1,720,959 research outputs found
A process for the preparation of phenyltetrazole compounds
No full textA process for the preparation of olmesartan medoxomil, and derivatives thereof, by use of novel phenyltetrazole intermediate
A process for the preparation of nitrile compounds used as intermediates in the synthesis of cysteinyl leukotrienes antagonists
No full textA process for the preparation of a compound of formula (I) or a salt thereof wherein R is an amino, nitro or -NHCOR 1 group, wherein R 1 is C 1 -C 6 alkyl or phenyl optionally substituted by a -O-(CH 2 ) n -phenyl group, wherein n is an integer of 1 to 6; comprising reacting a compound of formula (II) or a salt thereof, both as the individual isomer and as an isomeric mixture, wherein R is as defined above; with a dehydrating agent, if necessary in the presence of an organic solvent, and optionally in the presence of a basic agent; and, if desired, converting a compound of formula (I) to another compound of formula (I) or a salt thereof
Improving Zonisamide Manufacturing: Insights into Stereochemistry and Mechanisms for Continuous Optimization
No full textZonisamide is a heterocyclic sulfonamide widely employed as anticonvulsant. In this work, we report an efficient process for the preparation of zonisamide, obtained in a six-step synthesis from phenyl salicylate with an overall 31% yield. The key step is represented by a base-promoted intramolecular rearrangement of a β-ketosultone oxime, leading to the concomitant formation of the benzisoxazole ring and of the exocyclic sulfonic group. This intriguing transformation is investigated with a combination of analytical techniques (NMR, HRMS, PXRD), leading to a preliminary mechanistic proposal
Method for preparing a farnesoid X receptor agonist obeticholic acid from hyodeoxycholic acid
No full textThe invention relates to a process for prepg. a compd. I in particular obeticholic acid (II) and intermediates suitable for its synthesis. A process for the prepn. of II comprises the use of hyodeoxycholic acid (III) as the starting material, Wittig reaction of oxocholate IV [wherein; Ra is H or an (un)substituted linear or branched C1-6-alkyl, or an (un)substituted aryl; Rb is H; and, Rc is OH or O-PG; wherein PG is an alc. protecting group;]. [Or, Rb is OR1 and Rc is OR2; wherein each of R1 and R2, which are the same or different, is a C1-6-alkyl group; or, R1 and R2 taken together form a (CH2)n chain; wherein n is 2 or 3,] with EtPh3P+Br-;allylic oxidn. of ethylidenechenodeoxycholate V; and hydrogenation, stereoselective redn. and sapon. of ethyldioxocholate VI
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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