21,594 research outputs found

    Interplay between European regulation and national policies in biodiversity conflict reconciliation

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    Successful public conservation policies at various governmental levels have increased some populations of protected species to the extent that they are causing damage to human activities. As a reaction public authorities are developing biodiversity reconciliation policies. Finland and Germany have both created reconciliation policies including a package of measures like management of population, support of technical measures and compensation for damage. All these measures are affected by European policy and law, though no special reconciliation policy has been adopted at European level. This article explores the options European legislation offers and the restrictions it imposes on member states. Based on experiences with German and Finnish biodiversity reconciliation policies, the interrelationship between European and national regulation is elaborated, leading to suggestions for better coordination of reconciliation policies between different governmental levels. --Biodiversity conflict reconciliation,European regulation,fisheries and aquaculture,local damage management,nature conservation,policy instruments

    Protecting Animals 36: Author Witi Ihimaera

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    In this very special episode of Knowing Animals I am joined by beloved New Zealand author Witi Ihimaera. Witi has written many books featuring nonhuman animals. He offers us a non-colonial lens through which to think about the human/nonhuman relationship

    Verfolgte, Widerständige, Mitläuferinnen und Täterinnen: Marburger Frauen im Nationalsozialismus

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    Ausstellungskatalog zur Ausstellung “Verfolgte, Widerständige, Mitläuferinnen und Täterinnen: Marburger Frauen im Nationalsozialismus” Die Ausstellung „Marburger Frauen im Nationalsozialismus“ ist aus einem Seminar der Soziologin Randi Becker am Marburger Zentrum für Gender Studies und feministische Zukunftsforschung hervorgegangen: Studierende haben darin die Geschichten von 22 Marburger Frauen im Nationalsozialismus erforscht, darunter Verfolgte, Widerständige aber auch Täterinnern. Ihre Geschichten werden in der Ausstellung vorgestellt. Der Druck der Ausstellung wurde durch die freundliche Förderung des Fachbereichs Gleichstellung der Stadt Marburg unter der Leitung von Christine Amend-Wegmann, sowie der Frauen- und Gleichstellungsbeauftragten der Universität Marburg Dr. Nina Schumacher ermöglicht. Die Erstellung des Ausstellungskatalogs wurde durch die freundliche Förderung des Projekt-Fonds zur Antisemitismusprävention der Stabsstelle Antidiskriminierung und Diversität der Universität Marburg ermöglicht

    Pregnancy and oral contraceptives in congenital bleeding disorders of the vitamin K-dependent coagulation factors.

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    Pregnancies and deliveries represent important hemostatic challenges for congenital coagulation disorders. The same is true for the assumption of oral contraceptives. Available information mainly deals with von Willebrand's disease, factor XI (FXI) deficiency and carriers of hemophilia A. Data concerning patients with congenital prothrombin complex factor deficiencies are very scanty. In the present study, data of a total of 27 women are presented, 11 patients with homozygous or double heterozygous deficiencies of FII, FVII and FX, together with 16 cases of hemophilia B carriers. The patients with FII, FVII or FX defects had a total of 14 pregnancies and often needed transfusion therapy. Proper management resulted in a decrease in postpartum bleeding and satisfactory fetal outcome. Elective cesarean delivery seems indicated only in recent years. Carriers of hemophilia B had a total of 19 pregnancies but showed no bleeding and needed no substitutive therapy. Searching the literature, we discovered only 9 additional patients with prothrombin deficiency or FX deficiency, having a total of 16 pregnancies. On the contrary, there were at least 17 additional patients with FVII deficiency, with a total of 21 pregnancies. The management of the diseases has been variable, but in substantial agreement with the personal observations. Oral contraceptive therapy was administered in some of our patients and in a few additional cases described in the literature. Medication was always well tolerated and patients who took it for a long period of time showed a decrease in menometrorrhagia and an improvement in hematocrit levels. This led to a decrease in transfusional needs and to improved general conditions

    Thrombosis-free surgical procedures in severe (Homozygote) factor XII deficiency: report of four additional cases and literature review

