814 research outputs found
The Golden and the Diamond Light: Lorena Carrington’s Fairy-Tale Illustrations
No full textA fairy-tale author discusses her inspiration and admiration for the fairy-tale illustrations of artist Lorena Carrington
Assessment of disease severity in pediatric laryngopharyngeal reflux
No full textLaringofaringealni refluks predstavlja retrogradno kretanje gastroduodenalnog sadržaja iznad gornjeg ezofagealnog sfinktera s mogućnošću dosezanja osjetljive sluznice ždrijela, grkljana i nosne šupljine. Od sredine 1990-ih godina, LPR se sve jasnije diferencira od gastroezofagealnog refluksa i postaje predmet brojnih kliničkih istraživanja. Unatoč tome, zbog nedefiniranih dijagnostičkih kriterija te značajnih ograničenja u dostupnim dijagnostičkim metodama, ne postoje objektivna istraživanja koja bi precizno prikazala stvarnu incidenciju i prevalenciju LPR-a u pedijatrijskoj populaciji. PLPR se učestalije javlja u dojenačkoj dobi što se ponajprije pripisuje nezrelosti antirefluksnih mehanizama. Patofiziologija bolesti temelji se na kombinaciji refluksne i refleksne teorije uz značajnu ulogu psihobihevioralnih čimbenika. Oštećenje sluznice rezultat je djelovanja agresivnih kemijskih
komponenti refluksnog sadržaja kao što su klorovodična kiselina, pepsin, žučne kiseline i tripsin čija štetnost nije strogo ovisna o pH vrijednosti. Refluks može biti kiseli, slabokiseli ili nekiseli po tipu te se može pojaviti u tekućem ili plinovitom obliku. Dijagnostička obrada trebala bi se primarno temeljiti na detaljnoj analizi simptomatologije i lokalnim nalazima uz izbjegavanje invazivnih postupaka kada je to moguće. Međutim, simptomatologija u djece je raznolika i često nespecifična uz jasne razlike po dobnim skupinama. Najčešći simptomi PLPRa uključuju poremećaje disanja, kronični kašalj, promuklost i postnazalno čišćenje sekreta. Postoje brojni upitnici koji procjenjuju vjerojatnost prisutnosti bolesti no većina nije validirana za sve dobne skupine. Nakon početne procjene, definitivna dijagnoza najčešće se postavlja pHmjerenjem ili impedancijskim monitoringom, a u novije se vrijeme pozornost skreće prema neinvazivnim metodama poput određivanja koncentracije salivarnog pepsina. Neophodan je
razvoj standardiziranog, osjetljivog i sveobuhvatnog dijagnostičkog alata koji će biti primjenjiv u različitim dobnim skupinama djece. Liječenje PLPR-a temelji se na stupnjevitom pristupu koji uključuje promjene životnih i prehrambenih navika, farmakološko liječenje (IPP i/ili alginati) i kirurško liječenje koje se primjenjuje samo u najtežim, terapijski rezistentnim slučajevima. Rana identifikacija i pravovremeno liječenje od ključnog su značaja zbog rizika od ozbiljnih komplikacija. Dodatna istraživanja usmjerena na validaciju dijagnostičkih kriterija i optimizaciju terapijskih protokola u djece moraju ostati prioritet kliničkih istraživanja.Laryngopharyngeal reflux refers to the retrograde movement of gastroduodenal contents above the upper esophageal sphincter potentially reaching the sensitive mucosa of the pharynx, larynx and nasal cavity. Since the mid-1990s, LPR has been increasingly recognized as a distinct clinical entity from gastroesophageal reflux and has become the focus of numerous clinical studies. However, due to undefined diagnostic criteria and significant limitations of available
diagnostic methods, there are no objective studies that accurately depict the true incidence and prevalence of LPR in the pediatric population. PLPR is more common in infancy primarily due to the immaturity of anti-reflux mechanisms. The pathophysiology of the condition is based on a combination of reflux and reflex theories with a significant contribution from
psychobehavioral factors. Mucosal damage results from the action of aggressive chemical components of the refluxate such as hydrochloric acid, pepsin, bile acids and trypsin whose harmful effects are not strictly dependent on pH levels. Reflux may be acidic, non-acidic or mixed in type and may occur in liquid or gaseous form. Diagnostic evaluation should primarily
