101 research outputs found
Emm Types and clusters and macrolide resistance of pediatric group A streptococcal isolates in Central Greece during 2011-2017
No full textBackground The surveillance of emm types and macrolide susceptibility of group A streptococcus (GAS) in various areas and time periods enhances the understanding of the epidemiology of GAS infections and may guide treatment strategies and the formulation of type-specific vaccines. Greece has emerged as a country with high macrolide use. However, studies suggest a gradual reduction in macrolide consumption after 2007. Methods During a 7-year period (2011–2017), 604 GAS isolates were recovered from consecutive children presenting with pharyngeal or nonpharyngeal infections in Central Greece; 517 viable isolates underwent molecular analysis, including emm typing. Results Isolates belonged to 20 different emm types (in decreasing order of prevalence: 1, 89, 4, 12, 28, 3, 75 and 6, accounting for 88.2% of total isolates). The emm types comprised 10 emm clusters (five most common clusters: E4, A-C3, E1, A-C4 and A-C5). The emm89 isolates were acapsular (‘new clade‘). Overall macrolide resistance rate was 15.4%, and cMLSB emerged as the predominant resistance phenotype (56.4%). The lowest annual resistance rates occurred in 2014 (13.1%), 2016 (5.5%) and 2017(8.0%) (P for trend = 0.002). Consumption of macrolide/lincosamide/streptogramin B declined by 22.6% during 2011–2017. Macrolide resistance and emm28 and emm77 types were associated (both P<0.001). The most frequently identified genetic lineages of macrolide-resistant GAS included emm28/ ST52, emm77/ST63, emm12/ST36, emm89/ST101 and emm4/ST39. We estimated that 98.8% of the isolates belonged to emm types incorporated into a novel 30-valent M protein vaccine. Conclusions In Central Greece during 2011–2017, the acapsular emm89 isolates comprised the second most prevalent type. Susceptibility testing and molecular analyses revealed decreasing GAS macrolide resistance rates, which may be attributed to the reduction in the consumption of macrolides and/or the reduced circulation of macrolide-resistant clones in recent years. Such data may provide valuable baseline information in targeting therapeutic intervention and the formulation of type-specific GAS vaccines. © 2020 Grivea et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
An LU-gradient formulation for the eigenvalue moment method, 1995
No full textThe Eigenvalue Moment Method (EMM) has proven to be an effective technique for generating converging lower and upper bounds to the bosonic ground state energy of singular, strongly coupled, quantum systems. An alternate gradient method formulation for the EMM as previously developed by Dr. Carlos Handy is presented. The present method is numerically faster and is based on an LU decomposition formulation for the underlying Hankel-Hadamard moment matrices. The LU-EMM gradient formulation deals with a sequence of functions, each convex over a corresponding subset. The LU-EMM gradient method is applied to the octic, sextic and quartic anharmonic oscillator potentials in one dimension
emm typing, antibiotic resistance and PFGE analysis of Streptococcus pyogenes in Lebanon
