128,590 research outputs found
Formal REA model at operational level
No full textDespite a lot of attention gained by the Resource-Event-Agent (REA) framework among researchers in enterprise modeling, it still lacks comprehensive formal description. Most of the formalization approaches to REA use only UML or other graphical representation. This paper aims to define REA ontology at operational level using formal logic tools. The general approach to formal logic description of REA was motivated by LTAP introduced by Ito, Hagihara and Yonezaki. After basic REA concepts are presented, semantics and logical language LREA are defined including axioms for the REA operational level. Future research is shortly described in conclusion.REA framework; formal models; modal logic
Enterprise modeling:process and REA value chain perspective
No full textThe paper focuses on enterprise business value chain modeling as an alternative to business process modeling. Well known REA methodology proposed by McCarthy and Geerts is used as the basic modeling framework. The research presented in the paper results in a generic semantic enterprise model using REA ontology. This rather static model is then converted into UML activity, sequence and state diagrams thus achieving dynamic view of the REA model. The dynamic REA view connects the process model and the value chain perspectives. It is shown that by using REA model transition called dynamization not only process models at task level can be achieved but also a consistency check of the REA model can be accomplished. By means of step by step value chain modeling of the enterprise a consistent process model can be reached preserving all advantages of the typical business process modeling methodsProcess model; Value chain model; REA; Production planning
Enterprise planning model using REA ontology
No full textThe aim of the paper is to describe using REA framework to model enterprise planning not only at the operational level but also at the policy level. Using policy level enlarges the possibility of the models on the base of the REA framework because the policy level in this way represents metalevel of the model. The policy level of the REA framework itself is comprised of both the typification and grouping semantic abstractions and the Commitment entity. This entity may be viewed as either a sublayer or a middle layer of the REA framework. The Commitment entity belongs to the fundamental entities of the policy level but has some specifications that are expressed by the fulfillment relationship. This many-to-many relationship forms the link to the operational level. The paper thinks over the problem and suggests some solution that gets the Commitment entity closer to the typification semantic abstraction.REA framework; policy level; production planning model; typification; grouping; cardinality
Jennifer L. Rea
No full textThis photograph shows Jennifer L. Rea (class of 1999), a member of the Springfield College women's basketball team.Rea grew up in Winsted, Connecticut, and majored in recreation management. She was the team's captain during the 1999 season
Activation of an Estrogen/ Estrogen Receptor Signaling by BIG3 Through Its Inhibitory Effect on Nuclear Transport of PHB2/REA in Breast Cancer
No full textBreast cancer is known to be a hormone-dependent disease, and estrogens through an interaction with estrogen receptor (ER) enhance the proliferative and metastatic activity of breast tumor cells. Here we show a critical role of transactivation of BIG3, brefeldin A-inhibited guanine nucleotide-exchange protein 3, in activation of the estrogen/ER signaling in breast cancer cells. Knocking-down of BIG3 expression with small-interfering RNA (siRNA) drastically suppressed the growth of breast cancer cells. Subsequent co-immunoprecipitation and immunoblotting assays revealed an interaction of BIG3 with prohibitin 2/repressor of estrogen receptor activity (PHB2/REA). When BIG3 was absent, stimulation of estradiol caused the translocation of PHB2/REA to the nucleus, enhanced the interaction of PHB2/REA and ER[alpha], and resulted in suppression of the ER[alpha]; transcriptional activity. On the other hand, when BIG3 was present, BIG3 trapped PHB2/REA in cytoplasm and inhibited its nuclear translocation, and caused enhancement of ER[alpha]; transcriptional activity. Our results imply that BIG3 overexpression is one of the important mechanisms causing the activation of the estrogen/ER[alpha]; signaling pathway in the hormone-related growth of breast cancer cells
Domenico Rea e l’Agro sarnese nocerino tra storia e racconto
No full textL’«Estro furioso» è il titolo di uno dei dodici racconti che compongono l’indice di Gesù, fate luce, il secondo libro di Domenico Rea pubblicato nel 1950, a tre anni di distanza dal suo esordio ‘ufficiale’ – sempre una raccolta di testi brevi narrativi, in prosa – con Spaccanapoli. E, di nuovo, potrebbe adesso servire l’espressione «estro furioso»: a mo’ di ‘campione’ di stile o come possibile traccia di lettura condivisa nei cinque capitoli (Domenico Rea nostro contemporaneo; Domenico Rea, poeta e romanziere; Domenico Rea, l’editoria nazionale e l’editoria campana; Domenico Rea tra Storia, Antropologia, Giornalismo e Fotografia; Domenico Rea tra Vecchio e Nuovo Continente: la lingua, la letteratura) contenitori tematici di quindici saggi del presente volume dedicato a Domenico Rea. Gli interventi critici sono firmati da studiosi provenienti da atenei italiani e stranieri, da giornalisti, da esperti del mondo della fotografia e dell’editoria
sj-docx-1-rea-10.1177_17470161231198402 – Supplemental material for Can moral case deliberation in research groups help to navigate research integrity dilemmas? A pilot study
No full textSupplemental material, sj-docx-1-rea-10.1177_17470161231198402 for Can moral case deliberation in research groups help to navigate research integrity dilemmas? A pilot study by Tamarinde L Haven, Bert Molewijk, Lex Bouter, Guy Widdershoven, Fenneke Blom and Joeri Tijdink in Research Ethics</p
sj-docx-2-rea-10.1177_17470161231198402 – Supplemental material for Can moral case deliberation in research groups help to navigate research integrity dilemmas? A pilot study
No full textSupplemental material, sj-docx-2-rea-10.1177_17470161231198402 for Can moral case deliberation in research groups help to navigate research integrity dilemmas? A pilot study by Tamarinde L Haven, Bert Molewijk, Lex Bouter, Guy Widdershoven, Fenneke Blom and Joeri Tijdink in Research Ethics</p
sj-docx-3-rea-10.1177_17470161231198402 – Supplemental material for Can moral case deliberation in research groups help to navigate research integrity dilemmas? A pilot study
No full textSupplemental material, sj-docx-3-rea-10.1177_17470161231198402 for Can moral case deliberation in research groups help to navigate research integrity dilemmas? A pilot study by Tamarinde L Haven, Bert Molewijk, Lex Bouter, Guy Widdershoven, Fenneke Blom and Joeri Tijdink in Research Ethics</p
Prevention des metastases hepatique dans le cancer du colon opere' radicalement.
No full textThe prognosis of colon cancer, after curative resection, is mainly related to the outcome of metastases, and especially of liver metastases. It is generally accepted that adjuvant medical therapy is important in order to prevent the incidence of metastatic recurrences. The aim of the present review is to analyse the conclusions of the main recent randomized trials assessing the comparative value of different adjuvant protocols. The results obtained using either systemic infusion, the classical one, or intraportal infusion, which is mainly designed to prevent liver metastases, are reported. On the basis of the review, we can conclude that : adjuvant chemotherapy using combined drugs (MF, MOF) did not prove to be more active than 5-FU alone. The beneficial action of a combined 5-FU + levamisole regimen has been clearly demonstrated for patients with a Dukes C tumour. According to a unique and limited trial, intraportal adjuvant therapy has been shown to be effective for patients with Dukes B tumours, but this remains to be confirmed. On the basis of the present data, new adjuvant programs using combined chemotherapeutic and immunotherapeutic coupounds, and combined systemic and loco-regional infusion, could be developed
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