526 research outputs found
Decrease of angiogenic t cells associated to the presence of interstitial lung disease in patients with connective tissue diseases
No full textAbstract number: 1508American College of Rheumatology, ACR Convergence (2021. Virtual)VP- C: PREVAL18/01 (IDIVAL); SR- M: RD16/0012/0009 (ISCIII- ERDF); LL- G: INNVAL20/06 (IDIVAL); RP- F: START PROJECT (FOREUM18/34); RL- M: Miguel Servet type I CP16/00033 (ISCIII- ESF).Pulito-Cueto, V (Pulito-Cueto, Veronica); Remuzgo-Martinez, S (Remuzgo-Martinez, Sara); Genre, F (Genre, Fernanda); Atienza-Mateo, B (Atienza-Mateo, Belen); Mora-Cuesta, VM (Mora-Cuesta, Victor M.); Iturbe-Fernandez, D (Iturbe-Fernandez, David); Lera-Gomez, L (Lera-Gomez, Leticia); Perez-Fernandez, R (Perez-Fernandez, Raquel); Alonso-Lecue, P (Alonso-Lecue, Pilar); Rodriguez-Carrio, J (Rodriguez-Carrio, Javier); Prieto-Pena, D (Prieto-Pena, Diana); Portilla, V (Portilla, Virginia); Blanco, R (Blanco, Ricardo); Corrales, A (Corrales, Alfosno); Cifrian, JM (Cifrian, Jose M.); Lopez-Mejias, R (Lopez-Mejias, Raquel); Gonzalez-Gay, MA (Angel Gonzalez-Gay, Miguel
ROTATIONAL SPECTROSCOPY UNVEILS ELEVEN CONFORMERS OF ADRENALINE
No full textAuthor Institution: Grupo de Espectroscopia Molecular (GEM), Edificio Quifima, Laboratorios de Espectroscopia y Bioespectroscopia, Parque Cientifico, Universidad de Valladolid, 47011 Valladolid, SpainRecent improvements in our LA-MB-FTMW instrumentation have allowed the characterization of eleven and eight conformers for the neurotransmitters adrenaline and noradrenaline respectively. The observation of this rich conformational behavior is in accordance with the recent observation of seven conformers for dopaminea, J.~C.~Lopez, J.~L.~Alonso \textit{J. Phys. Chem. Lett.} \textbf{2013}, \textit{4}, 486.} and in sharp contrast with the conformational reduction proposed for catecholamines. \textbf{2010}, \textit{1}, 1130.
GAS PHASE STRUCTURE OF AMINO ACIDS: LASER ABLATION JET-COOLED ROTATIONAL STUDIES
No full textAuthor Institution: Grupo de Espectroscop\ia Molecular (GEM), Departamento de Qu\imica F\isica y; Qu\imica Inorganica, Facultad de Ciencias, Universidad de Valladolid, 47005 Valladolid, SpainThe structural analysis of natural amino acids using rotational spectroscopy was hindered in the past by the high melting points and thermal fragility of these compounds. Recently, these studies have received an important impulse with the introduction of a technique which combines laser ablation with Fourier transform microwave spectroscopy in supersonic jets} 74 (2003) 4799.} (Laser-ablation molecular-beam Fourier transform microwave spectroscopy, LA-MB-FTMW). Using this technique we have studied under isolation conditions in gas phase more than 15 amino acids} 41 (2002) 4673; S. Blanco, A. Lesarri, J. C. Lopez, J. L. Alonso, \textit{J. Am. Chem. Soc.} 126 (2004) 11675; A. Lesarri, E. J. Cocinero, J. C. Lopez, J. L. Alonso, \textit{Angew. Chem. Int. Ed.} 43 (2004) 605; A. Lesarri, E. J. Cocinero, J. C. Lopez, J. L. Alonso, \textit{J. Am. Chem. Soc.} 127 (2005) 2572; A. Lesarri, E. J. Cocinero, J. C. Lopez, J. L. Alonso, \textit{ChemPhysChem.} 6 (2005) 1559; M. E. Sanz, V. Cortijo, W. Caminati, J. C. Lopez, J. L. Alonso, \textit{Chem. Eur. J.} (2006), in press; M. E. Sanz, A. Lesarri, I. Pe\ {n}a, V. Vaquero, V. Cortijo, J. C. Lopez, J. L. Alonso, \textit{J. Am. Chem. Soc.} (2006), in press.} to date. Several conformers (up to six for serine, cysteine, and aspartic acid and five for -aminobutyric acid) have been detected in the jet-cooled rotational spectrum and their rotational and N-nuclear quadrupole coupling constants determined; the latter are crucial to distinguish unequivocally between conformations with similar rotational constants. The observed conformers present different intramolecular hydrogen bonds involving the --COOH, --NH, --OH and --SH groups which influence their stability. The first observation of the 1:1 complex of glycine-water} (2006), accepted.} is also presented. The water molecule has been reliably located in the complex from the analysis of several isotopomers. The complex is stabilized by two intermolecular hydrogen bonds formed between the carbonyl group and one of the hydrogen atoms of water (Ow--HO=C) and between the hydroxyl group and the electron lone pair at the oxygen atom of water (OwH--O--C))
