22 research outputs found
The measurement of household cost functions: Revealed preference versus subjective measures
Get PDFHousehold Economics;Costs
Living conditions and subjective well-being of farmers - An ordered response analysis of regional differences and changes over time
Get PDFThe liberalisation of trade with building down of tariffs and quotas, and with subsequently lower output prices, has enforced considerable structural changes in the agricultural sector. In Norway, both naturally given factors such as climate and topography, and social conditions such as a tradition for small family farms and strong governmental regulations, contribute in making this process even harder on the individual farmer. So how do the farmers respond? National farm statistics show that the amount of cultivated land stays approximately the same even though the number of farm units and agricultural employment falls annually. This implies that both farm size and productivity have increased. In this paper we utilise sample survey data on living conditions in agricultural households to examine whether we can observe changes in farmers ’experienced utility. Have contentment dropped and are there any obvious regional differences in contentment? The data consists of non-overlapping cross-sections for the years 1995 and 2002 and we make use of a standard ordered probability model in the estimations.
The benefits of being economics professor A (and not Z)
Get PDFAlphabetic name ordering on multi-authored academic papers, which is the convention in theeconomics discipline and various other disciplines, is to the advantage of people whose lastname initials are placed early in the alphabet. As it turns out, Professor A, who has been afirst author more often than Professor Z, will have published more articles and experienced afaster growth rate over the course of her career as a result of reputation and visibility.Moreover, authors know that name ordering matters and indeed take ordering seriously:Several characteristics of an author group composition determine the decision to deviatefrom the default alphabetic name order to a significant extent
Evolution and modulation of antigen-specific T cell responses in melanoma patients
Get PDFFunding Information: We are deeply grateful to all patients who participated in the study and generously contributed samples. We acknowledge the computational resources provided by the Aalto Science-IT project and all the personnel in the Hematology Research Unit Helsinki for insightful conversations. We especially thank Dr. Nathalie Labarriere for providing information of MAA-specific TCR sequences of their study; Dr. Michael Durante and Dr. J. William Harbor for providing information related to their study; Dr. Olli Dufva for his help with interpreting the data. We additionally acknowledge Ms. Lotta Länsman for providing administrative advice. This study was supported by the European Research Council (Project: M-IMM 647355)(SM), Academy of Finland (314442, S.M., H.L. and 335527 S.M.), Sigrid Juselius Foundation (S.M.), Signe and Ane Gyllenberg Foundation (S.M.), Helsinki Institute for Life Science (S.M.), Cancer Foundation Finland (S.M.) and State funding for the University-level Health Research in Finland (S.M.). J.H. was supported by Finnish Hematology Association, Blood Disease Research Foundation, Helsinki Institute for Life Science, Biomedicum Helsinki Foundation, Finnish Medical Foundation, K. Albin Johansson Foundation, Kaute Foundation, Suomalais-Norjalainen Lääketieteen Säätiö, and Emil Aaltonen Foundation. T.L. was supported by Academy of Finland (Decision 311081). Funding Information: M.H. has received honoraria from Pierre Fabre, Novartis, Bristol-Myers Squibb (B.M.S.), Merck Sharp & Dohme (M.S.D.), Roche, Amgen, Sanofi, and Incyte. S.M. has received honoraria and research funding from B.M.S. and research funding from Novartis and Pfizer. M.M.D. has received honoraria and/or equity from Amgen, Chugai, Vir, IGMS, Janux, A2, 3T, Mozart, Red Tree, and research funding from Sanofi. The remaining authors declare no competing interests. Publisher Copyright: © 2022, The Author(s).Analyzing antigen-specific T cell responses at scale has been challenging. Here, we analyze three types of T cell receptor (TCR) repertoire data (antigen-specific TCRs, TCR-repertoire, and single-cell RNA + TCRαβ-sequencing data) from 515 patients with primary or metastatic melanoma and compare it to 783 healthy controls. Although melanoma-associated antigen (MAA) -specific TCRs are restricted to individuals, they share sequence similarities that allow us to build classifiers for predicting anti-MAA T cells. The frequency of anti-MAA T cells distinguishes melanoma patients from healthy and predicts metastatic recurrence from primary melanoma. Anti-MAA T cells have stem-like properties and frequent interactions with regulatory T cells and tumor cells via Galectin9-TIM3 and PVR-TIGIT -axes, respectively. In the responding patients, the number of expanded anti-MAA clones are higher after the anti-PD1(+anti-CTLA4) therapy and the exhaustion phenotype is rescued. Our systems immunology approach paves the way for understanding antigen-specific responses in human disorders.Peer reviewe
