332 research outputs found
Toxicological profile for hexachlorobutadiene
Get PDFATSDR/TP-93/08Chemical manager(s)/author(s): Gangadhar Choudhary, Joyce M. Donohue, Yvonne N. Hales.Prepared by Life Systems, Inc., under subcontract to Clement International Corporation;prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry under contract no. 205-88-0608.Includes bibliographical references (p. 105-128).205-88-060
Detection of Hg2+ ion using fluorescent carbon dots derived from elephant foot yum via green-chemistry
No full textAuthor response: Multiple short windows of calcium-dependent protein kinase 4 activity coordinate distinct cell cycle events during Plasmodium gametogenesis
No full textMalaria transmission relies on the production of gametes following ingestion by a mosquito. Here, we show that Ca2+-dependent protein kinase 4 controls three processes essential to progress from a single haploid microgametocyte to the release of eight flagellated microgametes in Plasmodium berghei. A myristoylated isoform is activated by Ca2+ to initiate a first genome replication within twenty seconds of activation. This role is mediated by a protein of the SAPS-domain family involved in S-phase entry. At the same time, CDPK4 is required for the assembly of the subsequent mitotic spindle and to phosphorylate a microtubule-associated protein important for mitotic spindle formation. Finally, a non-myristoylated isoform is essential to complete cytokinesis by activating motility of the male flagellum. This role has been linked to phosphorylation of an uncharacterised flagellar protein. Altogether, this study reveals how a kinase integrates and transduces multiple signals to control key cell-cycle transitions during Plasmodium gametogenesis.</jats:p
Microbial transformation of nandrolone with Cunninghamella echinulata and Cunninghamella blakesleeana and evaluation of leishmaniacidal activity of transformed products
No full textTherapeutic potential of nandrolone and its derivatives against leishmaniasis has been studied. A number of derivatives of nandrolone (1) were synthesized through biotransformation. Microbial transformation of nandrolone (1) with Cunninghamella echinulata and Cunninghamella blakesleeana yielded three new metabolites, 10β,12β,17β-trihydroxy-19-nor-4-androsten-3-one (2), 10β,16α,17β-trihydroxy-19-nor-4-androsten-3-one (3), and 6β,10β,17β-trihydroxy-19-nor-4-androsten-3-one (4), along with four known metabolites, 10β,17β-dihydroxy-19-nor-4-androsten-3-one (5), 6β,17β-dihydroxy-19-nor-4-androsten-3-one (6) 10β-hydroxy-19-nor-4-androsten-3,17-dione (7) and 16β,17β- dihydroxy-19-nor-4-androsten-3-one (8). Compounds 1-8 were evaluated for their anti-leishmanial activity. Compounds 1 and 8 showed a significant activity in vitro against Leishmania major. The leishmanicidal potential of compounds 1-8 (IC50 = 32.0 ± 0.5, andgt;100, 77.39 ± 5.52, 70.90 ± 1.16, 54.94 ± 1.01, 80.23 ± 3.39, 61.12 ± 1.39 and 29.55 ± 1.14 μM, respectively) can form the basis for the development of effective therapies against the protozoal tropical disease leishmaniasis. © 2014 Elsevier Inc. All rights reserved.Al-Aboudi A, 2009, STEROIDS, V74, P483, DOI 10.1016-j.steroids.2009.01.002; Alarcon J, 2007, J MOL CATAL B-ENZYM, V48, P23, DOI 10.1016-j.molcatb.2007.06.001; Antinarelli Luciana Mr, 2012, Org Med Chem Lett, V2, P16, DOI 10.1186-2191-2858-2-16; Borges KB, 2008, J PHARMACEUT BIOMED, V46, P945, DOI 10.1016-j.jpba.2007.05.018; Borges KB, 2009, TETRAHEDRON-ASYMMETR, V20, P385, DOI 10.1016-j.tetasy.2009.02.009; BORIS A, 1967, STEROIDS, V9, P299, DOI 10.1016-0039-128X(67)90114-6; CASPI E, 1989, J CHEM SOC CHEM COMM, P1699, DOI 10.1039-c39890001699; Choudhary MI, 2010, STEROIDS, V75, P956, DOI 10.1016-j.steroids.2010.05.017; Choudhary MI, 2008, NAT PROD RES, V22, P1289, DOI 10.1080-14786410500462660; Choudhary MI, 2005, CHEM BIODIVERS, V2, P392, DOI 10.1002-cbdv.200590019; Choudhary MI, 2011, STEROIDS, V76, P1288, DOI 10.1016-j.steroids.2011.06.007; Choudhary MI, 2009, STEROIDS, V74, P1040, DOI 10.1016-j.steroids.2009.08.003; Choudhary MI, 2007, STEROIDS, V72, P923, DOI 10.1016-j.steroids.2007.08.002; Choudhary MI, 2012, J ENZYM INHIB MED CH, V27, P348, DOI 10.3109-14756366.2011.590804; de Flines J, 1963, RECL TRAV CHIM PAY B, V82, P129; de Flines J, 1963, RECL TRAV CHIM PAY B, V82, P121; de Flines J, 1963, RECL TRAV CHIM PAY B, V82, P149; Desjeux P, 2004, COMP IMMUNOL MICROB, V27, P305, DOI 10.1016-j.cimid.2004.03.004; Farooq A, 2002, Z NATURFORSCH C, V57, P303; Hazra S, 2013, EXP PARASITOL, V135, P407, DOI 10.1016-j.exppara.2013.07.021; Hernandez-Torres A, 2013, SCAND J INFECT DIS, V45, P567, DOI 10.3109-00365548.2012.752859; Huszcza E, 2003, J BASIC MICROB, V43, P113, DOI 10.1002-jobm.200390011; Kolet SP, 2013, STEROIDS, V78, P1152, DOI 10.1016-j.steroids.2013.08.004; Kouvelas D, 2008, INT J NEUROPSYCHOPH, V11, P925, DOI 10.1017-S1461145708008754; Oliveira-Silva FD, 2008, AM J TROP MED HYG, V78, P745; Parshikov IA, 2000, APPL ENVIRON MICROB, V66, P2664, DOI 10.1128-AEM.66.6.2664-2667.2000; Shao-rui C, 2010, CHEM RES CHINESE U, V26, P922; Yazdi MT, 2006, ARCH PHARM, V339, P473, DOI 10.1002-ardp.2005002350
