42 research outputs found
O compromisso político de Bertolt Brecht
No full textBertolt Brecht (1898-1956), dramaturgo e diretor alemão, dedicou o conjunto de sua obra ao pensamento crítico e à exploração dos funcionamentos dos processos sociais. Seu compromisso com as questões políticas e culturais de sua época – como o avanço do nazifascismo, sua vida no exílio e as críticas ao capitalismo –, assim como a formulação teórica de uma nova forma de produção teatral que se contrapõe ao teatro burguês, hegemônico e mercadológico, encontram concretude em sua prática artística, realizada coletivamente no trabalho do Berliner Ensemble, grupo teatral criado por ele e Helene Weigel, em setembro de 1949. Foi seu envolvimento com as questões sociais que o levou a desenvolver um novo jeito de fazer teatro e a radicalizar e refuncionalizar o aparelho. A partir do diálogo com Adorno e Benjamin, o artigo debate a questão do engajamento brechtiano, à luz de aspectos de sua obra.Bertolt Brecht (1898-1956), German playwright and director, devoted his entire oeuvre to critical thinking and exploring the workings of social processes. His commitment to the political and cultural issues of his time - such as the advance of Nazi-fascism, his life in exile, and his criticism of capitalism –, as well as the theoretical formulation of a new form of theatrical production that opposes the bourgeois, hegemonic and market theater, find concreteness in his artistic practice, collectively realized in the work of the Berliner Ensemble, a theater group created by him and Helene Weigel in September 1949. It was his involvement with social issues that led him to develop a new way of making theater and to radicalize and refunctionalize the device. Based on a dialogue with Adorno and Benjamin, the article discusses the question of Brechtian engagement in light of aspects of his work
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Prevalence of Concurrent Hearing and Visual Impairment in US Adults: The National Health Interview Survey, 1997–2002
No full textAnalysis of data from a nationally representative sample of US adults (n=195801) showed that concurrent hearing and visual impairment prevalence rates were highest for participants older than 79 years of age (16.6%); a 3-fold increase in age-adjusted rates of reported hearing and visual impairment was observed for Native Americans compared with Asian Americans. Research on preventing concurrent hearing and visual impairment and countering its consequences is warranted, especially in population subgroups, such as Native and older Americans
Correlation of functional connectivity with cognitive performance and positive symptom.
No full text<p>Combined group data (black line), collapsed across groups, and SZ group data (orange line) showed significant correlation between functional connectivity and cognitive performance. LH, left hemisphere; RH, right hemisphere; HC, healthy controls(blue circle); UHR, ultra-high risk(green circle); SZ, schizophrenia(orange circle); PANSS, Positive and Negative Syndrome Scale.</p
Analisis Normatif Kedudukan Undang-Undang Dasar Negara Republik Indonesia Tahun 1945 Dalam Jenis Dan Hierarki Peraturan Perundang-Undangan
No full textBerdasarkan teori norma hukum berjenjang Hans Nawiansky, susunan atau
hierarki sistem norma, norma yang tertinggi (norma dasar) itu berkembang
menjadi Norma fundamental Negara atau
Staatsfundamentalnorm. Maka, dalam
susunan hierarkis peraturan perundang-undangan di dalam Pasal 7 ayat (1) UU
Nomor 12 Tahun 2011 tentang Pembentukan Peraturan Perundang-Undangan,
letak
Staatsfundamentalnorm dan
Staatsgrundgesetz di dalamnya dirasa kurang
tepat, adapun logika yang dibangun sebagaimana yang telah dijelaskan
sebelumnya menurut pendapat Prof. A. Hamid S. Attamimi maupun Prof. Maria
Farida Indrati Soeprapto, bahwa definisi peraturan perundang-undangan adalah
keseluruhan susunan hierarkis peraturan perundang-undangan yang berbentuk
Undang-Undang (
formell gesetz) ke bawah. Sedangkan kedudukan
Staatsfundamentalnorm dan
Staatsgrundgesetz dalam Teori norma hukum
berjenjang berada diatas
formell gesetz (Undang-Undang). Pasal 7 ayat (1) UU
No. 12 Tahun 2011 menyebutkan jenis dan hierarki peraturan perundang-
undangan sehingga menimbulkan adanya ketidakpastian hukum berdasarkan teori
norma hukum berjenjang
, selain itu disebutkan pula dalam Pasal 3 ayat (1) UU No.