A novel-type luciferin from Siberian luminous earthworm Fridericia heliota : structure elucidation by spectral studies and total synthesis
Get PDFAuthor Posting. © The Author(s), 2014. This is the author's version of the work. It is posted here by permission of Wiley-VCH Verlag GmbH & Co for personal use, not for redistribution. The definitive version was published in Angewandte Chemie International Edition 53 (2014): 5566–5568, doi:10.1002/anie.201400529.We report structure elucidation and synthesis of the luciferin from the recently discovered luminous earthworm Fridericia heliota. This luciferin represents a key component of a novel ATP-dependent bioluminescence system. The UV, fluorescence, NMR and HRMS spectral studies were performed on 5 mkg of the isolated substance, and gave four isomeric structures, conforming with spectral data. These isomers were chemically synthesized and one of them was found to produce light in the reaction with a protein extract from Fridericia. The novel luciferin was found to have an unusual deeply modified peptidic nature, implying an unprecedented mechanism of action.We acknowledge support from the Program of the Government of the Russian Federation “Measures to attract leading scientists to Russian educational institutions” (grant no. 11. G34.31.0058), the programs MCB RAS, President of the Russian Federation “Leading science school” (grant 3951.2012.4) and the Russian Foundation for Basic Research (grant 14-03-01015). B.M.S. was supported by a stipend from the Program of the President of the Russian Federation.2015-04-1
The Benefits of Being Economics Professor A (rather than Z)
Get PDFAlphabetical name ordering on multi-authored academic papers, which is the convention in economics and various other disciplines, is to the advantage of people whose last name initials are placed early in the alphabet. Professor A, who has been a first author more often than Professor Z, will have published more articles and experienced a faster productivity rate over the course of her career as a result of reputation and visibility. Authors know that name ordering matters and take ordering seriously. Several characteristics of an author-group composition determine the decision to deviate from the default alphabetical name order to a significant extent. Copyright (c) The London School of Economics and Political Science 2007.
"Rotterdam econometrics": publications of the econometric institute 1956-2005
Get PDFThis paper contains a list of all publications over the period 1956-2005, as reported in the Rotterdam Econometric Institute Reprint series during 1957-2005.
Dynamic magnetic properties of amorphous Fe80B20 thin films and their relation to interfaces
No full textThis paper was presented at the 64th Annual Conference on Magnetism and Magnetic Materials.We present a ferromagnetic resonance study of the dynamic properties of a set of amorphous Fe-B films deposited on Corning Glass® and MgO (001) substrates, either with or without capping. We show that the in plane anisotropy of the MgO grown films contains both uniaxial and biaxial components whereas it is just uniaxial for those grown on glass. The angular dependence of the linewidth strongly differs in terms of symmetry and magnitude depending on the substrate and capping. We discuss the role of the interfaces on the magnetization damping and the generation of the anisotropy. We obtained values of the intrinsic damping parameters comparable to the lowest ones reported for amorphous films of similar compositions. © 2020 Author(s).We thank the financial support by Spanish MINECO,
Grant Nos. MAT2013-47878-C2-R and MAT2016-80394-R. U.U.
acknowledges FPI grant BES-2014-070387. B.M.S.T. and N.A.S.
acknowledge financial support of the FCT of Portugal through the
Project No. I3N/FSCOSD (Ref. FCT UID/CTM/50025/2019) and
through the bursary PD/BD/113944/2015. N.A.S. was supported by
the Ministry of Education and Science of the Russian Federation in
the framework of the Increase Competitiveness Program of NUST
“MISiS” (no. K2-2019-015).Peer reviewe
