42 research outputs found

    An expedient and new synthesis of pyrrolo[1,2-b]pyridazine derivatives

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    The reaction of 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-pentanoic acid phenylamide with tertiary butyl carbazate and subsequent condensation of the resulting carbamate derivative with a chalcone provided a facile new approach to pyrrolo[1,2-b]pyridazine derivatives

    Estudo de métodos diretos e indiretos de estimativa de irradiação solar global diária horizontal a partir de observações superficiais de cobertura total de nuvens em Florianópolis, SC

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    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Civil.Este trabalho investiga métodos de estimativa de irradiação solar H a partir de observações superficiais de cobertura de nuvens C em Florianópolis, SC, Brasil (-17,50o S; 48,34o O). Dados medidos de H, C e da duração de brilho do sol n em três anos (1994-1997) são utilizados para estimar coeficientes de vários modelos empíricos de predição do índice de claridade KT através de análise de regressão simples. Os erros da estimativa segundo dois métodos selecionados - um Direto (estima KT a partir de C) e um Indireto (corrige dados de C mediante regressão com n para, dessa aproximação, predizer KT) - são avaliados pela comparação com dados correspondentes de H observados no período, mostrando uma concordância maior que 82%. Os melhores resultados mostram superestimação média de 0,28% (42,13 KJ/m2), erro médio percentual de 11,24% e randômico de 19,33% (2882,92 KJ/m2). Cerca de 40% e 70% dos desvios super/subestima até 1100 e 3300 KJ/m2, respectivamente. A diferença relativa média percentual é menor que 4% na classe de maior ocorrência de irradiação (13875 ± 2884 KJ/m2). O desempenho dos métodos é satisfatório em H ³ 6765 KJ/m2 (onde a freqüência acumulada soma acima de 85%), mostrando-os úteis à predição de H em Florianópolis quando outros dados não são disponíveis

    Zodarion beroni Komnenov & Chatzaki, sp. n.

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    Zodarion beroni Komnenov & Chatzaki sp. n. Figs 97–111 Type material. Holotype: male (NHMC, FC 12159), Dadia National Park, low maqui, Site, 5, 03– 27.07.2011, leg. K. Zografou. Paratypes: 1 ♀ (NHMC, FC 12159, used for description), same data as holotype; Site 5 (c: 2 ♂), Site 8 (a: 1 ♂), Site 12 (a: 1 ♂), Site 14 (b: 1 ♂). Etymology. This species is named in honor of the colleague and good friend of the first author, the prominent zoologist, Dr Petar Beron (Bulgaria). Noun in genitive case. Diagnosis. Zodarion beroni sp. n. is one of the smallest species of the thoni group, closely related to its members, namely, Zodarion thoni, Z. granulatum, Z. nigrifemur and Z. reticulatum. The new species differs from Z. thoni, Z. nigrifemur and Z. reticulatum by its smaller body length (2.03–2.2 in new species vs 2.9–4.2 in Z. thoni, 3.8–6.2 in Z. nigrifemur and 5.0– 6.6 in Z. reticulatum). Males of Z. beroni sp. n. differ from Z. granulatum by the asymmetrically bi-concave tip of the embolus (convex in Z. granulatum), females by the shape of spermathecae. FIGURES 97–107. Zodarion beroni sp. n. male holotype (97, 99, 101, 105 – 107) and female paratype (98, 100, 102, 103 – 104). 97–98 habitus, dorsal view; 99–100 same, ventral view; 101–102 same, lateral view; 103 epigyne, ventral view; 104 vulva, dorsal view; 105 palp, ventral view showing embolus taken in front of median apophysis; 106 same, ventral view showing natural position of the embolus behind the median apophysis; 107 same, retrolateral view. Scale bars: 0.5 mm (97–102); 0.2 mm (103–107). Description. Male (holotype). Total length 2.03; carapace 0.95 long, 0.68 wide, with a few small bristles, some longer ones in ocular area. Abdomen 1.08 long, 0.7 wide. Eye sizes and interdistances: AME 0.09, ALE 0.07, PME 0.06, PLE 0.06, AME-AME 0.03, AME-ALE 0.02, ALE-PLE 0.02, PME-PME 0.13, PME-PLE 0.04; MOQ: 0.2 long, 0.18 anterior width, 0.25 posterior width. Coloration and habitus as in Figs 97, 99, 101. Chelicerae and carapace orange, area around AME darkened; legs and sternum yellowish orange. Carapace with several erect hairs on the front and median line behind PME; thoracic part densely granulated. Abdomen oval; dorsum almost completely covered with smooth, shiny dark-brown scutum; venter whitish, in front of spinnerets provided with row of 10 setae. Palp as in Figs 105–109. Tibia with finger-like apophysis, with black, upright pointed tip; median apophysis very large, with large triangular prolateral process; embolus semi-circular, curving over apical part of bulb, tip of embolus asymmetrically bi-concave (Nike-like shaped), terminally pointed. Female (paratype). Total length 2.2; carapace 1.0 long, 0.6 wide. Abdomen 1.2 long, 0.8 wide. Coloration and habitus (Figs 98, 100, 102) as for male except: abdomen dorsally dark sepia, without scutum. Epigyne as in Figs 103, 110. Dark silhouettes of spermathecae visible through integument; copulatory orifices right in the middle of the atrium. Vulva as in Figs 104, 111. Spermathecal tubes stand parallel to each other. Distribution. Known only from the type locality in NE-Greece (Fig. 1). Chorotype. Probably Greek endemic.Published as part of Marjan Komnenov, Eva Pitta, Konstantina Zografou & Maria Chatzaki, 2016, Discovering the still unexplored arachnofauna of the National Park of Dadia-Lefkimi-Soufli, NE Greece: a taxonomic review with description of new species, pp. 1-66 in Zootaxa 4096 (1) on pages 41-43, DOI: 10.11646/zootaxa.4096.1.1, http://zenodo.org/record/26307

