3,268 research outputs found
Recovery through contradiction?
No full textWith this new drug strategy, the circle has turned. It was a Conservative government
that introduced the first drug strategy, Tackling Drugs Together, in 1995. This aimed
to reduce drug related crime, protect young people and reduce health harms by
discouraging drug use. It was criticised at the time for having unrealistic, intangible
aims and for not providing the necessary funding. New Labour’s strategies introduced
increasingly specific targets and massively expanded the funding of treatment. This
new Coalition strategy has no targets and provides no new funding
105 - Alex M Fout
No full textIncludes bibliographical references.This poster was presented at the 2017 Colorado State University Graduate Student Showcase, 9 November 2017.Determining the interface between two interacting proteins can help illuminate cellular biology, improve our understanding of disease, and aid pharmaceutical research. Such determination is expensive and time consuming using wet-lab experiments, which has motivated the development of computational methods. Inspired by the success of deep learning in image processing and other application areas, we adapt convolutional neural networks to work with irregularly structured data, such as proteins. We construct a novel pairwise classification architecture which is trained and tested with data from the Docking Benchmark Dataset versions 4.0 and 5.0. This outperforms the existing state-of-the-art prediction method, PAIRpred.Graduate Student Council - New Graduate Student - Research Top Scholar
Correlated long-term optical and x-ray variations in NGC 5548
No full textWe combine the long-term optical light curve of the Seyfert 1 galaxy NGC5548 with the X-ray light curve measured by the Rossi X-ray Timing Explorer over 6 years, to determine the relationship between the optical and X-ray continua. The X-ray light curve is strongly correlated with the optical light curve on long (~year) time-scales. The amplitude of the long-term optical variability in NGC5548 is larger than that of the X-ray variability (after accounting for the host galaxy contribution), implying that X-ray reprocessing is not the main source of the optical/X-ray correlation. The correlated X-ray and optical variations in NGC5548 may be caused by instabilities in the inner part of the accretion flow, where both the X-ray and optical emission regions may be locate
Infrastructure bottlenecks, private provision, and industrial productivity : a study of Indonesian and Thai cities
No full textThis research project followed an earlier similar project on Nigeria, applying the same methods. A sample of manufacturers was surveyed to document their responses to infrastructure deficiencies in electricity, water, transport, telecommunications, and waste disposal. They found the manufacturers undertook significant expenditures to offset deficiencies in publicly provided infrastructure services, and that changing public policy toward privately supplied infrastructure and changing the pricing of public infrastructure could yield significant savings in social costs. Thailand and Indonesia have made significant strides in following the policies for private sector participation in infrastructure provision. Nigeria, where public infrastructure monopolies still dominate, lags behind, yet stands to benefit most from such policy reform. Government policy toward the industrial organization and pricing of infrastructure sectors can significantly help a developing economy realize the benefits of private sector participation in the provision of infrastructure services.Banks&Banking Reform,Decentralization,Public Sector Economics&Finance,Environmental Economics&Policies,Municipal Financial Management,Banks&Banking Reform,Municipal Financial Management,Urban Services to the Poor,Urban Services to the Poor,Public Sector Economics&Finance
Correction to: The ‘can do, do do’ concept in COPD; quadrant interpretation, affiliation and tracking longitudinal changes
No full textFollowing publication of the original article [1], the authors identified a mistake in the author names, as both forename and initials were stated. Initially published author names: A. J. Alex van ’t Hul, E. H. Noortje Koolen, H. W. Jeroen van Hees, B. Bram van den Borst and M. A. Martijn Spruit Correct author names: Alex J. van ‘t Hul, Noortje H. Koolen, Jeroen W. van Hees, Bram van den Borst, Martijn A. Spruit. The original article has been corrected.</p
Optical simulations for the laboratory-based expanded and collimated x-ray beam facility BEaTriX
No full textThe construction of BEaTriX, the Beam Expander Testing X-ray facility, is underway at INAF-OAB (Osservatorio Astronomico di Brera). This laboratory-based X-ray source was designed to generate a broad (170 mm x 60 mm), uniform, and collimated X-ray beam, with a residual divergence of 1.5 arcsec HEW at either 1.49 keV and 4.51 keV. The main scientific driver for BEaTriX is represented by the opportunity to routinely calibrate the modular elements of the ATHENA (ESA) X-ray telescope, based on the silicon pore optics (SPO) technology. Nevertheless, the application domain of BEaTriX is potentially much wider (e.g., X-ray tomography). BEaTriX comprises a microfocus source of X-rays, followed by an optical chain including a collimating mirror, crystal monochromators, and an asymmetric beam expander. The final beam collimation and homogeneity relies on the optical quality of the optical components (X-ray source dimension, mirror polishing, crystal lattice regularity) and on their mutual alignment. In order to determine the most critical parameters, focus the development efforts, and establish specifications, a set of optical simulations has been built. Our paper describes the simulation tool we developed to this specific aim, and discusses the results achieved in terms of manufacturing and alignment tolerances
When the lights go down in Chinatown. / Words by / ALEX GERBER. / Music by / MALIVIN M FRANKLIN.
