457 research outputs found
Read Poster Featuring Tracy Seeley
No full textRead poster featuring Tracy Seeley and her book: My ruby slippers : the road back to Kansashttps://repository.usfca.edu/read_gallery/1007/thumbnail.jp
John Robert Seeley, natural religion, and the Victorian conflict between science and religion
No full textThis essay examines the publishing and reception of J. R. Seeley’s Natural Religion (1882), a book that sought to bring about a reconciliation between science and religion. While Natural Religion has long been overlooked, it is argued that its reception gives us insight into changing views about the relationship between science and religion in the late Victorian period. The essay also explores how the reception of the book was conditioned by its bibliographic lineage as it was signed not by Seeley, but “by the Author of Ecce Homo.
Restructuring of the male mice peripheral circadian network after bariatric surgery
No full textBariatric surgery is still the most effective long-term weight-loss therapy. Recent data indicate that surgical outcomes may be affected by diurnal food intake patterns. In this study, we aimed to investigate how surgery-induced metabolic adaptations (i.e. weight loss) interact with circadian clock function. For that reason, vertical sleeve gastrectomy (VSG) was performed in obese mice and rhythms in behavior, tissue rhythmicity, and white adipose tissue transcriptome were evaluated. VSG under constant darkness conditions led to a maximum weight loss of 18% compared to a loss of 3% after sham surgery. Post-surgical weight development was characterized by two distinct intervals of catabolic and subsequent anabolic metabolic state. Locomotor activity was not affected. However, VSG significantly increased active phase meal frequency in the anabolic state. No significant effects on clock gene rhythmicity were detected in adrenal and white adipose tissue (WAT) explant cultures. Transcriptome rhythm analyses of subcutaneous WAT revealed a reduction of cycling genes after VSG (sham: 2493 vs VSG: 1013) independent of sustained rhythms in core clock gene expression. This may be a consequence of weight loss-induced morphological reconstruction of WAT that overwrites the direct influence of the local clock machinery on the transcriptome. However, VSG altered rhythmic transcriptional regulation of WAT lipid metabolism pathways. Thus, our data suggest a reorganization of diurnal metabolic rhythms after VSG downstream of the molecular clock machinery.Bariatric surgery is still the most effective long-term weight-loss therapy. Recent data indicate that surgical outcomes may be affected by diurnal food intake patterns. In this study, we aimed to investigate how surgery-induced metabolic adaptations (i.e. weight loss) interact with circadian clock function. For that reason, vertical sleeve gastrectomy (VSG) was performed in obese mice and rhythms in behavior, tissue rhythmicity, and white adipose tissue transcriptome were evaluated. VSG under constant darkness conditions led to a maximum weight loss of 18% compared to a loss of 3% after sham surgery. Post-surgical weight development was characterized by two distinct intervals of catabolic and subsequent anabolic metabolic state. Locomotor activity was not affected. However, VSG significantly increased active phase meal frequency in the anabolic state. No significant effects on clock gene rhythmicity were detected in adrenal and white adipose tissue (WAT) explant cultures. Transcriptome rhythm analyses of subcutaneous WAT revealed a reduction of cycling genes after VSG (sham: 2493 vs VSG: 1013) independent of sustained rhythms in core clock gene expression. This may be a consequence of weight loss-induced morphological reconstruction of WAT that overwrites the direct influence of the local clock machinery on the transcriptome. However, VSG altered rhythmic transcriptional regulation of WAT lipid metabolism pathways. Thus, our data suggest a reorganization of diurnal metabolic rhythms after VSG downstream of the molecular clock machinery
Communications Cerveau-Périphérie et Contrôle Métabolique / Brain-Periphery Communications in Metabolic Control
No full textSéminaire organisé par Gilles Mithieux (INSERM U855, Lyon, France) et Matthias Tschöp (Helmholtz Zentrum München, Institute for Diabetes and Obesity, Germany) du 16 au 21 avril 2018 Participants Sébastien Bouret, Jens C. Brüning, Marc Claret, Daniela Cota, Marcelo Dietrich, Ana Domingos, Christina Garcia Caceres, Lora Heisler, Gilles Mithieux, Richard Palmiter, Paul Pfluger, Elena Porro (Cell Press), Matthew Poy, Frank Reimann, Sonja C. Schriever, Randy Seeley, Maud Soty, Matthias Tschöp . Ré..
The general population cohort in rural south-western Uganda: a platform for communicable and non-communicable disease studies.
No full textThe General Population Cohort (GPC) was set up in 1989 to examine trends in HIV prevalence and incidence, and their determinants in rural south-western Uganda. Recently, the research questions have included the epidemiology and genetics of communicable and non-communicable diseases (NCDs) to address the limited data on the burden and risk factors for NCDs in sub-Saharan Africa. The cohort comprises all residents (52% aged ≥13years, men and women in equal proportions) within one-half of a rural sub-county, residing in scattered houses, and largely farmers of three major ethnic groups. Data collected through annual surveys include; mapping for spatial analysis and participant location; census for individual socio-demographic and household socioeconomic status assessment; and a medical survey for health, lifestyle and biophysical and blood measurements to ascertain disease outcomes and risk factors for selected participants. This cohort offers a rich platform to investigate the interplay between communicable diseases and NCDs. There is robust infrastructure for data management, sample processing and storage, and diverse expertise in epidemiology, social and basic sciences. For any data access enquiries you may contact the director, MRC/UVRI, Uganda Research Unit on AIDS by email to [email protected] or the corresponding author
Connections Volume 11, Number 1, Fall 2000
No full textFeatured articles:
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Satiation and satiety in the intraoral intake test
No full textThe intraoral intake test is a model of a meal in which a nutritive liquid stimulus is delivered directly into the mouth of a rat via indwelling intraoral cannulae. The amount consumed before the stimulus is rejected can be considered a measure of meal size. The intraoral intake test has three primary advantages over more traditional tests of meal size: (1) the rate at which the stimulus is ingested is under control of the experimenter, (2) the onset of the meal is under control of the experimenter, (3) by delivering the stimulus directly into the mouth, the test engages primarily the highly stereotyped consummatory phase of ingestion rather than the more varied appetitive phase. The first set of experiments exploits the experimenter controlled ingestion rate to demonstrate that rats defend a meal size goal in the face of changing meal durations. The second set of experiments exploits the experimenter controlled onset of the intraoral intake test to demonstrate that the period between meals when the rat is not usually eating masks a gradually increasing willingness to consume. Interestingly, the amount consumed during this interval appears to be under volumetric rather than caloric control. Finally, the last two experiments use the intraoral intake test to probe the ingestive competence of neurologically impaired rats which are aphagic and adipsic in traditional measures of intake. These experiments demonstrate that the caudal portion of the brainstem in isolation from the forebrain is capable of mediating the decrease in intake seen after stomach distention but not capable of responding to food deprivation or maintaining a constant daily intake
Treating Obesity Like a Tumor
No full textExpanding adipose tissue in obesity requires a great deal of angiogenesis to support increasing volumes of tissue. A growing body of evidence indicates that inhibiting these blood vessels can result in substantial weight loss, and now this has been demonstrated in nonhuman primates
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