PSEUDOROTATION IN TETRAHYDROFURAN: SUPPLEMENTARY DATA FROM THE FREE JET ROTATIONAL SPECTRUM OF THE SPECIES
No full text{R. Meyer, J. C. Lopez, J. L. Alonso, S. Melandri, W. Caminati, and P. G. Favero, J. Chem. Phys. 1999, 111, 7871.{D. G. Melnik, S. Gopalakrishnan, T. A. Miller, F. C. D. Lucia, J. Chem. Phys. 2003, 118, 3589.Author Institution: Dipartimento di Chimica "G. Ciamician" dell'Universita, Via Selmi 2, I-40126 Bologna, Italy; Departamento de Quimica-Fisica y Quimica-Inorganica, Facultad de Ciencias,; Universidad de Valladolid, E-47005 Valladolid, Spain; Sonnenbergstrasse 18, Zufikon, CH-5621, SwitzerlandTetrahydrofuran (THF) is a model molecule for the investigation of the hindered pseudorotation in saturated five-membered rings. Two recent papers, based on millimeter-wave investigations, reported the vibrational spacings among the four lowest pseudorotation states of normal THF, and obtained contrastant results on the potential energy function: four equivalent minima}, or 2 sets of two equivalent minima}. In order to have more information on this problem, we planned to investigate the millimeter wave spectrum of the species. We obtained a vibrational spacing of 15 GHz between the two lowest pseudorotation states: a result which is not in agreement with both the above mentioned potential energy functions
UNVEILING THE SWEET CONFORMATIONS OF KETOHEXOSES
No full textAuthor Institution: Grupo de Espectroscopia Molecular (GEM), Edificio Quifima, Laboratorios de Espectroscopia y Bioespectroscopia, Parque Cientifico, Universidad de Valladolid, 47011 Valladolid, SpainThe conformational behavior of ketohexoses D-Fructose, L-Sorbose, D-Tagatose and D-Psicose has been revealed from their rotational spectra. A broadband microwave spectrometer (CP-FTMW) \textbf{2008}, \textit{79}, 053103.} combined with a laser ablation (LA) sourcea, C.~Cabezas, J.~C.~Lopez, J.~L.~Alonso, \textit{J. Mol. Spectrosc.} \textbf{2012}, \textit{280}, 91.} has been used to rapidly acquire the rotational spectra in the 6 to 12 GHz frequency range. All observed species are stabilized by complicated intramolecular hydrogen-bonding networks. Structural motifs related to the sweetness of ketohexoses are revealed
A ROTATIONAL STUDY OF D-MANNOSE AND D-GALACTOSE
No full textAuthor Institution: Grupo de Espectroscopia Molecular (GEM), Edificio Quifima, Laboratorios de Espectroscopia y Bioespectroscopia, Parque Cientifico, Universidad de Valladolid, 47011 Valladolid, SpainThe rotational spectrum of two aldohexoses, D-mannose and D-galactose, has been investigated in the 6 -- 12~GHz frequency range by means of a combination of laser ablation and broadband Fourier transform microwave spectroscopy (CP-FTMW). \textbf{2008}, \textit{79}, 053103.} a, C.~Cabezas, J.~C.~Lopez, J.~L.~Alonso, \textit{J. Mol. Spectrosc.} \textbf{2012}, \textit{280}, 91.} Five conformers of -D-mannopyranose and two of -D-galactopyranose, showing the C ring configuration, have been identified from the rotational constants in conjunction with \textit{ab initio} computations. Stabilization factors, which include stereolectronic effects, such as anomeric effect or gauche effect, and the network of clockwise or anticlockwise hydrogen bonds have been analyzed in terms of the observed conformers
Eccentricity and Vulnerability: Helmuth Plessner’s Philosophical and Political Anthropology
No full textThis text is a written and extended version of the lecture I gave on 7 November 2017 at the First Spanish-Serbian Workshop on Philosophy and Social Theory, ‘Engaging Vulnerability and Exclusion. Rethinking the Subject in the 21st Century’. On that occasion, I focused on Helmuth Plessner’s conception of the individual and underlined the connection between the notions of ‘eccentricity’ and ‘vulnerability’ from that point of view. The present version also explores at the very end that same connection from the perspective of relations between nations and peoples as it is thematized by Plessner himself in the last chapter of his 1931 book Macht und menschliche Natur. In this way, I try to contribute to the revitalization of the reception of Plessner’s philosophical and political anthropology, which I have been working on during recent years, as well as to reclaim the importance