1,721,024 research outputs found
Kallikrein-related peptidase 15 (prostinogen)
No full textThe third edition of the Handbook of Proteolytic Enzymes aims to be a comprehensive reference work for the enzymes that cleave proteins and peptides, and contains over 800 chapters. Each chapter is organized into sections describing the name and history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features for a specific peptidase. The subject of Chapter 619 is Kallikrein-related Peptidase 15 (Prostinogen)
The Human Tissue Kallikrein and Kallikrein-related Peptidase Family
No full textThe human kallikrein-related peptidases are a subgroup of trypsin and chymotrypsin-like serine peptidases that are characterized by their homology to tissue kallikrein or kallikrein 1 (KLK1) encoded by the KLK1 gene (reviewed in[1-4]). The human KLK locus spans an approximately 320 kb region on chromosome 19q13.3-13.4 and contains fifteen genes encoding KLK1 and fourteen other kallikrein-related peptidases, KLK2-KLK15, which have been named contiguously in the locus in the order of their discovery [5-8] (Figure 606.1). It is the largest contiguous cluster of serine protease encoding genes in the human genome which has evolved from gene duplication of KLK1 and then subsequent reduplication of the newly evolved KLK genes [2]. The high conservation noted for KLK1-KLK3 (62-77%) reflects the proposed duplication of the KLK1 gene that produced the KLK2 gene which further generated the KLK3 gene. In contrast, the newer KLK4-KLK15 proteases share much less similarity, from 24-66%, although strong homology between KLK4 and KLK5, KLK9 and KLK11, and KLK10 and KLK12 suggests these genes are duplications of each other [2]..
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Carboxypeptidase A4
No full textCapitulo en: Rawlings, Neil D.; Salvesen, Guy (eds.). Handbook of Proteolytic Enzymes. 3rd ed. London: Academic Press, 2013, vol. 1, chapter 291, p.1307-1310. ISBN 978-0-12-382219-2. ISBN (V1) 978-0-12-407744-7Peer Reviewe
HmrA peptidase
No full textCapítulo en: Rawlings, Neil D.; Salvesen, Guy (eds.). Handbook of Proteolytic Enzymes. 3rd ed. London: Academic Press, 2013, vol. 2, chapter 373, p.1651-1654. ISBN 978-0-12-382219-2. ISBN (V2) 978-0-12-407743-0Peer Reviewe
Karilysin
No full textCapítulo en: Rawlings, Neil D.; Salvesen, Guy (eds.). Handbook of Proteolytic Enzymes. 3rd ed. London: Academic Press, 2013, vol. 1, chapter 185, p.883-886. ISBN 978-0-12-382219-2. ISBN (V1) 978-0-12-407744-7Peer Reviewe
Ulilysin
No full textCapítulo en: Rawlings, Neil D.; Salvesen, Guy (eds.). Handbook of Proteolytic Enzymes. 3rd ed. London: Academic Press, 2013, vol. 1, chapter 270, p.1208-1211. ISBN 978-0-12-382219-2. ISBN (V1) 978-0-12-407744-7Peer Reviewe
- …
