8,620 research outputs found
Tubulin Genes in Human Disorder of Cerebral Cortex Dvelopment
No full textBy:Cushion, TD (Cushion, T. D.)[ 1 ] ; Mullins, JGJ (Mullins, J. G. J.)[ 1 ] ; Chung, S (Chung, S.)[ 1 ] ; Harvey, RJ (Harvey, R. J.)[ 2 ] ; Dobyns, WB (Dobyns, W. B.)[ 3 ] ; Pilz, DT (Pilz, D. T.)[ 4 ] ; Rees, MI (Rees, M. I.)[ 5
Encoding of temporal probabilities in the human brain
No full textAnticipating the timing of future events is a necessary precursor to preparing actions and allocating resources to sensory processing. This requires elapsed time to be represented in the brain and used to predict the temporal probability of upcoming events. While neuropsychological, imaging, magnetic stimulation studies, and single-unit recordings implicate the role of higher parietal and motor-related areas in temporal estimation, the role of earlier, purely sensory structures remains more controversial. Here we demonstrate that the temporal probability of expected visual events is encoded not by a single area but by a wide network that importantly includes neuronal populations at the very earliest cortical stages of visual processing. Moreover, we show that activity in those areas changes dynamically in a manner that closely accords with temporal expectations
Educational attainment of children born to mothers with epilepsy
No full text102.Lacey AS, Pickrell OW, Thomas RH, Kerr MP, White CP, Rees MI (2018)
Joint angle affects volitional and magnetically-evoked neuromuscular performance differentially
No full textThis study examined the volitional and magnetically-evoked neuromuscular performance of the quadriceps femoris at functional knee joint angles adjacent to full extension. Indices of volitional and magnetically-evoked neuromuscular performance (N= 15 healthy males; 23.5 ± 2.9 years; 71.5 ± 5.4 kg; 176.5 ± 5.5 cm) were obtained at 25°; 35° and 45° of knee flexion. Results showed that volitional and magnetically-evoked peak force (PFV; PTFE, respectively) and electromechanical delay (EMDV; EMDE, respectively) were enhanced by increased knee flexion. However, greater relative improvements in volitional compared to evoked indices of neuromuscular performance were observed with increasing flexion from 25° to 45° (e.g. EMDV; EMDE: 36% vs. 11% improvement, respectively; F[2,14] = 6.8; p < 0.05). There were no significant correlations between EMDV and EMDE or PFV and PTFE, respectively at analogous joint positions. These findings suggest that the extent of the relative differential between volitional and evoked neuromuscular performance capabilities is joint angle-specific and not correlated with performance capabilities at adjacent angles, but tends to be smaller with increased flexion. As such, effective prediction of volitional from evoked performance capabilities at both analogous and adjacent knee joint positions would lack robustness
A transient hyperekplexia phenotype associated with compound heterozygote mutations in the human beta-subunit of the inhibitory glycine receptor (GLRB)
No full textRees MI, Lewis TM, Mortier G, Snell RG, Schofield PR, Owen M
Marknadsföring av kurser inom fria bildningen : Utvecklande av en hemsida för sykurser i Pedersöre MI
No full textFöreliggande examensarbete omfattar utarbetande av en hemsida som marknadsföringskanal för sykurser i Pedersöre MI. Syftet var att denna kanal skulle ge flera kursdeltagare samt behålla de tidigare kursdeltagarna. Som uppdragsgivare fungerade Åsa Nyberg-Sundqvist, rektor på Pedersöre MI.
Som teoridelar i arbetet gjordes definition och beskrivning av marknadsföring och traditionella och digitala marknadsföringskanaler, samt av skillnaderna mellan dessa. Fria bildningen och medborgarinstitutens verksamhet generellt, samt skapande av en hemsida, beskrevs som teoridelar i detta arbete. Skapande av en hemsida beskrevs som bakgrund till det praktiska arbetet, utvecklandet av en hemsida.
Som metod användes intervju med intervjuguide för beskrivning av marknadsföring med betoning på marknadsföringskanaler inom Pedersöre MI 2002 – 2021. Som bakgrund och forskningsmetoder till teoridelarna samt utvecklande av hemsidan låg litteraturstudier, nätstudier via webbsökning samt egen fortbildning i digital kompetens för undervisning inom fria bildningen.
Vid utvecklandet av hemsidan testades och jämfördes två olika digitala verktyg för att erhålla den optimala hemsidans utseende och användning för sykurser i Pedersöre MI. Det praktiska skapandet av hemsidan beskrevs och resultatet diskuterades samt förslag gavs för uppdragsgivaren om hemsidan som en digital marknadsföringskanal för sykurser i Pedersöre MI.This thesis includes developing a website as a digital marketing channel for the sewing courses in Pedersöre Adult Education Centre. The aim was to get more participants to the sewing courses and encourage the current participants to continue participating. Åsa Nyberg–Sundqvist, principal of Pedersöre Adult Education Centre, was acting as the supervisor.
A description of marketing and traditional and digital marketing channels and the distinction between those were included in the theoretical part. A description of the liberal adult education and Adult Education Centre in general as well as developing of website were presented as theoretical parts in this thesis. The marketing of Pedersöre Adult Education Centre during 2002-2021 was described by two interviews. The theory on creating websites worked as a background to the practical part and the development of the website for the commissioner.