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    The outcome of various surgical procedures carried out in patients with severe (homozygote) factor XII deficiency were investigated for the appearance of blood coagulation-related complications with particular emphasis on thrombotic complications. The surgical procedures were total mastectomy, tonsillectomy and adenoidectomy, placement of a hip prosthesis, and double hernia repair. None of the patients slowed any complication. Several other reported cases of surgical procedures carried out in several patients ware found in the literature. Bleeding or thrombotic complications were noted in none of these cases. The surgical procedures in some cases were minor such as adenoidectomy, tonsillectomy, or nasal polyp removal. However several major surgical procedures were carried out in some patients (cholecystectomy, gastrectomy, repair of atrial septal defect, coronary bypass). All patients remained asymptomatic. In some cases whole blood and/or plasma were used as requested by the caring surgeons. In a few patients, the plasma was given prophylactically because of the long partial thromboplastin time. Finally, three patients (two for cardiac surgery and one after hip replacement) received heparin prophylaxis as foreseen by accepted procedures without the undue sequels. These data supply further evidence that factor XII deficiency does not only show any bleeding tendency but also can withstand even major surgical procedures without thrombotic complications

    Hemostatic proteins gene polymorphisms in patients with unusal vein thrombosis and Ph-myeloproliferative disorders

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    The polymorphisms of FBG, F12 and GPIIIa do not determine an increased thrombotic risk in myeloproliferative disoredrs even if associated wuth JAK2 mutation and the development of spontaneous colony formatio

    The occasional venous thromboses seen in patients with severe (homozygous) FXII deficiency are probably due to associated risk factors: a study of prevalence in 21 patients and review of the literature.

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    According to our personal experience and to the study of the literature, 11 cases of venous thrombosis have been described as sporadic reports in patients with severe (homozygous) factor XII (FXII) deficiencies. In every cases but 4, associated risk factors were found to be present (pregnancy, post-partum period, surgery, trauma, in dwelling catheter, AT deficiency, heterozygous factor V Leiden, Burger's disease). In some instances more then one condition was present. The four patients for whom no information is supplied, were cases gathered from old and logically incomplete files and therefore the existence of associated risk factors cannot be excluded. The papers which investigated the presence of venous thrombosis in cohorts of patients with homoxygous FXII deficiency demonstrated the occurrence of venous thrombosis in 2 additional cases out of a total of 63 patients investigated. In these latter cases thrombosis occurred during pregnancy. This brings the total number of patients with FXII deficiency who showed a venous thrombosis to 13. Only a few of these patients were investigated for the presence of concomitant congenital prothrombotic conditions. The conclusion of the study seem to suggest that the role played by FXII deficiency in the pathogenesis of venous thrombosis is minor, if any

    Novel point mutation in a leucine-rich repeat of the GP1balfa chain of the platelet von Willebrand factor receptor, GP1b/IX/V, resulting in an inherited dominant form of Bernard-Soulier syndrome affecting two unrelated families: the N41H variant

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    In Italy, a significant proportion of patients with autosomal dominant inheritance of macrothrombocytopenia have been recognized as having heterozygous Bernard-Soulier syndrome carrying the Bolzano-type defect. This condition prompted a systematic review of our out-patients with chronic isolated macrothrombocytopenia. We recognized that the affected members of two unrelated families represented a new variant of heterozygous Bernard-Soulier Syndrome with autosomal dominant inheritance. Sequencing analysis of the GPIbalpha gene revealed a novel heterozygous mutation, A169C, resulting in an N41H substitution in the protein. This aminoacid belongs to the first leucine-rich repeat of the chain. The molecular modeling suggests that the replacement of the N41 with a histidine (N41H) drastically disturbs the structure of the first portion of GPIbalpha N-terminal, directly involved in von Willebrand factor binding. As a consequence, platelet aggregation to 1.2 mg/mL of ristocetin is slightly impaired and flow cytometry reveals a reduced binding of monoclonals directed against N-terminal epitopes of the GPIbalpha
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