diabetic people with mild vitamin B₁₂ deficiency. All subjects were randomly assigned to take either methylcobalamin 1000 microgram or two similar looking placebo tablets once daily for 27 months and in the following 18 months all subjects took methylcobalamin as an open label extension trial. All subjects were followed up at 9 monthly intervals.Brain volumetric magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) scans were performed to a subsample of subjects with consent at baseline, 27 months and 45 months. Seven lipid classes were analyzed by liquid-chromatography mass spectrometric (LC-MS) at baseline.Data from two other studies was selected to make cross-sectional comparisons between DM and non-DM in older people with aMCI or AD.Results:The randomized controlled trial with vitamin B₁₂ supplementation did not show significant group difference in the rate of brain changes and cognitive decline at follow up. At month 27, the rate of atrophy in whole brain and hippocampus per year in active group was 0.80% and 0.66%, respectively, and in placebo group it was 0.79% and 0.39%, respectively. At month 45, the rate of atrophy in hippocampus per year in the active group and placebo group was 0.45% and 0.11%, respectively. 23 (18.9%) and 15 (15.2%) active treatment group subjects and 18 (14.9%) and 16 (17.6%) placebo group subjects had cognitive decline (defined by any increase in clinical dementia rating scale (CDR) global scores) at month 27 and 45, respectively. As vitamin B₁₂ supplementation did not have significant effect on cognitive function or brain structures, we considered all trial group subjects as a cohort to look for risk factors associated with cognitive decline in older people with DM.Baseline serum high-density lipoprotein cholesterol (HDL-C) level was positively associated with executive function in older people with DM at month 27. Lipidomic analysis of serum samples at baseline found that 8 metabolites (7 phosphatidylcholines (PC), 1 lyso-PC) were significantly decreased in subjects with cognitive decline at month 27 after adjusting for age, sex, education level and group assignment. Out of the eight lipids, 5 and 2 correlated significantly with HDL and statin use respectively. 6 lipids were significantly associated with cognitive decline independent of statin use.MRI imaging markers of baseline higher white matter hyperintensities (WMH) and lower hippocampal volume ratio (hippocampal volume/intracranial volume) were associated with declining in executive function at month 45 and the association between WMH and executive function was not independent of hippocampal volume ratio (P>0.05). Both hippocampal and cingulate volume ratios were positively and independently associated with memory function at month 45. Higher novel DTI-based marker for white matter integrity (peak width of skeletonized mean diffusivity [PSMD]) at baseline was significantly associated with worse executive function at both month 27 and month 45 after controlling for confounding factors. However, this association was not independent of baseline hippocampal volume ratio (P=0.092). One unit of PSMD change could result in more executive dysfunction at month 45 compared with WMH (Beta was -3.97 and -0.51, respectively).Cross-sectional comparison between aMCI with and without DM found that DM-aMCI group had more hypertension and history of stroke, whereas, lipids profile (except HDL-C level) was better due to the more users of statin than their counterparts without DM and also HDL-C was lower in subjects with DM. Serum homocysteine concentration was independently raised in DM-aMCI group. Non-DM aMCI had smaller whole brain and hippocampal volumes than the DM-aMCI group. Linear regression models found that executive function, memory function and daily function (measured by CDR-sum of box (SOB)) were impaired more in aMCI with DM compared to those without DM after controlling for age, sex, education levels, serum homocysteine, active vitamin B₁₂, folate, creatinine, HDL-C levels and history of stroke. The relationship between executive dysfunction, CDR-SOB and DM was not independent of WMH while the association between memory function and DM was independent of hippocampal volume ratio.In the cross-sectional comparison between DM-AD and non-DM AD, there was no any significant group difference in regard to cognitive profiles (MoCA, ADAS-cog and verbal fluency test), brain volumes and WMH. Whereas, subjects with DM got lower scores in Disability assessment for dementia (DAD) especially in the domain of initiation, when compared with their counterparts without DM. This association was independent of ADAS-cog and hippocampal volume ratio, but not independent of WMH.ConclusionVitamin B₁₂ supplementation did not show any beneficial effects on cognitive function or brain atrophy in older people with diabetes mellitus and mild vitamin B₁₂ deficiency over 27 months.Overall, eight lipids at baseline were associated with global cognitive deterioration at month 27. Lower baseline serum HDL-C level was associated with more cognitive decline in executive function in older people with DM. Lower hippocampal volume ratio was independently associated with decline in executive and memory function. White matter integrity was significantly associated with executive function. Taken together, both hippocampal atrophy and white matter integrity are important mediators of cognitive impairment in older people with DM. Furthermore, DM had an independent effect on memory function and DM could also affect executive function through WMH in the presence of aMCI. In contrast, DM did not appear to have significant influence on cognitive function in older people with AD, which may suggest DM affects cognitive function in the very early stage of AD. However, AD patients with DM were relatively more impaired in daily functioning especially in initiation. This was probably mediated by white matter disease.研究背景老年糖尿病增加了患阿兹海默氏症的危险，以及某些特定认知功能的下降（例如执行功能和精神运动速度）。此外，维生素B₁₂的缺乏在老年糖尿病人中也很常见。因此检查老年糖尿病人的认知功能，以及发现认知功能下降的危险因素和探究维生素B₁₂的供给对于糖尿病人的认知功能的改善有很重大意义。研究目的1. 评估维生素B₁₂的干预对于认知功能的下降和脑萎缩在老年糖尿病并有轻微的维生素B₁₂的缺乏的人群中的作用2. 从临床，血液生化以及影像学的角度来检测老年糖尿病人的认知功能减退的危险因子3. 比较记忆功能损害和阿兹海默氏症的老年患者在合并糖尿病和无糖尿病时各个方面的差异比较4. 探究老年糖尿病人的认知功能损害的可能机制研究方法主研究是来自维生素B₁₂干预的随机对照研究。271个老年糖尿病人合并有轻微维生素B₁₂缺乏被随机分为实验组和对照组，并随访27个月。后面18个月，所有的人都被给予维生素B₁₂的干预。每隔9个月进行一次随访。部分同意进行核磁共振和扩散磁振造影的人在开始，第27个月和第45个月分别给予这两个影像学检测。在开始阶段，同时对受试者进行脂类组学的分析。我们同时对于记忆功能损害和阿兹海默氏症的老年患者在合并糖尿病和无糖尿病时各个方面的差异也进行了断代比较。研究结果维生素B12的干预在实验组和对照组中没有显著性差异。在第27个月，全脑和海马体积萎缩率在实验组中为0.80%和0.66%，在对照组中为0.79%和0.39%。在第45个月，海马体积的年萎缩率在实验组和对照组中分别为0.45%和0.11%。在第27个月和45个月，分别有23（18.9%）和15（15.2%）的实验组的人和18 （14.9%）和16（17.6%）的对照组的人有认知功能的损害。由于该干预实验是阴性结果，我们因此探究本人群的认知功能下降的危险因素。初始的高密度脂蛋白的浓度越高，27个月的执行功能就越好。脂类组学同时发现了8个脂质和认知功能的下降有关。 但是这8个中有5个和高密度脂蛋白，2个和他汀类药物的使用有密切关联。只有6个脂质是独立于他汀类药物的使用和认识功能的下降有关。影像学的结果发现，强的白质高强度信号和小的海马体积和第45个月的执行功能下降有关，小的海马体积参与白质高强度和下降的执行功能之间关系的调节。初始的小海马体积和小的扣带体积分别独立的与记忆功能的下降有关。另外初始的PSMD同时和执行功能在第27和45个月的下降均有显著性的关联。27个月的PSMD的大小也和第45个月的执行功能减退有关。断代研究表明记忆功能轻微损害的糖尿病人对比无糖尿病的人发现，糖尿病者患有高血压和中风的比例更高，但是他们的血脂水平比非糖尿病患者好，因为大部分人都使用了降脂药，同时糖尿病人的高密度脂蛋白水平也低。糖尿病患者的血同型半胱氨酸显著升高。非糖尿病患者的全脑体积和海马体积明显小于糖尿病患者。执行功能，记忆能力和日常功能在糖尿病患者中显著下降。执行功能和日常功能的下降可能是通过白质的病变影响的。断代研究表明在阿兹海默氏症的患者当中，有无糖尿病对于认知功能和脑结构没有显著性影响。但是糖尿病患者在日常功能表现要差于非糖尿病患者，而且这个关系也有可能是通过白质的病变引起的。研究结论维生素B₁₂干预对于老年糖尿病人的认知功能和脑萎缩都无显著性影响。低浓度的高密度脂蛋白，小的海马体积和白质的病变都同执行功能的减退有关。小的海马体积和扣带体积还同记忆的下降有关。糖尿病对于执行功能和记忆功能的影响主要发生在阿兹海默氏症的早期阶段，但是对于日常功能的影响却是持续性的。对于执行功能和日常功能的影响可能通过白质病变调节，但是对于记忆功能，糖尿病却有独立的影响。Sun, Yue.Thesis Ph.D. Chinese University of Hong Kong 2018.Includes bibliographical references (leaves 214-249).Abstracts also in Chinese; some appendices in Chinese.Title from PDF title page (viewed on 26 May, 2021).Sun, Yue