No full textOne hundred and three Streptococcus pyogenes isolates recovered mainly from streptococcal throat infections in Lebanon were characterized by emm and PFGE typing. Thirty-three emm types and subtypes were detected among the isolates. PFGE was more discriminatory as a typing method. The prevalent emm types were emm1 (12.6 percent), emm22 (8.7 percent), emm28 (7.7 percent), emm88 (7.7 percent) and emm4 (6.8 percent) and all isolates were susceptible to vancomycin and penicillin G. Ten per cent of the isolates were resistant to erythromycin and 3percent were resistant to erythromycin and clindamycin, showing the macrolide-lincosamide-streptogramin B phenotype. The emm sequences and PFGE pattern database that were generated in this study will serve as a basis for information for long-term evolutionary and epidemiological studies of local S. pyogenes recovered not only in Lebanon, but also in neighbouring countries. © 2011 SGM.Aziz RK, 2008, EMERG INFECT DIS, V14, P1511, DOI 10.3201-eid1410.071660; Beall B, 2000, MICROBIOL-UK, V146, P1195; Bessen DE, 2009, INFECT GENET EVOL, V9, P581, DOI 10.1016-j.meegid.2009.03.002; Chan JCK, 2009, PATHOLOGY, V41, P681, DOI 10.3109-00313020903257723; Chen YY, 2007, DIAGN MICR INFEC DIS, V58, P289, DOI 10.1016-j.diagmicrobio.2007.01.013; Chiou CS, 2004, J CLIN MICROBIOL, V42, P3998, DOI 10.1128-JCM.42.9.3998-4006.2004; CLSI, 2006, M100S16 CLSI, V26-2, pM2; Desai M, 1999, J CLIN MICROBIOL, V37, P1948; Ekelund K, 2005, J CLIN MICROBIOL, V43, P3101, DOI 10.1128-JCM.43.7.3101-3109.2005; Gracia M, 2009, DIAGN MICR INFEC DIS, V64, P52, DOI 10.1016-j.diagmicrobio.2008.12.018; Guilherme L, 2006, AUTOIMMUNITY, V39, P31, DOI 10.1080-08916930500484674; Kao Chia-Hui, 2005, Journal of Microbiology Immunology and Infection, V38, P105; Lavergne V, 2007, CAN MED ASSOC J, V177, P177, DOI 10.1503-cmaj.1070070; Luca-Harai B, 2008, J MED MICROBIOL, V57, P1354, DOI 10.1099-jmm.0.2008-001875-0; Metzgar D, 2009, PLOS ONE, V4, DOI 10.1371-journal.pone.0006897; Michos AG, 2009, DIAGN MICR INFEC DIS, V64, P295, DOI 10.1016-j.diagmicrobio.2009.03.004; Nir-Paz R, 2010, EPIDEMIOL INFECT, V138, P53, DOI 10.1017-S0950268809002805; Sagar V, 2008, BMC MICROBIOL, V8, DOI 10.1186-1471-2180-8-150; SEPPALA H, 1994, J CLIN MICROBIOL, V32, P1945; Shulman ST, 2009, CLIN INFECT DIS, V49, P78, DOI 10.1086-599344; STANLEY J, 1995, J CLIN MICROBIOL, V33, P2850; Steer AC, 2009, LANCET INFECT DIS, V9, P611, DOI 10.1016-S1473-3099(09)70178-1; Yoonim N, 2005, BMC MICROBIOL, V5, DOI 10.1186-1471-2180-5-6378
Euclidean-time formulation of the eigenvalue moment method for finite dimensional systems, 1992
No full textThe eigenvalue moment method (EMM), developed by Handy and Bessis is examined from a Euclidean time reformulation. This alternative approach offers a more elegant and rigorous analysis than the conventional EMM theory. We will look at finite matrix analogues for the Euclidean time dependent problem H'F(x,t) = dt^x.t), analyzed from a moments problem perspective. This will enable the generation of converging upper and lower bounds to the "ground state" eigenvalue without the necessity of a discretization ansatz as is the case in conventional EMM theory
Towards a robust and versatile method for monitoring E-modulus of concrete since casting: enhancements and extensions of EMM-ARM
No full textIn face of the importance of assessing mechanical properties of cement‐based materials
since early ages, as well as the known limitations of existing methods, the
EMM‐ARM (Elasticity Modulus Measurement through Ambient Response
Method) was initially proposed in 2009. Since its first application, this method
has been under constant development and extension to the study of other materials
such as stabilized soils or epoxy resins. Extensive use has revealed several limitations
on robustness and versatility that are addressed through a set of improvements
proposed in this paper. Such improvements attempt to make EMM‐ARM more
appropriate for systematic applications both in laboratory and in situ environments.
These objectives were achieved through the application of a new test mould material,
redesigned support systems, and the development of a new reusable mould.
