162,615 research outputs found
ChemInform Abstract: First Determination of the Rate Acceleration of a Palladium-Catalyzed Coupling Reaction by Use of High Pressure.
No full textChemInform Abstract: Novel Strategies for the Synthesis of Peptides Containing cis- or trans-β-Aminocyclopropanecarboxylic Acids.
No full textChemInform Abstract: An Efficient Synthesis of Conformationally Restricted Peptides Containing β-Aminocyclopropanecarboxylic Acids.
No full textVariations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
SupraBox: a New Class of Chiral Supramolecular Oxazoline Ligands
No full textA new class of oxazoline ligands, named SupraBox, was studied. These ligands possess an additional urea functionality to generate supramolecular bidentate ligands in transition metal complexes, by the establishment of hydrogen bonds between the urea N-hydrogens of one ligand and the carbonyl oxygen of a second one. A library of 16 SupraBox ligands was prepared containing five differently substituted oxazoline nuclei, four linkers and three different urea substituents. The formation of copper(II) and palladium(II) complexes was investigated by MS, UV-Vis and 1H-NMR spectroscopy. The SupraBox library was screened in the copper catalyzed asymmetric benzoylation of vic-diols. Good selectivities were obtained in the kinetic resolution of racemic hydrobenzoin (ee up to 86% and selectivity (s) = 28) and in the desymmetrization of meso-hydrobenzoin (ee up to 88%)
Synthesis of (S)- and (R)-5-oxo-piperazine-2-carboxylic acid and its application to peptidomimetics.
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Larry O. Spencer, Conference Author Presentation
No full textGen. Larry O. Spencer, USAF (Ret.), author of Dark Horse: A Journey from the Horseshoe to the Pentago
Effect of continuous phase drug concentration, evaporation and partitioning on transdermal drug permeation kinetics with lipophilic vehicles
No full textIn this work the dependence of transdermal drug permeation kinetics on continuous phase drug concentration, partitioning between formulation phases, partitioning between stratum corneum and continuous oil phase and evaporation of volatile formulation components for a hydrophilic (caffeine) and a lipophilic (ibuprofen) model drug incorporated into w/o-emulsions of varying composition was investigated. The studied w/o-emulsions consisted of an oil phase into which water phase was dispersed in mass fractions of 70%, 50% and 30% (E70, E50 and E30, respectively). The oil phase consisted of a single oil component (isopropyl myristate, miglyol 812N or paraffinum liquidum) and the polymeric emulsifier Isolan PDI. Water phase contained sodium chloride and was buffered to pH 4.5 in all emulsions containing ibuprofen. Pure oil with and without emulsifier were selected as reference formulations. Transport experiments were carried out in Franz-type diffusion cells across pig ear skin at 32° under occlusive and non-occlusive C conditions with an infinite dosing of 0.3 g/cm2 and 0.7 g/cm2. Continuous phase drug concentration was determined experimentally by ultracentrifugation and theoretically by calculation taking into account drug partitioning between distinct phases. A concept for the interpretation of drug permeation was proposed that considered continuous phase drug concentration as the driving force for transdermal permeation. Drug distribution within the formulation and partitioning between stratum corneum and continuous oil phase were determined in order to gain a full understanding of the examined absorption processes. Dependence of apparent permeability coefficient Papp on fraction of drug concentration in the continuous phase was analyzed with a model taking into account the permeability coefficient of the skin Pm and the permeability coefficient of the diffusion boundary layer Pdbl. Pdbl reflects the diffusivity of the drug in the vehicle. By fitting this model to the experimental data using non-linear regression, parameter values for Pm and Pdbl were deduced. Pm values were consistent with the drug partitioning between stratum corneum and continuous oil phase. For isopropyl myristate a permeation enhancement was found in agreement with literature. Pdbl values were compared with calculated values using a literature model for diffusion in heterogeneous matrix systems. These were found in most cases to be in fairly good agreement with the Pdbl values.
Free emulsifier present in the continuous oil phase affected neither saturation concentration
nor continuous phase drug concentration nor transdermal absorption of the model drugs.
Thickener Aerosil 200 tremendously decreased transdermal permeation of caffeine, but did
not show any interaction with ibuprofen. A reduction of applied dose (0.3 g/cm2 instead of 0.7
g/cm2) did not significantly affect apparent permeability coefficient P-app. Evaporation pattern
of all examined formulations revealed that relative water loss was independent of the
dispersed mass fractions and the employed experimental setup, but increased as the applied
formulation dose was reduced.
For implementing continuous phase drug concentration concept to non-occlusive conditions,
a formula was derived that considered observed water loss and permeated drug amount in
order to calculate the resulting drug concentration in the continuous formulation phase over
time. An increase of the drug concentration in the continuous oil phase was estimated which,
however, did not lead to a measurable increase of the apparent permeability coefficient.
To conclude, the proposed concept considering continuous phase drug concentration can be
used to explain experimentally measured apparent permeability coefficient P-app for lipophilic
vehicles. Applying this concept to w/o-emulsions comprising varying mass fractions provides
a predictive tool in order to delineate the effect of physicochemical formulations parameters
and transdermal drug delivery rate, if occlusive conditions are assumed. In case of nonocclusive
transport conditions, however, evaporation will lead to compositional changes and
consequently changes in continuous phase drug concentration. How these alterations will
affect apparent permeability coefficient using a finite dose requires further investigations
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