57 research outputs found
International Conference on Industry, Engineering, and Management Systems (1994 : Cocoa Beach, Fla.)
No full textDigitized and published in SOAR: Shocker Open Access Repository by Wichita State University Libraries Technical Services, May 2022.The IEMS'94 conference committee: University of Central Florida Department of Industrial Engineering and Management Systems (Sponsor); Dr. William Swart (Conference General Chair); Dr. Ahman K. Elshennawy (Program Chair); Dr. Yasser A. Hosni (Publications Chair).Includes author index.This book features the proceedings of the 1994 Annual International Conference on Industry, Engineering, and Management Systems (IEMS '94), held March 14 -16, 1994 in Cocoa Beach, Florida. IEMS is organized by the University of Central Florida, Department of Industrial Engineering and Management Systems (UCF-IEMS). The conference is an excellent opportunity for academicians and practitioners to present their work and to exchange views on a variety of issues which relate to industry and its engineering management.
Authors from 11 countries have contributed more than 135 papers and presentations. All papers submitted for the proceedings went through a blind peer refereeing process where each paper was reviewed by at least two reviewers. Abstracts for presentations only and for those papers which did not make it in the final cut are also included in this document.Sponsor: Department of Industrial Engineering and Management Systems, University of Central Florida.The papers are organized into eight tracks encompassing all sessions of the conference. The tracks are: I. Quality Issues -- II. CIM and Manufacturing Technologies -- III. Computer Based Systems -- IV. Human Engineering -- V. Systems Engineering and Control -- VI. Simulation, Training, and Engineering Education -- VII. Optimization and Decision Support Systems -- VIII. Global Issues
Essays on river mechanics
No full textCER89-90-PYJ-14.Presented by the Graduate Students in CE 717 River Mechanics (Spring 1990).Instructor: P. Y. Julien.Includes bibliographical references.May 1990.Predicting Sediment Yield of a Watershed by Margaret Tauzer -- Particle Entrainment by River Flows by Kathy Chase -- Bed Forms and Resistance to Flow by Yasser Raslan -- An Examination of the Dynamic Loop Rating Curve in Alluvial Rivers by Phil G. Combs -- Scour Downstream of Hydraulic Structures by T. K. Burke -- Distorted Physical Hydraulic Models, Theory and Practice by Fred L. Ogden -- Life Expectancy of Reservoirs by T. G. Anthony Balan
Foreign Bodies Ingestion in Children
No full textBackground: Foreign body (FB) ingestion is a worldwide problem, commonly occurs in children younger than 6 years, and the incidence of FBI has increased in recent years.Aim: To review our experience of FB ingestions management in children over a 7 year period and compared our findings with previous reports. Patients and Methods: The medical records of 250 patients who were hospitalized for FB ingestion between 2007 and May 2014 were evaluated retrospectively. The age and sex, clinical findings, diagnostic methods, modalities of treatment as well as outcome of all patients were noted.Statistical Analysis: Descriptive.Results: There were 250 patients enrolled into the study. The main presenting symptoms were abdominal pain (38%), vomiting (6.4%), dysphagia (3.2%), chest pain (3.2%), cough (2.4%), and melena (1.2%). No symptom was encountered in the remaining (45.6%) patients. Radiological examinations showed that FB was located in the esophagus in 44.8%, in the stomach of 35.2%, in the duodenum of 1.2%, and in the intestine or colon segments in 18.8% (n = 47) patients.Conclusions: We concluded that the public health education could reduce exposure to injuries from FB ingestion and we found the endoscopic extraction of FB is safe and effective
Micellar chromatographic partition coefficients and their application in predicting skin permeability
No full textThe major goal for physicochemical screening of pharmaceuticals is to predict human drug absorption, distribution, elimination, excretion and toxicity. These are all dependent on the lipophilicity of the drug, which is expressed as a partition coefficient i.e. a measure of a drug’s preference for the lipophilic or hydrophilic phases. The most common method of determining a partition coefficient is the shake flask method using octanol and water as partitioning media. However, this system has many limitations when modeling the interaction of ionised compounds with membranes, therefore, unreliable partitioning data for many solutes has been reported. In addition to these concerns, the procedure is tedious and time consuming and requires a high level of solute and solvent purity. Micellar liquid chromatography (MLC) has been proposed as an alternative technique for measuring partition coefficients utilising surfactant aggregates, known as micelles.