Additionally, the use of a small excitation applied to the beam to decrease the sensitivity
of the method to the environmental noise was assessed.This work was supported by FEDER funds through the Operational Program for Competitiveness Factors––COMPETE and National Funds through FCT––Portuguese Foundation for Science and Technology under the project IntegraCrete FIGURE 17 Comparison of the results obtained with ambient vibration and forced
vibration tests: (a) frequency evolution; (b) E‐modulus evolution (a) (b) GRANJA AND AZENHA 17 of 19 PTDC/ECM‐EST/1056/2014, as well to the Research Unit ISISE. The first author also acknowledges the PhD grant SFRH/BD/80338/2011 provided by FCT. The authors acknowledge the kind assistance of the colleague Jacinto Silva in the scope of the custom electromagnetic actuator developed in this work.info:eu-repo/semantics/publishedVersio
The antiquity in "Pope Joan" of Emm. Roidis :
No full textΗ διδακτορική διατριβή έχει ως αντικείμενό της την έρευνα, την καταγραφή και τη μελέτη του αρχαιογνωστικού υλικού στο έργο του Εμμ. Ροΐδη Πάπισσα Ιωάννα.
Το αρχαιογνωστικό υλικό περιλαμβάνει έργα της αρχαίας ελληνικής και λατινικής γραμματείας, από τον Όμηρο μέχρι το τέλος της ύστερης αρχαιότητας (6ο αιώνα μ.Χ). Συμπληρωματικό τμήμα του αρχαιογνωστικού υλικού αποτελούν οι μελέτες και τα βιβλία Ελλήνων και ξένων συγγραφέων που έγραψαν για τον αρχαίο ελληνικό και ρωμαϊκό πολιτισμό και τη χριστιανική θρησκεία.
Ως προς την ταξινόμηση του αρχαιογνωστικού υλικού της Πάπισσας Ιωάννας διακρίνεται σε δύο κατηγορίες, ανάλογα με τον τρόπο που το χειρίζεται ο συγγραφέας:
Α)Ειδική Αρχαιογνωσία: πρόκειται για το σύνολο των αρχαιογνωστικών πηγών, που αντλούνται από αρχαίους συγγραφείς, με τις αρχαίες φράσεις να τοποθετούνται στο έργο σε εισαγωγικά. Η πορεία έρευνας και επεξεργασίας των αρχαιογνωστικών πηγών ξεκινά από τον δέκτη, δηλ. τον συγγραφέα ή το έργο που επηρεάζεται από άλλους συγγραφείς ή έργα, και οδηγείται στον πομπό, εκείνον που αποτελεί την πηγή έμπνευσης. Μέσα από την έρευνα των αρχαίων πηγών εντοπίζονται οι γλωσσικές– υφολογικές παρεμβάσεις του συγγραφέα. Β)Γενική Αρχαιογνωσία: πρόκειται για το σύνολο των αρχαιογνωστικών επιδράσεων που έχει δεχτεί ο συγγραφέας, με αποτέλεσμα το έργο να λειτουργεί ως υποδοχέας– δέκτης πλούσιας αρχαίας λογοτεχνικής παραγωγής.
Από τη μελέτη των αρχαιογνωστικών πηγών και επιδράσεων στην Πάπισσα Ιωάννα συμπεραίνεται ότι η αρχαιογνωσία χρησιμοποιείται από τον Εμμ. Ροΐδη:
1. ως επιχειρηματολογική στρατηγική για τον καυτηριασμό των «κακώς κειμένων» του μεσαιωνικού ιερατείου και της τάσης μέρους του αναγνωστικού κοινού να ελκύεται από ηδονιστικά στοιχεία και
2. ως ανεξάντλητη πηγή γνώσεων, ως πνευματική τροφή για άσκηση κριτικής και αυτοκριτικής από το αναγνωστικό κοινό, με στόχο την πνευματική του καλλιέργεια.The object of the doctoral dissertation is the investigation, recording and study of the ancient material in the work of Emm. Roidis Pope Joan.
The ancient material includes works of ancient Greek and Latin literature, from Homer to the end of late antiquity (6th century AD). Supplemental section of ancient material are studies and books of Greek and foreign authors who have written about the ancient Greek and Roman culture and the Christian religion.