of the so-called ‘continental philosophy’ with regard to the discourse on the vulnerability issue.This chapter will focus on "Macht und menschliche Natur", Plessner’s last book of the Weimar period, published just two years before the collapse of the Republic and the content of which is related to another two major figures of German intellectuality during this epoch of upheaval: the author of "Sein und Zeit", Martin Heidegger, and Carl Schmitt. I will examine the affinities and discrepancies which may be found between Schmitt and Plessner regarding the meaning which the conceptual pair friend-enemy acquires according to both authors. Schmitt understood it as the difference which determines human groupings, whereas Plessner comprehended it as a relation which does not institute identity and has not only to do with groups, but also with individuals.Depto. de Filosofía y SociedadFac. de FilosofíaFALSEpu
Meconium staining of the skin and meconium aspiration in porcine intrapartum stillbirths
No full textRates and severity of meconium staining on skin and mcconium aspiration into the respiratory tract of porcine intrapartum stillbirths were determined in an intensively managed farm. Heartbeats, inspiratory efforts and umbilical cord morphology were evaluated at birth. The lungs of all intrapartum stillborn piglets were grossly examined and microscopically evaluated for the presence of ammotic fluid cells, meconium and inflammatory cells. Thirty four percent of the intrapartum stillbirths had ruptured umbilical cords. Heartbeats and inspiratory efforts were rarely detectable. All intrapartum stillbirths (100%) were stained with meconium, and 60% had meconium grossly visible in the oropharynx and 40% in trachea and bronchi. Microscopically, 72% of the lungs contained meconium. The most common site where meconium was found was the bronchi (66%) followed by bronchioles (48%), and alveoli (34%). There was no microscopic evidence of inflammation in lungs with meconium aspiration. No significant association was found between the severity of skin staining and the degree of meconium aspiration. It was concluded that meconium staining is consistently present in intrapartum stillbirths suggesting that severe hypoxia takes place during parturition. However, meconium staining appears to be a poor predictor for intrapartum aspiration in stillbirth piglets. These findings also suggest that intrapartum death due to asphyxia occurs rapidly thus providing insufficient time in the stillborn to mount a typical inflammatory response in the lung. (c) 2006 Elsevier B.V. All rights reserved.PT: J; CR: BERKUS MD, 1994, OBSTET GYNECOL, V84, P115 CARVAJALDELAFUE.V, 1998, VET MEXICO, V29, P147 CLEARY GM, 1998, PEDIATR CLIN N AM, V45, P511 CURTIS SE, 1974, J ANIM SCI, V38, P1031 DAVIS RO, 1985, AM J OBSTET GYNECOL, V151, P731 DEROTH L, 1976, CAN VET J, V17, P275 FAHMY MH, 1981, WORLD REV ANIM PROD, V18, P17 FIRST NL, 1979, J ANIM SCI, V48, P1407 FRIEND DW, 1962, CAN J COMP MED, V26, P127 HERPIN P, 1996, J ANIM SCI, V74, P2067 HERPIN P, 2001, J ANIM SCI, V79, P5 HOLYOAKE PK, 1995, J ANIM SCI, V73, P3543 HUGHES PE, 1992, NEONATAL SURVIVAL GR LEMAN AD, 1972, J AM VET MED ASSOC, V161, P1248 LOPEZ A, 1992, VET PATHOL, V29, P104 LOPEZ A, 2001, THOMSONS SPECIAL VET, P125 MARCHANT JN, 2000, VET REC, V147, P209 MARTINEZBURNES J, 2001, AM J VET RES, V62, P1636 MARTINEZBURNES J, 2002, HISTOL HISTOPATHOL, V17, P1067 MEIS PJ, 1978, AM J OBSTET GYNECOL, V131, P509 MOTAROJAS D, 2002, AM J VET RES, V63, P1571 RANDALL GCB, 1967, VET REC, V81, P359 RANDALL GCB, 1970, BR VET J, V126, P593 RANDALL GCB, 1971, CAN J COMP MED, V35, P141 RANDALL GCB, 1972, VET REC, V90, P178 RANDALL GCB, 1972, VET REC, V90, P183 SPRECHER DJ, 1974, JAVMA, V165, P698 SRINIVASAN HB, 1999, COMPR THER, V25, P82 STANTON HC, 1974, J ANIM SCI, V38, P1037 STARKS GC, 1980, OBSTET GYNECOL, V56, P604 SUN B, 1993, ACTA PAEDIATR, V82, P182 THIBEAULT DW, 1984, AM J OBSTET GYNECOL, V150, P393 TYLER DC, 1978, PEDIATRICS, V62, P454 VANDERLENDE T, 2001, 6 P 6 INT C PIG REPR, P247 WISWELL TE, 1992, AM J DIS CHILD, V146, P1287 WISWELL TE, 1993, PEDIATR CLIN N AM, V40, P955 WRATHALL AE, 1971, VET REC, V89, P61; NR: 37; TC: 0; J9: LIVEST SCI; PG: 8; GA: 060BMSource type: Electronic(1
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