This thesis investigates the application of MLC in determining micelle-water partition coefficients (logPMW) of pharmaceutical compounds of varying physicochemical properties. The effect of mobile phase pH and column temperature on the partitioning of compounds was evaluated. Results revealed that partitioning of drugs solely into the micellar core was influenced by the interaction of charged and neutral species with the surface of the micelle. Furthermore, the pH of the mobile phase significantly influenced the partitioning behaviour and a good correlation of logPMW was observed with calculated distribution coefficient (logD) values. More interestingly, a significant change in partitioning was observed near the dissociation constant of each drug indicating an influence of ionised species on the association with the micelle and retention on the stationary phase. Elevated column temperatures confirmed partitioning of drugs considered in this study was enthalpically driven with a small change in the entropy of the system because of the change in the nature of hydrogen bonding. Finally, a quantitative structure property relationship was developed to evaluate biological relevance in terms of predicting skin permeability of the newly developed partition coefficient values. This study provides a better surrogate for predicting skin permeability based on an easy, fast and cheap experimental methodology, and the method holds the predictive capability for a wider population of drugs.
In summary, it can be concluded that MLC has the ability to generate partition
coefficient values in a shorter time with higher accuracy, and has the potential to replace the octanol-water system for pharmaceutical compounds
The characteristics and dynamics of wave-driven flow across a platform coral reef in the Red Sea
No full textCurrent dynamics across a platform reef in the Red Sea near Jeddah, Saudi Arabia, are examined using 18 months of current profile, pressure, surface wave, and wind observations. The platform reef is 700 m long, 200 m across with spatial and temporal variations in water depth over the reef ranging from 0.6 to 1.6 m. Surface waves breaking at the seaward edge of the reef cause a 2-10 cm setup of sea level that drives cross-reef currents of 5-20 cm s-1. Bottom stress is a significant component of the wave setup balance in the surf zone. Over the reef flat, where waves are not breaking, the cross-reef pressure gradient associated with wave setup is balanced by bottom stress. The quadratic drag coefficient for the depth-average flow decreases with increasing water depth from Cda = 0.17 in 0.4 m of water to Cda = 0.03 in 1.2 m of water. The observed dependence of the drag coefficient on water depth is consistent with open-channel flow theory and a hydrodynamic roughness of zo = 0.06 m. A simple one-dimensional model driven by incident surface waves and wind stress accurately reproduces the observed depth-averaged cross-reef currents and a portion of the weaker along-reef currents over the focus reef and two other Red Sea platform reefs. The model indicates the cross-reef current is wave forced and the along-reef current is partially wind forced.The authors are grateful for the scientific and technical support provided by colleagues at King Abdullah University of Sciences and Technology (KAUST), in particular Yasser Abualnaja, Abdulaziz Al-Suwailem, Haitham Aljahdali, Mohsen Aljahdali, Ramzi Aljahdali, Wael Almoazen, Captain Evangelos G. Aravantinos, Yasser Kattan, and all the crew members of the Boston Whaler used in our field work. We also thank C. Marquette, J. Kemp, J. Ryder, S. Whelan, J. Smith, P. Bouchard, J. Lord and the rigging shop, all of Woods Hole Oceanographic Institution, for their efforts in instrument preparation, deployment, and recovery. This research is based on work supported by awards USA 00002 and KSA 00011 KAUST. K. Davis was supported by a WHOI Postdoctoral Fellowship. T. Farrar was partly supported by NSF grant OCE-1435665. S. Lentz was partly supported by NSF grants OCE-1332646 and OCE-1357290. Data are available from the corresponding author ([email protected]) upon request, subject to approval from KAUST. The authors thank two anonymous reviewers for comments and suggestions that improved the manuscript
Coral reef drag coefficients – surface gravity wave enhancement
