102,993 research outputs found
Correction to: Phase-contrast magnetic resonance imaging to assess renal perfusion: a systematic review and statement paper, in "Magnetic Resonance Materials in Physics, Biology and Medicine", 33 (2020), 1, pp. 3-21, doi: 10.1007/s10334-019-00772-0
No full textThe article Phase‐contrast magnetic resonance imaging to assess renal perfusion: a systematic review and statement paper, written by Giulia Villa, Steffen Ringgaard, Ingo Hermann, Rebecca Noble, Paolo Brambilla, Dinah S. Khatir, Frank G. Zöllner, Susan T. Francis, Nicholas M. Selby, Andrea Remuzzi and Anna Caroli, was originally published electronically on the publisher’s internet portal on 17 August 2019 without open access
Ci curano o ci curiamo? Il malato tra crisi economica e responsabilità indivduale
No full textIn medicina si sono realizzati più cambiamenti negli ultimi cinquanta anni che nei secoli precedenti. Le scoperte della medicina hanno modificato profondamente l'aspettativa di vita, che dagli inizi del Novecento a oggi è raddoppiata, pur con enormi disparità tra le diverse zone del mondo. Nei paesi sviluppati, ma anche in quelli emergenti, le malattie infettive non sono più le cause principali di morte, oggi costituite da malattie croniche e tumori. Se lo straordinario sviluppo delle conoscenze ha reso disponibili terapie sofisticate, ha determinato anche l'esplodere del costo dei sistemi sanitari dei paesi sviluppati, che paventano ora l'insostenibilità delle conquiste della medicina. Tanto meno possono trarre vantaggio da queste conquiste molti paesi poveri che non hanno i mezzi per accedere a terapie innovative.
Su questi e altri aspetti i più autorevoli scienziati italiani hanno raccontato e descritto quelle che saranno le principali sfide che attendono la nostra società. Gli articoli scritti da Giuseppe Remuzzi sul Corriere della Sera sono uno stimolo alla riflessione. Antonio Maturo ha invece fornito l'inquadramento sociologico.
L'inequità nell'accesso alle cure è oggi uno dei problemi morali più importanti posti alla coscienza di quanti lavorano per la salute dell'uomo
Renal bioengineering with scaffolds generated from rat and pig kidneys
No full textBackground: Chronic kidney disease (CKD) is a global public health issue with an estimated prevalence of 8-16% worldwide. End-stage renal disease eventually develops every year in 0.15-0.2% of patients with overt CKD, and renal replacement therapy (RRT) with dialysis or transplantation is required. Although approximately 2 million people worldwide are currently on RRT to sustain life, this likely represents less than 10% of those who need it. The kidney transplant approach is also seriously impaired by limited graft survival and by the scarce availability of donors. Innovative tissue-engineering strategies have been recently proposed to overcome these challenges. It is anticipated that these novel approaches will also be cost-effective in the long term. Although the initial setup of these innovative technologies could be quite expensive, there would be a single application for each patient, with no additional costs thereafter, compared to the lifelong costs of dialysis or immunosuppressive medications required for transplantation. One of the most innovative tools currently being investigated in experimental models is based on the idea of using decellularized kidneys to engineer a new functional organ as a potential future treatment option for end-stage renal disease. Summary: In the last 5 years, several interesting observations have been reported regarding the possibility of using an acellular matrix from the whole kidney and the attempt to recellularize this scaffold using stem or differentiated cells. This review provides an overview of the decellularization methods tested so far and their effects on the resulting extracellular matrix structure and composition. In addition, we also discuss methods recently described by us and others for the perfusion of kidney scaffolds for recellularization. Key Messages: Despite difficulties in achieving the import goal of kidney engineering in the laboratory, we discuss the problems with and limits of the experimental results obtained so far and point out the strategies that need to be adopted in order for this line of research to advance
Assessment of glomerular size-selective function with fractional clearance of neutral dextran
No full textDreaming of normoglycaemia with fewer diet restrictions
No full textComment on: Lancet Diabetes Endocrinol. 2014 May;2(5):369-84. doi: 10.1016/S2213-8587(13)70208-0. Epub 2014 Jan 24.
Efficacy and safety of empagliflozin added to existing antidiabetes treatment in patients with type 2 diabetes and chronic kidney disease: a randomised, double-blind, placebo-controlled trial.
Barnett AH, Mithal A, Manassie J, Jones R, Rattunde H, Woerle HJ, Broedl UC; EMPA-REG RENAL trial investigators
Comparison of bibliographic search strategies for systematic review on kidney and urinary diseases epidemiology for the Global Burden of Disease Study
No full textCongress abstract "Bikbov B., Perico N, Remuzzi G. Comparison of bibliographic search strategies for systematic review on kidney and urinary diseases epidemiology for the Global Burden of Disease Study. Abstract book of the 21th World Congress of Epidemiology "Global, regional, local health and epidemiology in a changing world" (Saitama, Japan). 2017; P2-129
Worsening kidney function in decompensated heart failure: treat the heart, dont mind the kidney
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