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2. Genetic prothrombotic factors in children with otogenic lateral sinus thrombosis: five case reports
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Genetic prothrombotic factors in children with otogenic lateral sinus thrombosis: five case reports
Author(s): Zangari, P (Zangari, Paola)1; Messia, V (Messia, Virginia)1; Viccaro, M (Viccaro, Marika)2; Bottero, S (Bottero, Sergio)2; Randisi, F (Randisi, Francesco)3; Marsella, P (Marsella, Pasquale)2; Luciani, M (Luciani, Matteo)4; Locatelli, F (Locatelli, Franco)4
Source: BLOOD COAGULATION & FIBRINOLYSIS Volume: 23 Issue: 2 Pages: 158-163 DOI: 10.1097/MBC.0b013e328349cafb Published: MAR 2012
Times Cited: 0 (from Web of Science)
Cited References: 20 [ view related records ] Citation Map
Abstract: Lateral sinus thrombosis (LST) is an uncommon, but life-threatening complication of both acute and chronic otitis media. There is some evidence that acquired or hereditary prothrombotic disorders are risk factors for LST. The aim of this work was to evaluate the role of thrombotic screening, anticoagulant therapy or prophylaxis in patients with either acute or chronic otitis media and LST. The medical records of five children hospitalized at Pediatric Hospital Bambino Gesu of Rome because of acute or chronic otitis media complicated by mastoiditis and LST were reviewed. All children underwent laboratory workup for hypercoagulability. All the five children were found to be heterozygote for the C677T MTHFR mutation and a child presented also heterozygosity for factor V Leiden mutation. They have been successfully treated with anticoagulant therapy without sequels. Children with acute or chronic otitis media may have a prothrombotic tendency that becomes clinically evident because of the inflammatory state. Patients with a family and/or personal history of thrombosis and/or thrombophilic conditions need anticoagulant prophylaxis also in the absence of clear signs of LST. Treatment with low molecular weight is successful in patients with LST. Blood Coagul Fibrinolysis 23:158-163 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins
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No full textObjective: The purpose of this study was the introduction in clinical practice of the combined application of
traditional reconstructive surgery and intense pulsed light (IPL) for the restoration of a post-traumatic eyebrow
defect. Case: The authors present a case of surgical eyebrow reconstruction with an axial temporal hair-bearing
scalp island flap. A persistent localized erythema and a marked difference in hair density in comparison with the
contralateral one harmed the eventual surgical outcome. Results: A combined sequential treatment with IPL
achieved both hair density and skin erythema reduction, and eventually allowed for a very satisfactory result.
Conclusions: Our experience demonstrated the efficacy of the integrated multidisciplinary approach involving
traditional plastic reconstructive surgery and the innovative new technologies in aiming for perfectio
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