No full textA primary challenge in modeling flow over shallow coral reefs is accurately characterizing the bottom drag. Previous studies over continental shelves and sandy beaches suggest surface gravity waves should enhance the drag on the circulation over coral reefs. The influence of surface gravity waves on drag over four platform reefs in the Red Sea is examined using observations from 6-month deployments of current and pressure sensors burst sampling at 1 Hz for 4–5 min. Depth-average current fluctuations U′ within each burst are dominated by wave orbital velocities uw that account for 80%–90% of the burst variance and have a magnitude of order 10 cm s−1, similar to the lower-frequency depth-average current Uavg. Previous studies have shown that the cross-reef bottom stress balances the pressure gradient over these reefs. A bottom stress estimate that neglects the waves (ρCdaUavg|Uavg|, where ρ is water density and Cda is a drag coefficient) balances the observed pressure gradient when uw is smaller than Uavg but underestimates the pressure gradient when uw is larger than Uavg (by a factor of 3–5 when uw = 2Uavg), indicating the neglected waves enhance the bottom stress. In contrast, a bottom stress estimate that includes the waves [ρCda(Uavg + U′)|Uavg + U′|)] balances the observed pressure gradient independent of the relative size of uw and Uavg, indicating that this estimate accounts for the wave enhancement of the bottom stress. A parameterization proposed by Wright and Thompson provides a reasonable estimate of the total bottom stress (including the waves) given the burst-averaged current and the wave orbital velocity.The authors thank Dr. Yasser Abualnaja, Dr. Abdulaziz Al-Suwailem, Haitham Aljahdali, Mohsen Aljahdali, Ramzi Aljahdali, Wael Almoazen, Captain Evangelos G. Aravantinos, Yasser Kattan, the whaler crew from King Abdullah University of Sciences and Technology (KAUST), and C. Marquette of Woods Hole Oceanographic Institution (WHOI) for providing logistical and field support. Suggestions from an anonymous reviewer substantially improved the manuscript. The Red Sea field program was supported by Awards USA 00002 and KSA 00011 made by KAUST. Data are available from corresponding author ([email protected]) upon request, subject to approval from KAUST. S. Lentz was supported for the analysis by NSF Award OCE-1558343
Helicobacter pylori infection and celiac disease in children, what is the relationship?
Get PDFBackground: Celiac disease (CD) is an autoimmune disease affecting the small intestine, triggered by gluten. The pathogenesis of CD has been well defined, and the increasing prevalence of this disease had led to studying several environmental risk factors that may trigger an autoimmune process in the small intestine. Infection is one of the most important factors that can trigger autoimmune processes. The researchers have studied the association between H. pylori infection and CD, the authors have reported conflicting results. Purpose: to study the association of H. pylori and celiac disease (CD) at the time of CD diagnosis in children. Patient and Methods: All patients in the study were subjected to full history taking, thorough clinical examination, and laboratory investigations including Anti-tissue transglutaminase antibodies (IgA), anti-endomysial (IgA EMA), Stool Ag for H. pylori, CLO test for H. pylori, Immunoglobulins level, Upper gastrointestinal endoscopy with multiple biopsies for histopathological examination. Results: Anti TTG Ig A and Endomysial Ab were positive in 49 patients, while one patient showed negative results. 7 patients (14%) had H. 
Histopathological features and accuracy for diagnosing biliary atresia by prelaparotomy liver biopsy in Egypt
No full textAbstractBackground and study aimsBiliary atresia (BA) is the most common cause of chronic cholestasis in infants. The most important objective in such cases is to distinguish obstructive cholestasis from non-obstructive causes.Aim of the studyTo evaluate the hepatic histopathology for the presence of features that correlate best with the diagnosis of BA.Patients and methodsWe retrospectively study the data of 81 infants who presented with neonatal cholestatic syndrome (NCS) (58 diagnosed as BA and 23 as not BA). We evaluated 6 histopathological parameters including ductular proliferation, bile plugs, intracellular bile pigments, giant cells transformation, Portal cellular infiltration and fibrosis.ResultsThe study showed that ductular proliferation, bile plugs and intracellular bile pigments emerged as the best indicators of BA while multinucleate giant cells transformation and portal cellular infiltration were seen in NH.ConclusionIn developing countries, we therefore recommend doing prelaparotomy liver biopsy for all suspected cases of BA to decrease the frequency of negative laparotomy to achieve cost benefit with reduced morbidity
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