rely on a detailed analysis of symptoms and local findings while avoiding invasive procedures whenever possible. However, symptoms in children are diverse and often nonspecific with clear distinctions across different age groups. The most common symptoms of PLPR include breathing disorders, chronic cough, hoarseness and postnasal drip. Numerous questionnaires exist to assess the likelihood of disease presence but most are not validated across all age
groups. Following initial assessment, a definitive diagnosis is most commonly established via pH monitoring or impedance testing. In recent years, attention has shifted toward non-invasive methods such as measuring salivary pepsin concentration. There is a pressing need to develop a standardized, sensitive and comprehensive diagnostic tool applicable across various pediatric age groups. The treatment of PLPR is based on a stepwise approach that includes lifestyle and
dietary modifications followed by pharmacological therapy (proton pump inhibitors and/or alginates) while surgical intervention is reserved for the most severe, therapy-resistant cases. Early identification and timely treatment are crucial due to the risk of serious complications. Further research focused on validating diagnostic criteria and optimizing therapeutic protocols in children remains a priority
Assessment of disease severity in pediatric laryngopharyngeal reflux
No full textLaringofaringealni refluks predstavlja retrogradno kretanje gastroduodenalnog sadržaja iznad gornjeg ezofagealnog sfinktera s mogućnošću dosezanja osjetljive sluznice ždrijela, grkljana i nosne šupljine. Od sredine 1990-ih godina, LPR se sve jasnije diferencira od gastroezofagealnog refluksa i postaje predmet brojnih kliničkih istraživanja. Unatoč tome, zbog nedefiniranih dijagnostičkih kriterija te značajnih ograničenja u dostupnim dijagnostičkim metodama, ne postoje objektivna istraživanja koja bi precizno prikazala stvarnu incidenciju i prevalenciju LPR-a u pedijatrijskoj populaciji. PLPR se učestalije javlja u dojenačkoj dobi što se ponajprije pripisuje nezrelosti antirefluksnih mehanizama. Patofiziologija bolesti temelji se na kombinaciji refluksne i refleksne teorije uz značajnu ulogu psihobihevioralnih čimbenika. Oštećenje sluznice rezultat je djelovanja agresivnih kemijskih
komponenti refluksnog sadržaja kao što su klorovodična kiselina, pepsin, žučne kiseline i tripsin čija štetnost nije strogo ovisna o pH vrijednosti. Refluks može biti kiseli, slabokiseli ili nekiseli po tipu te se može pojaviti u tekućem ili plinovitom obliku. Dijagnostička obrada trebala bi se primarno temeljiti na detaljnoj analizi simptomatologije i lokalnim nalazima uz izbjegavanje invazivnih postupaka kada je to moguće. Međutim, simptomatologija u djece je raznolika i često nespecifična uz jasne razlike po dobnim skupinama. Najčešći simptomi PLPRa uključuju poremećaje disanja, kronični kašalj, promuklost i postnazalno čišćenje sekreta. Postoje brojni upitnici koji procjenjuju vjerojatnost prisutnosti bolesti no većina nije validirana za sve dobne skupine. Nakon početne procjene, definitivna dijagnoza najčešće se postavlja pHmjerenjem ili impedancijskim monitoringom, a u novije se vrijeme pozornost skreće prema neinvazivnim metodama poput određivanja koncentracije salivarnog pepsina. Neophodan je
razvoj standardiziranog, osjetljivog i sveobuhvatnog dijagnostičkog alata koji će biti primjenjiv u različitim dobnim skupinama djece. Liječenje PLPR-a temelji se na stupnjevitom pristupu koji uključuje promjene životnih i prehrambenih navika, farmakološko liječenje (IPP i/ili alginati) i kirurško liječenje koje se primjenjuje samo u najtežim, terapijski rezistentnim slučajevima. Rana identifikacija i pravovremeno liječenje od ključnog su značaja zbog rizika od ozbiljnih komplikacija. Dodatna istraživanja usmjerena na validaciju dijagnostičkih kriterija i optimizaciju terapijskih protokola u djece moraju ostati prioritet kliničkih istraživanja.Laryngopharyngeal reflux refers to the retrograde movement of gastroduodenal contents above the upper esophageal sphincter potentially reaching the sensitive mucosa of the pharynx, larynx and nasal cavity. Since the mid-1990s, LPR has been increasingly recognized as a distinct clinical entity from gastroesophageal reflux and has become the focus of numerous clinical studies. However, due to undefined diagnostic criteria and significant limitations of available