As research method on the marketing of Pedersöre Adult Education Centre an interview with interview guide were made. As background and research methods for the developing of the website were used different literature studies, web searches and the author´s continuing education in digital competences for teaching in liberal adult education. During the developing of the website two different digital website programs and tools were tested and compared, to get the most optimized look and use for sewing courses in Pedersöre Adult Education Centre.
The thesis resulted in a website for sewing courses in Pedersöre Adult Education Centre. The process of developing the website and the result were discussed and suggestions for future marketing were given to the commissioner
UnBoxing the MI Box: A study on how to transfer from monitoring to coaching with the MI Box to increase self-care activities
No full textProblem Background:Cardiovascular disease (CVD) is the most common cause of death in the world (Johnston et al., 2016). One of the main causes for cardiovascular mortality is a myocardial infarction (MI) (Jneid et al., 2013; Mishra & Ramavataram, 2021; Verburg et al., 2019). A myocardial infarction is an event in which the heart muscle is damaged because of a complete or partial absence of oxygen supply (Mishra & Ramavataram, 2021)The healthcare system is pressured by the enormous number of CVD cases (Kaushik et al., 2020). Digital care has gained recognition in the past decade because of its potential to release some pressure from the healthcare system. With the potential of digital care in mind, Leiden University Medical Center (LUMC) has developed a concept called “The MI Box” which provides patients who have had an MI with self-monitoring devices (The Box, 2021). During the hospitalisation phase of the MI care trajectory, there is little time to involve patients in their care because healthcare professionals (HCPs) need to work as quickly as possible to avoid as much heart damage as possible. This is causing patients to have a bad discharge experience. The MI Box shows potential to involve patients more after the discharge as the concept shows the monitored values to patients. However, it can be difficult for patients to understand these values and how to use them for self-care activities, especially because of the little involvement during hospitalisation. If LUMC wants to satisfy its aim to change from monitoring to coaching, it is crucial to provide patients with enough support to work with their monitored values and perform self-care activities. Increasing patient involvement is an essential first step before shared decision making (SDM) can be realised. SDM is a suitable approach for the change towards coaching as it invites patients to make their own care choices. In the MI care trajectory, the implementation of SDM is currently lacking. Therefore, further analysis of SDM is needed. A tool that is valuable for the analysis and increasement of SDM, and which is used in this thesis, is the Metro Mapping tool (Metro Mapping, n.d.). Besides, because the MI Box causes care to be transferred to a patient’s home environment, it is necessary to consider the home context of a patient as care activities do not happen in a controlled hospital environment. Currently, little is known about the context in which the MI Box is used. Therefore, more knowledge about the context is necessary to consider what support means would be suitable to offer to patients to make them more empowered to perform self-care activities.Research Question:How to shift from monitoring to coaching with the MI Box?Research activities:-Literature research;-Interviews: HCPs (n=5), MI patients (n=4), MI Box users (n=2);-Context mapping;-Metro Mapping.Design Goal:The goal is to increase patients’ confidence to perform self-care activities by increasing patients’ involvement and guidance with the use of the MI Box.Final Concept:“UnBoxing the MI Box”Design for Interaction | Medisig
SOBRE MI TRADUCCIÓN DE “SER Y TIEMPO”
No full textIn this article the author develops his own idea of a translation and explains the solutions given to problems arisen in the translation of Heidegger’s Being and Time.Este escrito pretende dos cosas: primero, desarrollar brevemente mi propia idea de lo que es traducir, y, segundo, explicar la solución que di a ciertos problemas que surgieron en mi traducción de la obra Ser y Tiempo de Heidegger
Sobre mi traducción de “Ser y Tiempo”
No full textIn this article the author develops his own idea of a translation and explains
the solutions given to problems arisen in the translation of Heidegger’s Being
and TimeEste escrito pretende dos cosas: primero, desarrollar brevemente mi propia
idea de lo que es traducir, y, segundo, explicar la solución que di a ciertos
problemas que surgieron en mi traducción de la obra Ser y Tiempo de
Heidegge
Independence or Development?: An Overview of TurkeyÃs Foreign Language Education Policies
No full textMany countries have long had two sorts of interests; on the one hand, they have had to remain independent via protecting and promoting their official languages as a powerful symbol of their identities, and on the other hand, they have had to enable technological and economic development, which essentially involves international communication, usually by means of a foreign language. These two sorts of interests have often posed a dilemma for those countries and their peoples, because protecting and promoting identities have often implied closed and egocentric policies while international communication has involved more open and other-conscious policies. In todayÃs world, this dilemma is even more highlighted because of the so-called "globalization", which is taking place. In this article, I will present this dilemma by focussing on one country, Turkey, and its foreign language education policies. An historical account of the countryÃs interaction with other languages (than Turkish) will precede a presentation of the recent shape the recurring dilemma took, namely, teaching foreign languages versus teaching in a foreign language, in the daily national papers and publications in the1989 and 1997 discussions. I will then make personal suggestions of conduct for decision-makers in Turkey and other countries facing the same dilemma.Turkey, foreign language education, language planning
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