    Lisbon 'Fado': the European Union under reform.

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    To address the uncertainties surrounding the Treaty of Lisbon, this book examines several issues from various angles. Regardless of the results of the second referendum in Ireland and the pending ratifications in Poland, the Czech Republic and Germany, the European Union (EU) will not be the same after the Lisbon Treaty. If it comes into effect, Europeans will enter into a new stage in the deepening of the integration process; if it is rejected, the first decade of the 21st Century will represent a period of institutional stagnation in Europe’s integration. Nonetheless, the chapters in this book share the consensus that, despite its limitations, the Lisbon Treaty will make the EU decision making process more efficient, enhance regional democracy and strengthenits international voice

    <i>EGLN1</i> involvement in high-altitude adaptation revealed through genetic analysis of extreme constitution types defined in Ayurveda

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    It is being realized that identification of subgroups within normal controls corresponding to contrasting disease susceptibility is likely to lead to more effective predictive marker discovery. We have previously used the Ayurvedic concept of Prakriti , which relates to phenotypic differences in normal individuals, including response to external environment as well as susceptibility to diseases, to explore molecular differences between three contrasting Prakriti types: Vata, Pitta, and Kapha . EGLN1 was one among 251 differentially expressed genes between the Prakriti types. In the present study, we report a link between high-altitude adaptation and common variations rs479200 (C/T) and rs480902 (T/C) in the EGLN1 gene. Furthermore, the TT genotype of rs479200, which was more frequent in Kapha types and correlated with higher expression of EGLN1 , was associated with patients suffering from high-altitude pulmonary edema, whereas it was present at a significantly lower frequency in Pitta and nearly absent in natives of high altitude. Analysis of Human Genome Diversity Panel-Centre d’Etude du Polymorphisme Humain (HGDP-CEPH) and Indian Genome Variation Consortium panels showed that disparate genetic lineages at high altitudes share the same ancestral allele (T) of rs480902 that is overrepresented in Pitta and positively correlated with altitude globally ( P &lt; 0.001), including in India. Thus, EGLN1 polymorphisms are associated with high-altitude adaptation, and a genotype rare in highlanders but overrepresented in a subgroup of normal lowlanders discernable by Ayurveda may confer increased risk for high-altitude pulmonary edema. </jats:p