diagnostic methods, there are no objective studies that accurately depict the true incidence and prevalence of LPR in the pediatric population. PLPR is more common in infancy primarily due to the immaturity of anti-reflux mechanisms. The pathophysiology of the condition is based on a combination of reflux and reflex theories with a significant contribution from
psychobehavioral factors. Mucosal damage results from the action of aggressive chemical components of the refluxate such as hydrochloric acid, pepsin, bile acids and trypsin whose harmful effects are not strictly dependent on pH levels. Reflux may be acidic, non-acidic or mixed in type and may occur in liquid or gaseous form. Diagnostic evaluation should primarily
rely on a detailed analysis of symptoms and local findings while avoiding invasive procedures whenever possible. However, symptoms in children are diverse and often nonspecific with clear distinctions across different age groups. The most common symptoms of PLPR include breathing disorders, chronic cough, hoarseness and postnasal drip. Numerous questionnaires exist to assess the likelihood of disease presence but most are not validated across all age
groups. Following initial assessment, a definitive diagnosis is most commonly established via pH monitoring or impedance testing. In recent years, attention has shifted toward non-invasive methods such as measuring salivary pepsin concentration. There is a pressing need to develop a standardized, sensitive and comprehensive diagnostic tool applicable across various pediatric age groups. The treatment of PLPR is based on a stepwise approach that includes lifestyle and
dietary modifications followed by pharmacological therapy (proton pump inhibitors and/or alginates) while surgical intervention is reserved for the most severe, therapy-resistant cases. Early identification and timely treatment are crucial due to the risk of serious complications. Further research focused on validating diagnostic criteria and optimizing therapeutic protocols in children remains a priority
Women making IT - interplay of personal and cultural values influencing career choices of women working in IT consulting
No full textAuthor Selina Lorena IllenseerMasterarbeit Johannes Kepler Universität Linz 2024Arbeit nach Ablauf der Sperre auf den öffentlichen PCs in den Bibliotheken der JKU+Medizin abrufba
Women making IT - interplay of personal and cultural values influencing career choices of women working in IT consulting
No full textAuthor Selina Lorena IllenseerMasterarbeit Johannes Kepler Universität Linz 2024Arbeit nach Ablauf der Sperre auf den öffentlichen PCs in den Bibliotheken der JKU+Medizin abrufba
O começo da Revolução de 1842 em Lorena
No full textAs an introduction, the author presents a short appreciation of the causes which led to the outburst of the seditions movement in 1842. He outlines the historical background of the events in Lorena and Silveiras. He tries to explain the reasons for personal involvement in the revolutionary process caused by hatred between the Brazilian and the Portuguese people. He reminds us of the geographical importance of Lorena and the chacteristics of its inhabitants. He demonstrates how gossiping incites animosity. He ends up with the proceedings and their results. O autor, pretendendo uma introdução, faz uma rápida apreciação das causas que levaram à eclosão do movimento sedicioso de 1842. Estabelece o quadro histórico dos acontecimentos nas localidades de Lorena e Silveiras. Procura explicar os motivos dos envolvimentos pessoais com o processo revolucionário, atribuindo a este o ódio entre brasileiros e portugueses. Lembra a importância geográfica de Lorena e o tipo de seus habitantes. Demonstra o acirramento de ânimos e como os boatos os provocam. Finaliza com a instauração dos processos e seus resultados. 