No full textBox no. 1This item has been bound together with items gma-doc-00525 and gma-doc-00034.Malvin M. Franklin: When the lights go down in Chinatown; music printItem type: book | Content type: music and text | Counting of pages: page numbersVocal-instrumental score | staff notation; tonic sol-fa | voice; piano"Ev'ry evening when the sun goes down [...]
Multi-Objective Calibration For Agent-Based Models
No full textAgent-based modelling is already proving to be an immensely useful tool for scientific and industrial modelling applications. Whilst the building of such models will always be something between an art and a science, once a detailed model has been built, the process of parameter calibration should be performed as precisely as possible. This task is often made difficult by the proliferation of model parameters with non-linear interactions. In addition to this, these models generate a large number of outputs, and their ‘accuracy’ can be measured by many different, often conflicting, criteria. In this paper we demonstrate the use of multi-objective optimisation tools to calibrate just such an agent-based model. We use an agent-based model of a financial market as an exemplar and calibrate the model using a multi-objective genetic algorithm. The technique is automated and requires no explicit weighting of criteria prior to calibration. The final choice of parameter set can be made after calibration with the additional input of the domain expert
Development of the Zimbabwe family planning program
No full textFamily planning was introduced in Zimbabwe as a voluntary movement in the 1950s. Volunteers formed a Family Planning Association in the mid-1960s. The government became interested in family planning in the late 1960s after analysis of the 1961 population census. It gave the Family Planning Association an annual grant, allowed contraceptives to be available through Ministry of Health facilities, and allowed nonmedical personnel to initiate and resupply family planning clients with condoms and pills. But before Zimbabwe achieved independence in 1980, family planning was viewed with great suspicion by the black majority, so the program's effectiveness was limited to the urban few. A new era began after independence. The new government took over theFamily Planning Association and changed its outlook completely. Through government and international donor support, the family planning program was restructured and expanded. The number of family planning personnel more than doubled in some units. More service delivery points were set up - particularly in rural areas. And the information, education, and communication and evaluation and research units were established. Through a World Bank-assisted project (with grant funding from Norway and Denmark), the Ministry of Health began strengthening its family planning capabilities. These efforts helped increase the contraceptive prevalence rate from about 14 percent in 1982 to 43 percent in 1988. But the program's growth is beginning to stall. More effort and resources are needed if the program is to grow or even maintain its present status. Particularly important are the following: designing innovative strategies to reach hard-to-reach populations; giving more emphasis to information, education, and communication, especially for men and youths, using multimedia; involving other sectors in the delivery of family planning services; broadening the mix of contraceptive methods (especially promoting long-term and permanent methods); making use of alternative family planning delivery systems, such as the use of depot holders, volunteers, and government extension workers; establishing a national population policy; and considering cost recovery and other measures for self-sustainment and program growth.Agricultural Knowledge&Information Systems,ICT Policy and Strategies,Gender and Health,Health Monitoring&Evaluation,Adolescent Health
- …