12 Tahun 2011 bahwa UUD NRI 1945 merupakan hukum dasar dalam Peraturan
Perundang-Undangan yang berarti norma dasar bagi Pembentukan Peraturan
Perundang-Undangan yang merupakan sumber hukum bagi Pembentukan
Peraturan Perundang-Undangan dibawah Undang-Undang Dasar Negara Republik
Indonesia Tahun 1945. Sehingga, baik bentuk
Staatsfundamentalnorm maupun
Staatsgrundgesetz tidak dapat diklasifikasikan ke dalam jenis peraturan
perundang-undangan, dilain sisi keduanya pun memiliki tingkat hierarki norma
yang berbeda oleh karena itu, memasukan bentuk
Staatsfundamentalnorm
maupun
Staatsgrundgesetz ke dalam “jenis dan hierarki peraturan perundang-
undangan” yang disebutkan Pasal 7 ayat (1) UU No. 12 Tahun 2011 dianggap tidak
tepat sehingga perlu dilakukan peninjauan ulang. Selain itu apabila melihat konsep
Hak Uji Materiil, apabila bentuk
Staatsgrundgesetz dipaksakan sebagai bagian dari
peraturan perundang-undangan maka tentu, harus diperhatikan
konstitusionalitasnya, disebabkan bahwa suatu norma hukum/peraturan tidak bisa
dilepaskan dari sifat pengujian terhadap norma yang mendasarinya baik melalui
hak menguji formiil (
formale toetsingrecht), maupun hak menguji materiil
(
materiele toetsingrecht). Sedangkan
Staatsgrundgesetz merupakan norma
tunggal dan mendasar dan pada
Staatsfundamentalnorm hak menguji tidak dapat
dilaksanakan karena
Staatsfundamentalnorm merupakan norma tertinggi atau
norma dasar. Sehingga kedudukan hierarki norma dalam Pasal 7 ayat (1) UU No.
12 Tahun 2011 perlu dilakukan peninjauan ulang dengan melakukan pemisahan
kedudukan sesuai tingkatan norma yang ad
Evaluation of antioxidant and anticancer effects of Piper betle L (Piperaceae) leaf extract on MCF-7 cells, and preparation of transdermal patches of the extract
No full textPurpose: To determine the antioxidant and anticancer effects of Piper betle (P. betle) leaf extract on human breast cancer MCF-7 cells, and to develop transdermal patches containing the extract.
Methods: The leaf extract of P. betle was prepared by maceration method, and its antioxidant activity was evaluated using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. Cytotoxicity and suppression of cell migration (indices of anticancer activity) were also assessed in MCF-7 cells by sulforhodamine B (SRB) and wound healing assays, respectively. Transdermal patches were developed using the casting method, and the resultant patches were evaluated with regard to their physical appearance and mechanical properties before and after a stability test.
Results: The extract exhibited antioxidant activity with half-maximal inhibitory concentration (IC50) of 30.0 ± 0.1 µg/mL. It also showed cytotoxicity with an IC50 of 114.3 ± 14.9 µg/mL, and significantly suppressed the migration of MCF-7 cells at a dose of 25 µg/mL. Based on desirable characteristics, patch base formulations containing 4.2 % pectin, 0.4 % hydroxyl propyl methylcellulose (HPMC), 0.4 % polyvinyl pyrrolidine K-90 (PVP-K90) and 3 % propylene glycol (PG) were selected for incorporation into the extract.
Conclusion: Leaf extract of P. betle exhibits potential anti-breast cancer properties. A transdermal patch containing 0.03 % of the extract can be successfully developed for treatment of breast cancer
Emoji Data Dashboard
No full textThis archival publication may not reflect current scientific knowledge or recommendations. Current information available from the University of Minnesota Extension: https://www.extension.umn.edu.Use the Emoji Reflection activity (under Creating the Learning Environment) to track changes over time by creating a data dashboard. At the individual level, the Emoji Reflection activity is a tool for personal growth. At the program-level, it is well-suited for youth-directed measurement and continuous improvement. There are no-tech and low-tech options for creating a data dashboard.University of Minnesota Extension Center for Youth Development. (2017). Emoji Data Dashboard. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/195801
Punicalagin alleviates brain injury and inflammatory responses, and regulates HO-1/Nrf-2/ARE signaling in rats after experimental intracerebral haemorrhage
No full textPurpose: To investigate the effect of punicalagin, an ellagitannin present in pomegranates, on intracerebral haemorrhage (ICH)-induced inflammatory responses and oxidative stress, and also unravel the underlying mechanism(s) of action.
Methods: Collagenase type IV (0.2 U) was used to induce ICH in adult male Sprague-Dawley rats. Punicalagin was given to the rats at doses of 25, 50, and 75 mg/kg body weight via oral gavage for 15 days before ICH induction. The animals were sacrificed 24h following induction of ICH, and their brains were excised immediately and used for analysis. Histological changes were determined with Haematoxylin and Eosin (H&E) staining. Permeability to blood-brain barrier (BBB) was determined by quantifying the extent of extravasation of Evan Blue (EB). Protein expressions of HO-1/Nrf-2/ARE and NF-κB signaling were assayed using immunoblotting and RT-PCR. Levels of reactive oxygen species (ROS) and serum levels of cytokines were also determined.
Results: Punicalagin treatment reduced inflammatory cell infiltration and cell damage, improved brain tissue architecture and BBB integrity. The punicalagin treatment increased the activities of antioxidant enzymes, and enhanced antioxidant status via activation of Nrf-2/ARE/HO-1 signaling pathway (p < 0.05). The treatment upregulated the expressions of HO-1 to 174 %, relative to 127 % in ICH control rats. Furthermore, it enhanced NF-κB levels and reversed the ICH injury-induced upregulations of IL-6, IL-18 and IL-1β.
Conclusion: These findings indicate that punicalagin exerts neuroprotective effect in rats after experimental ICH through regulation of theHO-1/Nrf-2/ARE signaling pathway. Thus, punicalagin has therapeutic potential for ICH.
Keywords: Brain injury, Haemoxygenase-1, Intracerebral haemorrhage, Inflammatory responses, Nrf2/ARE signalling, Punicalagi