Rezension: "Besuch in der Hölle. Dantes Göttliche Komödie. Biographie eines Jahrtausendbuchs" von Franziska Meier
No full textFranziska Meiers vorliegende Studie stellt einen wichtigen Beitrag zur aktuellen wissenschaftlichen Erforschung von Dantes Divina Commedia dar. In ihrer Untersuchung erläutert sie nicht nur die grundlegenden Kontexte der Entstehungsgeschichte und die Biografie des schon zu Lebzeiten umstrittenen Verfassers. Vielmehr gelingt es Meier, auch linguistische Aspekte, Fragen der Übersetzung und der Rezeption außerhalb Europas schlüssig darzustellen. Die Autorin und Übersetzerin Lorena Pircher, selbst auch Romanistin, hat diese Studie für die Medienimpulse rezensiert.Franziska Meier\u27s study represents an important contribution to current scholarly research on Dante\u27s Divina Commedia. In her new book, she not only explains the fundamental contexts of the genesis of the Commedia and biography of the author, who was already controversial during his lifetime. Rather, Meier also succeeds in coherently presenting linguistic aspects, questions of translation and reception outside Europe. The author and translator Lorena Pircher, herself also a Romance scholar, reviewed this study for Medienimpulse
ASO Author Reflections: Recurrence After Pathological Complete Response in Esophageal Cancer: Analysis of Risk Factors for this Unexpected Event
No full textASO Author Reflections: Recurrence After Pathological Complete Response in Esophageal Cancer: Analysis of Risk Factors for this Unexpected Even
El Tlacuache Núm. 50 (2002). 50 Año 2 (2002) julio. El Tlacuache
No full text- Museo Regional Cuauhnáhuac por Lorena del Río de Icaza. - Nuestro patrimonio desconocido por Teresita Loera y Anaite Monterforte. - El Yauhtli por Margarita Avilés y Macrina Fuentes. - El camino de los archivos por Antonio García de Léon. - Estudio de objetos metálicos arqueológicos por Alma Graciela de la Cruz
2017 Open Access Week Keynote Address: Lorena Barba
No full textAn open scholar’s work can be accessed and read earlier, and by more people. It can be quickly cited and built upon, and is more likely to have impact. Open access doesn’t require paying hefty author fees: savvy scholars use preprint servers, institutional repositories, and archival data repositories to make their work visible and public. ArXiv, born in 1991, is integral to the physical-sciences publishing tradition. In other fields, green open access with preprint servers is just taking off: bioRxiv, SocArxiv, EngrXiv, ChemRxiv, and others, are gaining acceptance. A large majority of journals now accept submissions previously deposited in preprint servers. Scholars who update their preprints post-peer review ensure their corrected articles are accessible. Archiving data and figures on data repositories to get digital object identifiers and an open license, then citing them in the manuscript, simplifies future reuse of the figures. Savvy open scholars are working to slash the hurdles for researchers to receive academic credit for all their output, including software and data. New-wave journals led by open scholars carry out double-open peer review, in public. Open scholars know about implicit bias in the review process, and seek to protect early career researchers and minority groups. They also scoff at metrics like the journal impact factor used to evaluate researchers, and work in their communities to change flawed promotion processes. The more savvy scholars invest in teaching their students about all this, planting the seeds of infrastructural change towards open science.
[NOTE: The audio for this recording is poor, and captions may be inaccurate.]Virginia Tech. University LibrariesVirginia Tech. Pamplin College of Busines
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