132,142 research outputs found
Efficient extraction of hierarchical B-Splines for local refinement and coarsening of Isogeometric Analysis
No full textThe main motivation for hierarchical B-Splines in Isogeometric Analysis is to perform a local refinement that is globally not a tensor product. Compared to standard knot insertion, this allows to increase refinement locality. Moreover, the implementation of hierarchical refinement on existing codes can be facilitated by Bézier extraction. This approach was initially developed for unrefined patches and then extended to local refinement. In case of B-Spline patches that are not locally refined, extraction and projection algorithms can be optimized by leveraging the tensor structure. However, these optimizations are not straightforwardly applicable to hierarchical B-Splines. In this contribution, we show an approach where all extraction operations are formulated to work directly on the univariate extraction operators, without explicitly computing and storing the full tensor product. In particular, we consider the extraction of functions, and projection of degrees of freedom for refinement and coarsening. A slightly modified Bézier projection is proposed to fully exploit the developed algorithms. We finally compare our approach to an explicit computation of the extraction operator in both a linear transient and a nonlinear example
Sicurezza alimentare ed ambientale nella filiera dell'acquacoltura: strategie per uno sviluppo sostenibile.
No full textAssessment of estrogenic activity of flavonoids from Mediterranean plants using an in vitro short term test
No full textSix isoflavones, daidzein (40,7,-dihydroxyisoflavone), genistein (40,5,7-trihydroxyisoflavone), genistin (genistein 7-O- b-D-glucopyranoside), isoprunetin (40,7-dihydroxy, 5-metoxyisoflavone), isoprunetin 7-O-b-D-glucopyranoside, iso- prunetin 40,7-di-O-b-D-glucopyranoside and four flavones, luteolin (30,40,5,7-tetrahydroxyflavone), luteolin 7-O-b-D- glucopyranoside, luteolin 40-O-b-D-glucopyranoside, licoflavone C (40,5,7-trihydroxy,8-isoprenylflavone) were purified from Mediterranean plants (Genista morisii and Genista ephedroides) and their estrogenic activity was assessed by a yeast reporter gene assay (Saccharomyces cerevisiae RMY326 ER-ERE). Licoflavone C showed a powerful estrogenic activity at 107 M (0.0338 mg/ml) and it was 47.45% than 108 M 17b-estradiol (0.00272 mg/ml). The estrogenicity of this flavone was found to be comparable to the activity showed by genistein at 106 M (0.27 mg/ml). This study points out that a glucose substituent in flavones and isoflavones modulates the hormone-like activity in a different way. Isoflavone aglycones showed a more estrogenic activity than the corresponding glucosides. Conversely, the glucosidation made estrogenic the flavone luteolin and the position of substitution differently influenced the estrogenic activity of compounds
Le garanzie reali
No full textIl contributo offre una rassegna critica delle garanzie reali nell'elaborazione dell'arbitro bancario finanziari
A novel numerical technique to investigate nonlinear guided waves: approximation of nonlinear Schroedinger equation by nonperiodic pseudospectral methods
No full textA new numerical technique for investigating light waves guided by planar nonlinear dielectric films is presented. The method implements a multidomain spectral type approximation based on orthogonal algebraic polynomials, and makes possible to deal with nonperiodic boundary conditions and discontinuities of the data, overcoming the known deficiencies of the trigonometric polynomials. Results of preliminary numerical experiments for the solution of the nonlinear Schrödinger equation are presented
I trusts di protezione patrimoniale : la disciplina di common law e il loro inserimento negli ordinamenti di civil law : la realtà svizzera alla luce dell'art. 335 CCS
No full textThe book analyzes the growth and development of Asset Protection Trusts and Protective Trusts within common law jurisdictions and their potential circulation within civil law systems, according to the 1st July 1985 Hague Convention on the Law Applicable to Trusts and on their Recognition
La storia del territorio
No full textLA STORIA DEL TERRITORIO
Dopo l’analisi ambientale della zona in esame, sarà l’analisi storica a dare ulteriore
rilevanza all’evoluzione del paesaggio. A tale proposito saranno analizzate le trasformazioni che
ogni singola civiltà ha apportato al territorio e saranno studiati i condizionamenti che ancora
oggi permangono o che hanno influenzato le diverse epoche storiche. Nello specifico le
trasformazioni economiche, i degradi creati nelle diverse epoche storiche, gli eventuali
cambiamenti di uso del suolo e le motivazioni più significative che hanno portato a ciò.
La conferma che la Sardegna è stata abitata fin dall’Età Paleolitica è venuta dagli
scavi, in territorio di Oliena, della grotta Corbeddu. I livelli indagati, che fra l’altro, hanno
restituito un frammento di osso umano, si possono datare tra 13.500 e 12.500 anni da oggi. La
probabile organizzazione delle genti preistoriche della Sardegna centro-orientale e in particolare
di quelle dei territori dei comuni campione, richiama a un forte bisogno di coesione sociale,
queste genti, infatti, hanno dovuto rispondere a un ambiente parcellizzato per natura, un
ambiente che ha diviso e che divide con un’aggregazione per clan, fatta di pochi nuclei familiari.
Numerosi nuraghi e villaggi, e in misura minore, tombe di giganti segnano l’età
dei nuraghi la cui testimonianza appare molto diffusa. Alcuni esempi significativi
testimoniano l’importante diffusione di questa civiltà nei territori studiati, ma anche la
complessità della loro distribuzione, certamente non casuale.
