251 research outputs found
New roles for EPHB4 in prostate cancer
No full textThis thesis presents insight into the signalling pathways of EphB4, a protein known to be involved in cancer progression. A new method was developed and used to identify a number of proteins that can interact with EphB4; and a novel mechanism of action for EphB4 was identified, where EphB4 was transported outside of the host cell by small vesicles called exosomes. These findings suggest that EphB4 may play important roles in pathways in both normal and disease states, and opens up new research directions into understanding the mechanisms, signalling pathways and cellular consequences of these new roles for EphB4
Does strict employment protection discourage job creation? Evidence from Croatia
No full textEmployment protection legislation in Croatia is among the most strict in Europe. Firing is difficult and costly, and flexible forms of employment are limited. Is this apparent rigidity reflected-as one would expect based on standard economic theory-in low labor market dynamics? Is job creation low and hiring limited? Is the job security of insiders achieved at the cost of outsiders not being able to enter thelabor market? The author attempts to answer these questions by examining job flows. If the employment protection legislation is binding, then job and worker turnover should be low. He shows that this is indeed the case. Hiring is limited and the average job tenure is very long in Croatia. Job destruction is low, however job creation is still lower. The result is accumulation of unemployment, in large part due to new labor market entrants not being able to find a job. The high degree of job protection also seems to strengthen the bargaining position of insiders and results in relatively high wages. So, wages in Croatia are higher than among its competitors, even after adjusting for productivity. These high labor costs are likely to contribute to limited job creation in existing firms, but also are likely to discourage the entry of-and thus job creation in-new firms. The author presents evidence that firm growth has been indeed limited in Croatia, contributing to the low employment level. The author examines other potential causes of high unemployment in Croatia (the unemployment benefit system, labor taxation, the wage structure, and skill and spatial mismatches). He argues that they do not play a substantial part in accounting for poor labor market outcomes in Croatia. The author concludes that the stringent employment protection legislation is the key labor market institution behind low job creation and high unemployment. Based on this he recommends specific measures aimed at liberalizing the labor market to foster job creation and employment.Labor Management and Relations,Labor Policies,Labor Markets,Environmental Economics&Policies,Trade Finance and Investment,Labor Markets,Labor Management and Relations,Labor Standards,Banks&Banking Reform,Environmental Economics&Policies
Why is unemployment so high in Bulgaria?
No full textThe author seeks to determine the main factors behind poor labor market outcomes in Bulgaria. Unemployment in Bulgaria is high and of long duration. The accumulation of the unemployment stock has been caused by relatively high inflows into unemployment coupled with limited outflows. These features of the Bulgarian labor market are typical of other transition economies in Central Europe and exploring their sources is of broad interest. The author focuses on determinants of and constraints to job creation. He uses data on job creation and job destruction from a survey of employment in all registered firms. He finds that the source of large inflows into unemployment is intensive enterprise restructuring associated with a high pace of job reallocation. However, job creation falls short of job destruction. Three main factors account for the limited job creation and hiring, and thus for low outflows from unemployment: a) The unfriendly business environment, reflected by a low rate of new firm formation, and a relatively small, small and medium enterprise sector. b) Labor market rigidities, including excessive hiring and firing costs. c) Skill and spatial mismatches brought about by enterprise restructuring, as well as low skills and marginalization of the long-term unemployed who cannot successfully compete for new jobs. The author recommends a three pronged strategy to improve labor market performance: (1) removing bureaucratic constraints to entry and expansion of firms; (2) enhancing labor market flexibility through lowering hiring and firing costs; and (3) improving the educational system so as to equip workers with broad and portable skills.Environmental Economics&Policies,Labor Policies,Labor Markets,Public Health Promotion,Health Monitoring&Evaluation,Environmental Economics&Policies,Labor Markets,Health Monitoring&Evaluation,Labor Standards,Banks&Banking Reform
Staring down the barrel: portrayals of Black heroes in the westerns of the 1970s and today
No full textThe scope and topic of my thesis project is to investigate the figure of the black western hero, primarily in films from the 1970s. I analyze Sydney Poitier’s Buck and the Preacher (1972), Martin Goldman’s The Legend of Nigger Charley (1972), and Mel Brooks’s Blazing Saddles (1974). My argument rests in the consideration of filmmakers who use western tropes and cultural cues to provide an alternate understanding of American social and racial realities by incorporating blackness into this tradition. On a grander scale my thesis topic forces re-evaluations of the usual questions of mimesis, genre reproduction, and authorship that plague film study. To ground my study in theories of visual representation, I use Laura Mulvey’s concept of visual pleasure and gazing in film and Homi K. Bhabha’s theory of colonial mimicry. My thesis project argues that studying the black western protagonist brings forth questions of American artistic, economic, and socio-political realities. I also look at a recent manifestation of this phenomenon, Quentin Tarantino’s Django Unchained (2012), to grasp what about these realities has changed and what has remained constant.M.A.Includes bibliographical referencesby John Rutkowsk
Corrections to “Gastrointestinal stromal tumours: ESMO–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up” (Annals of Oncology (2018) 29(S4) (iv68–iv78), (S0923753419316916), (10.1093/annonc/mdy095))
No full textAnn Oncol 2018; 29: iv68–iv78 (doi:10.1093/annonc/mdy095) The following corrections have been made under authorship: The author R.L. Haas has been added with the corresponding affiliation and author disclosure statement. The author name P. Rutkovski has been replaced with: P. Rutkowski Under authorship, the author name: A. Hannu has been replaced with: H.T. Aro. Under authorship, A. A. Safwat's affiliation: Finland has been replaced with: Denmark. Under authorship, the author name: W. Van der Graaf has been replaced with: W.T.A. van der Graaf. W.T.A. van der Graaf's institution: 30 has been replaced with: 30, 33, 51
Soft tissue and visceral sarcomas: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up
No full textAnn Oncol 2018; 29: iv51-iv67 (doi:10.1093/annonc/mdy096) The following corrections have been made under authorship: The author R.L. Haas has been added with the corresponding affiliation and author disclosure statement. The author name P. Rutkovski has been replaced with: P. Rutkowski Under authorship, the author name: A. Hannu has been replaced with: H.T. Aro. Under authorship, A. A. Safwat s affiliation: Finland has been replaced with: Denmark. Under authorship, the author name: W. Van der Graaf has been replaced with: W.T.A. van der Graaf. W.T.A. van der Graaf s institution: 30 has been replaced with: 30, 33, 51
Efektywne projektowanie oferty marketingowej przedsiębiorstwa z wykorzystaniem metody Conjoint Analysis
No full textIn today’s economy managers have to put more and more pressure on effective offer
design, as it is becoming a crucial factor of success or even a survival. That is why, the author
wanted to take up this topic and provide a great understanding of the properly conducted
planning process. In the following white paper several subjects can be found, including
measuring company’s effectiveness, consumer behavior and consumer research.