    Odontacarus audyi Radford 1946

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    Odontacarus audyi (Radford, 1946) Material examined. Location A: 1 larva from Turdus cardis (Passeriformes: Turdidae), 1 February 2010; 3 larvae from Niltava davidi (Passeriformes: Muscicapidae), 4 February 2010; 6 larvae from Niltava davidi, 5 February 2010; 5 larvae from Larvivora sibilans (Passeriformes: Muscicapidae), 5 February 2010. Location B: 12 larvae from Larvivora sibilans, 7 February 2010; 8 larvae from Pellorneum ruficeps (Passeriformes: Pellorneidae), 7 February 2010; 1 larva from Hemixos flavala (Passeriformes: Pycnonotidae), 7 February 2010; 14 larvae from Copsychus malabaricus (Passeriformes: Muscicapidae), 8 February 2010. Distribution and hosts. O. audyi is widely distributed in South-East Asia (India, Malaysia, Thailand) and infests various birds (Nadchatram 1963). This author found O. audyi on Clamator coromandus (Linnaeus) (Cuculiformes: Cuculidae), Centropus sinensis (Stephens) (Cuculiformes: Cuculidae), Pitta brachyura (Linnaeus) (Passeriformes: Pittidae), Pellorneum ruficeps (Passeriformes: Pellorneidae), Luscinia cyane (Pallas) (Passeriformes: Muscicapidae), Saxicola ferreus Gray (Passeriformes: Muscicapidae), Garrulax moniliger (Hodgson) (Passeriformes: Leiothrichidae), Copsychus malabricus (Passeriformes: Muscicapidae), Anthus hodgsoni Richmond (Passeriformes: Motacillidae), Lanius collurioides Lesson (Passeriformes: Laniidae), and Cyornis banyumas (Horsfield) (Passeriformes: Muscicapidae). O. audyi is recorded in Vietnam for the first time. Turdus cardis, Niltava davidi and Larvivora sibilans are new hosts for this species.Published as part of Kaluz, Stanislav, Hung, Nguyen Manh, Capek, Miroslav & Literak, Ivan, 2016, Two new species and new records of chiggers (Acari: Leeuwenhoekiidae, Trombiculidae) from birds in Vietnam, pp. 483-503 in Zootaxa 4061 (5) on page 484, DOI: 10.11646/zootaxa.4061.5.2, http://zenodo.org/record/26771

    Design, Synthesis, and Biological Testing of 4β-[(4-Substituted)-1,2,3-triazol-1-yl]podophyllotoxin Analogues as Antitumor Agents

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    A series of 4b-[(4-substituted)-1,2,3-triazol-1-yl]podophyllotoxin analogues have been synthesized with high regio-selectivity by employing copper(I)-catalyzed 1,3-dipolar cycloaddition of 1-O-propargyl monosaccharides with C4b-azido podophyllotoxin and C4b-azido-49-O-demethyl podophyllotoxin.All the compounds were evaluated for their anticancer activity against a panel of six human cancer cell lines. Among these, 49-O-demethyl podophyllotoxin congeners are showing promising anticancer activity mainly against HCT-15 (colon) and DU-145 (prostate) cells

    Rarefaction plots for three different primer pairs.

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    <p>Sequence depths a) 200, b) 5000 and c) 7000 displaying species richness (Chao 1 and Observed species) and phylogenetic relationship (Shannon index); (P1: targeting V1–V3 region; P2: targeting V4–V5 region and P3: targeting V6–V8 region).</p

    Fold changes in STabundant bacterial lineages at family level.

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    <p>Bacterial lineages a) loss of lineages in <i>Bacteroidetes</i>; b) gain in lineages in <i>Firmicutes</i>, across both fractions and primers, as the animals transitioned from K1 (50% dry/green forage: 50% concentrate) to K3 (100% dry/green forage).</p
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