Con l’occupazione romana assistiamo a un processo di integrazione molto rapido
nelle regioni costiere ma quasi inesistente nei territori interni per i quali il processo di
integrazione nella romanità potrebbe slittare al II o addirittura al III secolo d.C. L’area da
noi proposta appare caratterizzata dalla presenza di villaggi e di piccoli centri costieri, ma
con un’urbanizzazione limitata e in alcune aree addirittura inesistente; del resto nelle zone
isolate, interne, era prevalentemente insediata una popolazione locale ostile agli immigrati
italici e che ha lasciato pochissime testimonianze scritte.
Il periodo medioevale vede un territorio con un’ampia presenza di abitati sparsi e
luoghi fortificati a difesa di località ad alto valore strategico. Purtroppo, in seguito a calamità
naturali e politiche, i centri più piccoli subirono un facile dissolvimento e gli abitanti superstiti si
concentrarono nelle città maggiori e nei villaggi risparmiati da queste devastanti vicende.
Nei primi anni del XIV secolo i territori in esame si trovavano sotto la Repubblica
marinara di Pisa, quando l’Infante Alfonso d’Aragona, con le sue truppe, sbarcò in Ogliastra per
conquistare il regno di Sardegna e Corsica. L’arrivo delle armate iberiche fu accolto con favore
da gran parte dei sardi, e in particolare da quelli sottoposti al dominio pisano, tra i quali si era
creata la speranza di ottenere, con il nuovo governo, un miglioramento delle condizioni di vita.
L’unificazione nazionale mise, infine, in evidenza la gravità dei problemi irrisolti che
ancora affliggevano l’Isola: la sicurezza delle campagne, il banditismo, la viabilità interna e le
comunicazioni marittime, l’arretratezza economica e sociale, l’istruzione; tutti problemi che dalla
unificazione ai giorni nostri hanno costituito il fondamento e l’essenza della “Questione Sarda”.HISTORY OF THE TERRITORY
After having analyzed the environment of the examined area, an historic analysis
can give further insight into the evolution of the landscape. In this regard, the
transformations which each single civilization brought to the territory will be analyzed and
the conditions which today still exist or which have influenced the various historic periods
will be studied. More specifically, economic transformations, degradation created in the
different historic periods, possible changes to soil use and the most important motivations
which led to these factors will be considered.
Confirmation that Sardinia has been inhabited since the Paleolithic has come
from excavations in the Corbeddu cave in the area of Oliena. The investigated layers,
which have even yield a human bone fragment, can be dated to 13,500 to 12,500 years ago.
The organization of prehistoric inhabitants of central-eastern Sardinia (in particular in
territories under study) was probably driven by a strong need for social cohesion. In fact,
people had to deal with an environment, parcelled by nature, which tended to divide, and
yet still divides people into clans made up of a few family groups.
Numerous nuraghes and villages, and to a lesser extent, giant tombs are
widespread indicators of the age of nuraghe. Several noteworthy examples bear witness to
the important diffusion of this civilization in the studied territories, as well as to the
complexity of their surely not casual distribution.
With the Roman occupation there was a process of very rapid integration in the
coastal regions, but this process was nearly inexistent in the internal areas until the II or
III century A.D. The area under study appears characterized by villages and small coastal
settlements, but with little or no urbanization; in the internal, isolated areas there were
settlements by the local population, which was generally hostile toward Italic immigrants,
and of which few written accounts remain.
The inhabitants of the territory were, in the Medieval period, sparsely distributed
or located in correspondence to defensive fortifications in strategic areas. Unfortunately,
following natural or political disasters, the smaller settlements were easily destroyed and
the surviving inhabitants moved to larger towns or other unscathed villages.
At the beginning of the 14th century the territory examined in this study was under
the dominion of the Republic of Pisa when l’Infante Alfonso d’Aragona, with his troops,
disembarked in Ogliastra to conquer the kingdom of Sardinia and Corsica. The arrival of
Iberian troops was well accepted by the majority of Sardinians, and in particular by those
under Pisan rule as they hoped to obtain, with the new government, an improvement of
their living conditions.
The unification of Italy put in evidence the serious and unresolved problems,
which were still afflicting the island: safety of the countryside, bandits, road network,
maritime communications, economic and social backwardness, education. These problems
make up what has been considered, since the Unification, the essence of the so-called
“Sardinian Question
Novel finite particle formulations based on projection methodologies
No full textParticle methods are among the most studied meshless approaches, with applications ranging from solid mechanics to fluid-dynamics and thermo-dynamics. The objective of the present paper is to analyze the behavior of finite particle formulations based on projection methodologies, investigating in particular how these approaches behave in approximating 1D and 2D second-order problems. Moreover, the issue of choosing suitable projection functions is discussed and 1D and 2D numerical tests, showing the second-order accuracy of the methods under investigation, are performed
A recombinant Yeast Strain as a short term bioassay to assess estrogen-like activity of xenobiotics
No full textThe study investigated the responsiveness of a recombinant Saccharomyces cerevisiae yeast strain to screen estrogen-like chemicals in order to use it as a first level short-term bioassay for environmental preventive medicine purposes. We used the yeast strain RMY326 ER-ERE, containing the human estrogen receptor alpha and a reporter gene lacZ encoding the enzyme b-galactosidase. We tested the natural steroid hormone 17beta-estradiol, diethylstilbestrol, colchicine, some phytoestrogens and pesticides, and organochlorine insecticides. The relative inductive efficiency (RIE) and EC50 values confirmed the sensitivity and specificity of the yeast strain. A statistically significant reproducibility of results in repeated experiments was assessed
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