5,006 research outputs found

    Control of intestinal sweet taste receptor expression is impaired in type 2 diabetes

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    Oral Presentation #31R.L. Young, K Sutherland, N. Pezos, S.M. Brierley, J. Ma, C.K. Rayner, M. Horowitz and L.A. Blacksha

    Variations of blood glucose in the physiological range alter appetite, gastrointestinal sensation, and pyloric motility

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    Background: Marked hyperglycemia (blood glucose [BG] ~ 15 mmol/L) slows gastric emptying, and increases both perception of gastric distension and postprandial satiation, in normal and diabetic subjects. The aim of this study was to determine whether variations in blood glucose within the physiological range (4-8 mmol/L) influence appetite, gastrointestinal sensation, and/or antropyloroduodenal motility in normal subjects. Methods: Paired studies were done in random order in 8 healthy volunteers following an overnight fast. A multilumen manometric assembly was positioned with a sleeve sensor spanning the pylorus, and either glucose or saline was infused intravenously to maintain a BG of 8 or 4 mmol/L. Antropyloroduodenal pressures were recorded in the fasting state for up to 90 minutes. An intraduodenal infusion of lipid (Intralipid 10% at 1.5 kcal/min) was then administered for 90 minutes to simulate the fed state. Appetite (hunger and desire to eat) and gastrointestinal sensation (nausea and fullness) were evaluated using visual analogue questionnaires at 15 minute intervals. Results: In the fasting state fullness was greater (P<0.05) at a BG of 8 mmol/L when compared to 4 mmol/L, but there was no difference in nausea or hunger. During intraduodenal lipid infusion, there was an increase in nausea (P<0.005) and a decrease in hunger (P<0.05) at a BG of 8 mmol/L, but not at a BG of 4 mmol/L. Intraduodenal lipid stimulated (P<0.001) isolated pyloric pressure waves (IPPWs) in both studies. The frequency (P<0.05) and amplitude (P<0.05) of IPPWs was less at a BG of 8 mmol/L than at a BG of 4 mmol/L. Conclusions: Physiological changes in blood glucose affect gastrointestinal sensation and pyloric motility. At a BG of 8 mmol/L when compared to 4 mmol/L (i) hunger is less, (ii) fullness and nausea are increased, and (iii) the stimulation of phasic pyloric pressure waves by intraduodenal lipid is attenuated.J.M. Andrews, C.K. Rayner, S.M. Doran, M. Horowit

    The Sacramental Theory in John 19:26-27

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    About the author: Father Theodore Koehler, S.M., of the Seminaire Marianiste at the University of Fribourg, Switzerland, studied under Father Neubert

    Christian Insight

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    Very Rev . John A. Elbert, S.M., is Graduate Dean of Arts and Sciences, Professor of Philosophy, creator of the Interdisciplinary Seminar, former President of the University of Dayton. He is the author of a number of books

    Mary and American Protestants

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    About the author: Father William Cole, S.M., is Professor and director of graduate work in Theological Studies at the University of Dayton. He has long been associated with the Marian Library

    Overcoming the Obstacles to Counselling Research

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    The author of this article, Brother Marion F. Belka, S.M., is Vice President of St. Mary\u27s University in San Antonio, Texas, and President of the National Catholic Guidance Conference

    In Vivo Acticity of Bupropion at the Human Dopamine Transporter as Measured by Positron Emission Tomography

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    Article title: In vivo acticity of bupropion at the human dopamine transporter as measured by positron emission tomography. Reference: BPS7603 Journal title: Corresponding author: Dr. S.M. Learned-Coughlin First author: Dr. S.M. Learned-Coughlin Citation</p

    Report of the Committee on Foreign Relations, together with the views of the minority, upon the general arbitration treaties with Great Britain and France, signed on August 3, 1911, and the proposed committee amendments. With appendices ...

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    "Views of a minority" by S.M Cullom and Elihu Root: "Supplemental views of Mr. Burton": p. 9-15. "Views" by Mr. Rayner: and "Proposed resolution and ratification" presented by Mr. Lodge January 11, 1912, are included as parts 2-3 of Senate doc. 98, 62 Cong., 2d [i.e. 1st] sess.Presented by Mr. Lodge. Ordered printed August 15, 1911. Ordered reprinted with additional matter August 21, 1911. Parts 2-3 ordered printed January 4 and 11, 1912.Mode of access: Internet

    Direct numerical simulation of the flow around a wing section at moderate Reynolds numbers

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    A three dimensional direct numerical simulation has been performed to study the flow around the asymmetric NACA-4412 wing at a moderate chord Reynolds number (Rec = 400, 000) with an angle of attack of 5◦ . The flow case under investigation poses numerous challenges for a numerical method due to the wide range of scales and complicated flow physics induced by the geometry. The mesh is optimized and well resolved to account for such varying scales in the flow. An unsteady volume force is used to trip the flow to turbulence on both sides of the wing at 10% chord. Full turbulent statistics are computed on the fly to further investigate the complicated flow features around the wing. The present simulation shows the potential of high-order methods in simulating complex external flows at moderately high Reynolds numbers

    Unity of the World of Men

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    Very Reverend John A. Elbert, S.M., is the former Provincial Superior of the Cincinnati Province of the Society of Mary and was President of the University of Dayton from 1938 until 1944. He is the author of half a dozen books and numerous articles, several of which have appeared in this review
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