A Weekly Diary Study on Playful Study Design, Study Engagement, and Goal Attainment: The Role of Proactive Personality
Full text linkStudents’ learning processes are heavily impeded by the COVID-19 pandemic. Students are experiencing more online learning environment and less face-to-face idea exchange, which may make them feel exhausted and demotivated. Using self-determination and proactivity theories, we propose and examine whether playful study design (PSD)—a proactive study strategy including designing fun and designing competition in learning tasks—is effective in fostering study engagement, which, in turn, improves study goal attainment during the COVID-19 period. Moreover, we examine whether students who are high in proactive personality will benefit more (e.g., reach a higher level of study engagement) when using the PSD strategy. We collected data using a weekly diary approach during four consecutive weeks, including 97 people and 308 within-person observations. Results of multilevel analyses showed that weekly PSD was positively related to weekly study engagement, and in turn, facilitated weekly goal attainment. Moreover, we found that proactive personality moderated and strengthened the positive associations between PSD and goal attainment, study engagement and goal attainment, but not for the relationship between PSD and study engagement. Overall, we provide one of the first attempts to demonstrate how PSD strategy can be used in student study life to improve study engagement and reach their goals. We shed light on how proactive personality can safeguard the success of PSD strategy. Theoretical and practical contributions are discussed.Design Conceptualization and Communicatio
Wen ren de yin ji : " Xian ge bi du" yu er shi shi ji chu zhi Yue yue tui guang
No full textLee, King Chi.Thesis M.Phil. Chinese University of Hong Kong 2015.Includes bibliographical references (leaves 109-119).Abstracts also in Chinese.Title from PDF title page (viewed on 09, November, 2016).Lee, King Chi
Next-Generation Sequencing: Application in Liver Cancer—Past, Present and Future?
No full textHepatocellular Carcinoma (HCC) is the third most deadly malignancy worldwide characterized by phenotypic and molecular heterogeneity. In the past two decades, advances in genomic analyses have formed a comprehensive understanding of different underlying pathobiological layers resulting in hepatocarcinogenesis. More recently, improvements of sophisticated next-generation sequencing (NGS) technologies have enabled complete and cost-efficient analyses of cancer genomes at a single nucleotide resolution and advanced into valuable tools in translational medicine. Although the use of NGS in human liver cancer is still in its infancy, great promise rests in the systematic integration of different molecular analyses obtained by these methodologies, i.e., genomics, transcriptomics and epigenomics. This strategy is likely to be helpful in identifying relevant and recurrent pathophysiological hallmarks thereby elucidating our limited understanding of liver cancer. Beside tumor heterogeneity, progress in translational oncology is challenged by the amount of biological information and considerable “noise” in the data obtained from different NGS platforms. Nevertheless, the following review aims to provide an overview of the current status of next-generation approaches in liver cancer, and outline the prospects of these technologies in diagnosis, patient classification, and prediction of outcome. Further, the potential of NGS to identify novel applications for concept clinical trials and to accelerate the development of new cancer therapies will be summarized
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