1,720,991 research outputs found
Case report of a long-surviving man with metastatic renal cell carcinoma treated with pazopanib
No full textRenal cell carcinoma is the most common type of kidney cancer in adults. It accounts for approximately 3% of adult malignancies and 90-95% of neoplasms arising from the kidney. At the moment several biological agents are used for the treatment of metastatic renal cell carcinoma. We describe the case of a man who has been treated with pazopanib (Votrient) for metastatic renal cell carcinoma since July 2011. At the time of writing, the patient is still receiving treatment (29 months) and is showing a long-lasting response with a favorable safety profile. This is an excellent example of chronic neoplastic disease in a patient who can be defined as long-surviving
Caratteristiche psicometriche di una scala che misura l'orientamento autonomo-relazionale nel definire il valore dell'ingroup
No full textL’orientamento autonomo-relazionale nel definire il valore di un gruppo è un costrutto centrale nel modello di Hinkle e Brown (1990). I gruppi relazionali, per definire il proprio valore, confrontano i loro risultati con quelli di altri gruppi; i gruppi autonomi, invece, usano standard ideali o confronti temporali. A livello personale, gli individui autonomi non usano il confronto con altri gruppi per definire il valore del proprio, gli individui relazionali invece lo usano. Secondo Hinkle e Brown, la correlazione positiva tra identificazione con l’ingroup e differenziazione a suo favore, ipotizzata dalla teoria dell’identità sociale (Tajfel, 1981), sarebbe valida solo o sarebbe più forte per i gruppi e le persone con orientamento sia collettivistico (Triandis, 1995) sia relazionale. In questo lavoro vengono studiate alcune caratteristiche psicometriche della scala di orientamento autonomo-relazionale usata da Capozza et al. (1996). Anzitutto, viene confermata la struttura bifattoriale della scala. Viene, inoltre, dimostrata la sua validità convergente e discriminante rispetto alla distinzione tra la componente normativa e la componente conativa del costrutto. La fedeltà della scala, composta di soli cinque item e, quindi, di rapida somministrazione, risulta soddisfacente
Erratum: Safety and efficacy of cabozantinib for metastatic nonclear renal cell carcinoma: Real-world data from an Italian managed access program (American Journal of Clinical Oncology: Cancer Clinical Trials (2019) 42 (42-45) DOI: 10.1097/COC.0000000000000478)
No full textIn "Safety and Efficacy of Cabozantinib for Metastatic Nonclear Renal Cell Carcinoma: Real-world Data From an Italian Managed Access Program," which published in the January 2019 issue, the authors would like to make a few corrections. In the background it was wrongly stated that in the METEOR trial the median progression free survival (mPFS) of Everolimus was 3.08 months, but actually the real mPFS of everolimus arm was 3.8 months.1 In the treatment section and within the abstract, it was stated that Cabozantintib was administered in a 28 days cycles whereas its labeled administration is in continuous treatment. Furthermore, it was specified: "A lower starting dose of 40 mg were prescribed in patients in worse clinical conditions with a dose escalation to 60 mg in case of good tolerance." Actually, dose reescalation must be considered as off-lable use of the drug.2 Moreover, in the results section data were wrongly reported: the sentence "66 years (range, 46 to 83 y)" should read "65 years (range 41-84 y); the sentence "Three (18%) patients were diagnosed with type II papillary RCC, 9 (53%) type I papillary, 3 (18%) chromophobe, and 2 (11%) with Bellini duct carcinoma" should read "Three (18%) patients were diagnosed with type I papillary RCC, 9 (53%) type II papillary, 3 (18%) chromophobe, and 2 (11%) with Bellini duct carcinoma"; the sentence "Cabozantinib was administered as second-line therapy in 5 (30%) patients, as third line in 2 (11%) patients and in the remaining 10 (59%)" should read "Cabozantinib was administered as second line therapy in 1 (6%) patients, as third line in 4 (24%) patients and in the remaining 12 (70%)". In Table 1 the line "Line of treatment" should read "Previous lines of treatment"
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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