The main purpose of this thesis is to present the procedure of shaping marketing offer, so
that any manager could draw from this elaboration if needed. Secondly, the author wanted to
present the use of Conjoint Analysis, which according to her is an effective way of getting to
know consumer preferences – the factor so important in the whole process. Also, there was an
empirical issue arising that concerned building a service consisting of elements, which are
desired by consumers the most.
In order to explain the subject, as well as solve the problem, the author provided both
theoretical and empirical points of view. First part relates strictly to consumer behavior, offer
planning and Conjoint Analysis, while second part is a fitness market research and marketing
analysis conducted using multidimensional method. The last chapter is a result of previously
acquired knowledge and presents a marketing project of Aurum – Centrum Urody i Fitness
(Aurum – Beauty and Fitness Center), which was developed on the basis of research maintained.
Getting to know the process of creating a marketing offer and consumer behavior was
very useful to the author in shaping her own concept of the business. Conjoint Analysis also
provided some clue findings, which were a great part of the project. The author truly hopes that
her thesis will be as helpful to other managers and entrepreneurs as it was to her
Does Strict Employment Protection Discourage Job Creation? Evidence from Croatia
No full textEmployment protection legislation in
Croatia is among the most strict in Europe. Firing is
difficult and costly, and flexible forms of employment are
limited. Is this apparent rigidity reflected-as one would
expect based on standard economic theory-in low labor market
dynamics? Is job creation low and hiring limited? Is the job
security of insiders achieved at the cost of outsiders not
being able to enter the labor market? The author attempts to
answer these questions by examining job flows. If the
employment protection legislation is binding, then job and
worker turnover should be low. He shows that this is indeed
the case. Hiring is limited and the average job tenure is
very long in Croatia. Job destruction is low, however job
creation is still lower. The result is accumulation of
unemployment, in large part due to new labor market entrants
not being able to find a job. The high degree of job
protection also seems to strengthen the bargaining position
of insiders and results in relatively high wages. So, wages
in Croatia are higher than among its competitors, even after
adjusting for productivity. These high labor costs are
likely to contribute to limited job creation in existing
firms, but also are likely to discourage the entry of-and
thus job creation in-new firms. The author presents evidence
that firm growth has been indeed limited in Croatia,
contributing to the low employment level. The author
examines other potential causes of high unemployment in
Croatia (the unemployment benefit system, labor taxation,
the wage structure, and skill and spatial mismatches). He
argues that they do not play a substantial part in
accounting for poor labor market outcomes in Croatia. The
author concludes that the stringent employment protection
legislation is the key labor market institution behind low
job creation and high unemployment. Based on this he
recommends specific measures aimed at liberalizing the labor
market to foster job creation and employment
Why is Unemployment so High in Bulgaria?
No full textThe author seeks to determine the main
factors behind poor labor market outcomes in Bulgaria.
Unemployment in Bulgaria is high and of long duration. The
accumulation of the unemployment stock has been caused by
relatively high inflows into unemployment coupled with
limited outflows. These features of the Bulgarian labor
market are typical of other transition economies in Central
Europe and exploring their sources is of broad interest. The
author focuses on determinants of and constraints to job
creation. He uses data on job creation and job destruction
from a survey of employment in all registered firms. He
finds that the source of large inflows into unemployment is
intensive enterprise restructuring associated with a high
pace of job reallocation. However, job creation falls short
of job destruction. Three main factors account for the
limited job creation and hiring, and thus for low outflows
from unemployment: a) The unfriendly business environment,
reflected by a low rate of new firm formation, and a
relatively small, small and medium enterprise sector. b)
Labor market rigidities, including excessive hiring and
firing costs. c) Skill and spatial mismatches brought about
by enterprise restructuring, as well as low skills and
marginalization of the long-term unemployed who cannot
successfully compete for new jobs. The author recommends a
three pronged strategy to improve labor market performance:
(1) removing bureaucratic constraints to entry and expansion
of firms; (2) enhancing labor market flexibility through
lowering hiring and firing costs; and (3) improving the
educational system so as to equip workers with broad and
portable skills
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