Regarding the classification of the ancient material in Pope Joan, it falls into two categories, depending on how the author handles it:
A) Specific Antiquity: it includes all the ancient sources drawn upon ancient authors and the ancient phrases are put in quotation marks in the work. The process of research and treatment of ancient sources starts from the receiver, i.e. the author or work that is influenced by other authors or works, and is driven to the transmitter, the one who is the source of inspiration. Through the research of ancient sources the linguistic - stylistic interventions of the author are identified. B) General Antiquity: it includes all the ancient influences accepted by the author, so the work functions as a receptor – recipient of rich ancient literary production
Positivity and the quantization of physical systems : the c-shift' moment method, 1991
No full textThe Eigenvalue Moment Method (EMM) of Handy and Bessis is reformulated with special emphasis on the importance of positivity as a general quantization criterion
Evidence on Simulation Inference for Near Unit-Root Processes with Implications for Term Structure Estimation
No full textThe high persistence of interest rates has important implications for the preferred method used to estimate term structure models. We study the finite-sample properties of two standard dynamic simulation methods—efficient method of moments (EMM) and indirect inference—when they are applied to an first order autoregressive (AR[1]) process with Gaussian innovations. When simulated data are as persistent as interest rates, the finite-sample properties of EMM differ both from their asymptotic properties and from the finite-sample properties of indirect inference and maximum likelihood. EMM produces larger confidence bounds than indirect inference and maximum likelihood, yet is much less likely to contain the true parameter value. This is primarily because the population variance of the data plays a much larger role in the EMM conditions than in the moment conditions for either indirect inference or maximum likelihood. These results suggest that, under Gaussian assumptions, indirect inference (if practical) is preferable to EMM when working with persistent data such as interest rates. EMM's emphasis on the population variance strongly enforces stationarity on the underlying process, so this same reasoning suggests that EMM may be preferable in settings where stability and stationarity are important and difficult to impose. Copyright The Author 2007. Published by Oxford University Press. All rights reserved. For Permissions, please email: [email protected], Oxford University Press.
Apartado Postal
No full textThe first author was partially supported by the Asociación Mexicana de la Cultura A. C. A very general test statistic for contrasting two nested or nonnested dynamic nonlinear econometric models is presented. It is based on the idea of testing the specification of the first model by using the second model to generate moment conditions for the efficient method of moments (EMM) estimation procedure. The testing procedure also provides guidance as to what aspects of the model should be improved. A discussion of the large sample properties of the EMM estimator, the score function, and the associated specification test under model misspecification is also included
Bayesian Expectation-Maximization-Maximization: a latent-mixture-modeling-based Bayesian algorithm for the three-parameter logistic model
No full textThe current study proposes a Bayesian Expectation-Maximization-Maximization (Bayesian EMM, or BEMM), which is an alternative feasible Bayesian algorithm for the three-parameter logistic model (3PLM). The Bayesian EMM takes full advantage of both the EMM and the Bayesian approach. The BEMM not only successfully solves the issue of inaccurate estimates for few items in the EMM algorithm, but also alleviates the negative effect caused by different priors in the traditional Bayesian EM. The simulation studies and real data examples indicate that: (1) The Bayesian EMM can produce more accurate and stable item estimates. (2) Standard errors (SE) yielded by the Bayesian EMM tend to be smaller than the traditional Bayesian EM. (3) The Bayesian EMM is insensitive to priors, which means that the negative influence of different priors will be minimized.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-05-01The student, Shaoyang Guo, accepted the attached license on 2017-04-04 at 16:14.The student, Shaoyang Guo, submitted this Thesis for approval on 2017-04-04 at 18:14.This Thesis was approved for publication on 2017-04-05 at 11:26.DSpace SAF Submission Ingestion Package generated from Vireo submission #10635 on 2017-08-10 at 14:30:05Made available in DSpace on 2017-08-10T19:51:44Z (GMT). No. of bitstreams: 2
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