Ayurvedic management of Paripluta Yonivayapad - A Review
Get PDFYonivyapad comprises around 70% of gynaecological problems and commonly encountered in the practice of Gynaecology. Among them some are causing painful coitus, dysmenorrhoea etc., and Paripluta is one among them. Paripluta is one among the twenty Yoni Vyapads mentioned in the classics. In this disease Pitta and Vata Dusti are considered as primary cause. It can be correlated to pelvic inflammatory disease due its resemblance of clinical features. PID is of public health issue, especially in developing countries because of its high prevalence, economic and social implication. Delayed management of PID may result in higher rates of miscarriage, chronic pelvic pain, STD, progressive organ damage and long term reproductive disability due to its recurrence
Estimation of Distribution of Income in Pakistan, Using Micro Data
Get PDFIncome distribution entered the post war discussion of economic development fairly late. Until the 1960s much of the focus was on industrialisation and the need for capital accumulation. Pakistan was no exception as in the early 60s economic expansion became the main target and means to political identity. Rapid population growth associated with steep decline in mortality demanded acceleration of production to keep pace. Overall aggregate expansion was much faster than before but without benefit for the poor. In that context emerged a new professional interest in income distribution. Haq’s (1964) study was one of the oldest studies conducted to measure inequality in personal income distribution in the high income brackets in the urban areas of Pakistan. The main objective of the author was to present the income distribution pattern in terms of the relative shares of different income groups as well as in terms of Pareto coefficients and concentration ratio during the period 1948-49 to 1957-58 for which published tax data was available. While recognising the limitations of the data used, the author went on to calculate various measures of income inequality including Pareto coefficient and Lorenz curve. The author also made comparison of Pakistan’s income distribution with U.S.A. and U.K.
Parasitic Vaccines
No full textProtective immunity can be induced by either active or passive immunization. Passive immunization provides immediate immunity by administering preformed antibodies to an individual. Passive immunity is short lived since transferred antibodies are metabolized. Active immunization involves administration of antigen in the form of vaccine. By this way immunity provoked takes several weeks to develop but may persist for a longer time
‐aryl substituted itaconimide with methyl methacrylate: Effect of substituents on monomer reactivity ratio and thermal behavior
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Effect of Putrajeevakadi Yoga on Dhathukshayajanya Bandhya (Secondary Infertility) due to Low AMH
Get PDFSecondary infertility associated with diminished Anti-Mullerian Hormone (AMH) levels is predominantly linked to endocrine dysfunction. Elevated Follicle Stimulating Hormone (FSH), reduced AMH, and a low Antral Follicle Count (AFC) collectively compromise ovarian reserve, resulting in pregnancy rates below 5% and miscarriage rates exceeding 75%. AMH, secreted by granulosa cells of preantral and antral follicles, is a well-established biomarker for evaluating ovarian reserve and predicting response to controlled ovarian stimulation due to its strong correlation with follicular quantity and recruitment. Women undergoing in vitro fertilization (IVF) with low AMH levels often experience poor outcomes, making donor egg IVF the predominant option. Ayurveda offers a comprehensive and individualized approach to managing Vandhyatva (infertility), focusing on restoring systemic equilibrium, enhancing oocyte quality, and activating the body\u27s intrinsic healing mechanisms. This case study presents a 35-year-old woman with secondary infertility and markedly low AMH levels who was successfully treated with Putrajeevakadi Yoga Ksheerpaka. The intervention resulted in natural conception, highlighting the therapeutic potential of Ayurvedic protocols in addressing complex reproductive disorders and improving ovarian function
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